Found 82 hits Enz. Inhib. hit(s) with all data for entry = 50039631 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381179
(CHEMBL2018388)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCC1)C(F)(F)F |r| Show InChI InChI=1S/C29H38F3N5O4/c1-4-6-25(38)24(16-33-15-20-8-7-18(2)13-19(20)3)35-26(39)17-34-27(40)22-14-21(29(30,31)32)9-10-23(22)36-28(41)37-11-5-12-37/h7-10,13-14,24-25,33,38H,4-6,11-12,15-17H2,1-3H3,(H,34,40)(H,35,39)(H,36,41)/t24-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381182
(CHEMBL2018391)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCNCC1)C(F)(F)F |r| Show InChI InChI=1S/C30H41F3N6O4/c1-4-5-26(40)25(17-35-16-21-7-6-19(2)14-20(21)3)37-27(41)18-36-28(42)23-15-22(30(31,32)33)8-9-24(23)38-29(43)39-12-10-34-11-13-39/h6-9,14-15,25-26,34-35,40H,4-5,10-13,16-18H2,1-3H3,(H,36,42)(H,37,41)(H,38,43)/t25-,26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381174
(CHEMBL2018380)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(13-30-12-17-7-6-15(2)10-16(17)3)32-23(34)14-31-24(35)19-11-18(25(26,27)28)8-9-20(19)29/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,35)(H,32,34)/t21-,22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381177
(CHEMBL2018386)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NCC)C(F)(F)F |r| Show InChI InChI=1S/C28H38F3N5O4/c1-5-7-24(37)23(15-32-14-19-9-8-17(3)12-18(19)4)35-25(38)16-34-26(39)21-13-20(28(29,30)31)10-11-22(21)36-27(40)33-6-2/h8-13,23-24,32,37H,5-7,14-16H2,1-4H3,(H,34,39)(H,35,38)(H2,33,36,40)/t23-,24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381181
(CHEMBL2018390)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCOCC1)C(F)(F)F |r| Show InChI InChI=1S/C30H40F3N5O5/c1-4-5-26(39)25(17-34-16-21-7-6-19(2)14-20(21)3)36-27(40)18-35-28(41)23-15-22(30(31,32)33)8-9-24(23)37-29(42)38-10-12-43-13-11-38/h6-9,14-15,25-26,34,39H,4-5,10-13,16-18H2,1-3H3,(H,35,41)(H,36,40)(H,37,42)/t25-,26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381188
(CHEMBL2018400)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(N)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(14-30-13-17-7-6-15(2)8-16(17)3)32-24(35)12-23(34)31-20-10-18(25(26,27)28)9-19(29)11-20/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,34)(H,32,35)/t21-,22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Mus musculus) | BDBM50381177
(CHEMBL2018386)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NCC)C(F)(F)F |r| Show InChI InChI=1S/C28H38F3N5O4/c1-5-7-24(37)23(15-32-14-19-9-8-17(3)12-18(19)4)35-25(38)16-34-26(39)21-13-20(28(29,30)31)10-11-22(21)36-27(40)33-6-2/h8-13,23-24,32,37H,5-7,14-16H2,1-4H3,(H,34,39)(H,35,38)(H2,33,36,40)/t23-,24-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in mouse monocytes assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381175
(CHEMBL2018384)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)OC(C)(C)C)C(F)(F)F |r| Show InChI InChI=1S/C30H41F3N4O5/c1-7-8-25(38)24(16-34-15-20-10-9-18(2)13-19(20)3)36-26(39)17-35-27(40)22-14-21(30(31,32)33)11-12-23(22)37-28(41)42-29(4,5)6/h9-14,24-25,34,38H,7-8,15-17H2,1-6H3,(H,35,40)(H,36,39)(H,37,41)/t24-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381179
(CHEMBL2018388)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCC1)C(F)(F)F |r| Show InChI InChI=1S/C29H38F3N5O4/c1-4-6-25(38)24(16-33-15-20-8-7-18(2)13-19(20)3)35-26(39)17-34-27(40)22-14-21(29(30,31)32)9-10-23(22)36-28(41)37-11-5-12-37/h7-10,13-14,24-25,33,38H,4-6,11-12,15-17H2,1-3H3,(H,34,40)(H,35,39)(H,36,41)/t24-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381190
(CHEMBL2018402)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NCC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C27H37F3N4O3/c1-5-7-24(35)23(16-31-15-19-9-8-17(3)10-18(19)4)34-26(37)14-25(36)33-22-12-20(27(28,29)30)11-21(13-22)32-6-2/h8-13,23-24,31-32,35H,5-7,14-16H2,1-4H3,(H,33,36)(H,34,37)/t23-,24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381178
(CHEMBL2018387)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC(C)C)C(F)(F)F |r| Show InChI InChI=1S/C29H40F3N5O4/c1-6-7-25(38)24(15-33-14-20-9-8-18(4)12-19(20)5)36-26(39)16-34-27(40)22-13-21(29(30,31)32)10-11-23(22)37-28(41)35-17(2)3/h8-13,17,24-25,33,38H,6-7,14-16H2,1-5H3,(H,34,40)(H,36,39)(H2,35,37,41)/t24-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381201
(CHEMBL2018371)Show SMILES CCCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C26H34F3N3O3/c1-4-5-9-23(33)22(15-30-14-20-11-10-17(2)12-18(20)3)32-24(34)16-31-25(35)19-7-6-8-21(13-19)26(27,28)29/h6-8,10-13,22-23,30,33H,4-5,9,14-16H2,1-3H3,(H,31,35)(H,32,34)/t22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381173
(CHEMBL2018370)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H32F3N3O3/c1-4-6-22(32)21(14-29-13-19-10-9-16(2)11-17(19)3)31-23(33)15-30-24(34)18-7-5-8-20(12-18)25(26,27)28/h5,7-12,21-22,29,32H,4,6,13-15H2,1-3H3,(H,30,34)(H,31,33)/t21-,22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381176
(CHEMBL2018385)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC)C(F)(F)F |r| Show InChI InChI=1S/C27H36F3N5O4/c1-5-6-23(36)22(14-32-13-18-8-7-16(2)11-17(18)3)34-24(37)15-33-25(38)20-12-19(27(28,29)30)9-10-21(20)35-26(39)31-4/h7-12,22-23,32,36H,5-6,13-15H2,1-4H3,(H,33,38)(H,34,37)(H2,31,35,39)/t22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381180
(CHEMBL2018389)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCCC1)C(F)(F)F |r| Show InChI InChI=1S/C30H40F3N5O4/c1-4-7-26(39)25(17-34-16-21-9-8-19(2)14-20(21)3)36-27(40)18-35-28(41)23-15-22(30(31,32)33)10-11-24(23)37-29(42)38-12-5-6-13-38/h8-11,14-15,25-26,34,39H,4-7,12-13,16-18H2,1-3H3,(H,35,41)(H,36,40)(H,37,42)/t25-,26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381183
(CHEMBL2018392)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(C)C)C(F)(F)F |r| Show InChI InChI=1S/C28H39F3N4O3/c1-6-7-25(36)24(15-32-14-20-9-8-18(4)12-19(20)5)35-26(37)16-33-27(38)22-13-21(28(29,30)31)10-11-23(22)34-17(2)3/h8-13,17,24-25,32,34,36H,6-7,14-16H2,1-5H3,(H,33,38)(H,35,37)/t24-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381180
(CHEMBL2018389)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCCC1)C(F)(F)F |r| Show InChI InChI=1S/C30H40F3N5O4/c1-4-7-26(39)25(17-34-16-21-9-8-19(2)14-20(21)3)36-27(40)18-35-28(41)23-15-22(30(31,32)33)10-11-24(23)37-29(42)38-12-5-6-13-38/h8-11,14-15,25-26,34,39H,4-7,12-13,16-18H2,1-3H3,(H,35,41)(H,36,40)(H,37,42)/t25-,26-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381167
(CHEMBL2018396)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(N)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(13-30-12-17-7-6-15(2)8-16(17)3)32-23(34)14-31-24(35)18-9-19(25(26,27)28)11-20(29)10-18/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,35)(H,32,34)/t21-,22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381176
(CHEMBL2018385)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC)C(F)(F)F |r| Show InChI InChI=1S/C27H36F3N5O4/c1-5-6-23(36)22(14-32-13-18-8-7-16(2)11-17(18)3)34-24(37)15-33-25(38)20-12-19(27(28,29)30)9-10-21(20)35-26(39)31-4/h7-12,22-23,32,36H,5-6,13-15H2,1-4H3,(H,33,38)(H,34,37)(H2,31,35,39)/t22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381209
(CHEMBL2018381)Show SMILES CCC[C@@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(13-30-12-17-7-6-15(2)10-16(17)3)32-23(34)14-31-24(35)19-11-18(25(26,27)28)8-9-20(19)29/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,35)(H,32,34)/t21-,22+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381189
(CHEMBL2018401)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C26H35F3N4O3/c1-5-6-23(34)22(15-31-14-18-8-7-16(2)9-17(18)3)33-25(36)13-24(35)32-21-11-19(26(27,28)29)10-20(12-21)30-4/h7-12,22-23,30-31,34H,5-6,13-15H2,1-4H3,(H,32,35)(H,33,36)/t22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381185
(CHEMBL2018394)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NCc1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C32H39F3N4O3/c1-4-8-29(40)28(19-36-18-24-12-11-21(2)15-22(24)3)39-30(41)20-38-31(42)26-16-25(32(33,34)35)13-14-27(26)37-17-23-9-6-5-7-10-23/h5-7,9-16,28-29,36-37,40H,4,8,17-20H2,1-3H3,(H,38,42)(H,39,41)/t28-,29-/m0/s1 | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381184
(CHEMBL2018393)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(C)(C)C)C(F)(F)F |r| Show InChI InChI=1S/C29H41F3N4O3/c1-7-8-25(37)24(16-33-15-20-10-9-18(2)13-19(20)3)35-26(38)17-34-27(39)22-14-21(29(30,31)32)11-12-23(22)36-28(4,5)6/h9-14,24-25,33,36-37H,7-8,15-17H2,1-6H3,(H,34,39)(H,35,38)/t24-,25-/m0/s1 | PDB
KEGG
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381183
(CHEMBL2018392)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(C)C)C(F)(F)F |r| Show InChI InChI=1S/C28H39F3N4O3/c1-6-7-25(36)24(15-32-14-20-9-8-18(4)12-19(20)5)35-26(37)16-33-27(38)22-13-21(28(29,30)31)10-11-23(22)34-17(2)3/h8-13,17,24-25,32,34,36H,6-7,14-16H2,1-5H3,(H,33,38)(H,35,37)/t24-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381185
(CHEMBL2018394)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NCc1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C32H39F3N4O3/c1-4-8-29(40)28(19-36-18-24-12-11-21(2)15-22(24)3)39-30(41)20-38-31(42)26-16-25(32(33,34)35)13-14-27(26)37-17-23-9-6-5-7-10-23/h5-7,9-16,28-29,36-37,40H,4,8,17-20H2,1-3H3,(H,38,42)(H,39,41)/t28-,29-/m0/s1 | PDB
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381178
(CHEMBL2018387)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC(C)C)C(F)(F)F |r| Show InChI InChI=1S/C29H40F3N5O4/c1-6-7-25(38)24(15-33-14-20-9-8-18(4)12-19(20)5)36-26(39)16-34-27(40)22-13-21(29(30,31)32)10-11-23(22)37-28(41)35-17(2)3/h8-13,17,24-25,33,38H,6-7,14-16H2,1-5H3,(H,34,40)(H,36,39)(H2,35,37,41)/t24-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381182
(CHEMBL2018391)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCNCC1)C(F)(F)F |r| Show InChI InChI=1S/C30H41F3N6O4/c1-4-5-26(40)25(17-35-16-21-7-6-19(2)14-20(21)3)37-27(41)18-36-28(42)23-15-22(30(31,32)33)8-9-24(23)38-29(43)39-12-10-34-11-13-39/h6-9,14-15,25-26,34-35,40H,4-5,10-13,16-18H2,1-3H3,(H,36,42)(H,37,41)(H,38,43)/t25-,26-/m0/s1 | PDB
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GoogleScholar
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381186
(CHEMBL2018395)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNc1n[nH]c2ccc(cc12)C(F)(F)F |r| Show InChI InChI=1S/C25H32F3N5O2/c1-4-5-22(34)21(13-29-12-17-7-6-15(2)10-16(17)3)31-23(35)14-30-24-19-11-18(25(26,27)28)8-9-20(19)32-33-24/h6-11,21-22,29,34H,4-5,12-14H2,1-3H3,(H,31,35)(H2,30,32,33)/t21-,22-/m0/s1 | PDB
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PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381169
(CHEMBL2018538)Show SMILES CCC[C@H](OC)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C26H35F3N4O3/c1-5-6-23(36-4)22(14-31-13-18-8-7-16(2)11-17(18)3)33-24(34)15-32-25(35)20-12-19(26(27,28)29)9-10-21(20)30/h7-12,22-23,31H,5-6,13-15,30H2,1-4H3,(H,32,35)(H,33,34)/t22-,23-/m0/s1 | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381190
(CHEMBL2018402)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NCC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C27H37F3N4O3/c1-5-7-24(35)23(16-31-15-19-9-8-17(3)10-18(19)4)34-26(37)14-25(36)33-22-12-20(27(28,29)30)11-21(13-22)32-6-2/h8-13,23-24,31-32,35H,5-7,14-16H2,1-4H3,(H,33,36)(H,34,37)/t23-,24-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381181
(CHEMBL2018390)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCOCC1)C(F)(F)F |r| Show InChI InChI=1S/C30H40F3N5O5/c1-4-5-26(39)25(17-34-16-21-7-6-19(2)14-20(21)3)36-27(40)18-35-28(41)23-15-22(30(31,32)33)8-9-24(23)37-29(42)38-10-12-43-13-11-38/h6-9,14-15,25-26,34,39H,4-5,10-13,16-18H2,1-3H3,(H,35,41)(H,36,40)(H,37,42)/t25-,26-/m0/s1 | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381188
(CHEMBL2018400)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(N)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(14-30-13-17-7-6-15(2)8-16(17)3)32-24(35)12-23(34)31-20-10-18(25(26,27)28)9-19(29)11-20/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,34)(H,32,35)/t21-,22-/m0/s1 | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381207
(CHEMBL2018378)Show SMILES CC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C24H31F3N4O3/c1-4-21(32)20(12-29-11-16-6-5-14(2)9-15(16)3)31-22(33)13-30-23(34)18-10-17(24(25,26)27)7-8-19(18)28/h5-10,20-21,29,32H,4,11-13,28H2,1-3H3,(H,30,34)(H,31,33)/t20-,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381175
(CHEMBL2018384)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)OC(C)(C)C)C(F)(F)F |r| Show InChI InChI=1S/C30H41F3N4O5/c1-7-8-25(38)24(16-34-15-20-10-9-18(2)13-19(20)3)36-26(39)17-35-27(40)22-14-21(30(31,32)33)11-12-23(22)37-28(41)42-29(4,5)6/h9-14,24-25,34,38H,7-8,15-17H2,1-6H3,(H,35,40)(H,36,39)(H,37,41)/t24-,25-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381204
(CHEMBL2018374)Show SMILES Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)[C@@H](O)CC(C)(C)C)c(C)c1 |r| Show InChI InChI=1S/C27H36F3N3O3/c1-17-9-10-20(18(2)11-17)14-31-15-22(23(34)13-26(3,4)5)33-24(35)16-32-25(36)19-7-6-8-21(12-19)27(28,29)30/h6-12,22-23,31,34H,13-16H2,1-5H3,(H,32,36)(H,33,35)/t22-,23-/m0/s1 | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381203
(CHEMBL2018373)Show SMILES CC(C)C[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C26H34F3N3O3/c1-16(2)10-23(33)22(14-30-13-20-9-8-17(3)11-18(20)4)32-24(34)15-31-25(35)19-6-5-7-21(12-19)26(27,28)29/h5-9,11-12,16,22-23,30,33H,10,13-15H2,1-4H3,(H,31,35)(H,32,34)/t22-,23-/m0/s1 | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381167
(CHEMBL2018396)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(N)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(13-30-12-17-7-6-15(2)8-16(17)3)32-23(34)14-31-24(35)18-9-19(25(26,27)28)11-20(29)10-18/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,35)(H,32,34)/t21-,22-/m0/s1 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381214
(CHEMBL2018403)Show SMILES CCCNc1cc(NC(=O)CC(=O)N[C@@H](CNCc2ccc(C)cc2C)[C@@H](O)CCC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C28H39F3N4O3/c1-5-7-25(36)24(17-32-16-20-9-8-18(3)11-19(20)4)35-27(38)15-26(37)34-23-13-21(28(29,30)31)12-22(14-23)33-10-6-2/h8-9,11-14,24-25,32-33,36H,5-7,10,15-17H2,1-4H3,(H,34,37)(H,35,38)/t24-,25-/m0/s1 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381189
(CHEMBL2018401)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C26H35F3N4O3/c1-5-6-23(34)22(15-31-14-18-8-7-16(2)9-17(18)3)33-25(36)13-24(35)32-21-11-19(26(27,28)29)10-20(12-21)30-4/h7-12,22-23,30-31,34H,5-6,13-15H2,1-4H3,(H,32,35)(H,33,36)/t22-,23-/m0/s1 | PDB
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381191
(CHEMBL2018530)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(OC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C26H34F3N3O4/c1-5-6-23(33)22(15-30-14-18-8-7-16(2)9-17(18)3)32-25(35)13-24(34)31-20-10-19(26(27,28)29)11-21(12-20)36-4/h7-12,22-23,30,33H,5-6,13-15H2,1-4H3,(H,31,34)(H,32,35)/t22-,23-/m0/s1 | PDB
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381191
(CHEMBL2018530)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(OC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C26H34F3N3O4/c1-5-6-23(33)22(15-30-14-18-8-7-16(2)9-17(18)3)32-25(35)13-24(34)31-20-10-19(26(27,28)29)11-21(12-20)36-4/h7-12,22-23,30,33H,5-6,13-15H2,1-4H3,(H,31,34)(H,32,35)/t22-,23-/m0/s1 | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381177
(CHEMBL2018386)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NCC)C(F)(F)F |r| Show InChI InChI=1S/C28H38F3N5O4/c1-5-7-24(37)23(15-32-14-19-9-8-17(3)12-18(19)4)35-25(38)16-34-26(39)21-13-20(28(29,30)31)10-11-22(21)36-27(40)33-6-2/h8-13,23-24,32,37H,5-7,14-16H2,1-4H3,(H,34,39)(H,35,38)(H2,33,36,40)/t23-,24-/m0/s1 | PDB
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PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381210
(CHEMBL2018382)Show SMILES CCCC(O)(CCC)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C28H39F3N4O3/c1-5-11-27(38,12-6-2)24(16-33-15-20-8-7-18(3)13-19(20)4)35-25(36)17-34-26(37)22-14-21(28(29,30)31)9-10-23(22)32/h7-10,13-14,24,33,38H,5-6,11-12,15-17,32H2,1-4H3,(H,34,37)(H,35,36)/t24-/m0/s1 | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381187
(CHEMBL2018397)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H32F3N3O3/c1-4-6-22(32)21(15-29-14-18-10-9-16(2)11-17(18)3)31-24(34)13-23(33)30-20-8-5-7-19(12-20)25(26,27)28/h5,7-12,21-22,29,32H,4,6,13-15H2,1-3H3,(H,30,33)(H,31,34)/t21-,22-/m0/s1 | PDB
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PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381193
(CHEMBL2018363)Show SMILES CCC[C@@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H32F3N3O3/c1-4-6-22(32)21(14-29-13-19-10-9-16(2)11-17(19)3)31-23(33)15-30-24(34)18-7-5-8-20(12-18)25(26,27)28/h5,7-12,21-22,29,32H,4,6,13-15H2,1-3H3,(H,30,34)(H,31,33)/t21-,22+/m0/s1 | PDB
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PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381174
(CHEMBL2018380)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(13-30-12-17-7-6-15(2)10-16(17)3)32-23(34)14-31-24(35)19-11-18(25(26,27)28)8-9-20(19)29/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,35)(H,32,34)/t21-,22-/m0/s1 | PDB
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381184
(CHEMBL2018393)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(C)(C)C)C(F)(F)F |r| Show InChI InChI=1S/C29H41F3N4O3/c1-7-8-25(37)24(16-33-15-20-10-9-18(2)13-19(20)3)35-26(38)17-34-27(39)22-14-21(29(30,31)32)11-12-23(22)36-28(4,5)6/h9-14,24-25,33,36-37H,7-8,15-17H2,1-6H3,(H,34,39)(H,35,38)/t24-,25-/m0/s1 | PDB
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| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381216
(CHEMBL2018528)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NC(=O)NCC)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C28H38F3N5O4/c1-5-7-24(37)23(16-32-15-19-9-8-17(3)10-18(19)4)36-26(39)14-25(38)34-21-11-20(28(29,30)31)12-22(13-21)35-27(40)33-6-2/h8-13,23-24,32,37H,5-7,14-16H2,1-4H3,(H,34,38)(H,36,39)(H2,33,35,40)/t23-,24-/m0/s1 | PDB
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PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381208
(CHEMBL2018379)Show SMILES CCC(O)(CC)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C26H35F3N4O3/c1-5-25(36,6-2)22(14-31-13-18-8-7-16(3)11-17(18)4)33-23(34)15-32-24(35)20-12-19(26(27,28)29)9-10-21(20)30/h7-12,22,31,36H,5-6,13-15,30H2,1-4H3,(H,32,35)(H,33,34)/t22-/m0/s1 | PDB
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PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50381212
(CHEMBL2018398)Show SMILES CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(ccc1N)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N4O3/c1-4-5-22(33)21(14-30-13-17-7-6-15(2)10-16(17)3)32-24(35)12-23(34)31-20-11-18(25(26,27)28)8-9-19(20)29/h6-11,21-22,30,33H,4-5,12-14,29H2,1-3H3,(H,31,34)(H,32,35)/t21-,22-/m0/s1 | PDB
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PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Displacement of [125-I]MCP1 from CCR2 on human PBMC |
Bioorg Med Chem Lett 22: 3311-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.007
BindingDB Entry DOI: 10.7270/Q2PN96MB |
More data for this
Ligand-Target Pair | |
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