BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 41 hits Enz. Inhib. hit(s) with all data for entry = 50010273   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537001
PNG
(CHEMBL4520937)
Show SMILES CCn1c2ccc(cc2c2cccc(C)c12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-5-29-22-11-9-18(15-21(22)20-8-6-7-16(2)25(20)29)26-28-24-17(3)19(27(31)32)10-12-23(24)30(26)13-14-33-4/h6-12,15H,5,13-14H2,1-4H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.20n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261864
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-4-fluoro-1-(2-methoxy...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(F)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H22FN3O3/c1-3-28-19-7-5-4-6-16(19)18-14-15(8-10-20(18)28)24-27-23-21(29(24)12-13-32-2)11-9-17(22(23)26)25(30)31/h4-11,14H,3,12-13H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.30n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261893
PNG
(2-(6-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(Cl)cc2c2cc(ccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H24ClN3O3/c1-4-29-21-8-5-16(13-19(21)20-14-17(27)6-9-22(20)29)25-28-24-15(2)18(26(31)32)7-10-23(24)30(25)11-12-33-3/h5-10,13-14H,4,11-12H2,1-3H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.40n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537002
PNG
(CHEMBL4483026)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H23N3O3/c1-3-27-21-7-5-4-6-18(21)19-14-16(8-10-22(19)27)24-26-20-15-17(25(29)30)9-11-23(20)28(24)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.70n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261894
PNG
(2-(8-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(cc2c2cccc(Cl)c12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H24ClN3O3/c1-4-29-21-10-8-16(14-19(21)18-6-5-7-20(27)24(18)29)25-28-23-15(2)17(26(31)32)9-11-22(23)30(25)12-13-33-3/h5-11,14H,4,12-13H2,1-3H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.20n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261795
PNG
(3-[2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)-c1noc(=O)[nH]1
Show InChI InChI=1S/C26H23N5O3/c1-3-30-21-7-5-4-6-18(21)19-14-17(9-10-22(19)30)25-27-20-15-16(24-28-26(32)34-29-24)8-11-23(20)31(25)12-13-33-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261794
PNG
(9-Ethyl-3-[1-(2-methoxyethyl)-5-(1H-tetrazol-5-yl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)-c1nnn[nH]1
Show InChI InChI=1S/C25H23N7O/c1-3-31-21-7-5-4-6-18(21)19-14-17(9-10-22(19)31)25-26-20-15-16(24-27-29-30-28-24)8-11-23(20)32(25)12-13-33-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,27,28,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.80n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261884
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(tetrahydrofuran-2-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CCCO1)C(O)=O
Show InChI InChI=1S/C27H25N3O3/c1-2-29-23-8-4-3-7-20(23)21-14-17(9-11-24(21)29)26-28-22-15-18(27(31)32)10-12-25(22)30(26)16-19-6-5-13-33-19/h3-4,7-12,14-15,19H,2,5-6,13,16H2,1H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537004
PNG
(CHEMBL4584103)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C26H23N3O2/c1-2-28-22-6-4-3-5-19(22)20-13-17(9-11-23(20)28)25-27-21-14-18(26(30)31)10-12-24(21)29(25)15-16-7-8-16/h3-6,9-14,16H,2,7-8,15H2,1H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261892
PNG
(2-(9-Ethyl-6-methyl-9H-carbazol-3-yl)-1-(2-methoxy...)
Show SMILES CCn1c2ccc(C)cc2c2cc(ccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-5-29-22-9-6-16(2)14-20(22)21-15-18(7-10-23(21)29)26-28-25-17(3)19(27(31)32)8-11-24(25)30(26)12-13-33-4/h6-11,14-15H,5,12-13H2,1-4H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261766
PNG
(N-[(3-Chlorophenyl)sulphonyl]-2-(9-ethyl-9H-carbaz...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C31H27ClN4O4S/c1-3-35-27-10-5-4-9-24(27)25-17-20(11-13-28(25)35)30-33-26-18-21(12-14-29(26)36(30)15-16-40-2)31(37)34-41(38,39)23-8-6-7-22(32)19-23/h4-14,17-19H,3,15-16H2,1-2H3,(H,34,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537016
PNG
(CHEMBL4563081)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(Cl)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H22ClN3O3/c1-3-28-19-7-5-4-6-16(19)18-14-15(8-10-20(18)28)24-27-23-21(29(24)12-13-32-2)11-9-17(22(23)26)25(30)31/h4-11,14H,3,12-13H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537008
PNG
(CHEMBL4531968)
Show SMILES CCn1c2ccc(cc2c2cc(ccc12)C(F)(F)F)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C27H24F3N3O3/c1-4-32-21-8-5-16(13-19(21)20-14-17(27(28,29)30)6-9-22(20)32)25-31-24-15(2)18(26(34)35)7-10-23(24)33(25)11-12-36-3/h5-10,13-14H,4,11-12H2,1-3H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537003
PNG
(CHEMBL4548032)
Show SMILES COCCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O3/c1-33-13-12-29-23-5-3-2-4-20(23)21-14-18(8-10-24(21)29)26-28-22-15-19(27(31)32)9-11-25(22)30(26)16-17-6-7-17/h2-5,8-11,14-15,17H,6-7,12-13,16H2,1H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261867
PNG
(1-(2-Cyclopropylethyl)-2-(9-ethyl-9H-carbazol-3-yl...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCC1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O2/c1-2-29-23-6-4-3-5-20(23)21-15-18(9-11-24(21)29)26-28-22-16-19(27(31)32)10-12-25(22)30(26)14-13-17-7-8-17/h3-6,9-12,15-17H,2,7-8,13-14H2,1H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537005
PNG
(CHEMBL4587481)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C26H26N4O4S/c1-4-29-22-8-6-5-7-19(22)20-15-17(9-11-23(20)29)25-27-21-16-18(26(31)28-35(3,32)33)10-12-24(21)30(25)13-14-34-2/h5-12,15-16H,4,13-14H2,1-3H3,(H,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261855
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-4-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H25N3O3/c1-4-28-21-8-6-5-7-19(21)20-15-17(9-11-22(20)28)25-27-24-16(2)18(26(30)31)10-12-23(24)29(25)13-14-32-3/h5-12,15H,4,13-14H2,1-3H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537015
PNG
(CHEMBL4571025)
Show SMILES OC(=O)c1ccc2n(CC3CC3)c(nc2c1)-c1ccc2n(CC3CC3)c3ccccc3c2c1
Show InChI InChI=1S/C28H25N3O2/c32-28(33)20-10-12-26-23(14-20)29-27(31(26)16-18-7-8-18)19-9-11-25-22(13-19)21-3-1-2-4-24(21)30(25)15-17-5-6-17/h1-4,9-14,17-18H,5-8,15-16H2,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261783
PNG
(1-(Cyclopropylmethyl)-2-(9-methyl-9H-carbazol-3-yl...)
Show SMILES Cn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C25H21N3O2/c1-27-21-5-3-2-4-18(21)19-12-16(8-10-22(19)27)24-26-20-13-17(25(29)30)9-11-23(20)28(24)14-15-6-7-15/h2-5,8-13,15H,6-7,14H2,1H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261863
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-6-fluoro-1-(2-methoxy...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(F)cc2n1CCOC
Show InChI InChI=1S/C25H22FN3O3/c1-3-28-21-7-5-4-6-16(21)17-12-15(8-9-22(17)28)24-27-20-13-18(25(30)31)19(26)14-23(20)29(24)10-11-32-2/h4-9,12-14H,3,10-11H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261856
PNG
(5-[2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)-c1n[nH]c(=O)o1
Show InChI InChI=1S/C26H23N5O3/c1-3-30-21-7-5-4-6-18(21)19-14-16(8-10-22(19)30)24-27-20-15-17(25-28-29-26(32)34-25)9-11-23(20)31(24)12-13-33-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261883
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(oxetan-2-ylmethyl)...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CCO1)C(O)=O
Show InChI InChI=1S/C26H23N3O3/c1-2-28-22-6-4-3-5-19(22)20-13-16(7-9-23(20)28)25-27-21-14-17(26(30)31)8-10-24(21)29(25)15-18-11-12-32-18/h3-10,13-14,18H,2,11-12,15H2,1H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537013
PNG
(CHEMBL4554923)
Show SMILES CCn1c2ccc(cc2c2c(C)cccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C27H27N3O3/c1-5-29-21-11-9-18(15-20(21)24-16(2)7-6-8-22(24)29)26-28-25-17(3)19(27(31)32)10-12-23(25)30(26)13-14-33-4/h6-12,15H,5,13-14H2,1-4H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 55n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261871
PNG
(1-(Cyclopropylmethyl)-2-(9-propyl-9H-carbazol-3-yl...)
Show SMILES CCCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C27H25N3O2/c1-2-13-29-23-6-4-3-5-20(23)21-14-18(9-11-24(21)29)26-28-22-15-19(27(31)32)10-12-25(22)30(26)16-17-7-8-17/h3-6,9-12,14-15,17H,2,7-8,13,16H2,1H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537010
PNG
(CHEMBL4536877)
Show SMILES CCn1c2ccc(cc2c2c(Cl)cccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H24ClN3O3/c1-4-29-20-10-8-16(14-18(20)23-19(27)6-5-7-21(23)29)25-28-24-15(2)17(26(31)32)9-11-22(24)30(25)12-13-33-3/h5-11,14H,4,12-13H2,1-3H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 66n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50537002
PNG
(CHEMBL4483026)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H23N3O3/c1-3-27-21-7-5-4-6-18(21)19-14-16(8-10-22(19)27)24-26-20-15-17(25(29)30)9-11-23(20)28(24)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 81n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261821
PNG
(1-[2-(Dimethylamino)ethyl]-2-(9-ethyl-9H-carbazol-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCN(C)C)C(O)=O
Show InChI InChI=1S/C26H26N4O2/c1-4-29-22-8-6-5-7-19(22)20-15-17(9-11-23(20)29)25-27-21-16-18(26(31)32)10-12-24(21)30(25)14-13-28(2)3/h5-12,15-16H,4,13-14H2,1-3H3,(H,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 83n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50537004
PNG
(CHEMBL4584103)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O
Show InChI InChI=1S/C26H23N3O2/c1-2-28-22-6-4-3-5-19(22)20-13-17(9-11-23(20)28)25-27-21-14-18(26(30)31)10-12-24(21)29(25)15-16-7-8-16/h3-6,9-14,16H,2,7-8,15H2,1H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 113n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261831
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(N)=O
Show InChI InChI=1S/C25H24N4O2/c1-3-28-21-7-5-4-6-18(21)19-14-17(9-10-22(19)28)25-27-20-15-16(24(26)30)8-11-23(20)29(25)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H2,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 134n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537006
PNG
(CHEMBL4521321)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)N(C)C
Show InChI InChI=1S/C27H29N5O4S/c1-5-31-23-9-7-6-8-20(23)21-16-18(10-12-24(21)31)26-28-22-17-19(27(33)29-37(34,35)30(2)3)11-13-25(22)32(26)14-15-36-4/h6-13,16-17H,5,14-15H2,1-4H3,(H,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 148n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261850
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(3-methoxypropyl)-1...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCCOC)C(O)=O
Show InChI InChI=1S/C26H25N3O3/c1-3-28-22-8-5-4-7-19(22)20-15-17(9-11-23(20)28)25-27-21-16-18(26(30)31)10-12-24(21)29(25)13-6-14-32-2/h4-5,7-12,15-16H,3,6,13-14H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 158n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261844
PNG
(2-(9-Ethyl-9H-carbazol-3-y1)-1-methyl-1 H-benzimid...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C)C(O)=O
Show InChI InChI=1S/C23H19N3O2/c1-3-26-19-7-5-4-6-16(19)17-12-14(8-10-20(17)26)22-24-18-13-15(23(27)28)9-11-21(18)25(22)2/h4-13H,3H2,1-2H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 166n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537012
PNG
(CHEMBL4581855)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)S(O)(=O)=O
Show InChI InChI=1S/C24H23N3O4S/c1-3-26-21-7-5-4-6-18(21)19-14-16(8-10-22(19)26)24-25-20-15-17(32(28,29)30)9-11-23(20)27(24)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,28,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 222n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261876
PNG
(2-[9-(Cyclobutylmethyl)-9H-carbazol-3-yl]-1-(cyclo...)
Show SMILES OC(=O)c1ccc2n(CC3CC3)c(nc2c1)-c1ccc2n(CC3CCC3)c3ccccc3c2c1
Show InChI InChI=1S/C29H27N3O2/c33-29(34)21-11-13-27-24(15-21)30-28(32(27)17-19-8-9-19)20-10-12-26-23(14-20)22-6-1-2-7-25(22)31(26)16-18-4-3-5-18/h1-2,6-7,10-15,18-19H,3-5,8-9,16-17H2,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 257n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537011
PNG
(CHEMBL4593176)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)NC
Show InChI InChI=1S/C27H26N4O/c1-3-30-23-7-5-4-6-20(23)21-14-18(10-12-24(21)30)26-29-22-15-19(27(32)28-2)11-13-25(22)31(26)16-17-8-9-17/h4-7,10-15,17H,3,8-9,16H2,1-2H3,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 286n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537009
PNG
(CHEMBL4524507)
Show SMILES CCn1c2ccc(OC(F)(F)F)cc2c2cc(ccc12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C27H24F3N3O4/c1-4-32-21-8-5-16(13-19(21)20-14-17(6-9-22(20)32)37-27(28,29)30)25-31-24-15(2)18(26(34)35)7-10-23(24)33(25)11-12-36-3/h5-10,13-14H,4,11-12H2,1-3H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 366n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261861
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-6-...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(C)cc2n1CCOC
Show InChI InChI=1S/C26H25N3O3/c1-4-28-22-8-6-5-7-18(22)20-14-17(9-10-23(20)28)25-27-21-15-19(26(30)31)16(2)13-24(21)29(25)11-12-32-3/h5-10,13-15H,4,11-12H2,1-3H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 612n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM261843
PNG
(2-(9-Ethyl-9H-carbazol-3-yl)-1-isopropyl-1H-benzim...)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C(C)C)C(O)=O
Show InChI InChI=1S/C25H23N3O2/c1-4-27-21-8-6-5-7-18(21)19-13-16(9-11-22(19)27)24-26-20-14-17(25(29)30)10-12-23(20)28(24)15(2)3/h5-15H,4H2,1-3H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 733n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537007
PNG
(CHEMBL4527730)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(Cl)cc2n1CCOC
Show InChI InChI=1S/C25H22ClN3O3/c1-3-28-21-7-5-4-6-16(21)17-12-15(8-9-22(17)28)24-27-20-13-18(25(30)31)19(26)14-23(20)29(24)10-11-32-2/h4-9,12-14H,3,10-11H2,1-2H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 751n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537014
PNG
(CHEMBL4553842)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2ccc(cc2n1CCOC)C(O)=O
Show InChI InChI=1S/C25H23N3O3/c1-3-27-21-7-5-4-6-18(21)19-14-16(9-11-22(19)27)24-26-20-10-8-17(25(29)30)15-23(20)28(24)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.42E+3n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50537000
PNG
(CHEMBL4591445)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C28H21N3O2/c1-2-30-24-11-7-6-10-21(24)22-16-18(12-14-25(22)30)27-29-23-17-19(28(32)33)13-15-26(23)31(27)20-8-4-3-5-9-20/h3-17H,2H2,1H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.12E+3n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
BindingDB Entry DOI: 10.7270/Q25H7KSB
More data for this
Ligand-Target Pair