Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi... | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124950![]() (US8765972, 3) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi... | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124952![]() (US8765972, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 162 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi... | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM124950![]() (US8765972, 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of CYP2D6 (unknown origin) | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124945![]() (US8765972, 127) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi... | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2B6 (Homo sapiens (Human)) | BDBM124950![]() (US8765972, 3) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of CYP2B6 (unknown origin) | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of CYP2D6 (unknown origin) | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2B6 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Inhibition of CYP2B6 (unknown origin) | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | <30 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant full length His-tagged PARP1 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM124950![]() (US8765972, 3) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant full length His-tagged PARP2 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM124950![]() (US8765972, 3) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant His-tagged TNKS1 catalytic domain (1091-1325 residues) by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant His-tagged TNKS1 catalytic domain (1091-1325 residues) by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Binding affinity to human recombinant His/GST-tagged PARP1 catalytic domain (655-end residues) by surface plasma resonance method | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant His/GST-tagged PARP3 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124950![]() (US8765972, 3) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | <30 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant full length His-tagged PARP1 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124945![]() (US8765972, 127) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant full length His-tagged PARP1 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124952![]() (US8765972, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.76E+3 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Binding affinity to human recombinant His/GST-tagged PARP1 catalytic domain (655-end residues) by surface plasma resonance method | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens (Human)) | BDBM124950![]() (US8765972, 3) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant His/GST-tagged PARP3 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM124952![]() (US8765972, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant full length His-tagged PARP1 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM124951![]() (US8765972, 4) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.r.l. Curated by ChEMBL | Assay Description Displacement of fluorescent probe from human recombinant full length His-tagged PARP2 by fluorescent polarization assay | ACS Med Chem Lett 10: 534-538 (2019) Article DOI: 10.1021/acsmedchemlett.8b00569 BindingDB Entry DOI: 10.7270/Q2VQ365G | |||||||||||
More data for this Ligand-Target Pair |