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Compile Data Set for Download or QSAR

Found 68 hits Enz. Inhib. hit(s) with all data for entry = 50008228   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516930
PNG
(CHEMBL4448186)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccc(Cl)cc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25ClN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-7-8-15(24)11-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516916
PNG
(CHEMBL4465482)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(Cl)ccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25ClN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-11-15(24)7-8-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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n/an/a 0.180n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516911
PNG
(CHEMBL4461587)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccc(Br)cc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25BrN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-7-8-15(24)11-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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n/an/a 0.220n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516926
PNG
(CHEMBL4588692)
Show SMILES COc1ccc(C(O)=O)c(Cn2c(=O)n(C)c3nc(N4CCC[C@@H](N)C4)n(CC#CC)c3c2=O)c1 |r|
Show InChI InChI=1S/C24H28N6O5/c1-4-5-11-29-19-20(26-23(29)28-10-6-7-16(25)14-28)27(2)24(34)30(21(19)31)13-15-12-17(35-3)8-9-18(15)22(32)33/h8-9,12,16H,6-7,10-11,13-14,25H2,1-3H3,(H,32,33)/t16-/m1/s1
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n/an/a 0.440n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516922
PNG
(CHEMBL4536341)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(Br)ccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25BrN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-11-15(24)7-8-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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n/an/a 0.720n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516921
PNG
(CHEMBL4544024)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3c(Br)cccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25BrN6O4/c1-3-4-11-29-18-19(26-22(29)28-10-6-7-14(25)12-28)27(2)23(34)30(20(18)31)13-16-15(21(32)33)8-5-9-17(16)24/h5,8-9,14H,6-7,10-13,25H2,1-2H3,(H,32,33)/t14-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516913
PNG
(CHEMBL4452518)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H26N6O4/c1-3-4-12-28-18-19(25-22(28)27-11-7-9-16(24)14-27)26(2)23(33)29(20(18)30)13-15-8-5-6-10-17(15)21(31)32/h5-6,8,10,16H,7,9,11-14,24H2,1-2H3,(H,31,32)/t16-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516918
PNG
(CHEMBL4446618)
Show SMILES CC#CCn1c(cc(=O)n(Cc2cccc(F)c2C(O)=O)c1=O)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C21H23FN4O4/c1-2-3-10-25-17(24-9-5-7-15(23)13-24)11-18(27)26(21(25)30)12-14-6-4-8-16(22)19(14)20(28)29/h4,6,8,11,15H,5,7,9-10,12-13,23H2,1H3,(H,28,29)/t15-/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516927
PNG
(CHEMBL4464069)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(ccc3C(O)=O)C#N)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C24H25N7O4/c1-3-4-10-30-19-20(27-23(30)29-9-5-6-17(26)14-29)28(2)24(35)31(21(19)32)13-16-11-15(12-25)7-8-18(16)22(33)34/h7-8,11,17H,5-6,9-10,13-14,26H2,1-2H3,(H,33,34)/t17-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516919
PNG
(CHEMBL4528994)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccc(F)cc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25FN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-7-8-15(24)11-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516928
PNG
(CHEMBL4435383)
Show SMILES COC(=O)c1ccccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H28N6O4/c1-4-5-13-29-19-20(26-23(29)28-12-8-10-17(25)15-28)27(2)24(33)30(21(19)31)14-16-9-6-7-11-18(16)22(32)34-3/h6-7,9,11,17H,8,10,12-15,25H2,1-3H3/t17-/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516920
PNG
(CHEMBL4458949)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3c(Cl)cccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25ClN6O4/c1-3-4-11-29-18-19(26-22(29)28-10-6-7-14(25)12-28)27(2)23(34)30(20(18)31)13-16-15(21(32)33)8-5-9-17(16)24/h5,8-9,14H,6-7,10-13,25H2,1-2H3,(H,32,33)/t14-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM16285
PNG
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r|
Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1
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n/an/a 4.5n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516923
PNG
(CHEMBL4590999)
Show SMILES COC(=O)c1c(F)cccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27FN6O4/c1-4-5-12-30-19-20(27-23(30)29-11-7-9-16(26)14-29)28(2)24(34)31(21(19)32)13-15-8-6-10-17(25)18(15)22(33)35-3/h6,8,10,16H,7,9,11-14,26H2,1-3H3/t16-/m1/s1
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n/an/a 5.10n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516917
PNG
(CHEMBL4458152)
Show SMILES COC(=O)c1ccc(Cl)cc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27ClN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-12-16(25)8-9-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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n/an/a 5.60n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516914
PNG
(CHEMBL4458832)
Show SMILES COc1cccc(C(O)=O)c1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H28N6O5/c1-4-5-12-29-19-20(26-23(29)28-11-7-8-15(25)13-28)27(2)24(34)30(21(19)31)14-17-16(22(32)33)9-6-10-18(17)35-3/h6,9-10,15H,7-8,11-14,25H2,1-3H3,(H,32,33)/t15-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516931
PNG
(CHEMBL4441220)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cccc(F)c3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25FN6O4/c1-3-4-11-29-18-19(26-22(29)28-10-6-8-15(25)13-28)27(2)23(34)30(20(18)31)12-14-7-5-9-16(24)17(14)21(32)33/h5,7,9,15H,6,8,10-13,25H2,1-2H3,(H,32,33)/t15-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516929
PNG
(CHEMBL4567320)
Show SMILES COC(=O)c1cc(Cl)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27ClN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-8-9-16(25)12-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516912
PNG
(CHEMBL4465374)
Show SMILES COC(=O)c1cc(Br)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27BrN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-8-9-16(25)12-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM11695
PNG
((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N |r,TLB:9:8:6:3.2.4,4:3:10:7.6.5,4:5:10:3.2.9,THB:9:3:6:10.7.8,11:8:6:3.2.4|
Show InChI InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516924
PNG
(CHEMBL4465448)
Show SMILES COC(=O)c1cccc(Cl)c1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27ClN6O4/c1-4-5-12-30-19-20(27-23(30)29-11-7-8-15(26)13-29)28(2)24(34)31(21(19)32)14-17-16(22(33)35-3)9-6-10-18(17)25/h6,9-10,15H,7-8,11-14,26H2,1-3H3/t15-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516925
PNG
(CHEMBL4468590)
Show SMILES CCOC(=O)c1cc(Cl)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C25H29ClN6O4/c1-4-6-12-31-20-21(28-24(31)30-11-7-8-18(27)15-30)29(3)25(35)32(22(20)33)14-16-9-10-17(26)13-19(16)23(34)36-5-2/h9-10,13,18H,5,7-8,11-12,14-15,27H2,1-3H3/t18-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50516915
PNG
(CHEMBL4528149)
Show SMILES CCOC(=O)c1cc(Br)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C25H29BrN6O4/c1-4-6-12-31-20-21(28-24(31)30-11-7-8-18(27)15-30)29(3)25(35)32(22(20)33)14-16-9-10-17(26)13-19(16)23(34)36-5-2/h9-10,13,18H,5,7-8,11-12,14-15,27H2,1-3H3/t18-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM11695
PNG
((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N |r,TLB:9:8:6:3.2.4,4:3:10:7.6.5,4:5:10:3.2.9,THB:9:3:6:10.7.8,11:8:6:3.2.4|
Show InChI InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
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n/an/a 1.52E+3n/an/an/an/an/an/a



Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516911
PNG
(CHEMBL4461587)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccc(Br)cc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25BrN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-7-8-15(24)11-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516912
PNG
(CHEMBL4465374)
Show SMILES COC(=O)c1cc(Br)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27BrN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-8-9-16(25)12-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516916
PNG
(CHEMBL4465482)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(Cl)ccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25ClN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-11-15(24)7-8-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516917
PNG
(CHEMBL4458152)
Show SMILES COC(=O)c1ccc(Cl)cc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27ClN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-12-16(25)8-9-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516913
PNG
(CHEMBL4452518)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H26N6O4/c1-3-4-12-28-18-19(25-22(28)27-11-7-9-16(24)14-27)26(2)23(33)29(20(18)30)13-15-8-5-6-10-17(15)21(31)32/h5-6,8,10,16H,7,9,11-14,24H2,1-2H3,(H,31,32)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516919
PNG
(CHEMBL4528994)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccc(F)cc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25FN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-7-8-15(24)11-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516920
PNG
(CHEMBL4458949)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3c(Cl)cccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25ClN6O4/c1-3-4-11-29-18-19(26-22(29)28-10-6-7-14(25)12-28)27(2)23(34)30(20(18)31)13-16-15(21(32)33)8-5-9-17(16)24/h5,8-9,14H,6-7,10-13,25H2,1-2H3,(H,32,33)/t14-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516921
PNG
(CHEMBL4544024)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3c(Br)cccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25BrN6O4/c1-3-4-11-29-18-19(26-22(29)28-10-6-7-14(25)12-28)27(2)23(34)30(20(18)31)13-16-15(21(32)33)8-5-9-17(16)24/h5,8-9,14H,6-7,10-13,25H2,1-2H3,(H,32,33)/t14-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516922
PNG
(CHEMBL4536341)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(Br)ccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25BrN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-11-15(24)7-8-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516926
PNG
(CHEMBL4588692)
Show SMILES COc1ccc(C(O)=O)c(Cn2c(=O)n(C)c3nc(N4CCC[C@@H](N)C4)n(CC#CC)c3c2=O)c1 |r|
Show InChI InChI=1S/C24H28N6O5/c1-4-5-11-29-19-20(26-23(29)28-10-6-7-16(25)14-28)27(2)24(34)30(21(19)31)13-15-12-17(35-3)8-9-18(15)22(32)33/h8-9,12,16H,6-7,10-11,13-14,25H2,1-3H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516927
PNG
(CHEMBL4464069)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(ccc3C(O)=O)C#N)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C24H25N7O4/c1-3-4-10-30-19-20(27-23(30)29-9-5-6-17(26)14-29)28(2)24(35)31(21(19)32)13-16-11-15(12-25)7-8-18(16)22(33)34/h7-8,11,17H,5-6,9-10,13-14,26H2,1-2H3,(H,33,34)/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516928
PNG
(CHEMBL4435383)
Show SMILES COC(=O)c1ccccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H28N6O4/c1-4-5-13-29-19-20(26-23(29)28-12-8-10-17(25)15-28)27(2)24(33)30(21(19)31)14-16-9-6-7-11-18(16)22(32)34-3/h6-7,9,11,17H,8,10,12-15,25H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516929
PNG
(CHEMBL4567320)
Show SMILES COC(=O)c1cc(Cl)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27ClN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-8-9-16(25)12-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516925
PNG
(CHEMBL4468590)
Show SMILES CCOC(=O)c1cc(Cl)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C25H29ClN6O4/c1-4-6-12-31-20-21(28-24(31)30-11-7-8-18(27)15-30)29(3)25(35)32(22(20)33)14-16-9-10-17(26)13-19(16)23(34)36-5-2/h9-10,13,18H,5,7-8,11-12,14-15,27H2,1-3H3/t18-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516918
PNG
(CHEMBL4446618)
Show SMILES CC#CCn1c(cc(=O)n(Cc2cccc(F)c2C(O)=O)c1=O)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C21H23FN4O4/c1-2-3-10-25-17(24-9-5-7-15(23)13-24)11-18(27)26(21(25)30)12-14-6-4-8-16(22)19(14)20(28)29/h4,6,8,11,15H,5,7,9-10,12-13,23H2,1H3,(H,28,29)/t15-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516913
PNG
(CHEMBL4452518)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H26N6O4/c1-3-4-12-28-18-19(25-22(28)27-11-7-9-16(24)14-27)26(2)23(33)29(20(18)30)13-15-8-5-6-10-17(15)21(31)32/h5-6,8,10,16H,7,9,11-14,24H2,1-2H3,(H,31,32)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516919
PNG
(CHEMBL4528994)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccc(F)cc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25FN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-7-8-15(24)11-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516920
PNG
(CHEMBL4458949)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3c(Cl)cccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25ClN6O4/c1-3-4-11-29-18-19(26-22(29)28-10-6-7-14(25)12-28)27(2)23(34)30(20(18)31)13-16-15(21(32)33)8-5-9-17(16)24/h5,8-9,14H,6-7,10-13,25H2,1-2H3,(H,32,33)/t14-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516922
PNG
(CHEMBL4536341)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(Br)ccc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H25BrN6O4/c1-3-4-10-29-18-19(26-22(29)28-9-5-6-16(25)13-28)27(2)23(34)30(20(18)31)12-14-11-15(24)7-8-17(14)21(32)33/h7-8,11,16H,5-6,9-10,12-13,25H2,1-2H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516914
PNG
(CHEMBL4458832)
Show SMILES COc1cccc(C(O)=O)c1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H28N6O5/c1-4-5-12-29-19-20(26-23(29)28-11-7-8-15(25)13-28)27(2)24(34)30(21(19)31)14-17-16(22(32)33)9-6-10-18(17)35-3/h6,9-10,15H,7-8,11-14,25H2,1-3H3,(H,32,33)/t15-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516926
PNG
(CHEMBL4588692)
Show SMILES COc1ccc(C(O)=O)c(Cn2c(=O)n(C)c3nc(N4CCC[C@@H](N)C4)n(CC#CC)c3c2=O)c1 |r|
Show InChI InChI=1S/C24H28N6O5/c1-4-5-11-29-19-20(26-23(29)28-10-6-7-16(25)14-28)27(2)24(34)30(21(19)31)13-15-12-17(35-3)8-9-18(15)22(32)33/h8-9,12,16H,6-7,10-11,13-14,25H2,1-3H3,(H,32,33)/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516928
PNG
(CHEMBL4435383)
Show SMILES COC(=O)c1ccccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H28N6O4/c1-4-5-13-29-19-20(26-23(29)28-12-8-10-17(25)15-28)27(2)24(33)30(21(19)31)14-16-9-6-7-11-18(16)22(32)34-3/h6-7,9,11,17H,8,10,12-15,25H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516924
PNG
(CHEMBL4465448)
Show SMILES COC(=O)c1cccc(Cl)c1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27ClN6O4/c1-4-5-12-30-19-20(27-23(30)29-11-7-8-15(26)13-29)28(2)24(34)31(21(19)32)14-17-16(22(33)35-3)9-6-10-18(17)25/h6,9-10,15H,7-8,11-14,26H2,1-3H3/t15-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516929
PNG
(CHEMBL4567320)
Show SMILES COC(=O)c1cc(Cl)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27ClN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-8-9-16(25)12-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50516912
PNG
(CHEMBL4465374)
Show SMILES COC(=O)c1cc(Br)ccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27BrN6O4/c1-4-5-11-30-19-20(27-23(30)29-10-6-7-17(26)14-29)28(2)24(34)31(21(19)32)13-15-8-9-16(25)12-18(15)22(33)35-3/h8-9,12,17H,6-7,10-11,13-14,26H2,1-3H3/t17-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50516923
PNG
(CHEMBL4590999)
Show SMILES COC(=O)c1c(F)cccc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O |r|
Show InChI InChI=1S/C24H27FN6O4/c1-4-5-12-30-19-20(27-23(30)29-11-7-9-16(26)14-29)28(2)24(34)31(21(19)32)13-15-8-6-10-17(25)18(15)22(33)35-3/h6,8,10,16H,7,9,11-14,26H2,1-3H3/t16-/m1/s1
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Guangxi Medical University

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...

Eur J Med Chem 180: 509-523 (2019)


Article DOI: 10.1016/j.ejmech.2019.07.045
BindingDB Entry DOI: 10.7270/Q2Q243MN
More data for this
Ligand-Target Pair
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