Found 21 hits Enz. Inhib. hit(s) with all data for entry = 50018125 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50405267
(CHEMBL5267954)Show SMILES C[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C17H22N2O4/c1-12(16(21)19-11-5-8-14(19)17(22)23)18-15(20)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14H,5,8-11H2,1H3,(H,18,20)(H,22,23)/t12-,14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium berghei |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 3
(Homo sapiens (Human)) | BDBM50405267
(CHEMBL5267954)Show SMILES C[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C17H22N2O4/c1-12(16(21)19-11-5-8-14(19)17(22)23)18-15(20)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14H,5,8-11H2,1H3,(H,18,20)(H,22,23)/t12-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405263
(CHEMBL5274652)Show SMILES C[C@H](N[C@@H](C[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C26H31N3O6/c1-17(24(31)29-14-8-13-22(29)26(34)35)27-21(25(32)33)16-20(15-18-9-4-2-5-10-18)28-23(30)19-11-6-3-7-12-19/h2-7,9-12,17,20-22,27H,8,13-16H2,1H3,(H,28,30)(H,32,33)(H,34,35)/t17-,20-,21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405264
(CHEMBL5287768)Show SMILES CC(NC(C1CCCN1C(=O)NCC(O)=O)C(O)=O)C(=O)N1CCCC1C(O)=O Show InChI InChI=1S/C17H26N4O8/c1-9(14(24)20-6-3-5-11(20)15(25)26)19-13(16(27)28)10-4-2-7-21(10)17(29)18-8-12(22)23/h9-11,13,19H,2-8H2,1H3,(H,18,29)(H,22,23)(H,25,26)(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405265
(CHEMBL5274710)Show SMILES CC(NC(C1CCCN1C(=O)c1ccccc1)C(O)=O)C(=O)N1CCCC1C(O)=O Show InChI InChI=1S/C21H27N3O6/c1-13(18(25)24-12-6-10-16(24)20(27)28)22-17(21(29)30)15-9-5-11-23(15)19(26)14-7-3-2-4-8-14/h2-4,7-8,13,15-17,22H,5-6,9-12H2,1H3,(H,27,28)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405267
(CHEMBL5267954)Show SMILES C[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C17H22N2O4/c1-12(16(21)19-11-5-8-14(19)17(22)23)18-15(20)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14H,5,8-11H2,1H3,(H,18,20)(H,22,23)/t12-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405268
(CHEMBL5271765)Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C28H40N6O7/c1-17(27(39)34-15-7-11-22(34)28(40)41)30-26(38)21(16-18-8-3-2-4-9-18)33-24(36)19(10-5-6-14-29)32-25(37)20-12-13-23(35)31-20/h2-4,8-9,17,19-22H,5-7,10-16,29H2,1H3,(H,30,38)(H,31,35)(H,32,37)(H,33,36)(H,40,41)/t17-,19-,20-,21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coli |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405269
(CHEMBL5279908)Show SMILES C[C@H](N[C@H]([C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C25H29N3O6/c1-16(23(30)28-14-8-13-20(28)24(31)32)26-21(25(33)34)19(15-17-9-4-2-5-10-17)27-22(29)18-11-6-3-7-12-18/h2-7,9-12,16,19-21,26H,8,13-15H2,1H3,(H,27,29)(H,31,32)(H,33,34)/t16-,19-,20-,21+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405270
(CHEMBL5286275)Show SMILES C[C@H](NC(CNC(=O)c1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C18H23N3O6/c1-11(16(23)21-9-5-8-14(21)18(26)27)20-13(17(24)25)10-19-15(22)12-6-3-2-4-7-12/h2-4,6-7,11,13-14,20H,5,8-10H2,1H3,(H,19,22)(H,24,25)(H,26,27)/t11-,13?,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405271
(CHEMBL5279827)Show SMILES CC(NC(C1CCCN1C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)=O)C(O)=O)C(=O)N1CCCC1C(O)=O Show InChI InChI=1S/C33H41N5O9/c1-20(29(40)37-16-9-15-26(37)31(43)44)34-27(32(45)46)25-14-8-17-38(25)33(47)36-23(18-21-10-4-2-5-11-21)28(39)35-24(30(41)42)19-22-12-6-3-7-13-22/h2-7,10-13,20,23-27,34H,8-9,14-19H2,1H3,(H,35,39)(H,36,47)(H,41,42)(H,43,44)(H,45,46) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 545 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405272
(CHEMBL4596287)Show SMILES C[C@H](N[C@@H](CNC(=O)c1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C18H23N3O6/c1-11(16(23)21-9-5-8-14(21)18(26)27)20-13(17(24)25)10-19-15(22)12-6-3-2-4-7-12/h2-4,6-7,11,13-14,20H,5,8-10H2,1H3,(H,19,22)(H,24,25)(H,26,27)/t11-,13-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
| n/a | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405273
(CHEMBL5288133)Show SMILES CC(NC(C1CCCN1C(=O)NC(CCCCN)C(=O)N1C(CCC1=O)C(O)=O)C(O)=O)C(=O)N1CCCC1C(O)=O Show InChI InChI=1S/C26H40N6O10/c1-14(21(34)30-12-5-8-17(30)23(36)37)28-20(25(40)41)16-7-4-13-31(16)26(42)29-15(6-2-3-11-27)22(35)32-18(24(38)39)9-10-19(32)33/h14-18,20,28H,2-13,27H2,1H3,(H,29,42)(H,36,37)(H,38,39)(H,40,41) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405274
(CHEMBL5277359)Show SMILES C[C@H](N[C@H](C[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C26H31N3O6/c1-17(24(31)29-14-8-13-22(29)26(34)35)27-21(25(32)33)16-20(15-18-9-4-2-5-10-18)28-23(30)19-11-6-3-7-12-19/h2-7,9-12,17,20-22,27H,8,13-16H2,1H3,(H,28,30)(H,32,33)(H,34,35)/t17-,20-,21+,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405275
(CHEMBL5277405)Show SMILES [H][C@]1(CCCN1)[C@H](N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O)C(O)=O |r| Show InChI InChI=1S/C14H23N3O5/c1-8(12(18)17-7-3-5-10(17)13(19)20)16-11(14(21)22)9-4-2-6-15-9/h8-11,15-16H,2-7H2,1H3,(H,19,20)(H,21,22)/t8-,9-,10-,11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405277
(CHEMBL5286467)Show SMILES [#6]C([#6])([#6])[#7]-[#6]-[#6@@H](-[#8])-[#6]-[#8]\[#7]=[#6](/[#6]-1-[#6]-[#6]1)-[#6]-1-[#6]-[#6]-1 |r| Show InChI InChI=1S/C14H26N2O2/c1-14(2,3)15-8-12(17)9-18-16-13(10-4-5-10)11-6-7-11/h10-12,15,17H,4-9H2,1-3H3/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405278
(CHEMBL5288822)Show InChI InChI=1S/C12H24N2O2/c1-9(10-5-6-10)14-16-8-11(15)7-13-12(2,3)4/h10-11,13,15H,5-8H2,1-4H3/b14-9+ | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405279
(CHEMBL5277132)Show InChI InChI=1S/C12H24N2O2/c1-9(10-5-6-10)14-16-8-11(15)7-13-12(2,3)4/h10-11,13,15H,5-8H2,1-4H3/b14-9+/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 325 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405280
(CHEMBL5286856)Show SMILES [#6]C([#6])([#6])[#7]-[#6]-[#6]-[#6]-[#8]\[#7]=[#6](\[#6]-1-[#6]-[#6]1)-[#6]-1-[#6]-[#6]-1 Show InChI InChI=1S/C14H26N2O/c1-14(2,3)15-9-4-10-17-16-13(11-5-6-11)12-7-8-12/h11-12,15H,4-10H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50405267
(CHEMBL5267954)Show SMILES C[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C17H22N2O4/c1-12(16(21)19-11-5-8-14(19)17(22)23)18-15(20)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14H,5,8-11H2,1H3,(H,18,20)(H,22,23)/t12-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coli |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405261
(CHEMBL5276428)Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C24H27N3O5/c1-16(23(30)27-14-8-13-20(27)24(31)32)25-22(29)19(15-17-9-4-2-5-10-17)26-21(28)18-11-6-3-7-12-18/h2-7,9-12,16,19-20H,8,13-15H2,1H3,(H,25,29)(H,26,28)(H,31,32)/t16-,19-,20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50405262
(CHEMBL5290584)Show SMILES CC(NC(C1CCCN1C(C)=O)C(O)=O)C(=O)N1CCCC1C(O)=O Show InChI InChI=1S/C16H25N3O6/c1-9(14(21)19-8-4-6-12(19)15(22)23)17-13(16(24)25)11-5-3-7-18(11)10(2)20/h9,11-13,17H,3-8H2,1-2H3,(H,22,23)(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | 685 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Search and Browse
