Compile Data Set for Download or QSAR

Found 69 hits Enz. Inhib. hit(s) with all data for entry = 50033686   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7657 (4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...) Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3ccccn23)cc1 Show InChI InChI=1S/C17H14N6O2S/c18-26(24,25)13-6-4-12(5-7-13)21-17-19-9-8-14(22-17)15-11-20-16-3-1-2-10-23(15)16/h1-11H,(H2,18,24,25)(H,19,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349773 (CHEMBL1809194) Show SMILES COc1cc(ccc1Nc1ncc(Br)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24BrN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349765 (CHEMBL1809224) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccc(F)cn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23ClFN7O2/c1-15(34)31-7-9-32(10-8-31)17-4-5-19(21(11-17)35-2)29-24-28-12-18(25)23(30-24)20-13-27-22-6-3-16(26)14-33(20)22/h3-6,11-14H,7-10H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349785 (CHEMBL1809206) Show SMILES COc1ccn2c(cnc2c1)-c1nc(Nc2ccc(cc2OC)N2CCN(CC2)C(C)=O)ncc1Cl Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)31-8-10-32(11-9-31)17-4-5-20(22(12-17)36-3)29-25-28-14-19(26)24(30-25)21-15-27-23-13-18(35-2)6-7-33(21)23/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50349687 (CHEMBL1809044) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24ClN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of insulin receptor				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349784 (CHEMBL1809205) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(C)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O2/c1-16-6-7-33-21(15-27-23(33)12-16)24-19(26)14-28-25(30-24)29-20-5-4-18(13-22(20)35-3)32-10-8-31(9-11-32)17(2)34/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349773 (CHEMBL1809194) Show SMILES COc1cc(ccc1Nc1ncc(Br)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24BrN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349687 (CHEMBL1809044) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24ClN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349778 (CHEMBL1809198) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(F)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23ClFN7O2/c1-15(34)31-8-10-32(11-9-31)16-5-6-19(21(12-16)35-2)29-24-28-13-17(25)22(30-24)20-14-27-23-18(26)4-3-7-33(20)23/h3-7,12-14H,8-11H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349788 (CHEMBL1809222) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(Cl)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23Cl2N7O2/c1-15(34)31-7-9-32(10-8-31)17-3-4-19(21(12-17)35-2)29-24-28-13-18(26)23(30-24)20-14-27-22-11-16(25)5-6-33(20)22/h3-6,11-14H,7-10H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349789 (CHEMBL1809225) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccc(C)cn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O2/c1-16-4-7-23-27-14-21(33(23)15-16)24-19(26)13-28-25(30-24)29-20-6-5-18(12-22(20)35-3)32-10-8-31(9-11-32)17(2)34/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349783 (CHEMBL1809204) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(F)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23ClFN7O2/c1-15(34)31-7-9-32(10-8-31)17-3-4-19(21(12-17)35-2)29-24-28-13-18(25)23(30-24)20-14-27-22-11-16(26)5-6-33(20)22/h3-6,11-14H,7-10H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50349687 (CHEMBL1809044) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24ClN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of insulin-induced autophosphorylation of human insulin receptor expressed in CHO cells				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349789 (CHEMBL1809225) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccc(C)cn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O2/c1-16-4-7-23-27-14-21(33(23)15-16)24-19(26)13-28-25(30-24)29-20-6-5-18(12-22(20)35-3)32-10-8-31(9-11-32)17(2)34/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349765 (CHEMBL1809224) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccc(F)cn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23ClFN7O2/c1-15(34)31-7-9-32(10-8-31)17-4-5-19(21(11-17)35-2)29-24-28-12-18(25)23(30-24)20-13-27-22-6-3-16(26)14-33(20)22/h3-6,11-14H,7-10H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349779 (CHEMBL1809199) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(C)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O2/c1-16-5-4-8-33-21(15-27-24(16)33)23-19(26)14-28-25(30-23)29-20-7-6-18(13-22(20)35-3)32-11-9-31(10-12-32)17(2)34/h4-8,13-15H,9-12H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349775 (CHEMBL1809196) Show SMILES COc1cc(ccc1Nc1ncc(c(n1)-c1cnc2ccccn12)C(F)(F)F)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H24F3N7O2/c1-16(36)33-9-11-34(12-10-33)17-6-7-19(21(13-17)37-2)31-24-30-14-18(25(26,27)28)23(32-24)20-15-29-22-5-3-4-8-35(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349687 (CHEMBL1809044) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24ClN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349769 (CHEMBL1809229) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(F)cc(F)cn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H22ClF2N7O2/c1-14(35)32-5-7-33(8-6-32)16-3-4-19(21(10-16)36-2)30-24-29-11-17(25)22(31-24)20-12-28-23-18(27)9-15(26)13-34(20)23/h3-4,9-13H,5-8H2,1-2H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349778 (CHEMBL1809198) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(F)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23ClFN7O2/c1-15(34)31-8-10-32(11-9-31)16-5-6-19(21(12-16)35-2)29-24-28-13-17(25)22(30-24)20-14-27-23-18(26)4-3-7-33(20)23/h3-7,12-14H,8-11H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349769 (CHEMBL1809229) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(F)cc(F)cn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H22ClF2N7O2/c1-14(35)32-5-7-33(8-6-32)16-3-4-19(21(10-16)36-2)30-24-29-11-17(25)22(31-24)20-12-28-23-18(27)9-15(26)13-34(20)23/h3-4,9-13H,5-8H2,1-2H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349783 (CHEMBL1809204) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(F)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23ClFN7O2/c1-15(34)31-7-9-32(10-8-31)17-3-4-19(21(12-17)35-2)29-24-28-13-18(25)23(30-24)20-14-27-22-11-16(26)5-6-33(20)22/h3-6,11-14H,7-10H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349784 (CHEMBL1809205) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(C)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O2/c1-16-6-7-33-21(15-27-23(33)12-16)24-19(26)14-28-25(30-24)29-20-5-4-18(13-22(20)35-3)32-10-8-31(9-11-32)17(2)34/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349782 (CHEMBL1809202) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(CO)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O3/c1-16(35)31-8-10-32(11-9-31)18-5-6-20(22(12-18)36-2)29-25-28-13-19(26)23(30-25)21-14-27-24-17(15-34)4-3-7-33(21)24/h3-7,12-14,34H,8-11,15H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349781 (CHEMBL1809201) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(N)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H25ClN8O2/c1-15(34)31-8-10-32(11-9-31)16-5-6-19(21(12-16)35-2)29-24-28-13-17(25)22(30-24)20-14-27-23-18(26)4-3-7-33(20)23/h3-7,12-14H,8-11,26H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349779 (CHEMBL1809199) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(C)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O2/c1-16-5-4-8-33-21(15-27-24(16)33)23-19(26)14-28-25(30-23)29-20-7-6-18(13-22(20)35-3)32-11-9-31(10-12-32)17(2)34/h4-8,13-15H,9-12H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349780 (CHEMBL1809200) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(OC)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)31-9-11-32(12-10-31)17-6-7-19(22(13-17)36-3)29-25-28-14-18(26)23(30-25)20-15-27-24-21(35-2)5-4-8-33(20)24/h4-8,13-15H,9-12H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349785 (CHEMBL1809206) Show SMILES COc1ccn2c(cnc2c1)-c1nc(Nc2ccc(cc2OC)N2CCN(CC2)C(C)=O)ncc1Cl Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)31-8-10-32(11-9-31)17-4-5-20(22(12-17)36-3)29-25-28-14-19(26)24(30-25)21-15-27-23-13-18(35-2)6-7-33(21)23/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349774 (CHEMBL1809195) Show SMILES COc1cc(ccc1Nc1ncc(C)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H27N7O2/c1-17-15-27-25(29-24(17)21-16-26-23-6-4-5-9-32(21)23)28-20-8-7-19(14-22(20)34-3)31-12-10-30(11-13-31)18(2)33/h4-9,14-16H,10-13H2,1-3H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349786 (CHEMBL1809207) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(CO)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O3/c1-16(35)31-7-9-32(10-8-31)18-3-4-20(22(12-18)36-2)29-25-28-13-19(26)24(30-25)21-14-27-23-11-17(15-34)5-6-33(21)23/h3-6,11-14,34H,7-10,15H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349788 (CHEMBL1809222) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(Cl)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H23Cl2N7O2/c1-15(34)31-7-9-32(10-8-31)17-3-4-19(21(12-17)35-2)29-24-28-13-18(26)23(30-24)20-14-27-22-11-16(25)5-6-33(20)22/h3-6,11-14H,7-10H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349767 (CHEMBL1809227) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccc(cn12)C#N)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H23ClN8O2/c1-16(35)32-7-9-33(10-8-32)18-4-5-20(22(11-18)36-2)30-25-29-13-19(26)24(31-25)21-14-28-23-6-3-17(12-27)15-34(21)23/h3-6,11,13-15H,7-10H2,1-2H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349781 (CHEMBL1809201) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(N)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H25ClN8O2/c1-15(34)31-8-10-32(11-9-31)16-5-6-19(21(12-16)35-2)29-24-28-13-17(25)22(30-24)20-14-27-23-18(26)4-3-7-33(20)23/h3-7,12-14H,8-11,26H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349766 (CHEMBL1809226) Show SMILES COc1ccc2ncc(-c3nc(Nc4ccc(cc4OC)N4CCN(CC4)C(C)=O)ncc3Cl)n2c1 Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)31-8-10-32(11-9-31)17-4-6-20(22(12-17)36-3)29-25-28-13-19(26)24(30-25)21-14-27-23-7-5-18(35-2)15-33(21)23/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349775 (CHEMBL1809196) Show SMILES COc1cc(ccc1Nc1ncc(c(n1)-c1cnc2ccccn12)C(F)(F)F)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H24F3N7O2/c1-16(36)33-9-11-34(12-10-33)17-6-7-19(21(13-17)37-2)31-24-30-14-18(25(26,27)28)23(32-24)20-15-29-22-5-3-4-8-35(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349787 (CHEMBL1809221) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(ccn12)C#N)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H23ClN8O2/c1-16(35)32-7-9-33(10-8-32)18-3-4-20(22(12-18)36-2)30-25-29-14-19(26)24(31-25)21-15-28-23-11-17(13-27)5-6-34(21)23/h3-6,11-12,14-15H,7-10H2,1-2H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349766 (CHEMBL1809226) Show SMILES COc1ccc2ncc(-c3nc(Nc4ccc(cc4OC)N4CCN(CC4)C(C)=O)ncc3Cl)n2c1 Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)31-8-10-32(11-9-31)17-4-6-20(22(12-17)36-3)29-25-28-13-19(26)24(30-25)21-14-27-23-7-5-18(35-2)15-33(21)23/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349767 (CHEMBL1809227) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccc(cn12)C#N)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H23ClN8O2/c1-16(35)32-7-9-33(10-8-32)18-4-5-20(22(11-18)36-2)30-25-29-13-19(26)24(31-25)21-14-28-23-6-3-17(12-27)15-34(21)23/h3-6,11,13-15H,7-10H2,1-2H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50349770 (CHEMBL1809191) Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnc3ccccn23)cc1 Show InChI InChI=1S/C23H23N7O/c1-17(31)28-12-14-29(15-13-28)19-7-5-18(6-8-19)26-23-24-10-9-20(27-23)21-16-25-22-4-2-3-11-30(21)22/h2-11,16H,12-15H2,1H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349772 (CHEMBL1809193) Show SMILES COc1cc(ccc1Nc1ncc(F)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24FN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349776 (CHEMBL1809197) Show SMILES COc1cc(ccc1Nc1ncc(OC)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H27N7O3/c1-17(33)30-10-12-31(13-11-30)18-7-8-19(21(14-18)34-2)28-25-27-16-22(35-3)24(29-25)20-15-26-23-6-4-5-9-32(20)23/h4-9,14-16H,10-13H2,1-3H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349774 (CHEMBL1809195) Show SMILES COc1cc(ccc1Nc1ncc(C)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H27N7O2/c1-17-15-27-25(29-24(17)21-16-26-23-6-4-5-9-32(21)23)28-20-8-7-19(14-22(20)34-3)31-12-10-30(11-13-31)18(2)33/h4-9,14-16H,10-13H2,1-3H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349777 (CHEMBL1806525) Show SMILES COc1cc(ccc1Nc1ncc(C#N)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H24N8O2/c1-17(34)31-9-11-32(12-10-31)19-6-7-20(22(13-19)35-2)29-25-28-15-18(14-26)24(30-25)21-16-27-23-5-3-4-8-33(21)23/h3-8,13,15-16H,9-12H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349780 (CHEMBL1809200) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(OC)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)31-9-11-32(12-10-31)17-6-7-19(22(13-17)36-3)29-25-28-14-18(26)23(30-25)20-15-27-24-21(35-2)5-4-8-33(20)24/h4-8,13-15H,9-12H2,1-3H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349782 (CHEMBL1809202) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(CO)cccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O3/c1-16(35)31-8-10-32(11-9-31)18-5-6-20(22(12-18)36-2)29-25-28-13-19(26)23(30-25)21-14-27-24-17(15-34)4-3-7-33(21)24/h3-7,12-14,34H,8-11,15H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349772 (CHEMBL1809193) Show SMILES COc1cc(ccc1Nc1ncc(F)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H24FN7O2/c1-16(33)30-9-11-31(12-10-30)17-6-7-19(21(13-17)34-2)28-24-27-14-18(25)23(29-24)20-15-26-22-5-3-4-8-32(20)22/h3-8,13-15H,9-12H2,1-2H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349786 (CHEMBL1809207) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2cc(CO)ccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H26ClN7O3/c1-16(35)31-7-9-32(10-8-31)18-3-4-20(22(12-18)36-2)29-25-28-13-19(26)24(30-25)21-14-27-23-11-17(15-34)5-6-33(21)23/h3-6,11-14,34H,7-10,15H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349790 (CHEMBL1809203) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2c(cccn12)C#N)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H23ClN8O2/c1-16(35)32-8-10-33(11-9-32)18-5-6-20(22(12-18)36-2)30-25-29-14-19(26)23(31-25)21-15-28-24-17(13-27)4-3-7-34(21)24/h3-7,12,14-15H,8-11H2,1-2H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349777 (CHEMBL1806525) Show SMILES COc1cc(ccc1Nc1ncc(C#N)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H24N8O2/c1-17(34)31-9-11-32(12-10-31)19-6-7-20(22(13-19)35-2)29-25-28-15-18(14-26)24(30-25)21-16-27-23-5-3-4-8-33(21)23/h3-8,13,15-16H,9-12H2,1-2H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50349776 (CHEMBL1809197) Show SMILES COc1cc(ccc1Nc1ncc(OC)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H27N7O3/c1-17(33)30-10-12-31(13-11-30)18-7-8-19(21(14-18)34-2)28-25-27-16-22(35-3)24(29-25)20-15-26-23-6-4-5-9-32(20)23/h4-9,14-16H,10-13H2,1-3H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay				Bioorg Med Chem Lett 21: 4698-701 (2011) Article DOI: 10.1016/j.bmcl.2011.06.093 BindingDB Entry DOI: 10.7270/Q2GF0TVK
					More data for this Ligand-Target Pair

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