Found 6 hits Enz. Inhib. hit(s) with all data for entry = 50000462 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50250844
(CHEMBL4070191)Show SMILES CN(Cc1ccc(cc1)C(F)(F)F)c1cc(ncn1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1 Show InChI InChI=1S/C25H27F3N6O/c1-32-11-13-34(14-12-32)21-9-7-20(8-10-21)31-24(35)22-15-23(30-17-29-22)33(2)16-18-3-5-19(6-4-18)25(26,27)28/h3-10,15,17H,11-14,16H2,1-2H3,(H,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description
Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assay |
J Med Chem 60: 10118-10134 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01347
BindingDB Entry DOI: 10.7270/Q2RR21P5 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50250842
(CHEMBL4088721)Show SMILES CN(Cc1ccc(cc1)C(F)(F)F)c1cc(ncn1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C20H17F3N4O/c1-27(12-14-7-9-15(10-8-14)20(21,22)23)18-11-17(24-13-25-18)19(28)26-16-5-3-2-4-6-16/h2-11,13H,12H2,1H3,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description
Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assay |
J Med Chem 60: 10118-10134 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01347
BindingDB Entry DOI: 10.7270/Q2RR21P5 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50250847
(CHEMBL4088719)Show SMILES CC(C)Oc1ccc(NC(=O)c2cc(ncn2)N(C)Cc2ccc(F)cc2)cc1 Show InChI InChI=1S/C22H23FN4O2/c1-15(2)29-19-10-8-18(9-11-19)26-22(28)20-12-21(25-14-24-20)27(3)13-16-4-6-17(23)7-5-16/h4-12,14-15H,13H2,1-3H3,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description
Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assay |
J Med Chem 60: 10118-10134 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01347
BindingDB Entry DOI: 10.7270/Q2RR21P5 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50250845
(CHEMBL4101551)Show InChI InChI=1S/C15H13FN6OS/c1-22(7-10-2-4-11(16)5-3-10)13-6-12(17-8-18-13)14(23)20-15-21-19-9-24-15/h2-6,8-9H,7H2,1H3,(H,20,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description
Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assay |
J Med Chem 60: 10118-10134 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01347
BindingDB Entry DOI: 10.7270/Q2RR21P5 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50250843
(CHEMBL4075071)Show SMILES CN(Cc1ccc(nc1)C(F)(F)F)c1cc(ncn1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C19H16F3N5O/c1-27(11-13-7-8-16(23-10-13)19(20,21)22)17-9-15(24-12-25-17)18(28)26-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description
Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assay |
J Med Chem 60: 10118-10134 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01347
BindingDB Entry DOI: 10.7270/Q2RR21P5 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50250846
(CHEMBL4083549)Show SMILES CN(Cc1ccc(nc1)C(F)(F)F)c1cc(ncn1)C(=O)Nc1nncs1 Show InChI InChI=1S/C15H12F3N7OS/c1-25(6-9-2-3-11(19-5-9)15(16,17)18)12-4-10(20-7-21-12)13(26)23-14-24-22-8-27-14/h2-5,7-8H,6H2,1H3,(H,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description
Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assay |
J Med Chem 60: 10118-10134 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01347
BindingDB Entry DOI: 10.7270/Q2RR21P5 |
More data for this
Ligand-Target Pair | |
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