Found 48 hits Enz. Inhib. hit(s) with all data for entry = 50003925 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477612
(CHEMBL395834)Show SMILES C[C@H](CNc1ccc(cc1)-c1sccc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O3S/c1-14(24-13-20(26)16-3-2-4-17(23)11-16)12-25-18-7-5-15(6-8-18)21-19(22(27)28)9-10-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477622
(CHEMBL247520)Show SMILES C[C@H](CNc1ccc(cc1)-c1occc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O4/c1-14(24-13-20(26)16-3-2-4-17(23)11-16)12-25-18-7-5-15(6-8-18)21-19(22(27)28)9-10-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.316 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477614
(CHEMBL245874)Show SMILES O[C@@H](CNCCNc1cccc(c1)-c1occc1C(O)=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H21ClN2O4/c22-16-5-1-3-14(11-16)19(25)13-23-8-9-24-17-6-2-4-15(12-17)20-18(21(26)27)7-10-28-20/h1-7,10-12,19,23-25H,8-9,13H2,(H,26,27)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477615
(CHEMBL245673)Show SMILES C[C@H](CNc1cccc(c1)-c1occc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O4/c1-14(24-13-20(26)15-4-2-6-17(23)10-15)12-25-18-7-3-5-16(11-18)21-19(22(27)28)8-9-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477616
(CHEMBL246908)Show SMILES C[C@H](CNc1ccc(cc1)-c1nc(co1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50027813
(CHEMBL153558)Show SMILES C[C@H](CNc1ccc(CCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C20H25ClN2O3/c1-14(22-13-19(24)16-3-2-4-17(21)11-16)12-23-18-8-5-15(6-9-18)7-10-20(25)26/h2-6,8-9,11,14,19,22-24H,7,10,12-13H2,1H3,(H,25,26)/t14-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50027813
(CHEMBL153558)Show SMILES C[C@H](CNc1ccc(CCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C20H25ClN2O3/c1-14(22-13-19(24)16-3-2-4-17(21)11-16)12-23-18-8-5-15(6-9-18)7-10-20(25)26/h2-6,8-9,11,14,19,22-24H,7,10,12-13H2,1H3,(H,25,26)/t14-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477617
(CHEMBL393471)Show SMILES C[C@H](CNc1cccc(c1)-c1ocnc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-18(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-19(21(27)28)25-12-29-20/h2-9,12-13,18,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477615
(CHEMBL245673)Show SMILES C[C@H](CNc1cccc(c1)-c1occc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O4/c1-14(24-13-20(26)15-4-2-6-17(23)10-15)12-25-18-7-3-5-16(11-18)21-19(22(27)28)8-9-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.251 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477615
(CHEMBL245673)Show SMILES C[C@H](CNc1cccc(c1)-c1occc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O4/c1-14(24-13-20(26)15-4-2-6-17(23)10-15)12-25-18-7-3-5-16(11-18)21-19(22(27)28)8-9-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 126 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477618
(CHEMBL245873)Show SMILES C[C@H](CNc1cccc(c1)-c1sccc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O3S/c1-14(24-13-20(26)15-4-2-6-17(23)10-15)12-25-18-7-3-5-16(11-18)21-19(22(27)28)8-9-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477619
(CHEMBL245875)Show SMILES O[C@@H](CNCCNc1cccc(c1)-c1sccc1C(O)=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H21ClN2O3S/c22-16-5-1-3-14(11-16)19(25)13-23-8-9-24-17-6-2-4-15(12-17)20-18(21(26)27)7-10-28-20/h1-7,10-12,19,23-25H,8-9,13H2,(H,26,27)/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477620
(CHEMBL393469)Show SMILES C[C@H](CNc1cccc(c1)-c1nc(co1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-19(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477618
(CHEMBL245873)Show SMILES C[C@H](CNc1cccc(c1)-c1sccc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O3S/c1-14(24-13-20(26)15-4-2-6-17(23)10-15)12-25-18-7-3-5-16(11-18)21-19(22(27)28)8-9-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477613
(CHEMBL430390)Show SMILES C[C@H](CNc1ccc(cc1)-c1nc(cs1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50422411
(CHEMBL154419)Show SMILES C[C@H](CNc1ccc(CC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C19H23ClN2O3/c1-13(21-12-18(23)15-3-2-4-16(20)10-15)11-22-17-7-5-14(6-8-17)9-19(24)25/h2-8,10,13,18,21-23H,9,11-12H2,1H3,(H,24,25)/t13-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477621
(CHEMBL393470)Show SMILES C[C@H](CNc1cccc(c1)-c1csc(n1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-5-2-6-16(22)8-15)10-24-17-7-3-4-14(9-17)18-12-29-20(25-18)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477614
(CHEMBL245874)Show SMILES O[C@@H](CNCCNc1cccc(c1)-c1occc1C(O)=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H21ClN2O4/c22-16-5-1-3-14(11-16)19(25)13-23-8-9-24-17-6-2-4-15(12-17)20-18(21(26)27)7-10-28-20/h1-7,10-12,19,23-25H,8-9,13H2,(H,26,27)/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50422411
(CHEMBL154419)Show SMILES C[C@H](CNc1ccc(CC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C19H23ClN2O3/c1-13(21-12-18(23)15-3-2-4-16(20)10-15)11-22-17-7-5-14(6-8-17)9-19(24)25/h2-8,10,13,18,21-23H,9,11-12H2,1H3,(H,24,25)/t13-,18+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477617
(CHEMBL393471)Show SMILES C[C@H](CNc1cccc(c1)-c1ocnc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-18(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-19(21(27)28)25-12-29-20/h2-9,12-13,18,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,18+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477622
(CHEMBL247520)Show SMILES C[C@H](CNc1ccc(cc1)-c1occc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O4/c1-14(24-13-20(26)16-3-2-4-17(23)11-16)12-25-18-7-5-15(6-8-18)21-19(22(27)28)9-10-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477623
(CHEMBL247315)Show SMILES C[C@H](CNc1cccc(c1)-c1nc(cs1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477621
(CHEMBL393470)Show SMILES C[C@H](CNc1cccc(c1)-c1csc(n1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-5-2-6-16(22)8-15)10-24-17-7-3-4-14(9-17)18-12-29-20(25-18)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477618
(CHEMBL245873)Show SMILES C[C@H](CNc1cccc(c1)-c1sccc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O3S/c1-14(24-13-20(26)15-4-2-6-17(23)10-15)12-25-18-7-3-5-16(11-18)21-19(22(27)28)8-9-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0631 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477612
(CHEMBL395834)Show SMILES C[C@H](CNc1ccc(cc1)-c1sccc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O3S/c1-14(24-13-20(26)16-3-2-4-17(23)11-16)12-25-18-7-5-15(6-8-18)21-19(22(27)28)9-10-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477624
(CHEMBL247519)Show SMILES C[C@H](CNc1ccc(cc1)-c1ocnc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-18(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-19(21(27)28)25-12-29-20/h2-9,12-13,18,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477614
(CHEMBL245874)Show SMILES O[C@@H](CNCCNc1cccc(c1)-c1occc1C(O)=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H21ClN2O4/c22-16-5-1-3-14(11-16)19(25)13-23-8-9-24-17-6-2-4-15(12-17)20-18(21(26)27)7-10-28-20/h1-7,10-12,19,23-25H,8-9,13H2,(H,26,27)/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477624
(CHEMBL247519)Show SMILES C[C@H](CNc1ccc(cc1)-c1ocnc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-18(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-19(21(27)28)25-12-29-20/h2-9,12-13,18,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,18+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477616
(CHEMBL246908)Show SMILES C[C@H](CNc1ccc(cc1)-c1nc(co1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477623
(CHEMBL247315)Show SMILES C[C@H](CNc1cccc(c1)-c1nc(cs1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477625
(CHEMBL247518)Show SMILES C[C@H](CNc1ccc(cc1)-c1csc(n1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)18-12-29-20(25-18)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477619
(CHEMBL245875)Show SMILES O[C@@H](CNCCNc1cccc(c1)-c1sccc1C(O)=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H21ClN2O3S/c22-16-5-1-3-14(11-16)19(25)13-23-8-9-24-17-6-2-4-15(12-17)20-18(21(26)27)7-10-28-20/h1-7,10-12,19,23-25H,8-9,13H2,(H,26,27)/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50422411
(CHEMBL154419)Show SMILES C[C@H](CNc1ccc(CC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C19H23ClN2O3/c1-13(21-12-18(23)15-3-2-4-16(20)10-15)11-22-17-7-5-14(6-8-17)9-19(24)25/h2-8,10,13,18,21-23H,9,11-12H2,1H3,(H,24,25)/t13-,18+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477613
(CHEMBL430390)Show SMILES C[C@H](CNc1ccc(cc1)-c1nc(cs1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477612
(CHEMBL395834)Show SMILES C[C@H](CNc1ccc(cc1)-c1sccc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O3S/c1-14(24-13-20(26)16-3-2-4-17(23)11-16)12-25-18-7-5-15(6-8-18)21-19(22(27)28)9-10-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477622
(CHEMBL247520)Show SMILES C[C@H](CNc1ccc(cc1)-c1occc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H23ClN2O4/c1-14(24-13-20(26)16-3-2-4-17(23)11-16)12-25-18-7-5-15(6-8-18)21-19(22(27)28)9-10-29-21/h2-11,14,20,24-26H,12-13H2,1H3,(H,27,28)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477620
(CHEMBL393469)Show SMILES C[C@H](CNc1cccc(c1)-c1nc(co1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-19(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477621
(CHEMBL393470)Show SMILES C[C@H](CNc1cccc(c1)-c1csc(n1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-5-2-6-16(22)8-15)10-24-17-7-3-4-14(9-17)18-12-29-20(25-18)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477625
(CHEMBL247518)Show SMILES C[C@H](CNc1ccc(cc1)-c1csc(n1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)18-12-29-20(25-18)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477623
(CHEMBL247315)Show SMILES C[C@H](CNc1cccc(c1)-c1nc(cs1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.794 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477620
(CHEMBL393469)Show SMILES C[C@H](CNc1cccc(c1)-c1nc(co1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-19(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 126 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477625
(CHEMBL247518)Show SMILES C[C@H](CNc1ccc(cc1)-c1csc(n1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)18-12-29-20(25-18)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477617
(CHEMBL393471)Show SMILES C[C@H](CNc1cccc(c1)-c1ocnc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-18(26)14-4-2-6-16(22)8-14)10-24-17-7-3-5-15(9-17)20-19(21(27)28)25-12-29-20/h2-9,12-13,18,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,18+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477624
(CHEMBL247519)Show SMILES C[C@H](CNc1ccc(cc1)-c1ocnc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-18(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-19(21(27)28)25-12-29-20/h2-9,12-13,18,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,18+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50027813
(CHEMBL153558)Show SMILES C[C@H](CNc1ccc(CCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C20H25ClN2O3/c1-14(22-13-19(24)16-3-2-4-17(21)11-16)12-23-18-8-5-15(6-9-18)7-10-20(25)26/h2-6,8-9,11,14,19,22-24H,7,10,12-13H2,1H3,(H,25,26)/t14-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477619
(CHEMBL245875)Show SMILES O[C@@H](CNCCNc1cccc(c1)-c1sccc1C(O)=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H21ClN2O3S/c22-16-5-1-3-14(11-16)19(25)13-23-8-9-24-17-6-2-4-15(12-17)20-18(21(26)27)7-10-28-20/h1-7,10-12,19,23-25H,8-9,13H2,(H,26,27)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477616
(CHEMBL246908)Show SMILES C[C@H](CNc1ccc(cc1)-c1nc(co1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O4/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50477613
(CHEMBL430390)Show SMILES C[C@H](CNc1ccc(cc1)-c1nc(cs1)C(O)=O)NC[C@H](O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClN3O3S/c1-13(23-11-19(26)15-3-2-4-16(22)9-15)10-24-17-7-5-14(6-8-17)20-25-18(12-29-20)21(27)28/h2-9,12-13,19,23-24,26H,10-11H2,1H3,(H,27,28)/t13-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 17: 4670-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.069
BindingDB Entry DOI: 10.7270/Q2NV9N1V |
More data for this
Ligand-Target Pair | |
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