Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50451276 (CHEMBL4217987) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT6 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50451275 (CHEMBL4205716) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT6 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50451274 (CHEMBL4206619) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT6 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50017342 (CHEMBL1588664) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT6 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human)) | BDBM50451276 (CHEMBL4217987) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT2 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50451276 (CHEMBL4217987) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.24E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT1 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human)) | BDBM50451274 (CHEMBL4206619) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.53E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT2 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human)) | BDBM50451275 (CHEMBL4205716) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.82E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT2 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50451275 (CHEMBL4205716) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.99E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT1 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human)) | BDBM50017342 (CHEMBL1588664) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.51E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT2 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50451274 (CHEMBL4206619) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.83E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT1 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50017342 (CHEMBL1588664) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.58E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT1 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat... | Bioorg Med Chem 25: 5849-5858 (2017) Article DOI: 10.1016/j.bmc.2017.09.023 BindingDB Entry DOI: 10.7270/Q26Q20T7 | |||||||||||
More data for this Ligand-Target Pair |