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Compile Data Set for Download or QSAR

Found 40 hits Enz. Inhib. hit(s) with all data for entry = 50015516   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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n/an/a 14n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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n/an/a 53n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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n/an/a 69n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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PC sid
UniChem
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n/an/a 72n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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n/an/a 75n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of full length human C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as fluorogen...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 94n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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n/an/a 108n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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n/an/a 126n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of full length human C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as fluorogen...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of full length human C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as fluorogen...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC a...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC a...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC a...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of full length human C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as fluorogen...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of human N-terminal GST tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human N-terminal GST tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human N-terminal GST tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of human N-terminal GST tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of human HDAC5 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human HDAC5 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of human HDAC5 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human HDAC5 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC a...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of human HDAC4 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human HDAC4 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of human HDAC4 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of full length human HDAC2 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50587186
PNG
(CHEMBL5088034)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12 |r|
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TBA

Assay Description
Inhibition of full length human HDAC2 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50587185
PNG
(CHEMBL5093258)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of full length human HDAC2 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50587184
PNG
(CHEMBL5089854)
Show SMILES ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r|
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TBA

Assay Description
Inhibition of full length human HDAC2 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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TBA

Assay Description
Inhibition of human HDAC4 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113799
BindingDB Entry DOI: 10.7270/Q2V128Q6
More data for this
Ligand-Target Pair