Found 46 hits Enz. Inhib. hit(s) with all data for entry = 50014592 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Mus musculus) | BDBM50014619
(CHEMBL3184840)Show SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C69H108N22O16S/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55(94)89-28-11-19-51(89)62(101)84-46(24-31-108-3)66(105)91-30-13-21-53(91)64(103)87-49(67(106)107)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,92H,7-13,16-34,36-37,70H2,1-3H3,(H,75,79)(H,78,95)(H,80,93)(H,81,99)(H,82,102)(H,83,97)(H,84,101)(H,85,96)(H,86,100)(H,87,103)(H,88,98)(H,106,107)(H4,71,72,76)(H4,73,74,77)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [125I]Apelin13 from mouse APJ receptor expressed in HEK293T cells incubated for 1 hr by gamma counter method |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577755
(CHEMBL4861895)Show SMILES CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(C)cn3)o2)c(O)c1-c1c(OC)cccc1OC |(56.32,-36.8,;57.65,-37.57,;58.99,-36.8,;60.32,-37.56,;61.65,-36.79,;61.65,-35.25,;62.99,-34.48,;62.99,-32.94,;64.32,-35.25,;65.66,-34.48,;67.06,-35.1,;68.09,-33.96,;67.32,-32.63,;67.95,-31.22,;69.48,-31.06,;70.1,-29.66,;71.62,-29.49,;72.54,-30.74,;74.07,-30.58,;71.91,-32.15,;70.38,-32.31,;65.81,-32.95,;64.32,-36.78,;65.66,-37.55,;62.99,-37.55,;63,-39.08,;64.33,-39.85,;65.66,-39.07,;67,-39.84,;64.34,-41.4,;63,-42.17,;61.66,-41.4,;61.67,-39.85,;60.33,-39.08,;59,-39.85,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577739
(CHEMBL4863722)Show SMILES CCCCc1[nH]c(=O)c(C(=O)NCC)c(O)c1-c1c(OC)cccc1OC |(32.08,-11.24,;33.41,-12,;34.74,-11.23,;36.08,-12,;37.41,-11.23,;37.41,-9.68,;38.75,-8.91,;38.75,-7.37,;40.08,-9.68,;41.41,-8.91,;41.42,-7.37,;42.75,-9.69,;44.08,-8.92,;45.41,-9.69,;40.08,-11.22,;41.41,-11.99,;38.75,-11.99,;38.75,-13.52,;40.09,-14.28,;41.42,-13.51,;42.76,-14.27,;40.09,-15.83,;38.76,-16.6,;37.42,-15.83,;37.42,-14.29,;36.09,-13.52,;34.76,-14.29,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577740
(CHEMBL4854830)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N(C)C)c(O)c1-c1c(OC)cccc1OC |(50.69,-11.72,;52.02,-12.49,;53.35,-11.71,;54.69,-12.48,;56.02,-11.71,;56.02,-10.16,;57.36,-9.39,;57.36,-7.85,;58.69,-10.17,;60.03,-9.4,;60.03,-7.86,;61.36,-10.17,;62.69,-9.4,;61.36,-11.71,;58.69,-11.7,;60.03,-12.47,;57.36,-12.47,;57.36,-14,;58.7,-14.76,;60.03,-13.99,;61.37,-14.75,;58.71,-16.31,;57.37,-17.09,;56.03,-16.31,;56.04,-14.77,;54.7,-14,;53.37,-14.77,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577741
(CHEMBL4848469)Show SMILES CCCCc1[nH]c(=O)c(C(=O)NCc2ccccc2)c(O)c1-c1c(OC)cccc1OC |(66.14,-11.32,;67.48,-12.09,;68.81,-11.32,;70.14,-12.08,;71.48,-11.31,;71.48,-9.77,;72.81,-9,;72.82,-7.46,;74.15,-9.77,;75.48,-9,;75.48,-7.46,;76.81,-9.77,;78.15,-9,;79.48,-9.77,;79.48,-11.31,;80.81,-12.08,;82.14,-11.31,;82.14,-9.76,;80.81,-9,;74.15,-11.3,;75.48,-12.07,;72.81,-12.07,;72.82,-13.6,;74.16,-14.37,;75.49,-13.59,;76.82,-14.36,;74.16,-15.92,;72.82,-16.69,;71.49,-15.92,;71.49,-14.37,;70.16,-13.6,;68.82,-14.37,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577742
(CHEMBL4845664)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N(CCC)Cc2ccccc2)c(O)c1-c1c(OC)cccc1OC |(4.34,-34.51,;5.67,-35.28,;7.01,-34.5,;8.34,-35.27,;9.67,-34.5,;9.68,-32.95,;11.01,-32.18,;11.01,-30.64,;12.34,-32.95,;13.68,-32.18,;13.68,-30.64,;15.01,-32.96,;15.01,-34.5,;16.34,-35.27,;16.34,-36.81,;16.35,-32.19,;17.68,-32.96,;17.67,-34.5,;19,-35.27,;20.34,-34.5,;20.34,-32.95,;19,-32.19,;12.34,-34.49,;13.68,-35.26,;11.01,-35.26,;11.02,-36.79,;12.35,-37.55,;13.68,-36.78,;15.02,-37.54,;12.36,-39.1,;11.02,-39.87,;9.69,-39.1,;9.69,-37.56,;8.35,-36.79,;7.02,-37.56,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577743
(CHEMBL4856612)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N(C)CCc2ccc(Cl)cc2)c(O)c1-c1c(OC)cccc1OC |(24.44,-33.85,;25.77,-34.62,;27.1,-33.85,;28.44,-34.62,;29.77,-33.84,;29.77,-32.3,;31.11,-31.53,;31.11,-29.99,;32.44,-32.3,;33.78,-31.53,;33.78,-29.99,;35.11,-32.3,;35.11,-33.84,;36.44,-31.53,;37.78,-32.3,;39.11,-31.54,;40.44,-32.31,;41.77,-31.55,;41.77,-30,;43.11,-29.23,;40.43,-29.23,;39.1,-30.01,;32.44,-33.83,;33.78,-34.6,;31.11,-34.61,;31.11,-36.13,;32.45,-36.9,;33.78,-36.12,;35.12,-36.89,;32.46,-38.45,;31.12,-39.22,;29.78,-38.45,;29.79,-36.91,;28.45,-36.14,;27.12,-36.91,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577744
(CHEMBL4851693)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N2CC[C@@H](C2)c2ccccc2)c(O)c1-c1c(OC)cccc1OC |r,wU:14.16,(45.46,-32.95,;46.8,-33.72,;48.13,-32.95,;49.46,-33.71,;50.8,-32.94,;50.8,-31.4,;52.13,-30.63,;52.13,-29.09,;53.46,-31.4,;54.8,-30.63,;54.8,-29.09,;56.13,-31.4,;56.29,-32.92,;57.8,-33.25,;58.57,-31.91,;57.54,-30.77,;60.1,-31.75,;61,-33,;62.53,-32.84,;63.16,-31.44,;62.24,-30.19,;60.72,-30.35,;53.47,-32.93,;54.8,-33.7,;52.13,-33.7,;52.14,-35.23,;53.47,-36,;54.8,-35.22,;56.14,-35.99,;53.48,-37.55,;52.14,-38.32,;50.81,-37.55,;50.81,-36,;49.48,-35.23,;48.14,-36,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577745
(CHEMBL4869091)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N2CC[C@H](C2)c2ccccc2)c(O)c1-c1c(OC)cccc1OC |r,wD:14.16,(65.8,-33.08,;67.14,-33.84,;68.47,-33.07,;69.8,-33.84,;71.13,-33.07,;71.14,-31.52,;72.47,-30.75,;72.47,-29.21,;73.8,-31.52,;75.14,-30.75,;75.14,-29.21,;76.47,-31.53,;76.63,-33.05,;78.14,-33.37,;78.91,-32.04,;77.88,-30.89,;80.44,-31.88,;81.34,-33.13,;82.87,-32.97,;83.5,-31.56,;82.58,-30.31,;81.06,-30.48,;73.81,-33.06,;75.14,-33.83,;72.47,-33.83,;72.48,-35.36,;73.81,-36.12,;75.14,-35.35,;76.48,-36.11,;73.82,-37.67,;72.48,-38.44,;71.15,-37.67,;71.15,-36.13,;69.82,-35.36,;68.48,-36.13,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577746
(CHEMBL4855254)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@@H](C2)c2ccccc2)c(O)n1-c1c(OC)cccc1OC |r,wU:14.16,(5.13,-48.76,;6.47,-49.53,;7.8,-48.76,;9.14,-49.53,;10.49,-48.76,;10.48,-47.22,;11.81,-46.46,;11.81,-44.9,;13.13,-47.22,;14.47,-46.44,;14.47,-44.9,;15.8,-47.21,;15.96,-48.74,;17.47,-49.06,;18.24,-47.72,;17.21,-46.58,;19.77,-47.56,;20.67,-48.81,;22.2,-48.66,;22.83,-47.25,;21.92,-46,;20.39,-46.16,;13.14,-48.74,;14.47,-49.51,;11.81,-49.51,;11.81,-51.04,;13.15,-51.81,;14.48,-51.03,;15.81,-51.8,;13.15,-53.36,;11.81,-54.13,;10.48,-53.36,;10.48,-51.82,;9.15,-51.05,;7.81,-51.82,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.220 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577747
(CHEMBL4872407)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@H](C2)c2ccccc2)c(O)n1-c1c(OC)cccc1OC |r,wD:14.16,(25.17,-48.11,;26.5,-48.88,;27.83,-48.11,;29.17,-48.87,;30.52,-48.11,;30.52,-46.57,;31.84,-45.8,;31.84,-44.24,;33.17,-46.57,;34.51,-45.79,;34.51,-44.25,;35.84,-46.56,;36,-48.08,;37.51,-48.4,;38.28,-47.07,;37.25,-45.92,;39.81,-46.91,;40.71,-48.16,;42.24,-48,;42.86,-46.59,;41.95,-45.34,;40.42,-45.51,;33.17,-48.09,;34.51,-48.86,;31.85,-48.85,;31.85,-50.39,;33.18,-51.15,;34.51,-50.38,;35.85,-51.14,;33.19,-52.7,;31.85,-53.48,;30.51,-52.71,;30.52,-51.16,;29.18,-50.39,;27.85,-51.16,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577748
(CHEMBL4870497)Show SMILES CCOCc1nc(=O)c(C(=O)N2CC[C@@H](C2)c2ccccc2)c(O)n1-c1c(OC)cccc1OC |r,wU:14.16,(46,-48.12,;47.33,-48.89,;48.66,-48.11,;50,-48.88,;51.35,-48.11,;51.35,-46.58,;52.67,-45.81,;52.67,-44.25,;54,-46.58,;55.34,-45.8,;55.34,-44.26,;56.67,-46.57,;56.83,-48.09,;58.34,-48.41,;59.11,-47.08,;58.08,-45.93,;60.64,-46.92,;61.54,-48.17,;63.07,-48.01,;63.7,-46.6,;62.78,-45.35,;61.25,-45.52,;54,-48.1,;55.34,-48.87,;52.68,-48.86,;52.68,-50.4,;54.01,-51.16,;55.34,-50.39,;56.68,-51.15,;54.02,-52.71,;52.68,-53.49,;51.34,-52.71,;51.35,-51.17,;50.01,-50.4,;48.68,-51.17,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577749
(CHEMBL4854048)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577749
(CHEMBL4854048)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577750
(CHEMBL4874120)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccccn2)c(O)n1-c1c(OC)cccc1OC |(24.48,-6.08,;25.82,-6.85,;27.15,-6.07,;28.49,-6.84,;29.84,-6.07,;29.84,-4.54,;31.16,-3.77,;31.16,-2.21,;32.48,-4.54,;33.82,-3.76,;33.82,-2.22,;35.16,-4.53,;35.32,-6.05,;36.82,-6.37,;37.59,-5.04,;36.56,-3.89,;39.12,-4.88,;40.02,-6.13,;41.55,-5.97,;42.18,-4.56,;41.27,-3.31,;39.74,-3.48,;32.49,-6.06,;33.82,-6.83,;31.16,-6.82,;31.16,-8.36,;32.5,-9.12,;33.83,-8.35,;35.16,-9.11,;32.5,-10.67,;31.16,-11.45,;29.83,-10.68,;29.83,-9.13,;28.5,-8.36,;27.17,-9.13,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577750
(CHEMBL4874120)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccccn2)c(O)n1-c1c(OC)cccc1OC |(24.48,-6.08,;25.82,-6.85,;27.15,-6.07,;28.49,-6.84,;29.84,-6.07,;29.84,-4.54,;31.16,-3.77,;31.16,-2.21,;32.48,-4.54,;33.82,-3.76,;33.82,-2.22,;35.16,-4.53,;35.32,-6.05,;36.82,-6.37,;37.59,-5.04,;36.56,-3.89,;39.12,-4.88,;40.02,-6.13,;41.55,-5.97,;42.18,-4.56,;41.27,-3.31,;39.74,-3.48,;32.49,-6.06,;33.82,-6.83,;31.16,-6.82,;31.16,-8.36,;32.5,-9.12,;33.83,-8.35,;35.16,-9.11,;32.5,-10.67,;31.16,-11.45,;29.83,-10.68,;29.83,-9.13,;28.5,-8.36,;27.17,-9.13,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577751
(CHEMBL4863297)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577751
(CHEMBL4863297)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577752
(CHEMBL4875108)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccncc2)c(O)n1-c1c(OC)cccc1OC |(23.15,-20.44,;24.49,-21.21,;25.82,-20.43,;27.16,-21.2,;28.51,-20.43,;28.51,-18.9,;29.83,-18.13,;29.83,-16.57,;31.16,-18.89,;32.49,-18.12,;32.49,-16.58,;33.83,-18.89,;33.99,-20.41,;35.49,-20.73,;36.26,-19.4,;35.23,-18.25,;37.8,-19.24,;38.69,-20.49,;40.22,-20.33,;40.85,-18.92,;39.94,-17.67,;38.41,-17.84,;31.16,-20.42,;32.49,-21.19,;29.83,-21.18,;29.83,-22.72,;31.17,-23.48,;32.5,-22.71,;33.83,-23.47,;31.17,-25.03,;29.84,-25.8,;28.5,-25.03,;28.5,-23.49,;27.17,-22.72,;25.84,-23.49,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577752
(CHEMBL4875108)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccncc2)c(O)n1-c1c(OC)cccc1OC |(23.15,-20.44,;24.49,-21.21,;25.82,-20.43,;27.16,-21.2,;28.51,-20.43,;28.51,-18.9,;29.83,-18.13,;29.83,-16.57,;31.16,-18.89,;32.49,-18.12,;32.49,-16.58,;33.83,-18.89,;33.99,-20.41,;35.49,-20.73,;36.26,-19.4,;35.23,-18.25,;37.8,-19.24,;38.69,-20.49,;40.22,-20.33,;40.85,-18.92,;39.94,-17.67,;38.41,-17.84,;31.16,-20.42,;32.49,-21.19,;29.83,-21.18,;29.83,-22.72,;31.17,-23.48,;32.5,-22.71,;33.83,-23.47,;31.17,-25.03,;29.84,-25.8,;28.5,-25.03,;28.5,-23.49,;27.17,-22.72,;25.84,-23.49,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577753
(CHEMBL4854412)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@H](C2)c2ccc(Cl)cn2)c(O)n1-c1c(OC)cccc1OC |r,wD:14.16,(65.16,-22.29,;66.5,-23.06,;67.83,-22.28,;69.16,-23.05,;70.51,-22.28,;70.51,-20.75,;71.84,-19.98,;71.83,-18.42,;73.16,-20.75,;74.5,-19.97,;74.5,-18.43,;75.83,-20.74,;75.99,-22.26,;77.5,-22.58,;78.27,-21.25,;77.24,-20.1,;79.8,-21.09,;80.7,-22.34,;82.23,-22.18,;82.86,-20.77,;84.39,-20.61,;81.94,-19.52,;80.42,-19.69,;73.17,-22.27,;74.5,-23.04,;71.84,-23.03,;71.84,-24.57,;73.17,-25.33,;74.5,-24.56,;75.84,-25.32,;73.18,-26.88,;71.84,-27.65,;70.51,-26.88,;70.51,-25.34,;69.18,-24.57,;67.84,-25.34,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577754
(CHEMBL4867145)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@@H](C2)c2ccc(Cl)cn2)c(O)n1-c1c(OC)cccc1OC |r,wU:14.16,(2.45,-36.58,;3.78,-37.34,;5.12,-36.57,;6.45,-37.34,;7.8,-36.57,;7.8,-35.04,;9.13,-34.27,;9.12,-32.71,;10.45,-35.03,;11.79,-34.25,;11.79,-32.71,;13.12,-35.02,;13.28,-36.55,;14.79,-36.87,;15.56,-35.54,;14.53,-34.39,;17.09,-35.38,;17.99,-36.63,;19.52,-36.47,;20.15,-35.06,;21.68,-34.9,;19.23,-33.81,;17.71,-33.97,;10.45,-36.56,;11.79,-37.32,;9.13,-37.32,;9.13,-38.86,;10.46,-39.62,;11.79,-38.85,;13.13,-39.61,;10.47,-41.17,;9.13,-41.94,;7.8,-41.17,;7.8,-39.63,;6.46,-38.86,;5.13,-39.63,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0320 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363380
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,(1.29,1.57,;-.05,.8,;-1.38,1.57,;-1.38,3.11,;-2.71,3.88,;-4.05,3.11,;-4.05,1.57,;-5.38,.8,;-6.71,1.57,;-2.71,.8,;-2.71,-.74,;-1.47,-1.65,;.02,-1.25,;1.11,-2.34,;.34,-3.67,;1.88,-3.67,;2.44,-1.57,;2.44,-.03,;3.78,-2.34,;3.78,-3.88,;5.11,-1.57,;6.44,-2.34,;7.78,-1.57,;7.78,-.03,;9.11,.74,;6.44,.74,;5.11,-.03,;-1.94,-3.11,;-3.48,-3.11,;-3.96,-1.65,;-5.45,-1.25,;-5.84,.24,;-7.33,.64,;-8.42,-.45,;-8.02,-1.94,;-9.11,-3.03,;-6.54,-2.34,)| Show InChI InChI=1S/C25H29N7O4S/c1-15-10-19(14-26-11-15)24-29-30-25(32(24)22-20(35-5)8-7-9-21(22)36-6)31-37(33,34)18(4)17(3)23-27-12-16(2)13-28-23/h7-14,17-18H,1-6H3,(H,30,31)/t17-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50577755
(CHEMBL4861895)Show SMILES CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(C)cn3)o2)c(O)c1-c1c(OC)cccc1OC |(56.32,-36.8,;57.65,-37.57,;58.99,-36.8,;60.32,-37.56,;61.65,-36.79,;61.65,-35.25,;62.99,-34.48,;62.99,-32.94,;64.32,-35.25,;65.66,-34.48,;67.06,-35.1,;68.09,-33.96,;67.32,-32.63,;67.95,-31.22,;69.48,-31.06,;70.1,-29.66,;71.62,-29.49,;72.54,-30.74,;74.07,-30.58,;71.91,-32.15,;70.38,-32.31,;65.81,-32.95,;64.32,-36.78,;65.66,-37.55,;62.99,-37.55,;63,-39.08,;64.33,-39.85,;65.66,-39.07,;67,-39.84,;64.34,-41.4,;63,-42.17,;61.66,-41.4,;61.67,-39.85,;60.33,-39.08,;59,-39.85,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0230 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50014619
(CHEMBL3184840)Show SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C69H108N22O16S/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55(94)89-28-11-19-51(89)62(101)84-46(24-31-108-3)66(105)91-30-13-21-53(91)64(103)87-49(67(106)107)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,92H,7-13,16-34,36-37,70H2,1-3H3,(H,75,79)(H,78,95)(H,80,93)(H,81,99)(H,82,102)(H,83,97)(H,84,101)(H,85,96)(H,86,100)(H,87,103)(H,88,98)(H,106,107)(H4,71,72,76)(H4,73,74,77)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577739
(CHEMBL4863722)Show SMILES CCCCc1[nH]c(=O)c(C(=O)NCC)c(O)c1-c1c(OC)cccc1OC |(32.08,-11.24,;33.41,-12,;34.74,-11.23,;36.08,-12,;37.41,-11.23,;37.41,-9.68,;38.75,-8.91,;38.75,-7.37,;40.08,-9.68,;41.41,-8.91,;41.42,-7.37,;42.75,-9.69,;44.08,-8.92,;45.41,-9.69,;40.08,-11.22,;41.41,-11.99,;38.75,-11.99,;38.75,-13.52,;40.09,-14.28,;41.42,-13.51,;42.76,-14.27,;40.09,-15.83,;38.76,-16.6,;37.42,-15.83,;37.42,-14.29,;36.09,-13.52,;34.76,-14.29,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577740
(CHEMBL4854830)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N(C)C)c(O)c1-c1c(OC)cccc1OC |(50.69,-11.72,;52.02,-12.49,;53.35,-11.71,;54.69,-12.48,;56.02,-11.71,;56.02,-10.16,;57.36,-9.39,;57.36,-7.85,;58.69,-10.17,;60.03,-9.4,;60.03,-7.86,;61.36,-10.17,;62.69,-9.4,;61.36,-11.71,;58.69,-11.7,;60.03,-12.47,;57.36,-12.47,;57.36,-14,;58.7,-14.76,;60.03,-13.99,;61.37,-14.75,;58.71,-16.31,;57.37,-17.09,;56.03,-16.31,;56.04,-14.77,;54.7,-14,;53.37,-14.77,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577741
(CHEMBL4848469)Show SMILES CCCCc1[nH]c(=O)c(C(=O)NCc2ccccc2)c(O)c1-c1c(OC)cccc1OC |(66.14,-11.32,;67.48,-12.09,;68.81,-11.32,;70.14,-12.08,;71.48,-11.31,;71.48,-9.77,;72.81,-9,;72.82,-7.46,;74.15,-9.77,;75.48,-9,;75.48,-7.46,;76.81,-9.77,;78.15,-9,;79.48,-9.77,;79.48,-11.31,;80.81,-12.08,;82.14,-11.31,;82.14,-9.76,;80.81,-9,;74.15,-11.3,;75.48,-12.07,;72.81,-12.07,;72.82,-13.6,;74.16,-14.37,;75.49,-13.59,;76.82,-14.36,;74.16,-15.92,;72.82,-16.69,;71.49,-15.92,;71.49,-14.37,;70.16,-13.6,;68.82,-14.37,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577742
(CHEMBL4845664)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N(CCC)Cc2ccccc2)c(O)c1-c1c(OC)cccc1OC |(4.34,-34.51,;5.67,-35.28,;7.01,-34.5,;8.34,-35.27,;9.67,-34.5,;9.68,-32.95,;11.01,-32.18,;11.01,-30.64,;12.34,-32.95,;13.68,-32.18,;13.68,-30.64,;15.01,-32.96,;15.01,-34.5,;16.34,-35.27,;16.34,-36.81,;16.35,-32.19,;17.68,-32.96,;17.67,-34.5,;19,-35.27,;20.34,-34.5,;20.34,-32.95,;19,-32.19,;12.34,-34.49,;13.68,-35.26,;11.01,-35.26,;11.02,-36.79,;12.35,-37.55,;13.68,-36.78,;15.02,-37.54,;12.36,-39.1,;11.02,-39.87,;9.69,-39.1,;9.69,-37.56,;8.35,-36.79,;7.02,-37.56,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577743
(CHEMBL4856612)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N(C)CCc2ccc(Cl)cc2)c(O)c1-c1c(OC)cccc1OC |(24.44,-33.85,;25.77,-34.62,;27.1,-33.85,;28.44,-34.62,;29.77,-33.84,;29.77,-32.3,;31.11,-31.53,;31.11,-29.99,;32.44,-32.3,;33.78,-31.53,;33.78,-29.99,;35.11,-32.3,;35.11,-33.84,;36.44,-31.53,;37.78,-32.3,;39.11,-31.54,;40.44,-32.31,;41.77,-31.55,;41.77,-30,;43.11,-29.23,;40.43,-29.23,;39.1,-30.01,;32.44,-33.83,;33.78,-34.6,;31.11,-34.61,;31.11,-36.13,;32.45,-36.9,;33.78,-36.12,;35.12,-36.89,;32.46,-38.45,;31.12,-39.22,;29.78,-38.45,;29.79,-36.91,;28.45,-36.14,;27.12,-36.91,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577744
(CHEMBL4851693)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N2CC[C@@H](C2)c2ccccc2)c(O)c1-c1c(OC)cccc1OC |r,wU:14.16,(45.46,-32.95,;46.8,-33.72,;48.13,-32.95,;49.46,-33.71,;50.8,-32.94,;50.8,-31.4,;52.13,-30.63,;52.13,-29.09,;53.46,-31.4,;54.8,-30.63,;54.8,-29.09,;56.13,-31.4,;56.29,-32.92,;57.8,-33.25,;58.57,-31.91,;57.54,-30.77,;60.1,-31.75,;61,-33,;62.53,-32.84,;63.16,-31.44,;62.24,-30.19,;60.72,-30.35,;53.47,-32.93,;54.8,-33.7,;52.13,-33.7,;52.14,-35.23,;53.47,-36,;54.8,-35.22,;56.14,-35.99,;53.48,-37.55,;52.14,-38.32,;50.81,-37.55,;50.81,-36,;49.48,-35.23,;48.14,-36,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577745
(CHEMBL4869091)Show SMILES CCCCc1[nH]c(=O)c(C(=O)N2CC[C@H](C2)c2ccccc2)c(O)c1-c1c(OC)cccc1OC |r,wD:14.16,(65.8,-33.08,;67.14,-33.84,;68.47,-33.07,;69.8,-33.84,;71.13,-33.07,;71.14,-31.52,;72.47,-30.75,;72.47,-29.21,;73.8,-31.52,;75.14,-30.75,;75.14,-29.21,;76.47,-31.53,;76.63,-33.05,;78.14,-33.37,;78.91,-32.04,;77.88,-30.89,;80.44,-31.88,;81.34,-33.13,;82.87,-32.97,;83.5,-31.56,;82.58,-30.31,;81.06,-30.48,;73.81,-33.06,;75.14,-33.83,;72.47,-33.83,;72.48,-35.36,;73.81,-36.12,;75.14,-35.35,;76.48,-36.11,;73.82,-37.67,;72.48,-38.44,;71.15,-37.67,;71.15,-36.13,;69.82,-35.36,;68.48,-36.13,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577746
(CHEMBL4855254)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@@H](C2)c2ccccc2)c(O)n1-c1c(OC)cccc1OC |r,wU:14.16,(5.13,-48.76,;6.47,-49.53,;7.8,-48.76,;9.14,-49.53,;10.49,-48.76,;10.48,-47.22,;11.81,-46.46,;11.81,-44.9,;13.13,-47.22,;14.47,-46.44,;14.47,-44.9,;15.8,-47.21,;15.96,-48.74,;17.47,-49.06,;18.24,-47.72,;17.21,-46.58,;19.77,-47.56,;20.67,-48.81,;22.2,-48.66,;22.83,-47.25,;21.92,-46,;20.39,-46.16,;13.14,-48.74,;14.47,-49.51,;11.81,-49.51,;11.81,-51.04,;13.15,-51.81,;14.48,-51.03,;15.81,-51.8,;13.15,-53.36,;11.81,-54.13,;10.48,-53.36,;10.48,-51.82,;9.15,-51.05,;7.81,-51.82,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577747
(CHEMBL4872407)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@H](C2)c2ccccc2)c(O)n1-c1c(OC)cccc1OC |r,wD:14.16,(25.17,-48.11,;26.5,-48.88,;27.83,-48.11,;29.17,-48.87,;30.52,-48.11,;30.52,-46.57,;31.84,-45.8,;31.84,-44.24,;33.17,-46.57,;34.51,-45.79,;34.51,-44.25,;35.84,-46.56,;36,-48.08,;37.51,-48.4,;38.28,-47.07,;37.25,-45.92,;39.81,-46.91,;40.71,-48.16,;42.24,-48,;42.86,-46.59,;41.95,-45.34,;40.42,-45.51,;33.17,-48.09,;34.51,-48.86,;31.85,-48.85,;31.85,-50.39,;33.18,-51.15,;34.51,-50.38,;35.85,-51.14,;33.19,-52.7,;31.85,-53.48,;30.51,-52.71,;30.52,-51.16,;29.18,-50.39,;27.85,-51.16,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577748
(CHEMBL4870497)Show SMILES CCOCc1nc(=O)c(C(=O)N2CC[C@@H](C2)c2ccccc2)c(O)n1-c1c(OC)cccc1OC |r,wU:14.16,(46,-48.12,;47.33,-48.89,;48.66,-48.11,;50,-48.88,;51.35,-48.11,;51.35,-46.58,;52.67,-45.81,;52.67,-44.25,;54,-46.58,;55.34,-45.8,;55.34,-44.26,;56.67,-46.57,;56.83,-48.09,;58.34,-48.41,;59.11,-47.08,;58.08,-45.93,;60.64,-46.92,;61.54,-48.17,;63.07,-48.01,;63.7,-46.6,;62.78,-45.35,;61.25,-45.52,;54,-48.1,;55.34,-48.87,;52.68,-48.86,;52.68,-50.4,;54.01,-51.16,;55.34,-50.39,;56.68,-51.15,;54.02,-52.71,;52.68,-53.49,;51.34,-52.71,;51.35,-51.17,;50.01,-50.4,;48.68,-51.17,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.610 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577749
(CHEMBL4854048)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577749
(CHEMBL4854048)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577750
(CHEMBL4874120)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccccn2)c(O)n1-c1c(OC)cccc1OC |(24.48,-6.08,;25.82,-6.85,;27.15,-6.07,;28.49,-6.84,;29.84,-6.07,;29.84,-4.54,;31.16,-3.77,;31.16,-2.21,;32.48,-4.54,;33.82,-3.76,;33.82,-2.22,;35.16,-4.53,;35.32,-6.05,;36.82,-6.37,;37.59,-5.04,;36.56,-3.89,;39.12,-4.88,;40.02,-6.13,;41.55,-5.97,;42.18,-4.56,;41.27,-3.31,;39.74,-3.48,;32.49,-6.06,;33.82,-6.83,;31.16,-6.82,;31.16,-8.36,;32.5,-9.12,;33.83,-8.35,;35.16,-9.11,;32.5,-10.67,;31.16,-11.45,;29.83,-10.68,;29.83,-9.13,;28.5,-8.36,;27.17,-9.13,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577750
(CHEMBL4874120)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccccn2)c(O)n1-c1c(OC)cccc1OC |(24.48,-6.08,;25.82,-6.85,;27.15,-6.07,;28.49,-6.84,;29.84,-6.07,;29.84,-4.54,;31.16,-3.77,;31.16,-2.21,;32.48,-4.54,;33.82,-3.76,;33.82,-2.22,;35.16,-4.53,;35.32,-6.05,;36.82,-6.37,;37.59,-5.04,;36.56,-3.89,;39.12,-4.88,;40.02,-6.13,;41.55,-5.97,;42.18,-4.56,;41.27,-3.31,;39.74,-3.48,;32.49,-6.06,;33.82,-6.83,;31.16,-6.82,;31.16,-8.36,;32.5,-9.12,;33.83,-8.35,;35.16,-9.11,;32.5,-10.67,;31.16,-11.45,;29.83,-10.68,;29.83,-9.13,;28.5,-8.36,;27.17,-9.13,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577751
(CHEMBL4863297)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.330 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577751
(CHEMBL4863297)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.330 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577752
(CHEMBL4875108)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccncc2)c(O)n1-c1c(OC)cccc1OC |(23.15,-20.44,;24.49,-21.21,;25.82,-20.43,;27.16,-21.2,;28.51,-20.43,;28.51,-18.9,;29.83,-18.13,;29.83,-16.57,;31.16,-18.89,;32.49,-18.12,;32.49,-16.58,;33.83,-18.89,;33.99,-20.41,;35.49,-20.73,;36.26,-19.4,;35.23,-18.25,;37.8,-19.24,;38.69,-20.49,;40.22,-20.33,;40.85,-18.92,;39.94,-17.67,;38.41,-17.84,;31.16,-20.42,;32.49,-21.19,;29.83,-21.18,;29.83,-22.72,;31.17,-23.48,;32.5,-22.71,;33.83,-23.47,;31.17,-25.03,;29.84,-25.8,;28.5,-25.03,;28.5,-23.49,;27.17,-22.72,;25.84,-23.49,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577752
(CHEMBL4875108)Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccncc2)c(O)n1-c1c(OC)cccc1OC |(23.15,-20.44,;24.49,-21.21,;25.82,-20.43,;27.16,-21.2,;28.51,-20.43,;28.51,-18.9,;29.83,-18.13,;29.83,-16.57,;31.16,-18.89,;32.49,-18.12,;32.49,-16.58,;33.83,-18.89,;33.99,-20.41,;35.49,-20.73,;36.26,-19.4,;35.23,-18.25,;37.8,-19.24,;38.69,-20.49,;40.22,-20.33,;40.85,-18.92,;39.94,-17.67,;38.41,-17.84,;31.16,-20.42,;32.49,-21.19,;29.83,-21.18,;29.83,-22.72,;31.17,-23.48,;32.5,-22.71,;33.83,-23.47,;31.17,-25.03,;29.84,-25.8,;28.5,-25.03,;28.5,-23.49,;27.17,-22.72,;25.84,-23.49,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577753
(CHEMBL4854412)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@H](C2)c2ccc(Cl)cn2)c(O)n1-c1c(OC)cccc1OC |r,wD:14.16,(65.16,-22.29,;66.5,-23.06,;67.83,-22.28,;69.16,-23.05,;70.51,-22.28,;70.51,-20.75,;71.84,-19.98,;71.83,-18.42,;73.16,-20.75,;74.5,-19.97,;74.5,-18.43,;75.83,-20.74,;75.99,-22.26,;77.5,-22.58,;78.27,-21.25,;77.24,-20.1,;79.8,-21.09,;80.7,-22.34,;82.23,-22.18,;82.86,-20.77,;84.39,-20.61,;81.94,-19.52,;80.42,-19.69,;73.17,-22.27,;74.5,-23.04,;71.84,-23.03,;71.84,-24.57,;73.17,-25.33,;74.5,-24.56,;75.84,-25.32,;73.18,-26.88,;71.84,-27.65,;70.51,-26.88,;70.51,-25.34,;69.18,-24.57,;67.84,-25.34,)| | PDB
UniProtKB/SwissProt
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MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0350 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50577754
(CHEMBL4867145)Show SMILES CCCCc1nc(=O)c(C(=O)N2CC[C@@H](C2)c2ccc(Cl)cn2)c(O)n1-c1c(OC)cccc1OC |r,wU:14.16,(2.45,-36.58,;3.78,-37.34,;5.12,-36.57,;6.45,-37.34,;7.8,-36.57,;7.8,-35.04,;9.13,-34.27,;9.12,-32.71,;10.45,-35.03,;11.79,-34.25,;11.79,-32.71,;13.12,-35.02,;13.28,-36.55,;14.79,-36.87,;15.56,-35.54,;14.53,-34.39,;17.09,-35.38,;17.99,-36.63,;19.52,-36.47,;20.15,-35.06,;21.68,-34.9,;19.23,-33.81,;17.71,-33.97,;10.45,-36.56,;11.79,-37.32,;9.13,-37.32,;9.13,-38.86,;10.46,-39.62,;11.79,-38.85,;13.13,-39.61,;10.47,-41.17,;9.13,-41.94,;7.8,-41.17,;7.8,-39.63,;6.46,-38.86,;5.13,-39.63,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0630 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50014619
(CHEMBL3184840)Show SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C69H108N22O16S/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55(94)89-28-11-19-51(89)62(101)84-46(24-31-108-3)66(105)91-30-13-21-53(91)64(103)87-49(67(106)107)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,92H,7-13,16-34,36-37,70H2,1-3H3,(H,75,79)(H,78,95)(H,80,93)(H,81,99)(H,82,102)(H,83,97)(H,84,101)(H,85,96)(H,86,100)(H,87,103)(H,88,98)(H,106,107)(H4,71,72,76)(H4,73,74,77)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-/m0/s1 | PDB
Reactome pathway
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Similars
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| n/a | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00385
BindingDB Entry DOI: 10.7270/Q2M330MF |
More data for this
Ligand-Target Pair | |
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