Found 12 hits Enz. Inhib. hit(s) with all data for entry = 50048151 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206448
(CHEMBL3944542)Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of 5-FAM-DPPLHSpTAI-OH binding to PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) after 1 hr by fluoresc... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206451
(CHEMBL3894239)Show SMILES NS(=O)(=O)c1cc(Br)c(NC(=S)NC(=O)c2ccccc2)c(Br)c1 Show InChI InChI=1S/C14H11Br2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of 5-FAM-DPPLHSpTAI-OH binding to PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) after 1 hr by fluoresc... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206451
(CHEMBL3894239)Show SMILES NS(=O)(=O)c1cc(Br)c(NC(=S)NC(=O)c2ccccc2)c(Br)c1 Show InChI InChI=1S/C14H11Br2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of full-length PLK1 (unknown origin) expressed in Escherichia coli Rosetta (DE3) using ALMDASFADQ as substrate after 40 mins by fluorimetr... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206448
(CHEMBL3944542)Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206455
(CHEMBL3922258)Show SMILES NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccccc2)c(Br)c1 Show InChI InChI=1S/C14H12BrN3O3S2/c15-11-8-10(23(16,20)21)6-7-12(11)17-14(22)18-13(19)9-4-2-1-3-5-9/h1-8H,(H2,16,20,21)(H2,17,18,19,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206449
(CHEMBL3944679)Show SMILES NS(=O)(=O)c1cc(Cl)c(NC(=S)NC(=O)c2ccccc2)c(Cl)c1 Show InChI InChI=1S/C14H11Cl2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50005003
(CHEMBL2392423)Show InChI InChI=1S/C14H13N3O3S2/c15-22(19,20)12-8-6-11(7-9-12)16-14(21)17-13(18)10-4-2-1-3-5-10/h1-9H,(H2,15,19,20)(H2,16,17,18,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 6.88E+4 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206452
(CHEMBL3908343)Show InChI InChI=1S/C9H11N3O3S2/c1-6(13)11-9(16)12-7-2-4-8(5-3-7)17(10,14)15/h2-5H,1H3,(H2,10,14,15)(H2,11,12,13,16) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | 7.37E+4 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206453
(CHEMBL3978761)Show InChI InChI=1S/C10H13N3O3S2/c1-2-9(14)13-10(17)12-7-3-5-8(6-4-7)18(11,15)16/h3-6H,2H2,1H3,(H2,11,15,16)(H2,12,13,14,17) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 6.43E+4 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206454
(CHEMBL3928373)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C31H49N8O13P/c1-16(2)11-20(35-28(44)23-7-5-9-38(23)18(4)41)26(42)34-21(12-19-13-32-15-33-19)27(43)36-22(14-40)30(46)39-10-6-8-24(39)29(45)37-25(31(47)48)17(3)52-53(49,50)51/h13,15-17,20-25,40H,5-12,14H2,1-4H3,(H,32,33)(H,34,42)(H,35,44)(H,36,43)(H,37,45)(H,47,48)(H2,49,50,51)/t17-,20+,21+,22+,23+,24+,25+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206450
(CHEMBL3921162)Show SMILES NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccccc2)c(I)c1 Show InChI InChI=1S/C14H12IN3O3S2/c15-11-8-10(23(16,20)21)6-7-12(11)17-14(22)18-13(19)9-4-2-1-3-5-9/h1-8H,(H2,16,20,21)(H2,17,18,19,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50206451
(CHEMBL3894239)Show SMILES NS(=O)(=O)c1cc(Br)c(NC(=S)NC(=O)c2ccccc2)c(Br)c1 Show InChI InChI=1S/C14H11Br2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas... |
Eur J Med Chem 124: 229-236 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.043
BindingDB Entry DOI: 10.7270/Q22F7QFW |
More data for this
Ligand-Target Pair | |
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