Compile Data Set for Download or QSAR

Found 39 hits Enz. Inhib. hit(s) with all data for entry = 50012272   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 0.54/59)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.870	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 9.0/1800)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair				3D Structure (crystal)
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	8.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 25/1600)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	8.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound against Dopamine receptor D2 was measured using [3H]-pramipexole in Bovine striatal membranes				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat D2 short receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat D2 long receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human D4.2 receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (BOVINE)	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human Dopamine receptor D3				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 short (high/low affinity is given as 27/1800)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 27/5400)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 short (high/low affinity is given as 35/3700)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D4.4 (high/low affinity is given as 8.5/130)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D4.4 (high/low affinity is given as 50/2200)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound against Dopamine receptor D2 was measured using [3H]-pramipexole in Bovine striatal membranes				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	85	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human D4.2 receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	87	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D4.4 (high/low affinity is given as 87/23000)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 short (high/low affinity is given as 130/50000)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 16/16000)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured for 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT-labeled porcine brain homogenates				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound against Dopamine receptor D2 was measured using [3H]-pramipexole in Bovine striatal membranes				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (BOVINE)	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	9.80	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human D3 receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human D3 receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human D4.2 receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound against Dopamine receptor D2 was measured using [3H]-pramipexole in Bovine striatal membranes				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	9.20	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat D2 long receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat D2 short receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	430	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 0.87/44)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D4.4 (high/low affinity is given as 16/1300)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat D2 long receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 230/53000)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat D2 short receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D2L (high/low affinity is given as 85/6400)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50116765 (3-Propyl-1,2,3,4-tetrahydro-3,8a,9-triaza-fluorene...) Show SMILES CCCN1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C13H17N3/c1-2-7-15-9-6-12-11(10-15)13-5-3-4-8-16(13)14-12/h3-5,8H,2,6-7,9-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 short (high/low affinity is given as 40/3600)				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50116767 (CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...) Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat Dopamine receptor D2L				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50116766 ((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...) Show SMILES CCCN[C@H]1CCc2nc(N)sc2C1 |r| Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human D3 receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair				3D Structure (crystal)
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against rat D2 long receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50010617 ((-)-3-(1-Propyl-piperidin-3-yl)-phenol | (S)-3-(1-...) Show SMILES CCCN1CCC[C@H](C1)c1cccc(O)c1 Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity against human D4.2 receptor				Bioorg Med Chem Lett 12: 2377-80 (2002) BindingDB Entry DOI: 10.7270/Q2Z89BRG
					More data for this Ligand-Target Pair