Compile Data Set for Download or QSAR

Found 83 hits Enz. Inhib. hit(s) with all data for entry = 50001176   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271221 (CHEMBL3717769) Show SMILES [H][C@@]12CN(CC(F)F)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C19H22F5N5/c1-9(2)29-15(17-11-6-28(7-12(11)17)8-16(20)21)4-14(27-29)10-3-13(19(22,23)24)18(25)26-5-10/h3-5,9,11-12,16-17H,6-8H2,1-2H3,(H2,25,26)/t11-,12+,17+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271243 (CHEMBL3718344) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc2[nH]cc(c2c1)C(F)(F)F Show InChI InChI=1S/C22H26F3N5O/c1-13(2)30-20(14-3-5-29(6-4-14)16-11-31-12-16)8-19(28-30)15-7-17-18(22(23,24)25)10-27-21(17)26-9-15/h7-10,13-14,16H,3-6,11-12H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271208 (CHEMBL4128619) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC(C)C)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H26F3N5O/c1-11(2)6-29-18(19-14-7-28(8-15(14)19)13-9-30-10-13)4-17(27-29)12-3-16(21(22,23)24)20(25)26-5-12/h3-5,11,13-15,19H,6-10H2,1-2H3,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271207 (CHEMBL3719135) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C20H24F3N5O2/c1-10(2)28-16(18-13-6-27(7-14(13)18)12-8-29-9-12)4-15(26-28)11-3-17(19(24)25-5-11)30-20(21,22)23/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271233 (CHEMBL4129958) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C19H22F3N5O/c1-2-27-16(17-12-6-26(7-13(12)17)11-8-28-9-11)4-15(25-27)10-3-14(19(20,21)22)18(23)24-5-10/h3-5,11-13,17H,2,6-9H2,1H3,(H2,23,24)/t12-,13+,17+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271242 (CHEMBL4125721) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O2/c22-21(23,24)31-18-3-12(5-26-20(18)25)16-4-17(29(27-16)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271228 (CHEMBL4128889) Show SMILES [H][C@@]12CN(CC(C)O)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C20H26F3N5O/c1-10(2)28-17(18-13-8-27(7-11(3)29)9-14(13)18)5-16(26-28)12-4-15(20(21,22)23)19(24)25-6-12/h4-6,10-11,13-14,18,29H,7-9H2,1-3H3,(H2,24,25)/t11?,13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271241 (CHEMBL3718912) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc2[nH]cc(C)c2c1 Show InChI InChI=1S/C22H29N5O/c1-14(2)27-21(16-4-6-26(7-5-16)18-12-28-13-18)9-20(25-27)17-8-19-15(3)10-23-22(19)24-11-17/h8-11,14,16,18H,4-7,12-13H2,1-3H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271212 (CHEMBL3715238) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271219 (CHEMBL4125824) Show SMILES [H][C@@]12CN(CC3COC3)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C21H26F3N5O/c1-11(2)29-18(19-14-7-28(8-15(14)19)6-12-9-30-10-12)4-17(27-29)13-3-16(21(22,23)24)20(25)26-5-13/h3-5,11-12,14-15,19H,6-10H2,1-2H3,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271220 (CHEMBL3718265) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F)C(C)=O |r| Show InChI InChI=1S/C19H22F3N5O/c1-9(2)27-16(17-12-7-26(10(3)28)8-13(12)17)5-15(25-27)11-4-14(19(20,21)22)18(23)24-6-11/h4-6,9,12-13,17H,7-8H2,1-3H3,(H2,23,24)/t12-,13+,17+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271217 (CHEMBL3715469) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC)c1)C1COC1 |r| Show InChI InChI=1S/C20H27N5O2/c1-11(2)25-17(19-14-7-24(8-15(14)19)13-9-27-10-13)5-16(23-25)12-4-18(26-3)20(21)22-6-12/h4-6,11,13-15,19H,7-10H2,1-3H3,(H2,21,22)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271258 (CHEMBL3717481) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C20H24F3N5O/c1-10(2)28-17(18-13-6-27(7-14(13)18)12-8-29-9-12)4-16(26-28)11-3-15(20(21,22)23)19(24)25-5-11/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271218 (CHEMBL3714987) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C20H25F2N5O2/c1-10(2)27-16(18-13-6-26(7-14(13)18)12-8-28-9-12)4-15(25-27)11-3-17(29-20(21)22)19(23)24-5-11/h3-5,10,12-14,18,20H,6-9H2,1-2H3,(H2,23,24)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271211 (CHEMBL4128477) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CCCC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C23H28F3N5O/c24-23(25,26)18-5-14(7-28-22(18)27)19-6-20(31(29-19)8-13-3-1-2-4-13)21-16-9-30(10-17(16)21)15-11-32-12-15/h5-7,13,15-17,21H,1-4,8-12H2,(H2,27,28)/t16-,17+,21+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271227 (CHEMBL3716231) Show SMILES [H][C@@]12CN(CCOC)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C20H26F3N5O/c1-11(2)28-17(18-13-9-27(4-5-29-3)10-14(13)18)7-16(26-28)12-6-15(20(21,22)23)19(24)25-8-12/h6-8,11,13-14,18H,4-5,9-10H2,1-3H3,(H2,24,25)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271210 (CHEMBL3714822) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CCC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C22H26F3N5O/c23-22(24,25)17-4-13(6-27-21(17)26)18-5-19(30(28-18)7-12-2-1-3-12)20-15-8-29(9-16(15)20)14-10-31-11-14/h4-6,12,14-16,20H,1-3,7-11H2,(H2,26,27)/t15-,16+,20+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271230 (CHEMBL3716456) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc2[nH]cc(Cl)c2c1 Show InChI InChI=1S/C21H26ClN5O/c1-13(2)27-20(14-3-5-26(6-4-14)16-11-28-12-16)8-19(25-27)15-7-17-18(22)10-24-21(17)23-9-15/h7-10,13-14,16H,3-6,11-12H2,1-2H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271240 (CHEMBL3718522) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC(F)(F)F)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C19H19F6N5O/c20-18(21,22)8-30-15(16-11-4-29(5-12(11)16)10-6-31-7-10)2-14(28-30)9-1-13(19(23,24)25)17(26)27-3-9/h1-3,10-12,16H,4-8H2,(H2,26,27)/t11-,12+,16+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271209 (CHEMBL4127238) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC(C)(C)O)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H26F3N5O2/c1-20(2,30)10-29-17(18-13-6-28(7-14(13)18)12-8-31-9-12)4-16(27-29)11-3-15(21(22,23)24)19(25)26-5-11/h3-5,12-14,18,30H,6-10H2,1-2H3,(H2,25,26)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271216 (CHEMBL3717627) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)F)C1COC1 |r| Show InChI InChI=1S/C20H25F2N5O/c1-10(2)27-17(18-14-6-26(7-15(14)18)12-8-28-9-12)4-16(25-27)11-3-13(19(21)22)20(23)24-5-11/h3-5,10,12,14-15,18-19H,6-9H2,1-2H3,(H2,23,24)/t14-,15+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271232 (CHEMBL4127922) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C18H20F3N5O2/c1-25-14(16-11-5-26(6-12(11)16)10-7-27-8-10)3-13(24-25)9-2-15(17(22)23-4-9)28-18(19,20)21/h2-4,10-12,16H,5-8H2,1H3,(H2,22,23)/t11-,12+,16+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	67	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271231 (CHEMBL4126530) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C18H20F3N5O/c1-25-15(16-11-5-26(6-12(11)16)10-7-27-8-10)3-14(24-25)9-2-13(18(19,20)21)17(22)23-4-9/h2-4,10-12,16H,5-8H2,1H3,(H2,22,23)/t11-,12+,16+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	82	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271229 (CHEMBL3719209) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc2[nH]cc(F)c2c1 Show InChI InChI=1S/C21H26FN5O/c1-13(2)27-20(14-3-5-26(6-4-14)16-11-28-12-16)8-19(25-27)15-7-17-18(22)10-24-21(17)23-9-15/h7-10,13-14,16H,3-6,11-12H2,1-2H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	96	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271244 (CHEMBL3715637) Show SMILES COc1cc(cnc1N)-c1cc(C2CCN(CC2)C2COC2)n(n1)C(C)C Show InChI InChI=1S/C20H29N5O2/c1-13(2)25-18(14-4-6-24(7-5-14)16-11-27-12-16)9-17(23-25)15-8-19(26-3)20(21)22-10-15/h8-10,13-14,16H,4-7,11-12H2,1-3H3,(H2,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	142	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271249 (CHEMBL3719126) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C20H26F3N5O/c1-12(2)28-18(13-3-5-27(6-4-13)15-10-29-11-15)8-17(26-28)14-7-16(20(21,22)23)19(24)25-9-14/h7-9,12-13,15H,3-6,10-11H2,1-2H3,(H2,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	154	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271256 (CHEMBL3718750) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc(N)c(Cl)c1 Show InChI InChI=1S/C19H26ClN5O/c1-12(2)25-18(13-3-5-24(6-4-13)15-10-26-11-15)8-17(23-25)14-7-16(20)19(21)22-9-14/h7-9,12-13,15H,3-6,10-11H2,1-2H3,(H2,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271250 (CHEMBL3718894) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc(N)c(C)c1 Show InChI InChI=1S/C20H29N5O/c1-13(2)25-19(15-4-6-24(7-5-15)17-11-26-12-17)9-18(23-25)16-8-14(3)20(21)22-10-16/h8-10,13,15,17H,4-7,11-12H2,1-3H3,(H2,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271208 (CHEMBL4128619) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC(C)C)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H26F3N5O/c1-11(2)6-29-18(19-14-7-28(8-15(14)19)13-9-30-10-13)4-17(27-29)12-3-16(21(22,23)24)20(25)26-5-12/h3-5,11,13-15,19H,6-10H2,1-2H3,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271207 (CHEMBL3719135) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C20H24F3N5O2/c1-10(2)28-16(18-13-6-27(7-14(13)18)12-8-29-9-12)4-15(26-28)11-3-17(19(24)25-5-11)30-20(21,22)23/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs in presence of 10% bovine ser...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271212 (CHEMBL3715238) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271240 (CHEMBL3718522) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC(F)(F)F)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C19H19F6N5O/c20-18(21,22)8-30-15(16-11-4-29(5-12(11)16)10-6-31-7-10)2-14(28-30)9-1-13(19(23,24)25)17(26)27-3-9/h1-3,10-12,16H,4-8H2,(H2,26,27)/t11-,12+,16+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271207 (CHEMBL3719135) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C20H24F3N5O2/c1-10(2)28-16(18-13-6-27(7-14(13)18)12-8-29-9-12)4-15(26-28)11-3-17(19(24)25-5-11)30-20(21,22)23/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271211 (CHEMBL4128477) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CCCC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C23H28F3N5O/c24-23(25,26)18-5-14(7-28-22(18)27)19-6-20(31(29-19)8-13-3-1-2-4-13)21-16-9-30(10-17(16)21)15-11-32-12-15/h5-7,13,15-17,21H,1-4,8-12H2,(H2,27,28)/t16-,17+,21+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	202	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271228 (CHEMBL4128889) Show SMILES [H][C@@]12CN(CC(C)O)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C20H26F3N5O/c1-10(2)28-17(18-13-8-27(7-11(3)29)9-14(13)18)5-16(26-28)12-4-15(20(21,22)23)19(24)25-6-12/h4-6,10-11,13-14,18,29H,7-9H2,1-3H3,(H2,24,25)/t11?,13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	208	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271210 (CHEMBL3714822) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CCC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C22H26F3N5O/c23-22(24,25)17-4-13(6-27-21(17)26)18-5-19(30(28-18)7-12-2-1-3-12)20-15-8-29(9-16(15)20)14-10-31-11-14/h4-6,12,14-16,20H,1-3,7-11H2,(H2,26,27)/t15-,16+,20+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50271212 (CHEMBL3715238) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged human FLT3 cytoplasmic domain expressed in baculovirus expression system by FRET assay				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271258 (CHEMBL3717481) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C20H24F3N5O/c1-10(2)28-17(18-13-6-27(7-14(13)18)12-8-29-9-12)4-16(26-28)11-3-15(20(21,22)23)19(24)25-5-11/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271227 (CHEMBL3716231) Show SMILES [H][C@@]12CN(CCOC)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C20H26F3N5O/c1-11(2)28-17(18-13-9-27(4-5-29-3)10-14(13)18)7-16(26-28)12-6-15(20(21,22)23)19(24)25-8-12/h6-8,11,13-14,18H,4-5,9-10H2,1-3H3,(H2,24,25)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	265	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271219 (CHEMBL4125824) Show SMILES [H][C@@]12CN(CC3COC3)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C21H26F3N5O/c1-11(2)29-18(19-14-7-28(8-15(14)19)6-12-9-30-10-12)4-17(27-29)13-3-16(21(22,23)24)20(25)26-5-13/h3-5,11-12,14-15,19H,6-10H2,1-2H3,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	274	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271220 (CHEMBL3718265) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F)C(C)=O |r| Show InChI InChI=1S/C19H22F3N5O/c1-9(2)27-16(17-12-7-26(10(3)28)8-13(12)17)5-15(25-27)11-4-14(19(20,21)22)18(23)24-6-11/h4-6,9,12-13,17H,7-8H2,1-3H3,(H2,23,24)/t12-,13+,17+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	302	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271241 (CHEMBL3718912) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc2[nH]cc(C)c2c1 Show InChI InChI=1S/C22H29N5O/c1-14(2)27-21(16-4-6-26(7-5-16)18-12-28-13-18)9-20(25-27)17-8-19-15(3)10-23-22(19)24-11-17/h8-11,14,16,18H,4-7,12-13H2,1-3H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	303	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271242 (CHEMBL4125721) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O2/c22-21(23,24)31-18-3-12(5-26-20(18)25)16-4-17(29(27-16)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	304	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271218 (CHEMBL3714987) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C20H25F2N5O2/c1-10(2)27-16(18-13-6-26(7-14(13)18)12-8-28-9-12)4-15(25-27)11-3-17(29-20(21)22)19(23)24-5-11/h3-5,10,12-14,18,20H,6-9H2,1-2H3,(H2,23,24)/t13-,14+,18+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	328	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50271212 (CHEMBL3715238) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged human TrkA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system by FRET assay				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271233 (CHEMBL4129958) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C19H22F3N5O/c1-2-27-16(17-12-6-26(7-13(12)17)11-8-28-9-11)4-15(25-27)10-3-14(19(20,21)22)18(23)24-5-10/h3-5,11-13,17H,2,6-9H2,1H3,(H2,23,24)/t12-,13+,17+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	406	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50271212 (CHEMBL3715238) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	448	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged human AXL (473 to end residues) cytoplasmic domain expressed in insect cells by FRET assay				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271243 (CHEMBL3718344) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc2[nH]cc(c2c1)C(F)(F)F Show InChI InChI=1S/C22H26F3N5O/c1-13(2)30-20(14-3-5-29(6-4-14)16-11-31-12-16)8-19(28-30)15-7-17-18(22(23,24)25)10-27-21(17)26-9-15/h7-10,13-14,16H,3-6,11-12H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	485	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271230 (CHEMBL3716456) Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc2[nH]cc(Cl)c2c1 Show InChI InChI=1S/C21H26ClN5O/c1-13(2)27-20(14-3-5-26(6-4-14)16-11-28-12-16)8-19(25-27)15-7-17-18(22)10-24-21(17)23-9-15/h7-10,13-14,16H,3-6,11-12H2,1-2H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	574	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271221 (CHEMBL3717769) Show SMILES [H][C@@]12CN(CC(F)F)C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C19H22F5N5/c1-9(2)29-15(17-11-6-28(7-12(11)17)8-16(20)21)4-14(27-29)10-3-13(19(22,23)24)18(25)26-5-10/h3-5,9,11-12,16-17H,6-8H2,1-2H3,(H2,25,26)/t11-,12+,17+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	611	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 83 total )  |  Next  |  Last  >>

Jump to: