Found 40 hits Enz. Inhib. hit(s) with all data for entry = 50014175 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573270
(CHEMBL4852442)Show SMILES CCN(CC)CCCNc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(cc2)C(F)(F)F)CC1 |t:49| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573282
(CHEMBL4851332)Show SMILES CCN1CCC(COc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)CC1 |t:48| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573281
(CHEMBL4851700)Show SMILES CN1CCC(COc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)C1 |t:47| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573268
(CHEMBL4867128)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(c(Cl)c1)C(F)(F)F |c:57| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573264
(CHEMBL4863897)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1C(F)(F)F |c:57| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.860 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573269
(CHEMBL4860213)Show SMILES CN(C)CCCNc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(cc2)C(F)(F)F)CC1 |t:47| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50162774
(ABT-199 | US11420968, Example ABT-199 | Venetoclax)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)N(=O)=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573275
(CHEMBL4878326)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573265
(CHEMBL4868427)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573279
(CHEMBL4858527)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCSCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573267
(CHEMBL4861424)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccccc1C(F)(F)F |c:57| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573274
(CHEMBL4860155)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:55| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573271
(CHEMBL4858569)Show SMILES CN1CCC(CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)C1 |t:47| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573272
(CHEMBL4847514)Show SMILES CC(C)C(=O)N1CCC(CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)CC1 |t:51| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573278
(CHEMBL4855736)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573266
(CHEMBL4873467)Show SMILES COc1ccc(cc1)C1=C(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)CCC(C)(C)C1 |c:9| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573277
(CHEMBL4855086)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:56| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573273
(CHEMBL4862150)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:56| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573276
(CHEMBL4878411)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:56| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50573280
(CHEMBL4866646)Show SMILES CC(Oc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(cc2)C(F)(F)F)CC1)C1CCOCC1 |t:43| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-2 (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573281
(CHEMBL4851700)Show SMILES CN1CCC(COc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)C1 |t:47| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573270
(CHEMBL4852442)Show SMILES CCN(CC)CCCNc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(cc2)C(F)(F)F)CC1 |t:49| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573269
(CHEMBL4860213)Show SMILES CN(C)CCCNc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(cc2)C(F)(F)F)CC1 |t:47| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573282
(CHEMBL4851332)Show SMILES CCN1CCC(COc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)CC1 |t:48| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573271
(CHEMBL4858569)Show SMILES CN1CCC(CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)C1 |t:47| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50162774
(ABT-199 | US11420968, Example ABT-199 | Venetoclax)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)N(=O)=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573267
(CHEMBL4861424)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccccc1C(F)(F)F |c:57| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573272
(CHEMBL4847514)Show SMILES CC(C)C(=O)N1CCC(CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)CC1 |t:51| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 453 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573279
(CHEMBL4858527)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCSCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573280
(CHEMBL4866646)Show SMILES CC(Oc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(cc2)C(F)(F)F)CC1)C1CCOCC1 |t:43| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 618 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573278
(CHEMBL4855736)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 761 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573265
(CHEMBL4868427)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 788 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573266
(CHEMBL4873467)Show SMILES COc1ccc(cc1)C1=C(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)CCC(C)(C)C1 |c:9| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 813 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573274
(CHEMBL4860155)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:55| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 837 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573275
(CHEMBL4878326)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:57| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 862 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573273
(CHEMBL4862150)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:56| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 897 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573277
(CHEMBL4855086)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OCC4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:56| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573264
(CHEMBL4863897)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1C(F)(F)F |c:57| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573268
(CHEMBL4867128)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(c(Cl)c1)C(F)(F)F |c:57| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50573276
(CHEMBL4878411)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(cc1)C(F)(F)F |c:56| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of Bak derived peptide from Bcl-xL (unknown origin) measured after 15 mins by microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116350
BindingDB Entry DOI: 10.7270/Q2R2155T |
More data for this
Ligand-Target Pair | |
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