Found 14 hits Enz. Inhib. hit(s) with all data for entry = 50042155 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Motilin receptor
(Homo sapiens (Human)) | BDBM50421366
(CHEMBL353526)Show SMILES CCC1OC(=O)C(C)C(C[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O)OC1C[C@@](C)(OC)[C@@H](O)C(C)O1 |wU:35.39,41.44,wD:10.10,18.19,33.35,41.45,45.48,35.38,24.25,31.33,c:29,(5,-10.02,;5.02,-8.48,;6.11,-7.38,;6.1,-8.92,;7.43,-9.69,;7.42,-11.23,;8.76,-8.92,;10.09,-9.69,;8.75,-7.38,;10.08,-6.6,;10.08,-5.06,;11.41,-4.28,;12.74,-3.51,;14.07,-4.27,;15.4,-3.5,;16.73,-4.27,;15.4,-1.96,;14.05,-1.19,;12.72,-1.97,;11.39,-1.2,;14.05,.35,;15.38,1.14,;12.72,1.11,;12.7,2.65,;8.87,-4.11,;10.25,-3.44,;8.87,-2.57,;7.54,-1.82,;7.52,-.28,;6.21,-2.6,;6.96,-3.93,;6.21,-4.14,;4.88,-3.36,;4.88,-4.91,;3.55,-4.14,;4.88,-6.45,;4.48,-7.93,;3.55,-5.68,;10.08,-8.15,;11.41,-8.92,;11.41,-10.45,;12.72,-11.22,;11.39,-11.98,;14.05,-11.99,;14.05,-13.53,;14.07,-10.46,;15.4,-11.23,;14.07,-8.92,;15.4,-8.15,;12.74,-8.15,)| Show InChI InChI=1S/C37H65NO12/c1-13-26-37(10,43)31(40)22(6)30-19(3)17-35(8,50-30)27(49-34-29(39)24(38(11)14-2)15-20(4)45-34)16-25(21(5)33(42)48-26)47-28-18-36(9,44-12)32(41)23(7)46-28/h20-29,31-32,34,39-41,43H,13-18H2,1-12H3/t20?,21?,22-,23?,24?,25?,26?,27+,28?,29+,31+,32-,34?,35-,36+,37+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM85846
(CAS_33396-29-1 | EM523 | Erythromycin A 6,9-enolet...)Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O |r,wU:36.38,25.25,47.52,6.6,43.46,45.48,12.13,30.34,10.9,16.16,27.28,wD:8.8,23.24,47.51,31.33,21.22,12.12,2.1,18.18,c:42,(-6.58,-.4,;-6.58,1.13,;-5.23,1.91,;-3.9,1.13,;-3.9,-.4,;-5.23,-1.2,;-2.57,-1.2,;-2.57,-2.73,;-1.22,-.4,;.11,-1.2,;.11,-2.73,;1.44,-3.5,;1.44,-5.03,;2.99,-5.03,;2.19,-6.39,;3.75,-6.39,;.11,-5.81,;.11,-7.36,;-1.22,-5.03,;-2.57,-5.81,;-1.22,-3.5,;-1.22,1.13,;-2.57,1.91,;.11,1.91,;1.44,1.13,;2.77,1.91,;4.1,1.13,;5.45,1.91,;6.78,1.13,;5.45,3.44,;4.1,4.21,;2.77,3.44,;1.44,4.21,;4.1,5.76,;2.77,6.52,;5.45,6.52,;.11,3.44,;1.64,3.44,;.44,4.9,;-.44,6.16,;.55,7.36,;-2.33,6.72,;-1.88,4.46,;-3.9,5.76,;-5.23,6.52,;-3.9,4.21,;-2.57,3.44,;-5.23,3.44,;-6.78,3.44,;-6.01,4.79,)| Show InChI InChI=1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421369
(CHEMBL262052)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC |wU:48.53,12.12,wD:23.24,10.9,31.33,46.49,12.13,16.16,37.39,48.52,44.47,c:43,(5.06,-10.02,;5.07,-8.48,;6.17,-7.38,;6.16,-8.92,;7.49,-9.69,;7.49,-11.23,;8.82,-8.92,;10.15,-9.69,;8.82,-7.38,;10.15,-8.15,;11.48,-8.92,;11.46,-10.46,;12.79,-11.23,;11.46,-11.98,;14.12,-12,;14.12,-13.54,;14.12,-10.46,;15.45,-11.23,;14.12,-8.92,;15.45,-8.15,;12.79,-8.15,;10.15,-6.61,;11.48,-7.38,;10.13,-5.07,;11.46,-4.28,;12.79,-3.51,;14.14,-4.28,;15.45,-3.51,;16.8,-4.28,;15.45,-1.97,;14.12,-1.2,;12.79,-1.97,;11.44,-1.2,;14.12,.34,;15.45,1.14,;12.77,1.11,;12.76,2.65,;8.94,-4.11,;10.31,-3.44,;8.94,-2.57,;7.59,-1.83,;7.58,-.29,;6.26,-2.6,;7.35,-3.69,;6.28,-4.14,;4.93,-3.37,;4.95,-4.91,;3.6,-4.14,;4.95,-6.45,;4.18,-7.78,;3.45,-6.05,;2.12,-6.8,)| Show InChI InChI=1S/C39H69NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31-34,36,41-43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,32+,33-,34+,36?,37+,38-,39+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421367
(CHEMBL351216)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC |wU:49.54,12.12,wD:23.24,10.9,31.33,47.50,12.13,16.16,38.40,49.53,45.48,c:44,(5.06,-10.02,;5.09,-8.48,;6.18,-7.4,;6.16,-8.94,;7.49,-9.71,;7.49,-11.25,;8.82,-8.92,;10.15,-9.69,;8.82,-7.38,;10.15,-8.15,;11.48,-8.92,;11.48,-10.46,;12.79,-11.23,;11.46,-11.99,;14.12,-12,;14.12,-13.54,;14.14,-10.48,;15.47,-11.25,;14.14,-8.94,;15.47,-8.15,;12.81,-8.15,;10.15,-6.61,;11.48,-7.38,;10.15,-5.07,;11.48,-4.29,;12.81,-3.51,;14.14,-4.28,;15.47,-3.51,;16.8,-4.28,;15.47,-1.97,;14.12,-1.2,;12.79,-1.97,;11.46,-1.2,;14.12,.34,;12.79,1.11,;15.45,1.12,;15.42,2.66,;16.78,.37,;8.94,-4.13,;10.31,-3.44,;8.94,-2.59,;7.61,-1.83,;7.58,-.29,;6.28,-2.6,;7.35,-3.69,;6.28,-4.14,;4.95,-3.37,;4.95,-4.91,;3.62,-4.15,;4.95,-6.45,;4.18,-7.78,;3.45,-6.05,;2.12,-6.81,)| Show InChI InChI=1S/C40H71NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32-35,37,42-44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,33+,34-,35+,37?,38+,39-,40+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421368
(CHEMBL166642)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC |wU:47.52,12.12,wD:23.24,10.9,31.33,45.48,12.13,16.16,36.38,47.51,43.46,c:42,(-7.34,-20.52,;-7.33,-18.98,;-6.23,-17.88,;-6.25,-19.42,;-4.92,-20.19,;-4.92,-21.73,;-3.59,-19.42,;-2.26,-20.19,;-3.59,-17.88,;-2.26,-18.65,;-.93,-19.42,;-.93,-20.96,;.38,-21.73,;-.96,-22.48,;1.71,-22.5,;1.7,-24.04,;1.73,-20.96,;3.06,-21.73,;1.73,-19.42,;3.06,-18.65,;.4,-18.65,;-2.26,-17.11,;-.93,-17.88,;-2.26,-15.57,;-.93,-14.78,;.4,-14.01,;1.73,-14.78,;3.06,-14.01,;4.39,-14.78,;3.06,-12.47,;1.71,-11.7,;.37,-12.47,;-.96,-11.7,;1.7,-10.16,;3.03,-9.36,;.37,-9.39,;-3.47,-14.61,;-2.09,-13.94,;-3.48,-13.07,;-4.81,-12.3,;-4.82,-10.79,;-6.14,-13.1,;-5.06,-14.19,;-6.14,-14.64,;-7.47,-13.87,;-7.47,-15.41,;-8.81,-14.64,;-7.46,-16.95,;-8.24,-18.28,;-8.95,-16.55,;-10.31,-17.3,)| Show InChI InChI=1S/C38H67NO12/c1-15-26-38(10,45-14)31(41)21(4)29-19(2)17-37(9,51-29)33(50-35-28(40)25(39(11)12)16-20(3)46-35)22(5)30(23(6)34(43)48-26)49-27-18-36(8,44-13)32(42)24(7)47-27/h20-28,30-33,35,40-42H,15-18H2,1-14H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,31+,32-,33+,35?,36+,37-,38+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421369
(CHEMBL262052)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC |wU:48.53,12.12,wD:23.24,10.9,31.33,46.49,12.13,16.16,37.39,48.52,44.47,c:43,(5.06,-10.02,;5.07,-8.48,;6.17,-7.38,;6.16,-8.92,;7.49,-9.69,;7.49,-11.23,;8.82,-8.92,;10.15,-9.69,;8.82,-7.38,;10.15,-8.15,;11.48,-8.92,;11.46,-10.46,;12.79,-11.23,;11.46,-11.98,;14.12,-12,;14.12,-13.54,;14.12,-10.46,;15.45,-11.23,;14.12,-8.92,;15.45,-8.15,;12.79,-8.15,;10.15,-6.61,;11.48,-7.38,;10.13,-5.07,;11.46,-4.28,;12.79,-3.51,;14.14,-4.28,;15.45,-3.51,;16.8,-4.28,;15.45,-1.97,;14.12,-1.2,;12.79,-1.97,;11.44,-1.2,;14.12,.34,;15.45,1.14,;12.77,1.11,;12.76,2.65,;8.94,-4.11,;10.31,-3.44,;8.94,-2.57,;7.59,-1.83,;7.58,-.29,;6.26,-2.6,;7.35,-3.69,;6.28,-4.14,;4.93,-3.37,;4.95,-4.91,;3.6,-4.14,;4.95,-6.45,;4.18,-7.78,;3.45,-6.05,;2.12,-6.8,)| Show InChI InChI=1S/C39H69NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31-34,36,41-43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,32+,33-,34+,36?,37+,38-,39+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | 2.5 | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421367
(CHEMBL351216)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC |wU:49.54,12.12,wD:23.24,10.9,31.33,47.50,12.13,16.16,38.40,49.53,45.48,c:44,(5.06,-10.02,;5.09,-8.48,;6.18,-7.4,;6.16,-8.94,;7.49,-9.71,;7.49,-11.25,;8.82,-8.92,;10.15,-9.69,;8.82,-7.38,;10.15,-8.15,;11.48,-8.92,;11.48,-10.46,;12.79,-11.23,;11.46,-11.99,;14.12,-12,;14.12,-13.54,;14.14,-10.48,;15.47,-11.25,;14.14,-8.94,;15.47,-8.15,;12.81,-8.15,;10.15,-6.61,;11.48,-7.38,;10.15,-5.07,;11.48,-4.29,;12.81,-3.51,;14.14,-4.28,;15.47,-3.51,;16.8,-4.28,;15.47,-1.97,;14.12,-1.2,;12.79,-1.97,;11.46,-1.2,;14.12,.34,;12.79,1.11,;15.45,1.12,;15.42,2.66,;16.78,.37,;8.94,-4.13,;10.31,-3.44,;8.94,-2.59,;7.61,-1.83,;7.58,-.29,;6.28,-2.6,;7.35,-3.69,;6.28,-4.14,;4.95,-3.37,;4.95,-4.91,;3.62,-4.15,;4.95,-6.45,;4.18,-7.78,;3.45,-6.05,;2.12,-6.81,)| Show InChI InChI=1S/C40H71NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32-35,37,42-44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,33+,34-,35+,37?,38+,39-,40+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | 2.5 | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421368
(CHEMBL166642)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC |wU:47.52,12.12,wD:23.24,10.9,31.33,45.48,12.13,16.16,36.38,47.51,43.46,c:42,(-7.34,-20.52,;-7.33,-18.98,;-6.23,-17.88,;-6.25,-19.42,;-4.92,-20.19,;-4.92,-21.73,;-3.59,-19.42,;-2.26,-20.19,;-3.59,-17.88,;-2.26,-18.65,;-.93,-19.42,;-.93,-20.96,;.38,-21.73,;-.96,-22.48,;1.71,-22.5,;1.7,-24.04,;1.73,-20.96,;3.06,-21.73,;1.73,-19.42,;3.06,-18.65,;.4,-18.65,;-2.26,-17.11,;-.93,-17.88,;-2.26,-15.57,;-.93,-14.78,;.4,-14.01,;1.73,-14.78,;3.06,-14.01,;4.39,-14.78,;3.06,-12.47,;1.71,-11.7,;.37,-12.47,;-.96,-11.7,;1.7,-10.16,;3.03,-9.36,;.37,-9.39,;-3.47,-14.61,;-2.09,-13.94,;-3.48,-13.07,;-4.81,-12.3,;-4.82,-10.79,;-6.14,-13.1,;-5.06,-14.19,;-6.14,-14.64,;-7.47,-13.87,;-7.47,-15.41,;-8.81,-14.64,;-7.46,-16.95,;-8.24,-18.28,;-8.95,-16.55,;-10.31,-17.3,)| Show InChI InChI=1S/C38H67NO12/c1-15-26-38(10,45-14)31(41)21(4)29-19(2)17-37(9,51-29)33(50-35-28(40)25(39(11)12)16-20(3)46-35)22(5)30(23(6)34(43)48-26)49-27-18-36(8,44-13)32(42)24(7)47-27/h20-28,30-33,35,40-42H,15-18H2,1-14H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,31+,32-,33+,35?,36+,37-,38+/m0/s1 | PDB
Reactome pathway
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TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O |r| Show InChI InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 | PDB
Reactome pathway
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TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Motilin receptor
(Homo sapiens (Human)) | BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O |r| Show InChI InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 | PDB
Reactome pathway
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Article
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | 2.5 | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421352
(CHEMBL281952)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C Show InChI InChI=1S/C37H65NO12/c1-14-25-36(10)29(40)22(6)37(50-36)18(2)16-35(9,49-37)31(48-33-27(39)24(38(11)12)15-19(3)44-33)20(4)28(21(5)32(42)46-25)47-26-17-34(8,43-13)30(41)23(7)45-26/h18-31,33,39-41H,14-17H2,1-13H3/t18?,19?,20?,21?,22-,23?,24?,25?,26+,27-,28?,29-,30+,31-,33?,34-,35+,36+,37?/m1/s1 | PDB
Reactome pathway
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TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421352
(CHEMBL281952)Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)C3(O2)O[C@]1(C)[C@H](O)[C@H]3C Show InChI InChI=1S/C37H65NO12/c1-14-25-36(10)29(40)22(6)37(50-36)18(2)16-35(9,49-37)31(48-33-27(39)24(38(11)12)15-19(3)44-33)20(4)28(21(5)32(42)46-25)47-26-17-34(8,43-13)30(41)23(7)45-26/h18-31,33,39-41H,14-17H2,1-13H3/t18?,19?,20?,21?,22-,23?,24?,25?,26+,27-,28?,29-,30+,31-,33?,34-,35+,36+,37?/m1/s1 | PDB
Reactome pathway
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | 2.5 | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM85846
(CAS_33396-29-1 | EM523 | Erythromycin A 6,9-enolet...)Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O |r,wU:36.38,25.25,47.52,6.6,43.46,45.48,12.13,30.34,10.9,16.16,27.28,wD:8.8,23.24,47.51,31.33,21.22,12.12,2.1,18.18,c:42,(-6.58,-.4,;-6.58,1.13,;-5.23,1.91,;-3.9,1.13,;-3.9,-.4,;-5.23,-1.2,;-2.57,-1.2,;-2.57,-2.73,;-1.22,-.4,;.11,-1.2,;.11,-2.73,;1.44,-3.5,;1.44,-5.03,;2.99,-5.03,;2.19,-6.39,;3.75,-6.39,;.11,-5.81,;.11,-7.36,;-1.22,-5.03,;-2.57,-5.81,;-1.22,-3.5,;-1.22,1.13,;-2.57,1.91,;.11,1.91,;1.44,1.13,;2.77,1.91,;4.1,1.13,;5.45,1.91,;6.78,1.13,;5.45,3.44,;4.1,4.21,;2.77,3.44,;1.44,4.21,;4.1,5.76,;2.77,6.52,;5.45,6.52,;.11,3.44,;1.64,3.44,;.44,4.9,;-.44,6.16,;.55,7.36,;-2.33,6.72,;-1.88,4.46,;-3.9,5.76,;-5.23,6.52,;-3.9,4.21,;-2.57,3.44,;-5.23,3.44,;-6.78,3.44,;-6.01,4.79,)| Show InChI InChI=1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 | PDB
Reactome pathway
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| Article
| n/a | n/a | 224 | n/a | n/a | n/a | n/a | 2.5 | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5) |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50421366
(CHEMBL353526)Show SMILES CCC1OC(=O)C(C)C(C[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O)OC1C[C@@](C)(OC)[C@@H](O)C(C)O1 |wU:35.39,41.44,wD:10.10,18.19,33.35,41.45,45.48,35.38,24.25,31.33,c:29,(5,-10.02,;5.02,-8.48,;6.11,-7.38,;6.1,-8.92,;7.43,-9.69,;7.42,-11.23,;8.76,-8.92,;10.09,-9.69,;8.75,-7.38,;10.08,-6.6,;10.08,-5.06,;11.41,-4.28,;12.74,-3.51,;14.07,-4.27,;15.4,-3.5,;16.73,-4.27,;15.4,-1.96,;14.05,-1.19,;12.72,-1.97,;11.39,-1.2,;14.05,.35,;15.38,1.14,;12.72,1.11,;12.7,2.65,;8.87,-4.11,;10.25,-3.44,;8.87,-2.57,;7.54,-1.82,;7.52,-.28,;6.21,-2.6,;6.96,-3.93,;6.21,-4.14,;4.88,-3.36,;4.88,-4.91,;3.55,-4.14,;4.88,-6.45,;4.48,-7.93,;3.55,-5.68,;10.08,-8.15,;11.41,-8.92,;11.41,-10.45,;12.72,-11.22,;11.39,-11.98,;14.05,-11.99,;14.05,-13.53,;14.07,-10.46,;15.4,-11.23,;14.07,-8.92,;15.4,-8.15,;12.74,-8.15,)| Show InChI InChI=1S/C37H65NO12/c1-13-26-37(10,43)31(40)22(6)30-19(3)17-35(8,50-30)27(49-34-29(39)24(38(11)14-2)15-20(4)45-34)16-25(21(5)33(42)48-26)47-28-18-36(9,44-12)32(41)23(7)46-28/h20-29,31-32,34,39-41,43H,13-18H2,1-12H3/t20?,21?,22-,23?,24?,25?,26?,27+,28?,29+,31+,32-,34?,35-,36+,37+/m0/s1 | PDB
Reactome pathway
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| n/a | n/a | 302 | n/a | n/a | n/a | n/a | 2.5 | n/a |
TBA
| Assay Description
Compound was tested for in vitro motilin receptor binding affinity |
Citation and Details
Article DOI: 10.1016/0960-894X(95)00122-A
BindingDB Entry DOI: 10.7270/Q2222W2B |
More data for this
Ligand-Target Pair | |
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