Compile Data Set for Download or QSAR

Found 67 hits Enz. Inhib. hit(s) with all data for entry = 50033863   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50312752 ((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352815 (CHEMBL1823655) Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnccc2c1)C1CNC1 |r| Show InChI InChI=1S/C20H17Cl2N3O/c21-17-4-3-13(8-18(17)22)19(16-10-24-11-16)25-20(26)14-1-2-15-9-23-6-5-12(15)7-14/h1-9,16,19,24H,10-11H2,(H,25,26)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352823 (CHEMBL1823663) Show SMILES CN1CC(C1)[C@@H](NC(=O)c1ccc2cnccc2c1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C21H19Cl2N3O/c1-26-11-17(12-26)20(14-4-5-18(22)19(23)9-14)25-21(27)15-2-3-16-10-24-7-6-13(16)8-15/h2-10,17,20H,11-12H2,1H3,(H,25,27)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352839 (CHEMBL1823651) Show SMILES Fc1cc2cc(ccc2cn1)C(=O)NC(C1CCNCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C22H20Cl2FN3O/c23-18-4-3-14(10-19(18)24)21(13-5-7-26-8-6-13)28-22(29)15-1-2-16-12-27-20(25)11-17(16)9-15/h1-4,9-13,21,26H,5-8H2,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352813 (CHEMBL1823653) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCCNC1 Show InChI InChI=1S/C22H21Cl2N3O/c23-19-6-5-15(11-20(19)24)21(18-2-1-8-25-13-18)27-22(28)16-3-4-17-12-26-9-7-14(17)10-16/h3-7,9-12,18,21,25H,1-2,8,13H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352824 (CHEMBL1823630) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)14-4-1-11(2-5-14)7-15(24)10-25-19-28-27-18(30-19)12-3-6-16-13(8-12)9-17(29)26-16/h1-6,8,15H,7,9-10,24H2,(H,25,28)(H,26,29)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352814 (CHEMBL1823654) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCNC1 Show InChI InChI=1S/C21H19Cl2N3O/c22-18-4-3-14(10-19(18)23)20(17-6-8-25-12-17)26-21(27)15-1-2-16-11-24-7-5-13(16)9-15/h1-5,7,9-11,17,20,25H,6,8,12H2,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352844 (CHEMBL1823649) Show SMILES COc1cc2cnccc2cc1C(=O)NC(C1CCNCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C23H23Cl2N3O2/c1-30-21-12-17-13-27-9-6-15(17)10-18(21)23(29)28-22(14-4-7-26-8-5-14)16-2-3-19(24)20(25)11-16/h2-3,6,9-14,22,26H,4-5,7-8H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352837 (CHEMBL1823643) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H21Cl2N3O/c23-19-4-3-16(12-20(19)24)21(14-5-8-25-9-6-14)27-22(28)17-1-2-18-13-26-10-7-15(18)11-17/h1-4,7,10-14,21,25H,5-6,8-9H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352835 (CHEMBL1823641) Show SMILES Fc1cc(ccc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H21ClFN3O/c23-19-4-3-16(12-20(19)24)21(14-5-8-25-9-6-14)27-22(28)17-1-2-18-13-26-10-7-15(18)11-17/h1-4,7,10-14,21,25H,5-6,8-9H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50312752 ((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352833 (CHEMBL1823639) Show SMILES Clc1cccc(c1)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H22ClN3O/c23-20-3-1-2-17(13-20)21(15-6-9-24-10-7-15)26-22(27)18-4-5-19-14-25-11-8-16(19)12-18/h1-5,8,11-15,21,24H,6-7,9-10H2,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352832 (CHEMBL1823638) Show SMILES Clc1ccc(cc1C#N)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C23H21ClN4O/c24-21-4-3-17(12-20(21)13-25)22(15-5-8-26-9-6-15)28-23(29)18-1-2-19-14-27-10-7-16(19)11-18/h1-4,7,10-12,14-15,22,26H,5-6,8-9H2,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352816 (CHEMBL1823656) Show SMILES Clc1ccc(cc1Cl)[C@@H](NC(=O)c1ccc2cnccc2c1)C1CNC1 |r| Show InChI InChI=1S/C20H17Cl2N3O/c21-17-4-3-13(8-18(17)22)19(16-10-24-11-16)25-20(26)14-1-2-15-9-23-6-5-12(15)7-14/h1-9,16,19,24H,10-11H2,(H,25,26)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352836 (CHEMBL1823642) Show SMILES Clc1cccc(C(NC(=O)c2ccc3cnccc3c2)C2CCNCC2)c1Cl Show InChI InChI=1S/C22H21Cl2N3O/c23-19-3-1-2-18(20(19)24)21(14-6-9-25-10-7-14)27-22(28)16-4-5-17-13-26-11-8-15(17)12-16/h1-5,8,11-14,21,25H,6-7,9-10H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352838 (CHEMBL1823644) Show SMILES Clc1cc(cnc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C21H20Cl2N4O/c22-18-10-17(12-26-20(18)23)19(13-3-6-24-7-4-13)27-21(28)15-1-2-16-11-25-8-5-14(16)9-15/h1-2,5,8-13,19,24H,3-4,6-7H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352846 (CHEMBL1823652) Show SMILES Clc1cc2cc(ccc2cn1)C(=O)NC(C1CCNCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C22H20Cl3N3O/c23-18-4-3-14(10-19(18)24)21(13-5-7-26-8-6-13)28-22(29)15-1-2-16-12-27-20(25)11-17(16)9-15/h1-4,9-13,21,26H,5-8H2,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352824 (CHEMBL1823630) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)14-4-1-11(2-5-14)7-15(24)10-25-19-28-27-18(30-19)12-3-6-16-13(8-12)9-17(29)26-16/h1-6,8,15H,7,9-10,24H2,(H,25,28)(H,26,29)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352834 (CHEMBL1823640) Show SMILES Clc1ccc(cc1)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H22ClN3O/c23-20-5-3-15(4-6-20)21(16-7-10-24-11-8-16)26-22(27)18-1-2-19-14-25-12-9-17(19)13-18/h1-6,9,12-14,16,21,24H,7-8,10-11H2,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352831 (CHEMBL1823637) Show SMILES Clc1ccc(cc1-c1ccccc1)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C28H26ClN3O/c29-26-9-8-22(17-25(26)19-4-2-1-3-5-19)27(20-10-13-30-14-11-20)32-28(33)23-6-7-24-18-31-15-12-21(24)16-23/h1-9,12,15-18,20,27,30H,10-11,13-14H2,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352815 (CHEMBL1823655) Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnccc2c1)C1CNC1 |r| Show InChI InChI=1S/C20H17Cl2N3O/c21-17-4-3-13(8-18(17)22)19(16-10-24-11-16)25-20(26)14-1-2-15-9-23-6-5-12(15)7-14/h1-9,16,19,24H,10-11H2,(H,25,26)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352821 (CHEMBL1823661) Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnccc2c1)C1CCN(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C29H27Cl2N3O/c30-26-9-8-23(17-27(26)31)28(21-11-14-34(15-12-21)19-20-4-2-1-3-5-20)33-29(35)24-6-7-25-18-32-13-10-22(25)16-24/h1-10,13,16-18,21,28H,11-12,14-15,19H2,(H,33,35)/t28-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50312752 ((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352842 (CHEMBL1823647) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2[nH]ncc2c1)C1CCNCC1 Show InChI InChI=1S/C20H20Cl2N4O/c21-16-3-1-13(10-17(16)22)19(12-5-7-23-8-6-12)25-20(27)14-2-4-18-15(9-14)11-24-26-18/h1-4,9-12,19,23H,5-8H2,(H,24,26)(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352824 (CHEMBL1823630) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)14-4-1-11(2-5-14)7-15(24)10-25-19-28-27-18(30-19)12-3-6-16-13(8-12)9-17(29)26-16/h1-6,8,15H,7,9-10,24H2,(H,25,28)(H,26,29)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352843 (CHEMBL1823648) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnncc2c1)C1CCNCC1 Show InChI InChI=1S/C21H20Cl2N4O/c22-18-4-3-14(10-19(18)23)20(13-5-7-24-8-6-13)27-21(28)15-1-2-16-11-25-26-12-17(16)9-15/h1-4,9-13,20,24H,5-8H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352840 (CHEMBL1823645) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2NC(=O)Cc2c1)C1CCNCC1 Show InChI InChI=1S/C21H21Cl2N3O2/c22-16-3-1-13(10-17(16)23)20(12-5-7-24-8-6-12)26-21(28)14-2-4-18-15(9-14)11-19(27)25-18/h1-4,9-10,12,20,24H,5-8,11H2,(H,25,27)(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352823 (CHEMBL1823663) Show SMILES CN1CC(C1)[C@@H](NC(=O)c1ccc2cnccc2c1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C21H19Cl2N3O/c1-26-11-17(12-26)20(14-4-5-18(22)19(23)9-14)25-21(27)15-2-3-16-10-24-7-6-13(16)8-15/h2-10,17,20H,11-12H2,1H3,(H,25,27)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352839 (CHEMBL1823651) Show SMILES Fc1cc2cc(ccc2cn1)C(=O)NC(C1CCNCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C22H20Cl2FN3O/c23-18-4-3-14(10-19(18)24)21(13-5-7-26-8-6-13)28-22(29)15-1-2-16-12-27-20(25)11-17(16)9-15/h1-4,9-13,21,26H,5-8H2,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352827 (CHEMBL1823633) Show SMILES O=C(NC(C1CCNCC1)c1ccc2ccccc2c1)c1ccc2cnccc2c1 Show InChI InChI=1S/C26H25N3O/c30-26(23-7-8-24-17-28-14-11-21(24)16-23)29-25(19-9-12-27-13-10-19)22-6-5-18-3-1-2-4-20(18)15-22/h1-8,11,14-17,19,25,27H,9-10,12-13H2,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352841 (CHEMBL1823646) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2[nH]c(=O)oc2c1)C1CCNCC1 Show InChI InChI=1S/C20H19Cl2N3O3/c21-14-3-1-12(9-15(14)22)18(11-5-7-23-8-6-11)25-19(26)13-2-4-16-17(10-13)28-20(27)24-16/h1-4,9-11,18,23H,5-8H2,(H,24,27)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352815 (CHEMBL1823655) Show SMILES Clc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnccc2c1)C1CNC1 |r| Show InChI InChI=1S/C20H17Cl2N3O/c21-17-4-3-13(8-18(17)22)19(16-10-24-11-16)25-20(26)14-1-2-15-9-23-6-5-12(15)7-14/h1-9,16,19,24H,10-11H2,(H,25,26)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352826 (CHEMBL1823632) Show SMILES O=C(NC(C1CCNCC1)c1ccccc1)c1ccc2cnccc2c1 Show InChI InChI=1S/C22H23N3O/c26-22(19-6-7-20-15-24-13-10-18(20)14-19)25-21(16-4-2-1-3-5-16)17-8-11-23-12-9-17/h1-7,10,13-15,17,21,23H,8-9,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352829 (CHEMBL1823635) Show SMILES COc1ccc(cc1F)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C23H24FN3O2/c1-29-21-5-4-17(13-20(21)24)22(15-6-9-25-10-7-15)27-23(28)18-2-3-19-14-26-11-8-16(19)12-18/h2-5,8,11-15,22,25H,6-7,9-10H2,1H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352828 (CHEMBL1823634) Show SMILES O=C(NC(C1CCNCC1)c1nccs1)c1ccc2cnccc2c1 Show InChI InChI=1S/C19H20N4OS/c24-18(15-1-2-16-12-21-8-5-14(16)11-15)23-17(19-22-9-10-25-19)13-3-6-20-7-4-13/h1-2,5,8-13,17,20H,3-4,6-7H2,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352820 (CHEMBL1823660) Show SMILES CC(C)CN1CCC(CC1)[C@@H](NC(=O)c1ccc2cnccc2c1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C26H29Cl2N3O/c1-17(2)16-31-11-8-18(9-12-31)25(20-5-6-23(27)24(28)14-20)30-26(32)21-3-4-22-15-29-10-7-19(22)13-21/h3-7,10,13-15,17-18,25H,8-9,11-12,16H2,1-2H3,(H,30,32)/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352822 (CHEMBL1823662) Show SMILES FC(F)(F)c1ccc(CN2CCC(CC2)[C@@H](NC(=O)c2ccc3cnccc3c2)c2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C30H26Cl2F3N3O/c31-26-8-5-22(16-27(26)32)28(37-29(39)23-3-4-24-17-36-12-9-21(24)15-23)20-10-13-38(14-11-20)18-19-1-6-25(7-2-19)30(33,34)35/h1-9,12,15-17,20,28H,10-11,13-14,18H2,(H,37,39)/t28-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352830 (CHEMBL1823636) Show SMILES Fc1ccc(cc1F)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H21F2N3O/c23-19-4-3-16(12-20(19)24)21(14-5-8-25-9-6-14)27-22(28)17-1-2-18-13-26-10-7-15(18)11-17/h1-4,7,10-14,21,25H,5-6,8-9H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352825 (CHEMBL1823631) Show SMILES N[C@H](CNC(=O)c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N3O/c21-20(22,23)17-5-1-13(2-6-17)9-18(24)12-26-19(27)15-3-4-16-11-25-8-7-14(16)10-15/h1-8,10-11,18H,9,12,24H2,(H,26,27)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352817 (CHEMBL1823657) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCCCC1 Show InChI InChI=1S/C23H22Cl2N2O/c24-20-9-8-17(13-21(20)25)22(15-4-2-1-3-5-15)27-23(28)18-6-7-19-14-26-11-10-16(19)12-18/h6-15,22H,1-5H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352845 (CHEMBL1823650) Show SMILES COc1ccc(cc1)-c1cc2cnccc2cc1C(=O)NC(C1CCNCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H27Cl2N3O2/c1-36-23-5-2-18(3-6-23)24-15-22-17-33-13-10-20(22)14-25(24)29(35)34-28(19-8-11-32-12-9-19)21-4-7-26(30)27(31)16-21/h2-7,10,13-17,19,28,32H,8-9,11-12H2,1H3,(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352816 (CHEMBL1823656) Show SMILES Clc1ccc(cc1Cl)[C@@H](NC(=O)c1ccc2cnccc2c1)C1CNC1 |r| Show InChI InChI=1S/C20H17Cl2N3O/c21-17-4-3-13(8-18(17)22)19(16-10-24-11-16)25-20(26)14-1-2-15-9-23-6-5-12(15)7-14/h1-9,16,19,24H,10-11H2,(H,25,26)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352818 (CHEMBL1823658) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)c1cncnc1 Show InChI InChI=1S/C21H14Cl2N4O/c22-18-4-3-14(8-19(18)23)20(17-10-25-12-26-11-17)27-21(28)15-1-2-16-9-24-6-5-13(16)7-15/h1-12,20H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352826 (CHEMBL1823632) Show SMILES O=C(NC(C1CCNCC1)c1ccccc1)c1ccc2cnccc2c1 Show InChI InChI=1S/C22H23N3O/c26-22(19-6-7-20-15-24-13-10-18(20)14-19)25-21(16-4-2-1-3-5-16)17-8-11-23-12-9-17/h1-7,10,13-15,17,21,23H,8-9,11-12H2,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.97E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352819 (CHEMBL1823659) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)c1ccncc1 Show InChI InChI=1S/C22H15Cl2N3O/c23-19-4-3-16(12-20(19)24)21(14-5-8-25-9-6-14)27-22(28)17-1-2-18-13-26-10-7-15(18)11-17/h1-13,21H,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352813 (CHEMBL1823653) Show SMILES Clc1ccc(cc1Cl)C(NC(=O)c1ccc2cnccc2c1)C1CCCNC1 Show InChI InChI=1S/C22H21Cl2N3O/c23-19-6-5-15(11-20(19)24)21(18-2-1-8-25-13-18)27-22(28)16-3-4-17-12-26-9-7-14(17)10-16/h3-7,9-12,18,21,25H,1-2,8,13H2,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352831 (CHEMBL1823637) Show SMILES Clc1ccc(cc1-c1ccccc1)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C28H26ClN3O/c29-26-9-8-22(17-25(26)19-4-2-1-3-5-19)27(20-10-13-30-14-11-20)32-28(33)23-6-7-24-18-31-15-12-21(24)16-23/h1-9,12,15-18,20,27,30H,10-11,13-14H2,(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352830 (CHEMBL1823636) Show SMILES Fc1ccc(cc1F)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C22H21F2N3O/c23-19-4-3-16(12-20(19)24)21(14-5-8-25-9-6-14)27-22(28)17-1-2-18-13-26-10-7-15(18)11-17/h1-4,7,10-14,21,25H,5-6,8-9H2,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352829 (CHEMBL1823635) Show SMILES COc1ccc(cc1F)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1 Show InChI InChI=1S/C23H24FN3O2/c1-29-21-5-4-17(13-20(21)24)22(15-6-9-25-10-7-15)27-23(28)18-2-3-19-14-26-11-8-16(19)12-18/h2-5,8,11-15,22,25H,6-7,9-10H2,1H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352828 (CHEMBL1823634) Show SMILES O=C(NC(C1CCNCC1)c1nccs1)c1ccc2cnccc2c1 Show InChI InChI=1S/C19H20N4OS/c24-18(15-1-2-16-12-21-8-5-14(16)11-15)23-17(19-22-9-10-25-19)13-3-6-20-7-4-13/h1-2,5,8-13,17,20H,3-4,6-7H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair

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