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Compile Data Set for Download or QSAR

Found 53 hits Enz. Inhib. hit(s) with all data for entry = 50013292   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564437
PNG
(CHEMBL4795285)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(cc4)C(=O)NO)nc(Cl)nc23)cc1
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n/an/a 11.3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564442
PNG
(CHEMBL4789410)
Show SMILES COc1cc(Nc2nc(N)nc3n(Cc4ccc(cc4)C(=O)Nc4ccccc4N)cnc23)cc(OC)c1
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n/an/a 23.9n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564443
PNG
(CHEMBL4782132)
Show SMILES Nc1nc(Nc2ccc(F)c(Cl)c2)c2ccn(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2n1
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n/an/a 93.3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a 108n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564438
PNG
(CHEMBL4781354)
Show SMILES Cc1c[nH]nc1Nc1nc(Cl)nc2n(Cc3ccc(cc3)C(=O)Nc3ccccc3N)cnc12
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n/an/a 165n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564442
PNG
(CHEMBL4789410)
Show SMILES COc1cc(Nc2nc(N)nc3n(Cc4ccc(cc4)C(=O)Nc4ccccc4N)cnc23)cc(OC)c1
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n/an/a 179n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564437
PNG
(CHEMBL4795285)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(cc4)C(=O)NO)nc(Cl)nc23)cc1
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n/an/a 182n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50564442
PNG
(CHEMBL4789410)
Show SMILES COc1cc(Nc2nc(N)nc3n(Cc4ccc(cc4)C(=O)Nc4ccccc4N)cnc23)cc(OC)c1
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n/an/a 245n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC3 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564440
PNG
(CHEMBL4781490)
Show SMILES Nc1nc(Cl)c2ncn(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2n1
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n/an/a 271n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564437
PNG
(CHEMBL4795285)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(cc4)C(=O)NO)nc(Cl)nc23)cc1
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n/an/a 352n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a 544n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a 563n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC3 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
PDB
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n/an/a 585n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a 613n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a 624n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC3 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564436
PNG
(CHEMBL4784684)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(Cl)nc23)cc1
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n/an/a 685n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564438
PNG
(CHEMBL4781354)
Show SMILES Cc1c[nH]nc1Nc1nc(Cl)nc2n(Cc3ccc(cc3)C(=O)Nc3ccccc3N)cnc12
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n/an/a 739n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564440
PNG
(CHEMBL4781490)
Show SMILES Nc1nc(Cl)c2ncn(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2n1
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n/an/a 761n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564439
PNG
(CHEMBL4782990)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2ccc3c(Cl)nc(Cl)nc23)cc1
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n/an/a 861n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564444
PNG
(CHEMBL4790853)
Show SMILES Nc1nc(Cl)c2ccn(Cc3ccc(cc3)C(=O)Nc3cc(F)ccc3N)c2n1
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n/an/a 1.15E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50564444
PNG
(CHEMBL4790853)
Show SMILES Nc1nc(Cl)c2ccn(Cc3ccc(cc3)C(=O)Nc3cc(F)ccc3N)c2n1
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n/an/a 1.23E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC1 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564437
PNG
(CHEMBL4795285)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(cc4)C(=O)NO)nc(Cl)nc23)cc1
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n/an/a 1.45E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564443
PNG
(CHEMBL4782132)
Show SMILES Nc1nc(Nc2ccc(F)c(Cl)c2)c2ccn(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2n1
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n/an/a 1.46E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Polyamine deacetylase HDAC10


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a 3.15E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC10 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresc...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564436
PNG
(CHEMBL4784684)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(Cl)nc23)cc1
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n/an/a 3.78E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Polyamine deacetylase HDAC10


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a 5.75E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC10 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresc...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50564439
PNG
(CHEMBL4782990)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2ccc3c(Cl)nc(Cl)nc23)cc1
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n/an/a 6.51E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC2 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a 6.81E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564442
PNG
(CHEMBL4789410)
Show SMILES COc1cc(Nc2nc(N)nc3n(Cc4ccc(cc4)C(=O)Nc4ccccc4N)cnc23)cc(OC)c1
PDB
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n/an/a 9.61E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a 9.88E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC4 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC9 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC9 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC7 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC7 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC5 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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TBA

Assay Description
Inhibition of human recombinant HDAC5 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC4 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564444
PNG
(CHEMBL4790853)
Show SMILES Nc1nc(Cl)c2ccn(Cc3ccc(cc3)C(=O)Nc3cc(F)ccc3N)c2n1
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TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564441
PNG
(CHEMBL4790678)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(N)nc23)cc1
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n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564439
PNG
(CHEMBL4782990)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2ccc3c(Cl)nc(Cl)nc23)cc1
PDB
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TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564438
PNG
(CHEMBL4781354)
Show SMILES Cc1c[nH]nc1Nc1nc(Cl)nc2n(Cc3ccc(cc3)C(=O)Nc3ccccc3N)cnc12
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TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564436
PNG
(CHEMBL4784684)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cnc3c(Nc4ccc(F)c(Cl)c4)nc(Cl)nc23)cc1
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TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564442
PNG
(CHEMBL4789410)
Show SMILES COc1cc(Nc2nc(N)nc3n(Cc4ccc(cc4)C(=O)Nc4ccccc4N)cnc23)cc(OC)c1
PDB
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TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564443
PNG
(CHEMBL4782132)
Show SMILES Nc1nc(Nc2ccc(F)c(Cl)c2)c2ccn(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2n1
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TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564443
PNG
(CHEMBL4782132)
Show SMILES Nc1nc(Nc2ccc(F)c(Cl)c2)c2ccn(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2n1
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TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50564444
PNG
(CHEMBL4790853)
Show SMILES Nc1nc(Cl)c2ccn(Cc3ccc(cc3)C(=O)Nc3cc(F)ccc3N)c2n1
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TBA

Assay Description
Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564440
PNG
(CHEMBL4781490)
Show SMILES Nc1nc(Cl)c2ncn(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2n1
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TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564439
PNG
(CHEMBL4782990)
Show SMILES Nc1ccccc1NC(=O)c1ccc(Cn2ccc3c(Cl)nc(Cl)nc23)cc1
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TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50564438
PNG
(CHEMBL4781354)
Show SMILES Cc1c[nH]nc1Nc1nc(Cl)nc2n(Cc3ccc(cc3)C(=O)Nc3ccccc3N)cnc12
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n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC8 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112291
BindingDB Entry DOI: 10.7270/Q26W9FT0
More data for this
Ligand-Target Pair
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