Compile Data Set for Download or QSAR

Found 45 hits Enz. Inhib. hit(s) with all data for entry = 50007937   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514141 (CHEMBL4543348) Show SMILES [O-][N+](=O)c1c(I)cccc1Oc1ccc(cc1)-c1nnco1 Show InChI InChI=1S/C14H8IN3O4/c15-11-2-1-3-12(13(11)18(19)20)22-10-6-4-9(5-7-10)14-17-16-8-21-14/h1-8H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514141 (CHEMBL4543348) Show SMILES [O-][N+](=O)c1c(I)cccc1Oc1ccc(cc1)-c1nnco1 Show InChI InChI=1S/C14H8IN3O4/c15-11-2-1-3-12(13(11)18(19)20)22-10-6-4-9(5-7-10)14-17-16-8-21-14/h1-8H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in ssRNA-induced NFkappaB production incubated for 16 hrs by quanti-blue SEA...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514130 (CHEMBL4467356) Show SMILES [O-][N+](=O)c1c(Cl)cccc1Oc1ccc(cc1)-c1nnco1 Show InChI InChI=1S/C14H8ClN3O4/c15-11-2-1-3-12(13(11)18(19)20)22-10-6-4-9(5-7-10)14-17-16-8-21-14/h1-8H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514129 (CHEMBL4593624) Show SMILES Brc1cccc(Oc2ccc(cc2)-c2nnco2)c1C#N Show InChI InChI=1S/C15H8BrN3O2/c16-13-2-1-3-14(12(13)8-17)21-11-6-4-10(5-7-11)15-19-18-9-20-15/h1-7,9H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514126 (CHEMBL4553003) Show SMILES Fc1cccc(Br)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11BrF7NO2/c22-16-2-1-3-17(23)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514123 (CHEMBL4460125) Show SMILES Fc1cccc(I)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11F7INO2/c22-16-2-1-3-17(29)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(23,24)25)8-12(10-15)21(26,27)28/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514137 (CHEMBL4455524) Show SMILES Fc1ccc(Cl)cc1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11ClF7NO2/c22-13-1-6-18(23)17(10-13)19(31)30-14-2-4-15(5-3-14)32-16-8-11(20(24,25)26)7-12(9-16)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.11E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514128 (CHEMBL4460503) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C15H7ClF7NO/c16-10-2-1-3-11(17)12(10)13(25)24-9-5-7(14(18,19)20)4-8(6-9)15(21,22)23/h1-6H,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in resiquimod-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hr...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514145 (CHEMBL4556342) Show SMILES Clc1cccc(Oc2ccc(cc2)-c2nnco2)c1C#N Show InChI InChI=1S/C15H8ClN3O2/c16-13-2-1-3-14(12(13)8-17)21-11-6-4-10(5-7-11)15-19-18-9-20-15/h1-7,9H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514153 (CHEMBL4469304) Show SMILES Fc1cc(Oc2ccc(NC(=O)c3c(F)cccc3Cl)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C20H11ClF5NO2/c21-16-2-1-3-17(23)18(16)19(28)27-13-4-6-14(7-5-13)29-15-9-11(20(24,25)26)8-12(22)10-15/h1-10H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514148 (CHEMBL4475557) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11ClF7NO2/c22-16-2-1-3-17(23)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514133 (CHEMBL4517952) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(Cl)cc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H11Cl2F4NO2/c21-12-8-11(20(24,25)26)9-15(10-12)29-14-6-4-13(5-7-14)27-19(28)18-16(22)2-1-3-17(18)23/h1-10H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514132 (CHEMBL4460468) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(Br)cc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H11BrClF4NO2/c21-12-8-11(20(24,25)26)9-15(10-12)29-14-6-4-13(5-7-14)27-19(28)18-16(22)2-1-3-17(18)23/h1-10H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514134 (CHEMBL4435177) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cccc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H12ClF4NO2/c21-16-5-2-6-17(22)18(16)19(27)26-13-7-9-14(10-8-13)28-15-4-1-3-12(11-15)20(23,24)25/h1-11H,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514139 (CHEMBL4437017) Show SMILES Clc1cccc(COc2ccc(cc2)-c2nnco2)c1C#N Show InChI InChI=1S/C16H10ClN3O2/c17-15-3-1-2-12(14(15)8-18)9-21-13-6-4-11(5-7-13)16-20-19-10-22-16/h1-7,10H,9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514144 (CHEMBL4483769) Show SMILES Oc1cc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)ccc1NC(=O)c1c(F)cccc1I Show InChI InChI=1S/C21H11F7INO3/c22-14-2-1-3-15(29)18(14)19(32)30-16-5-4-12(9-17(16)31)33-13-7-10(20(23,24)25)6-11(8-13)21(26,27)28/h1-9,31H,(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514134 (CHEMBL4435177) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cccc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H12ClF4NO2/c21-16-5-2-6-17(22)18(16)19(27)26-13-7-9-14(10-8-13)28-15-4-1-3-12(11-15)20(23,24)25/h1-11H,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514151 (CHEMBL4456777) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cncc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C19H11ClF4N2O2/c20-15-2-1-3-16(21)17(15)18(27)26-12-4-6-13(7-5-12)28-14-8-11(9-25-10-14)19(22,23)24/h1-10H,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514148 (CHEMBL4475557) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11ClF7NO2/c22-16-2-1-3-17(23)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514127 (CHEMBL4468417) Show SMILES CN(C(=O)c1c(F)cccc1Cl)c1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C22H13ClF7NO2/c1-31(20(32)19-17(23)3-2-4-18(19)24)14-5-7-15(8-6-14)33-16-10-12(21(25,26)27)9-13(11-16)22(28,29)30/h2-11H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in resiquimod-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hr...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514138 (CHEMBL4572948) Show SMILES Fc1ccccc1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H12F7NO2/c22-18-4-2-1-3-17(18)19(30)29-14-5-7-15(8-6-14)31-16-10-12(20(23,24)25)9-13(11-16)21(26,27)28/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514135 (CHEMBL4542663) Show SMILES FC(F)(F)c1cc(Oc2ccc(NC(=O)c3sccc3Cl)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C19H10ClF6NO2S/c20-15-5-6-30-16(15)17(28)27-12-1-3-13(4-2-12)29-14-8-10(18(21,22)23)7-11(9-14)19(24,25)26/h1-9H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514140 (CHEMBL4546506) Show SMILES Oc1cc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)ccc1NC(=O)c1c(F)cccc1Cl Show InChI InChI=1S/C21H11ClF7NO3/c22-14-2-1-3-15(23)18(14)19(32)30-16-5-4-12(9-17(16)31)33-13-7-10(20(24,25)26)6-11(8-13)21(27,28)29/h1-9,31H,(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514144 (CHEMBL4483769) Show SMILES Oc1cc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)ccc1NC(=O)c1c(F)cccc1I Show InChI InChI=1S/C21H11F7INO3/c22-14-2-1-3-15(29)18(14)19(32)30-16-5-4-12(9-17(16)31)33-13-7-10(20(23,24)25)6-11(8-13)21(26,27)28/h1-9,31H,(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514124 (CHEMBL4443220) Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cc(I)cc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H11ClF4INO2/c21-16-2-1-3-17(22)18(16)19(28)27-13-4-6-14(7-5-13)29-15-9-11(20(23,24)25)8-12(26)10-15/h1-10H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514150 (CHEMBL4443600) Show SMILES Nc1c(Cl)cccc1Oc1ccc(cc1)-c1nnco1 Show InChI InChI=1S/C14H10ClN3O2/c15-11-2-1-3-12(13(11)16)20-10-6-4-9(5-7-10)14-18-17-8-19-14/h1-8H,16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514126 (CHEMBL4553003) Show SMILES Fc1cccc(Br)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11BrF7NO2/c22-16-2-1-3-17(23)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514149 (CHEMBL4524477) Show SMILES Fc1cccc(Cl)c1NC(=O)c1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11ClF7NO2/c22-16-2-1-3-17(23)18(16)30-19(31)11-4-6-14(7-5-11)32-15-9-12(20(24,25)26)8-13(10-15)21(27,28)29/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in resiquimod-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hr...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514131 (CHEMBL4568991) Show SMILES O(c1ccccc1)c1ccc(cc1)-c1nnco1 Show InChI InChI=1S/C14H10N2O2/c1-2-4-12(5-3-1)18-13-8-6-11(7-9-13)14-16-15-10-17-14/h1-10H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514141 (CHEMBL4543348) Show SMILES [O-][N+](=O)c1c(I)cccc1Oc1ccc(cc1)-c1nnco1 Show InChI InChI=1S/C14H8IN3O4/c15-11-2-1-3-12(13(11)18(19)20)22-10-6-4-9(5-7-10)14-17-16-8-21-14/h1-8H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514136 (CHEMBL4475425) Show SMILES Oc1ccc(C(=O)Nc2ccc(Oc3cc(cc(c3)C(F)(F)F)C(F)(F)F)cc2)c(F)c1 Show InChI InChI=1S/C21H12F7NO3/c22-18-10-14(30)3-6-17(18)19(31)29-13-1-4-15(5-2-13)32-16-8-11(20(23,24)25)7-12(9-16)21(26,27)28/h1-10,30H,(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514147 (CHEMBL4458917) Show SMILES Fc1cc(I)ccc1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11F7INO2/c22-18-10-13(29)1-6-17(18)19(31)30-14-2-4-15(5-3-14)32-16-8-11(20(23,24)25)7-12(9-16)21(26,27)28/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514152 (CHEMBL4435419) Show SMILES Fc1cccc(Cl)c1CNc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H13ClF7NO/c22-18-2-1-3-19(23)17(18)11-30-14-4-6-15(7-5-14)31-16-9-12(20(24,25)26)8-13(10-16)21(27,28)29/h1-10,30H,11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514152 (CHEMBL4435419) Show SMILES Fc1cccc(Cl)c1CNc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H13ClF7NO/c22-18-2-1-3-19(23)17(18)11-30-14-4-6-15(7-5-14)31-16-9-12(20(24,25)26)8-13(10-16)21(27,28)29/h1-10,30H,11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514143 (CHEMBL4466412) Show SMILES Nc1ccc(C(=O)Nc2ccc(Oc3cc(cc(c3)C(F)(F)F)C(F)(F)F)cc2)c(F)c1 Show InChI InChI=1S/C21H13F7N2O2/c22-18-10-13(29)1-6-17(18)19(31)30-14-2-4-15(5-3-14)32-16-8-11(20(23,24)25)7-12(9-16)21(26,27)28/h1-10H,29H2,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514142 (CHEMBL4475509) Show SMILES FC(F)(F)c1cc(Oc2ccc(NC(=O)c3ccc4nc[nH]c4c3)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C22H13F6N3O2/c23-21(24,25)13-8-14(22(26,27)28)10-17(9-13)33-16-4-2-15(3-5-16)31-20(32)12-1-6-18-19(7-12)30-11-29-18/h1-11H,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514147 (CHEMBL4458917) Show SMILES Fc1cc(I)ccc1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11F7INO2/c22-18-10-13(29)1-6-17(18)19(31)30-14-2-4-15(5-3-14)32-16-8-11(20(23,24)25)7-12(9-16)21(26,27)28/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514146 (CHEMBL4460132) Show SMILES Fc1cccnc1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C20H11F7N2O2/c21-16-2-1-7-28-17(16)18(30)29-13-3-5-14(6-4-13)31-15-9-11(19(22,23)24)8-12(10-15)20(25,26)27/h1-10H,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514138 (CHEMBL4572948) Show SMILES Fc1ccccc1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H12F7NO2/c22-18-4-2-1-3-17(18)19(30)29-14-5-7-15(8-6-14)31-16-10-12(20(23,24)25)9-13(11-16)21(26,27)28/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514143 (CHEMBL4466412) Show SMILES Nc1ccc(C(=O)Nc2ccc(Oc3cc(cc(c3)C(F)(F)F)C(F)(F)F)cc2)c(F)c1 Show InChI InChI=1S/C21H13F7N2O2/c22-18-10-13(29)1-6-17(18)19(31)30-14-2-4-15(5-3-14)32-16-8-11(20(23,24)25)7-12(9-16)21(26,27)28/h1-10H,29H2,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514125 (CHEMBL4463190) Show SMILES Fc1cccc(OC(F)(F)F)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C22H11F10NO3/c23-16-2-1-3-17(36-22(30,31)32)18(16)19(34)33-13-4-6-14(7-5-13)35-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514125 (CHEMBL4463190) Show SMILES Fc1cccc(OC(F)(F)F)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C22H11F10NO3/c23-16-2-1-3-17(36-22(30,31)32)18(16)19(34)33-13-4-6-14(7-5-13)35-15-9-11(20(24,25)26)8-12(10-15)21(27,28)29/h1-10H,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514154 (CHEMBL4581201) Show SMILES FC(F)(F)c1cc(Oc2ccc(NC(=O)c3ccc4cc[nH]c4c3)cc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C23H14F6N2O2/c24-22(25,26)15-10-16(23(27,28)29)12-19(11-15)33-18-5-3-17(4-6-18)31-21(32)14-2-1-13-7-8-30-20(13)9-14/h1-12,30H,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50514123 (CHEMBL4460125) Show SMILES Fc1cccc(I)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H11F7INO2/c22-16-2-1-3-17(29)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(23,24)25)8-12(10-15)21(26,27)28/h1-10H,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50514141 (CHEMBL4543348) Show SMILES [O-][N+](=O)c1c(I)cccc1Oc1ccc(cc1)-c1nnco1 Show InChI InChI=1S/C14H8IN3O4/c15-11-2-1-3-12(13(11)18(19)20)22-10-6-4-9(5-7-10)14-17-16-8-21-14/h1-8H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a
University of Colorado Boulder Curated by ChEMBL					Assay Description Binding affinity to human TLR8 (27 to 827 residues) expressed in HEK293 cells in presence of R848 by ITC analysis				J Med Chem 62: 10221-10244 (2019) Article DOI: 10.1021/acs.jmedchem.9b01201 BindingDB Entry DOI: 10.7270/Q2BP064W
					More data for this Ligand-Target Pair