Found 41 hits Enz. Inhib. hit(s) with all data for entry = 50003636 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474160
(CHEMBL61699)Show SMILES COc1ccc(cc1OC)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:39,t:11,26| Show InChI InChI=1S/C31H36N4O5/c1-20-18-28(36)32-33-29(20)21-10-13-23(14-11-21)40-17-7-6-16-35-31(37)25-9-5-4-8-24(25)30(34-35)22-12-15-26(38-2)27(19-22)39-3/h4-5,10-15,19-20,24-25H,6-9,16-18H2,1-3H3,(H,32,36) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474164
(CHEMBL304715)Show SMILES CCOc1ccc(cc1OCC)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:41,t:13,28| Show InChI InChI=1S/C33H40N4O5/c1-4-40-28-17-14-24(21-29(28)41-5-2)32-26-10-6-7-11-27(26)33(39)37(36-32)18-8-9-19-42-25-15-12-23(13-16-25)31-22(3)20-30(38)34-35-31/h6-7,12-17,21-22,26-27H,4-5,8-11,18-20H2,1-3H3,(H,34,38) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474165
(CHEMBL60026)Show SMILES COc1ccc(cc1OC)C1=NN(CC(=O)Nc2cccc(c2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:38,t:11,25| Show InChI InChI=1S/C29H31N5O5/c1-17-13-25(35)31-32-27(17)18-7-6-8-20(14-18)30-26(36)16-34-29(37)22-10-5-4-9-21(22)28(33-34)19-11-12-23(38-2)24(15-19)39-3/h4-8,11-12,14-15,17,21-22H,9-10,13,16H2,1-3H3,(H,30,36)(H,31,35) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474171
(CHEMBL62131)Show SMILES COc1ccc(cc1OC)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:18,t:11,31| Show InChI InChI=1S/C27H28N4O4/c1-16-14-24(32)28-29-25(16)17-8-11-19(12-9-17)31-27(33)21-7-5-4-6-20(21)26(30-31)18-10-13-22(34-2)23(15-18)35-3/h4-5,8-13,15-16,20-21H,6-7,14H2,1-3H3,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474161
(CHEMBL64824)Show SMILES COc1ccc(cc1OC)C1=NN(CC(=O)Nc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:38,t:11,25| Show InChI InChI=1S/C29H31N5O5/c1-17-14-25(35)31-32-27(17)18-8-11-20(12-9-18)30-26(36)16-34-29(37)22-7-5-4-6-21(22)28(33-34)19-10-13-23(38-2)24(15-19)39-3/h4-5,8-13,15,17,21-22H,6-7,14,16H2,1-3H3,(H,30,36)(H,31,35) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474163
(CHEMBL64544)Show SMILES COc1ccc(cc1OC)C1=NN(CCCCC(=O)Nc2ccc(cc2)-c2ccc(O)nn2)C(=O)C2CC=CCC12 |c:40,t:11| Show InChI InChI=1S/C31H33N5O5/c1-40-26-16-12-21(19-27(26)41-2)30-23-7-3-4-8-24(23)31(39)36(35-30)18-6-5-9-28(37)32-22-13-10-20(11-14-22)25-15-17-29(38)34-33-25/h3-4,10-17,19,23-24H,5-9,18H2,1-2H3,(H,32,37)(H,34,38) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474159
(CHEMBL64052)Show SMILES COc1ccc(cc1OC)C1=NN(CCCCC(=O)Nc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:41,t:11,28| Show InChI InChI=1S/C32H37N5O5/c1-20-18-29(39)34-35-30(20)21-11-14-23(15-12-21)33-28(38)10-6-7-17-37-32(40)25-9-5-4-8-24(25)31(36-37)22-13-16-26(41-2)27(19-22)42-3/h4-5,11-16,19-20,24-25H,6-10,17-18H2,1-3H3,(H,33,38)(H,34,39) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474162
(CHEMBL59953)Show SMILES COc1ccc(cc1OC)C1=NN(CC(=O)Nc2ccc(cc2)-c2ccc(O)nn2)C(=O)C2CC=CCC12 |c:37,t:11| Show InChI InChI=1S/C28H27N5O5/c1-37-23-13-9-18(15-24(23)38-2)27-20-5-3-4-6-21(20)28(36)33(32-27)16-26(35)29-19-10-7-17(8-11-19)22-12-14-25(34)31-30-22/h3-4,7-15,20-21H,5-6,16H2,1-2H3,(H,29,35)(H,31,34) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474157
(CHEMBL293589)Show SMILES CCOc1ccc(cc1OCC)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:20,t:13,33| Show InChI InChI=1S/C29H32N4O4/c1-4-36-24-15-12-20(17-25(24)37-5-2)28-22-8-6-7-9-23(22)29(35)33(32-28)21-13-10-19(11-14-21)27-18(3)16-26(34)30-31-27/h6-7,10-15,17-18,22-23H,4-5,8-9,16H2,1-3H3,(H,30,34) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474168
(CHEMBL294327)Show SMILES COc1ccc(cc1OC)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)-c1ccc(O)nn1 |c:18,t:11| Show InChI InChI=1S/C26H24N4O4/c1-33-22-13-9-17(15-23(22)34-2)25-19-5-3-4-6-20(19)26(32)30(29-25)18-10-7-16(8-11-18)21-12-14-24(31)28-27-21/h3-4,7-15,19-20H,5-6H2,1-2H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50228247
(CHEMBL38017 | LY-197055)Show SMILES CC1CC(=O)NN=C1c1ccc2NC(=O)C(C)(C)c2c1 |c:6| Show InChI InChI=1S/C15H17N3O2/c1-8-6-12(19)17-18-13(8)9-4-5-11-10(7-9)15(2,3)14(20)16-11/h4-5,7-8H,6H2,1-3H3,(H,16,20)(H,17,19) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474154
(CHEMBL60839)Show SMILES COc1ccc(cc1OC)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:18,t:11| Show InChI InChI=1S/C22H22N2O3/c1-26-19-13-12-15(14-20(19)27-2)21-17-10-6-7-11-18(17)22(25)24(23-21)16-8-4-3-5-9-16/h3-9,12-14,17-18H,10-11H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474166
(CHEMBL60999)Show SMILES COc1ccc(cc1OC1CCCC1)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:23,t:16| Show InChI InChI=1S/C26H28N2O3/c1-30-23-16-15-18(17-24(23)31-20-11-5-6-12-20)25-21-13-7-8-14-22(21)26(29)28(27-25)19-9-3-2-4-10-19/h2-4,7-10,15-17,20-22H,5-6,11-14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474167
(CHEMBL61822)Show SMILES COc1ccc(cc1OC1CCCC1)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:23,t:16,36| Show InChI InChI=1S/C31H34N4O4/c1-19-17-28(36)32-33-29(19)20-11-14-22(15-12-20)35-31(37)25-10-6-5-9-24(25)30(34-35)21-13-16-26(38-2)27(18-21)39-23-7-3-4-8-23/h5-6,11-16,18-19,23-25H,3-4,7-10,17H2,1-2H3,(H,32,36) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474155
(CHEMBL61116)Show SMILES COc1ccc(cc1Cl)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:38,t:10,25| Show InChI InChI=1S/C30H33ClN4O4/c1-19-17-27(36)32-33-28(19)20-9-12-22(13-10-20)39-16-6-5-15-35-30(37)24-8-4-3-7-23(24)29(34-35)21-11-14-26(38-2)25(31)18-21/h3-4,9-14,18-19,23-24H,5-8,15-17H2,1-2H3,(H,32,36) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474170
(CHEMBL303550)Show SMILES CCOc1ccc(cc1OCC)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:20,t:13| Show InChI InChI=1S/C24H26N2O3/c1-3-28-21-15-14-17(16-22(21)29-4-2)23-19-12-8-9-13-20(19)24(27)26(25-23)18-10-6-5-7-11-18/h5-11,14-16,19-20H,3-4,12-13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474155
(CHEMBL61116)Show SMILES COc1ccc(cc1Cl)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:38,t:10,25| Show InChI InChI=1S/C30H33ClN4O4/c1-19-17-27(36)32-33-28(19)20-9-12-22(13-10-20)39-16-6-5-15-35-30(37)24-8-4-3-7-23(24)29(34-35)21-11-14-26(38-2)25(31)18-21/h3-4,9-14,18-19,23-24H,5-8,15-17H2,1-2H3,(H,32,36) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474158
(CHEMBL61667)Show SMILES COc1ccc(cc1Cl)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:17,t:10,30| Show InChI InChI=1S/C26H25ClN4O3/c1-15-13-23(32)28-29-24(15)16-7-10-18(11-8-16)31-26(33)20-6-4-3-5-19(20)25(30-31)17-9-12-22(34-2)21(27)14-17/h3-4,7-12,14-15,19-20H,5-6,13H2,1-2H3,(H,28,32) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474156
(CHEMBL59996)Show SMILES COc1ccc(cc1Cl)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:17,t:10| Show InChI InChI=1S/C21H19ClN2O2/c1-26-19-12-11-14(13-18(19)22)20-16-9-5-6-10-17(16)21(25)24(23-20)15-7-3-2-4-8-15/h2-8,11-13,16-17H,9-10H2,1H3 | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474160
(CHEMBL61699)Show SMILES COc1ccc(cc1OC)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:39,t:11,26| Show InChI InChI=1S/C31H36N4O5/c1-20-18-28(36)32-33-29(20)21-10-13-23(14-11-21)40-17-7-6-16-35-31(37)25-9-5-4-8-24(25)30(34-35)22-12-15-26(38-2)27(19-22)39-3/h4-5,10-15,19-20,24-25H,6-9,16-18H2,1-3H3,(H,32,36) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50474158
(CHEMBL61667)Show SMILES COc1ccc(cc1Cl)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:17,t:10,30| Show InChI InChI=1S/C26H25ClN4O3/c1-15-13-23(32)28-29-24(15)16-7-10-18(11-8-16)31-26(33)20-6-4-3-5-19(20)25(30-31)17-9-12-22(34-2)21(27)14-17/h3-4,7-12,14-15,19-20H,5-6,13H2,1-2H3,(H,28,32) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50346088
((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N |r,wU:17.22,14.25,(4.79,2.97,;3.46,3.74,;2.12,2.97,;.79,3.74,;-.54,2.97,;-.54,1.43,;.79,.66,;2.12,1.43,;3.46,.66,;3.46,-.88,;4.7,-1.79,;4.23,-3.25,;2.69,-3.25,;2.21,-1.79,;-1.88,.66,;-3.42,.71,;-4.23,-.6,;-3.51,-1.96,;-1.97,-2.01,;-1.16,-.7,;-4.33,-3.26,;-3.6,-4.62,;-5.87,-3.21,;-1.77,2.19,;-1.66,3.73,)| Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20- | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474159
(CHEMBL64052)Show SMILES COc1ccc(cc1OC)C1=NN(CCCCC(=O)Nc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:41,t:11,28| Show InChI InChI=1S/C32H37N5O5/c1-20-18-29(39)34-35-30(20)21-11-14-23(15-12-21)33-28(38)10-6-7-17-37-32(40)25-9-5-4-8-24(25)31(36-37)22-13-16-26(41-2)27(19-22)42-3/h4-5,11-16,19-20,24-25H,6-10,17-18H2,1-3H3,(H,33,38)(H,34,39) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474169
(CHEMBL432717 | LY-264233)Show InChI InChI=1S/C14H13N3O2/c1-14(2)9-7-8(3-4-11(9)15-13(14)19)10-5-6-12(18)17-16-10/h3-7H,1-2H3,(H,15,19)(H,17,18) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14769
(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)Show InChI InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474164
(CHEMBL304715)Show SMILES CCOc1ccc(cc1OCC)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:41,t:13,28| Show InChI InChI=1S/C33H40N4O5/c1-4-40-28-17-14-24(21-29(28)41-5-2)32-26-10-6-7-11-27(26)33(39)37(36-32)18-8-9-19-42-25-15-12-23(13-16-25)31-22(3)20-30(38)34-35-31/h6-7,12-17,21-22,26-27H,4-5,8-11,18-20H2,1-3H3,(H,34,38) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474171
(CHEMBL62131)Show SMILES COc1ccc(cc1OC)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:18,t:11,31| Show InChI InChI=1S/C27H28N4O4/c1-16-14-24(32)28-29-25(16)17-8-11-19(12-9-17)31-27(33)21-7-5-4-6-20(21)26(30-31)18-10-13-22(34-2)23(15-18)35-3/h4-5,8-13,15-16,20-21H,6-7,14H2,1-3H3,(H,28,32) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474161
(CHEMBL64824)Show SMILES COc1ccc(cc1OC)C1=NN(CC(=O)Nc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:38,t:11,25| Show InChI InChI=1S/C29H31N5O5/c1-17-14-25(35)31-32-27(17)18-8-11-20(12-9-18)30-26(36)16-34-29(37)22-7-5-4-6-21(22)28(33-34)19-10-13-23(38-2)24(15-19)39-3/h4-5,8-13,15,17,21-22H,6-7,14,16H2,1-3H3,(H,30,36)(H,31,35) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474157
(CHEMBL293589)Show SMILES CCOc1ccc(cc1OCC)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:20,t:13,33| Show InChI InChI=1S/C29H32N4O4/c1-4-36-24-15-12-20(17-25(24)37-5-2)28-22-8-6-7-9-23(22)29(35)33(32-28)21-13-10-19(11-14-21)27-18(3)16-26(34)30-31-27/h6-7,10-15,17-18,22-23H,4-5,8-9,16H2,1-3H3,(H,30,34) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50016839
(5-Methyl-6-[4-(4,5,6,7-tetrahydro-benzoimidazol-1-...)Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1cnc2CCCCc12 |c:6| Show InChI InChI=1S/C18H20N4O/c1-12-10-17(23)20-21-18(12)13-6-8-14(9-7-13)22-11-19-15-4-2-3-5-16(15)22/h6-9,11-12H,2-5,10H2,1H3,(H,20,23) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474167
(CHEMBL61822)Show SMILES COc1ccc(cc1OC1CCCC1)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:23,t:16,36| Show InChI InChI=1S/C31H34N4O4/c1-19-17-28(36)32-33-29(19)20-11-14-22(15-12-20)35-31(37)25-10-6-5-9-24(25)30(34-35)21-13-16-26(38-2)27(18-21)39-23-7-3-4-8-23/h5-6,11-16,18-19,23-25H,3-4,7-10,17H2,1-2H3,(H,32,36) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM14769
(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)Show InChI InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474163
(CHEMBL64544)Show SMILES COc1ccc(cc1OC)C1=NN(CCCCC(=O)Nc2ccc(cc2)-c2ccc(O)nn2)C(=O)C2CC=CCC12 |c:40,t:11| Show InChI InChI=1S/C31H33N5O5/c1-40-26-16-12-21(19-27(26)41-2)30-23-7-3-4-8-24(23)31(39)36(35-30)18-6-5-9-28(37)32-22-13-10-20(11-14-22)25-15-17-29(38)34-33-25/h3-4,10-17,19,23-24H,5-9,18H2,1-2H3,(H,32,37)(H,34,38) | PDB
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Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474162
(CHEMBL59953)Show SMILES COc1ccc(cc1OC)C1=NN(CC(=O)Nc2ccc(cc2)-c2ccc(O)nn2)C(=O)C2CC=CCC12 |c:37,t:11| Show InChI InChI=1S/C28H27N5O5/c1-37-23-13-9-18(15-24(23)38-2)27-20-5-3-4-6-21(20)28(36)33(32-27)16-26(35)29-19-10-7-17(8-11-19)22-12-14-25(34)31-30-22/h3-4,7-15,20-21H,5-6,16H2,1-2H3,(H,29,35)(H,31,34) | PDB
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| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474165
(CHEMBL60026)Show SMILES COc1ccc(cc1OC)C1=NN(CC(=O)Nc2cccc(c2)C2=NNC(=O)CC2C)C(=O)C2CC=CCC12 |c:38,t:11,25| Show InChI InChI=1S/C29H31N5O5/c1-17-13-25(35)31-32-27(17)18-7-6-8-20(14-18)30-26(36)16-34-29(37)22-10-5-4-9-21(22)28(33-34)19-11-12-23(38-2)24(15-19)39-3/h4-8,11-12,14-15,17,21-22H,9-10,13,16H2,1-3H3,(H,30,36)(H,31,35) | PDB
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UniChem
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| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474168
(CHEMBL294327)Show SMILES COc1ccc(cc1OC)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)-c1ccc(O)nn1 |c:18,t:11| Show InChI InChI=1S/C26H24N4O4/c1-33-22-13-9-17(15-23(22)34-2)25-19-5-3-4-6-20(19)26(32)30(29-25)18-10-7-16(8-11-18)21-12-14-24(31)28-27-21/h3-4,7-15,19-20H,5-6H2,1-2H3,(H,28,31) | PDB
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| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474166
(CHEMBL60999)Show SMILES COc1ccc(cc1OC1CCCC1)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:23,t:16| Show InChI InChI=1S/C26H28N2O3/c1-30-23-16-15-18(17-24(23)31-20-11-5-6-12-20)25-21-13-7-8-14-22(21)26(29)28(27-25)19-9-3-2-4-10-19/h2-4,7-10,15-17,20-22H,5-6,11-14H2,1H3 | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474154
(CHEMBL60839)Show SMILES COc1ccc(cc1OC)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:18,t:11| Show InChI InChI=1S/C22H22N2O3/c1-26-19-13-12-15(14-20(19)27-2)21-17-10-6-7-11-18(17)22(25)24(23-21)16-8-4-3-5-9-16/h3-9,12-14,17-18H,10-11H2,1-2H3 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474156
(CHEMBL59996)Show SMILES COc1ccc(cc1Cl)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:17,t:10| Show InChI InChI=1S/C21H19ClN2O2/c1-26-19-12-11-14(13-18(19)22)20-16-9-5-6-10-17(16)21(25)24(23-20)15-7-3-2-4-8-15/h2-8,11-13,16-17H,9-10H2,1H3 | PDB
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antibodypedia
antibodypedia
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50346088
((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N |r,wU:17.22,14.25,(4.79,2.97,;3.46,3.74,;2.12,2.97,;.79,3.74,;-.54,2.97,;-.54,1.43,;.79,.66,;2.12,1.43,;3.46,.66,;3.46,-.88,;4.7,-1.79,;4.23,-3.25,;2.69,-3.25,;2.21,-1.79,;-1.88,.66,;-3.42,.71,;-4.23,-.6,;-3.51,-1.96,;-1.97,-2.01,;-1.16,-.7,;-4.33,-3.26,;-3.6,-4.62,;-5.87,-3.21,;-1.77,2.19,;-1.66,3.73,)| Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20- | PDB
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| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50474170
(CHEMBL303550)Show SMILES CCOc1ccc(cc1OCC)C1=NN(C(=O)C2CC=CCC12)c1ccccc1 |c:20,t:13| Show InChI InChI=1S/C24H26N2O3/c1-3-28-21-15-14-17(16-22(21)29-4-2)23-19-12-8-9-13-20(19)24(27)26(25-23)18-10-6-5-7-11-18/h5-11,14-16,19-20H,3-4,12-13H2,1-2H3 | PDB
MMDB
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B.MOAD
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antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets. |
J Med Chem 46: 2008-16 (2003)
Article DOI: 10.1021/jm030776l
BindingDB Entry DOI: 10.7270/Q2S1857B |
More data for this
Ligand-Target Pair | |
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