Found 6 hits Enz. Inhib. hit(s) with all data for entry = 50002911 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
MHC class II antigen
(Homo sapiens (Human)) | BDBM50464580
(CHEMBL4277461)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(O)=O)C(C)C)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C76H124N22O21/c1-12-40(10)59(70(113)92-58(39(8)9)69(112)94-60(41(11)99)74(117)97-28-16-20-50(97)64(107)85-44(75(118)119)18-13-25-83-76(80)81)93-63(106)46(32-53(78)100)86-62(105)45(30-36(2)3)87-65(108)49-19-15-27-96(49)73(116)52-22-17-29-98(52)71(114)47(31-42-34-82-35-84-42)89-67(110)56(37(4)5)91-68(111)57(38(6)7)90-66(109)51-21-14-26-95(51)72(115)48(33-54(79)101)88-61(104)43(77)23-24-55(102)103/h34-41,43-52,56-60,99H,12-33,77H2,1-11H3,(H2,78,100)(H2,79,101)(H,82,84)(H,85,107)(H,86,105)(H,87,108)(H,88,104)(H,89,110)(H,90,109)(H,91,111)(H,92,113)(H,93,106)(H,94,112)(H,102,103)(H,118,119)(H4,80,81,83)/t40-,41+,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,56-,57-,58-,59-,60-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Patras
Curated by ChEMBL
| Assay Description
Inhibition of biotin-labeled MBP (85 to 99 residues) binding to HLA class 2 DRB1*1501 mutant allele after 2 hrs by TMB + substrate-chromogen based as... |
Eur J Med Chem 143: 621-631 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.063
BindingDB Entry DOI: 10.7270/Q2NP273D |
More data for this
Ligand-Target Pair | |
MHC class II antigen
(Homo sapiens (Human)) | BDBM50464582
(CHEMBL4284706)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CCCCCN)C(C)C)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C82H135N23O22/c1-12-45(10)65(76(121)99-64(44(8)9)75(120)101-66(46(11)106)80(125)104-33-19-23-55(104)70(115)92-49(81(126)127)21-16-30-89-82(86)87)100-69(114)51(37-58(84)107)93-68(113)50(35-41(2)3)94-71(116)54-22-18-32-103(54)79(124)57-25-20-34-105(57)77(122)52(36-47-39-88-40-90-47)96-73(118)62(42(4)5)98-74(119)63(43(6)7)97-72(117)56-24-17-31-102(56)78(123)53(38-59(85)108)95-67(112)48(27-28-61(110)111)91-60(109)26-14-13-15-29-83/h39-46,48-57,62-66,106H,12-38,83H2,1-11H3,(H2,84,107)(H2,85,108)(H,88,90)(H,91,109)(H,92,115)(H,93,113)(H,94,116)(H,95,112)(H,96,118)(H,97,117)(H,98,119)(H,99,121)(H,100,114)(H,101,120)(H,110,111)(H,126,127)(H4,86,87,89)/t45-,46+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,62-,63-,64-,65-,66-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Patras
Curated by ChEMBL
| Assay Description
Inhibition of biotin-labeled MBP (85 to 99 residues) binding to HLA class 2 DRB1*1501 mutant allele after 2 hrs by TMB + substrate-chromogen based as... |
Eur J Med Chem 143: 621-631 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.063
BindingDB Entry DOI: 10.7270/Q2NP273D |
More data for this
Ligand-Target Pair | |
MHC class II antigen
(Homo sapiens (Human)) | BDBM50464581
(CHEMBL4292594)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CCCCCNC(=O)CCSSCC(=O)NCCCCNc1ccc(O)c2C(=O)c3ccccc3C(=O)c12)C(C)C)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C105H157N25O27S2/c1-12-58(10)86(99(151)124-85(57(8)9)98(150)126-87(59(11)131)103(155)129-44-23-29-71(129)93(145)117-65(104(156)157)27-20-41-114-105(108)109)125-92(144)67(49-75(106)133)118-91(143)66(47-54(2)3)119-94(146)70-28-22-43-128(70)102(154)73-31-24-45-130(73)100(152)68(48-60-51-110-53-115-60)121-96(148)83(55(4)5)123-97(149)84(56(6)7)122-95(147)72-30-21-42-127(72)101(153)69(50-76(107)134)120-90(142)64(34-36-80(138)139)116-78(136)32-14-13-17-39-112-77(135)37-46-158-159-52-79(137)113-40-19-18-38-111-63-33-35-74(132)82-81(63)88(140)61-25-15-16-26-62(61)89(82)141/h15-16,25-26,33,35,51,53-59,64-73,83-87,111,131-132H,12-14,17-24,27-32,34,36-50,52H2,1-11H3,(H2,106,133)(H2,107,134)(H,110,115)(H,112,135)(H,113,137)(H,116,136)(H,117,145)(H,118,143)(H,119,146)(H,120,142)(H,121,148)(H,122,147)(H,123,149)(H,124,151)(H,125,144)(H,126,150)(H,138,139)(H,156,157)(H4,108,109,114)/t58-,59+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,83-,84-,85-,86-,87-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Patras
Curated by ChEMBL
| Assay Description
Inhibition of biotin-labeled MBP (85 to 99 residues) binding to HLA class 2 DRB1*1501 mutant allele after 2 hrs by TMB + substrate-chromogen based as... |
Eur J Med Chem 143: 621-631 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.063
BindingDB Entry DOI: 10.7270/Q2NP273D |
More data for this
Ligand-Target Pair | |
MHC class II antigen
(Homo sapiens (Human)) | BDBM50464580
(CHEMBL4277461)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(O)=O)C(C)C)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C76H124N22O21/c1-12-40(10)59(70(113)92-58(39(8)9)69(112)94-60(41(11)99)74(117)97-28-16-20-50(97)64(107)85-44(75(118)119)18-13-25-83-76(80)81)93-63(106)46(32-53(78)100)86-62(105)45(30-36(2)3)87-65(108)49-19-15-27-96(49)73(116)52-22-17-29-98(52)71(114)47(31-42-34-82-35-84-42)89-67(110)56(37(4)5)91-68(111)57(38(6)7)90-66(109)51-21-14-26-95(51)72(115)48(33-54(79)101)88-61(104)43(77)23-24-55(102)103/h34-41,43-52,56-60,99H,12-33,77H2,1-11H3,(H2,78,100)(H2,79,101)(H,82,84)(H,85,107)(H,86,105)(H,87,108)(H,88,104)(H,89,110)(H,90,109)(H,91,111)(H,92,113)(H,93,106)(H,94,112)(H,102,103)(H,118,119)(H4,80,81,83)/t40-,41+,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,56-,57-,58-,59-,60-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Patras
Curated by ChEMBL
| Assay Description
Inhibition of biotin-labeled MBP (85 to 99 residues) binding to HLA class 2 DRB1*0101 mutant allele after 2 hrs by TMB + substrate-chromogen based as... |
Eur J Med Chem 143: 621-631 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.063
BindingDB Entry DOI: 10.7270/Q2NP273D |
More data for this
Ligand-Target Pair | |
MHC class II antigen
(Homo sapiens (Human)) | BDBM50464582
(CHEMBL4284706)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CCCCCN)C(C)C)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C82H135N23O22/c1-12-45(10)65(76(121)99-64(44(8)9)75(120)101-66(46(11)106)80(125)104-33-19-23-55(104)70(115)92-49(81(126)127)21-16-30-89-82(86)87)100-69(114)51(37-58(84)107)93-68(113)50(35-41(2)3)94-71(116)54-22-18-32-103(54)79(124)57-25-20-34-105(57)77(122)52(36-47-39-88-40-90-47)96-73(118)62(42(4)5)98-74(119)63(43(6)7)97-72(117)56-24-17-31-102(56)78(123)53(38-59(85)108)95-67(112)48(27-28-61(110)111)91-60(109)26-14-13-15-29-83/h39-46,48-57,62-66,106H,12-38,83H2,1-11H3,(H2,84,107)(H2,85,108)(H,88,90)(H,91,109)(H,92,115)(H,93,113)(H,94,116)(H,95,112)(H,96,118)(H,97,117)(H,98,119)(H,99,121)(H,100,114)(H,101,120)(H,110,111)(H,126,127)(H4,86,87,89)/t45-,46+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,62-,63-,64-,65-,66-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 355 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Patras
Curated by ChEMBL
| Assay Description
Inhibition of biotin-labeled MBP (85 to 99 residues) binding to HLA class 2 DRB1*0101 mutant allele after 2 hrs by TMB + substrate-chromogen based as... |
Eur J Med Chem 143: 621-631 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.063
BindingDB Entry DOI: 10.7270/Q2NP273D |
More data for this
Ligand-Target Pair | |
MHC class II antigen
(Homo sapiens (Human)) | BDBM50464581
(CHEMBL4292594)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CCCCCNC(=O)CCSSCC(=O)NCCCCNc1ccc(O)c2C(=O)c3ccccc3C(=O)c12)C(C)C)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C105H157N25O27S2/c1-12-58(10)86(99(151)124-85(57(8)9)98(150)126-87(59(11)131)103(155)129-44-23-29-71(129)93(145)117-65(104(156)157)27-20-41-114-105(108)109)125-92(144)67(49-75(106)133)118-91(143)66(47-54(2)3)119-94(146)70-28-22-43-128(70)102(154)73-31-24-45-130(73)100(152)68(48-60-51-110-53-115-60)121-96(148)83(55(4)5)123-97(149)84(56(6)7)122-95(147)72-30-21-42-127(72)101(153)69(50-76(107)134)120-90(142)64(34-36-80(138)139)116-78(136)32-14-13-17-39-112-77(135)37-46-158-159-52-79(137)113-40-19-18-38-111-63-33-35-74(132)82-81(63)88(140)61-25-15-16-26-62(61)89(82)141/h15-16,25-26,33,35,51,53-59,64-73,83-87,111,131-132H,12-14,17-24,27-32,34,36-50,52H2,1-11H3,(H2,106,133)(H2,107,134)(H,110,115)(H,112,135)(H,113,137)(H,116,136)(H,117,145)(H,118,143)(H,119,146)(H,120,142)(H,121,148)(H,122,147)(H,123,149)(H,124,151)(H,125,144)(H,126,150)(H,138,139)(H,156,157)(H4,108,109,114)/t58-,59+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,83-,84-,85-,86-,87-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Patras
Curated by ChEMBL
| Assay Description
Inhibition of biotin-labeled MBP (85 to 99 residues) binding to HLA class 2 DRB1*0101 mutant allele after 2 hrs by TMB + substrate-chromogen based as... |
Eur J Med Chem 143: 621-631 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.063
BindingDB Entry DOI: 10.7270/Q2NP273D |
More data for this
Ligand-Target Pair | |
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