Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bile acid receptor (Homo sapiens (Human)) | BDBM50011809![]() (CHEMBL3263245) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011810![]() (CHEMBL3263246) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011811![]() (CHEMBL3263247) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011812![]() (CHEMBL3263248) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011813![]() (CHEMBL3263249) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM21724![]() (3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at FXR (unknown origin) by coactivator recruitment assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011819![]() (CHEMBL3263244) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011814![]() (CHEMBL3262946) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011815![]() (CHEMBL3262947) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011816![]() (CHEMBL3263236) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.55E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011817![]() (CHEMBL3263240) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 720 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50011818![]() (CHEMBL3263243) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at human FXR expressed in human HeLa cells assessed as transactivation after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM21724![]() (3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Agonist activity at FXR (unknown origin) by reporter gene assay | Bioorg Med Chem 22: 2447-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.053 BindingDB Entry DOI: 10.7270/Q2Z89DZ0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |