Compile Data Set for Download or QSAR

Found 130 hits Enz. Inhib. hit(s) with all data for entry = 537   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277097 ((S) or (R)-4-(2,4- difluorophenyl)-8- methyl-7-{[1...) Show SMILES CC(C)n1nccc1CN1CCc2c(nc(cc2-c2ccc(F)cc2F)C(N)=O)C1C Show InChI InChI=1S/C23H25F2N5O/c1-13(2)30-16(6-8-27-30)12-29-9-7-18-19(17-5-4-15(24)10-20(17)25)11-21(23(26)31)28-22(18)14(29)3/h4-6,8,10-11,13-14H,7,9,12H2,1-3H3,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277085 (US10072003, Example 1-5A | US10072003, Example 1-5...) Show SMILES CC1(C)CC(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)CCO1 Show InChI InChI=1S/C23H27ClFN3O2/c1-23(2)11-14(6-8-30-23)12-28-7-5-17-18(16-4-3-15(24)9-19(16)25)10-20(22(26)29)27-21(17)13-28/h3-4,9-10,14H,5-8,11-13H2,1-2H3,(H2,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277201 (4-(2-chloro-4-fluorophenyl)-7- [(2-methoxypyridin-...) Show SMILES COc1cc(CN2CCc3c(C2)nc(cc3-c2ccc(F)cc2Cl)C(N)=O)ccn1 Show InChI InChI=1S/C22H20ClFN4O2/c1-30-21-8-13(4-6-26-21)11-28-7-5-16-17(15-3-2-14(24)9-18(15)23)10-19(22(25)29)27-20(16)12-28/h2-4,6,8-10H,5,7,11-12H2,1H3,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277130 (4-(2,4-difluorophenyl)-7-{[6- (trifluoromethyl)pyr...) Show SMILES NC(=O)c1cc(c2CCN(Cc3cc(ncn3)C(F)(F)F)Cc2n1)-c1ccc(F)cc1F Show InChI InChI=1S/C21H16F5N5O/c22-11-1-2-13(16(23)5-11)15-7-17(20(27)32)30-18-9-31(4-3-14(15)18)8-12-6-19(21(24,25)26)29-10-28-12/h1-2,5-7,10H,3-4,8-9H2,(H2,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277097 ((S) or (R)-4-(2,4- difluorophenyl)-8- methyl-7-{[1...) Show SMILES CC(C)n1nccc1CN1CCc2c(nc(cc2-c2ccc(F)cc2F)C(N)=O)C1C Show InChI InChI=1S/C23H25F2N5O/c1-13(2)30-16(6-8-27-30)12-29-9-7-18-19(17-5-4-15(24)10-20(17)25)11-21(23(26)31)28-22(18)14(29)3/h4-6,8,10-11,13-14H,7,9,12H2,1-3H3,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277189 (4-(4-chloro-2,6-difluorophenyl)-7-{[2- (trifluorom...) Show SMILES NC(=O)c1cc(c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1)-c1c(F)cc(Cl)cc1F |(-8,-3.08,;-6.67,-3.85,;-6.67,-5.39,;-5.33,-3.08,;-5.33,-1.54,;-4,-.77,;-2.67,-1.54,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;2.67,-3.08,;2.67,-1.54,;4,-.77,;5.33,-1.54,;5.33,-3.08,;4,-3.85,;6.67,-3.85,;8,-3.08,;6.67,-5.39,;8,-4.62,;-1.33,-3.85,;-2.67,-3.08,;-4,-3.85,;-4,.77,;-5.33,1.54,;-6.67,.77,;-5.33,3.08,;-4,3.85,;-4,5.39,;-2.67,3.08,;-2.67,1.54,;-1.33,.77,)| Show InChI InChI=1S/C21H15ClF5N5O/c22-10-5-14(23)18(15(24)6-10)13-7-16(19(28)33)31-17-9-32(4-2-12(13)17)8-11-1-3-29-20(30-11)21(25,26)27/h1,3,5-7H,2,4,8-9H2,(H2,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277199 (4-(2-fluoro-4-methoxyphenyl)-7- [(2-methoxypyridin...) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2CN(Cc3ccnc(OC)c3)CCc12)C(N)=O Show InChI InChI=1S/C23H23FN4O3/c1-30-15-3-4-16(19(24)10-15)18-11-20(23(25)29)27-21-13-28(8-6-17(18)21)12-14-5-7-26-22(9-14)31-2/h3-5,7,9-11H,6,8,12-13H2,1-2H3,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277183 (4-(4-chloro-2-fluorophenyl)-7-{[2- (trifluoromethy...) Show SMILES NC(=O)c1cc(c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1)-c1ccc(Cl)cc1F Show InChI InChI=1S/C21H16ClF4N5O/c22-11-1-2-13(16(23)7-11)15-8-17(19(27)32)30-18-10-31(6-4-14(15)18)9-12-3-5-28-20(29-12)21(24,25)26/h1-3,5,7-8H,4,6,9-10H2,(H2,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277100 (7-[(1-tert-butyl-1H-1,2,3- triazol-5-yl)methyl]-4-...) Show SMILES CC(C)(C)n1nncc1CN1CCc2c(C1)nc(cc2-c1c(F)cc(Cl)cc1F)C(N)=O |(-1.57,.85,;-3.06,.45,;-3.46,-1.04,;-1.97,-.64,;-4.15,1.54,;-5.61,1.06,;-6.52,2.31,;-5.61,3.56,;-4.15,3.08,;-2.82,3.85,;-1.48,3.08,;-1.48,1.54,;-.15,.77,;1.18,1.54,;1.18,3.08,;-.15,3.85,;2.52,3.85,;3.85,3.08,;3.85,1.54,;2.52,.77,;2.52,-.77,;3.85,-1.54,;5.19,-.77,;3.85,-3.08,;2.52,-3.85,;2.52,-5.39,;1.18,-3.08,;1.18,-1.54,;-.15,-.77,;5.19,3.85,;6.52,3.08,;5.19,5.39,)| Show InChI InChI=1S/C22H23ClF2N6O/c1-22(2,3)31-13(9-27-29-31)10-30-5-4-14-15(8-18(21(26)32)28-19(14)11-30)20-16(24)6-12(23)7-17(20)25/h6-9H,4-5,10-11H2,1-3H3,(H2,26,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277178 (4-(4-chloro-2-fluorophenyl)-7-[(2- methoxypyrimidi...) Show SMILES COc1ncc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)cn1 Show InChI InChI=1S/C21H19ClFN5O2/c1-30-21-25-8-12(9-26-21)10-28-5-4-15-16(14-3-2-13(22)6-17(14)23)7-18(20(24)29)27-19(15)11-28/h2-3,6-9H,4-5,10-11H2,1H3,(H2,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277085 (US10072003, Example 1-5A | US10072003, Example 1-5...) Show SMILES CC1(C)CC(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)CCO1 Show InChI InChI=1S/C23H27ClFN3O2/c1-23(2)11-14(6-8-30-23)12-28-7-5-17-18(16-4-3-15(24)9-19(16)25)10-20(22(26)29)27-21(17)13-28/h3-4,9-10,14H,5-8,11-13H2,1-2H3,(H2,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277114 (4-(2,4-difluorophenyl)-7-[(4-methyl-1,2,5- oxadiaz...) Show SMILES Cc1nonc1CN1CCc2c(C1)nc(cc2-c1ccc(F)cc1F)C(N)=O Show InChI InChI=1S/C19H17F2N5O2/c1-10-17(25-28-24-10)8-26-5-4-13-14(12-3-2-11(20)6-15(12)21)7-16(19(22)27)23-18(13)9-26/h2-3,6-7H,4-5,8-9H2,1H3,(H2,22,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277190 (4-(4-fluorophenyl)-7-{[6- (trifluoromethyl)pyrimid...) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2CCN(Cc3cc(ncn3)C(F)(F)F)Cc2n1 Show InChI InChI=1S/C21H17F4N5O/c22-13-3-1-12(2-4-13)16-8-17(20(26)31)29-18-10-30(6-5-15(16)18)9-14-7-19(21(23,24)25)28-11-27-14/h1-4,7-8,11H,5-6,9-10H2,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277198 (US10072003, Example 13-1) Show SMILES COc1cc(CN2CCc3c(C2)nc(cc3-c2ccc(F)cc2F)C(N)=O)ccn1 Show InChI InChI=1S/C22H20F2N4O2/c1-30-21-8-13(4-6-26-21)11-28-7-5-16-17(15-3-2-14(23)9-18(15)24)10-19(22(25)29)27-20(16)12-28/h2-4,6,8-10H,5,7,11-12H2,1H3,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277175 (4-(4-chloro-2-fluorophenyl)-7-{[3-(1- methylethyl)...) Show SMILES CC(C)c1noc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)n1 Show InChI InChI=1S/C21H21ClFN5O2/c1-11(2)21-26-19(30-27-21)10-28-6-5-14-15(13-4-3-12(22)7-16(13)23)8-17(20(24)29)25-18(14)9-28/h3-4,7-8,11H,5-6,9-10H2,1-2H3,(H2,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277090 (4-(2,4-difluorophenyl)-7- {[1-(1-methylethyl)-1H- ...) Show SMILES CC(C)n1nccc1CN1CCc2c(C1)nc(cc2-c1ccc(F)cc1F)C(N)=O Show InChI InChI=1S/C22H23F2N5O/c1-13(2)29-15(5-7-26-29)11-28-8-6-17-18(16-4-3-14(23)9-19(16)24)10-20(22(25)30)27-21(17)12-28/h3-5,7,9-10,13H,6,8,11-12H2,1-2H3,(H2,25,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277119 (7-{[2-(difluoromethoxy)pyridin-4- yl]methyl}-4-[1-...) Show SMILES NC(=O)c1cc(-c2cnn(c2)C(F)F)c2CCN(Cc3ccnc(OC(F)F)c3)Cc2n1 Show InChI InChI=1S/C20H18F4N6O2/c21-19(22)30-9-12(7-27-30)14-6-15(18(25)31)28-16-10-29(4-2-13(14)16)8-11-1-3-26-17(5-11)32-20(23)24/h1,3,5-7,9,19-20H,2,4,8,10H2,(H2,25,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277089 (4-(4-chloro-2- fluorophenyl)-7-[(1- methyl-1H-pyra...) Show SMILES Cn1nccc1CN1CCc2c(C1)nc(cc2-c1ccc(Cl)cc1F)C(N)=O Show InChI InChI=1S/C20H19ClFN5O/c1-26-13(4-6-24-26)10-27-7-5-15-16(14-3-2-12(21)8-17(14)22)9-18(20(23)28)25-19(15)11-27/h2-4,6,8-9H,5,7,10-11H2,1H3,(H2,23,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277104 ((S) or (R)-4-(4-chloro-2- fluorophenyl)-7-[(6,6- d...) Show SMILES CC1(C)CCC(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)CO1 Show InChI InChI=1S/C23H27ClFN3O2/c1-23(2)7-5-14(13-30-23)11-28-8-6-17-18(16-4-3-15(24)9-19(16)25)10-20(22(26)29)27-21(17)12-28/h3-4,9-10,14H,5-8,11-13H2,1-2H3,(H2,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277137 (US10072003, Example 3-2A | US10072003, Example 3-2...) Show SMILES COc1cc(ccn1)C(N1CCc2c(C1)nc(cc2-c1cnn(C)c1)C(N)=O)C(F)(F)F Show InChI InChI=1S/C21H21F3N6O2/c1-29-10-13(9-27-29)15-8-16(20(25)31)28-17-11-30(6-4-14(15)17)19(21(22,23)24)12-3-5-26-18(7-12)32-2/h3,5,7-10,19H,4,6,11H2,1-2H3,(H2,25,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277171 (4-(4-chloro-2-fluorophenyl)-7-[(5-methyl- 1,2,4-ox...) Show SMILES Cc1nc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)no1 Show InChI InChI=1S/C19H17ClFN5O2/c1-10-23-18(25-28-10)9-26-5-4-13-14(12-3-2-11(20)6-15(12)21)7-16(19(22)27)24-17(13)8-26/h2-3,6-7H,4-5,8-9H2,1H3,(H2,22,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277094 (4-(2-fluoro-4- methylphenyl)-7-{[1-(1- methylethyl...) Show SMILES CC(C)n1nccc1CN1CCc2c(C1)nc(cc2-c1ccc(C)cc1F)C(N)=O Show InChI InChI=1S/C23H26FN5O/c1-14(2)29-16(6-8-26-29)12-28-9-7-18-19(17-5-4-15(3)10-20(17)24)11-21(23(25)30)27-22(18)13-28/h4-6,8,10-11,14H,7,9,12-13H2,1-3H3,(H2,25,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277166 (US10072003, Example 8-2A | US10072003, Example 8-2...) Show SMILES NC(=O)c1cc(c2CCN(Cc2n1)C(CO)c1ccccc1)-c1ccc(F)cc1F Show InChI InChI=1S/C23H21F2N3O2/c24-15-6-7-16(19(25)10-15)18-11-20(23(26)30)27-21-12-28(9-8-17(18)21)22(13-29)14-4-2-1-3-5-14/h1-7,10-11,22,29H,8-9,12-13H2,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277192 (4-(4-chloro-2-fluorophenyl)-7-{[6- (trifluoromethy...) Show SMILES NC(=O)c1cc(c2CCN(Cc3cc(ncn3)C(F)(F)F)Cc2n1)-c1ccc(Cl)cc1F Show InChI InChI=1S/C21H16ClF4N5O/c22-11-1-2-13(16(23)5-11)15-7-17(20(27)32)30-18-9-31(4-3-14(15)18)8-12-6-19(21(24,25)26)29-10-28-12/h1-2,5-7,10H,3-4,8-9H2,(H2,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277118 (4-(2-chloro-4-fluorophenyl)-7-{[2- (difluoromethox...) Show SMILES NC(=O)c1cc(c2CCN(Cc3ccnc(OC(F)F)c3)Cc2n1)-c1ccc(F)cc1Cl Show InChI InChI=1S/C22H18ClF3N4O2/c23-17-8-13(24)1-2-14(17)16-9-18(21(27)31)29-19-11-30(6-4-15(16)19)10-12-3-5-28-20(7-12)32-22(25)26/h1-3,5,7-9,22H,4,6,10-11H2,(H2,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277116 (7-[(2-cyclopropylpyridin-4-yl)methyl]-4-[1- (diflu...) Show SMILES NC(=O)c1cc(-c2cnn(c2)C(F)F)c2CCN(Cc3ccnc(c3)C3CC3)Cc2n1 Show InChI InChI=1S/C22H22F2N6O/c23-22(24)30-11-15(9-27-30)17-8-19(21(25)31)28-20-12-29(6-4-16(17)20)10-13-3-5-26-18(7-13)14-1-2-14/h3,5,7-9,11,14,22H,1-2,4,6,10,12H2,(H2,25,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277127 (4-(4-chloro-2,6-difluorophenyl)-7-{[1- (difluorome...) Show SMILES NC(=O)c1cc(c2CCN(Cc3ccnn3C(F)F)Cc2n1)-c1c(F)cc(Cl)cc1F |(6.52,3.08,;5.19,3.85,;5.19,5.39,;3.85,3.08,;3.85,1.54,;2.52,.77,;1.18,1.54,;-.15,.77,;-1.48,1.54,;-1.48,3.08,;-2.82,3.85,;-4.15,3.08,;-5.61,3.56,;-6.52,2.31,;-5.61,1.06,;-4.15,1.54,;-3.06,.45,;-3.46,-1.04,;-1.57,.85,;-.15,3.85,;1.18,3.08,;2.52,3.85,;2.52,-.77,;1.18,-1.54,;-.15,-.77,;1.18,-3.08,;2.52,-3.85,;2.52,-5.39,;3.85,-3.08,;3.85,-1.54,;5.19,-.77,)| Show InChI InChI=1S/C20H16ClF4N5O/c21-10-5-14(22)18(15(23)6-10)13-7-16(19(26)31)28-17-9-29(4-2-12(13)17)8-11-1-3-27-30(11)20(24)25/h1,3,5-7,20H,2,4,8-9H2,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277137 (US10072003, Example 3-2A | US10072003, Example 3-2...) Show SMILES COc1cc(ccn1)C(N1CCc2c(C1)nc(cc2-c1cnn(C)c1)C(N)=O)C(F)(F)F Show InChI InChI=1S/C21H21F3N6O2/c1-29-10-13(9-27-29)15-8-16(20(25)31)28-17-11-30(6-4-14(15)17)19(21(22,23)24)12-3-5-26-18(7-12)32-2/h3,5,7-10,19H,4,6,11H2,1-2H3,(H2,25,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277166 (US10072003, Example 8-2A | US10072003, Example 8-2...) Show SMILES NC(=O)c1cc(c2CCN(Cc2n1)C(CO)c1ccccc1)-c1ccc(F)cc1F Show InChI InChI=1S/C23H21F2N3O2/c24-15-6-7-16(19(25)10-15)18-11-20(23(26)30)27-21-12-28(9-8-17(18)21)22(13-29)14-4-2-1-3-5-14/h1-7,10-11,22,29H,8-9,12-13H2,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277176 (4-(4-chloro-2-fluorophenyl)-7-[(4- methoxypyrimidi...) Show SMILES COc1ccnc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)n1 Show InChI InChI=1S/C21H19ClFN5O2/c1-30-20-4-6-25-19(27-20)11-28-7-5-14-15(13-3-2-12(22)8-16(13)23)9-17(21(24)29)26-18(14)10-28/h2-4,6,8-9H,5,7,10-11H2,1H3,(H2,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277155 (US10072003, Example 6-1) Show SMILES NC(=O)c1cc(-c2ccc(Cl)cn2)c2CCN(Cc3ccnc(c3)C(F)(F)F)Cc2n1 Show InChI InChI=1S/C21H17ClF3N5O/c22-13-1-2-16(28-9-13)15-8-17(20(26)31)29-18-11-30(6-4-14(15)18)10-12-3-5-27-19(7-12)21(23,24)25/h1-3,5,7-9H,4,6,10-11H2,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277188 (4-(2-fluorophenyl)-7-{[2- (trifluoromethyl)pyrimid...) Show SMILES NC(=O)c1cc(c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1)-c1ccccc1F Show InChI InChI=1S/C21H17F4N5O/c22-16-4-2-1-3-13(16)15-9-17(19(26)31)29-18-11-30(8-6-14(15)18)10-12-5-7-27-20(28-12)21(23,24)25/h1-5,7,9H,6,8,10-11H2,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277179 (4-(4-chloro-2-fluorophenyl)-7-(pyridin-3- ylmethyl...) Show SMILES NC(=O)c1cc(c2CCN(Cc3cccnc3)Cc2n1)-c1ccc(Cl)cc1F Show InChI InChI=1S/C21H18ClFN4O/c22-14-3-4-15(18(23)8-14)17-9-19(21(24)28)26-20-12-27(7-5-16(17)20)11-13-2-1-6-25-10-13/h1-4,6,8-10H,5,7,11-12H2,(H2,24,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277101 ((S) or (R)-4-(4-chloro-2- fluorophenyl)-7-(((S) or...) Show SMILES CC1N(CC2CCOC(C)(C)C2)CCc2c1nc(cc2-c1ccc(F)cc1F)C(N)=O Show InChI InChI=1S/C24H29F2N3O2/c1-14-22-18(6-8-29(14)13-15-7-9-31-24(2,3)12-15)19(11-21(28-22)23(27)30)17-5-4-16(25)10-20(17)26/h4-5,10-11,14-15H,6-9,12-13H2,1-3H3,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277164 (US10072003, Example 8-1A | US10072003, Example 8-1...) Show SMILES NC(=O)c1cc(c2CCN(CC(O)c3ccccc3)Cc2n1)-c1ccc(F)cc1F Show InChI InChI=1S/C23H21F2N3O2/c24-15-6-7-16(19(25)10-15)18-11-20(23(26)30)27-21-12-28(9-8-17(18)21)13-22(29)14-4-2-1-3-5-14/h1-7,10-11,22,29H,8-9,12-13H2,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277174 (4-(4-chloro-2-fluorophenyl)-7-[(3-methyl- 1,2,4-ox...) Show SMILES Cc1noc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)n1 Show InChI InChI=1S/C19H17ClFN5O2/c1-10-23-18(28-25-10)9-26-5-4-13-14(12-3-2-11(20)6-15(12)21)7-16(19(22)27)24-17(13)8-26/h2-3,6-7H,4-5,8-9H2,1H3,(H2,22,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277164 (US10072003, Example 8-1A | US10072003, Example 8-1...) Show SMILES NC(=O)c1cc(c2CCN(CC(O)c3ccccc3)Cc2n1)-c1ccc(F)cc1F Show InChI InChI=1S/C23H21F2N3O2/c24-15-6-7-16(19(25)10-15)18-11-20(23(26)30)27-21-12-28(9-8-17(18)21)13-22(29)14-4-2-1-3-5-14/h1-7,10-11,22,29H,8-9,12-13H2,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277147 ((S) or (R)-4-(3- methylpiperidin-1-yl)-7- ((2- (tr...) Show SMILES CC1CCCN(C1)c1cc(nc2CN(Cc3ccnc(c3)C(F)(F)F)CCc12)C(N)=O Show InChI InChI=1S/C22H26F3N5O/c1-14-3-2-7-30(11-14)19-10-17(21(26)31)28-18-13-29(8-5-16(18)19)12-15-4-6-27-20(9-15)22(23,24)25/h4,6,9-10,14H,2-3,5,7-8,11-13H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277194 (4-(6-azaspiro[2.5]oct-6-yl)-7-{[2- (trifluoromethy...) Show SMILES NC(=O)c1cc(N2CCC3(CC3)CC2)c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1 Show InChI InChI=1S/C22H25F3N6O/c23-22(24,25)20-27-7-1-14(28-20)12-30-8-2-15-17(13-30)29-16(19(26)32)11-18(15)31-9-5-21(3-4-21)6-10-31/h1,7,11H,2-6,8-10,12-13H2,(H2,26,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277133 (4-(2,4-difluorophenyl)-7-[(4- methylisoxazol-3-yl)...) Show SMILES Cc1conc1CN1CCc2c(C1)nc(cc2-c1ccc(F)cc1F)C(N)=O Show InChI InChI=1S/C20H18F2N4O2/c1-11-10-28-25-18(11)8-26-5-4-14-15(13-3-2-12(21)6-16(13)22)7-17(20(23)27)24-19(14)9-26/h2-3,6-7,10H,4-5,8-9H2,1H3,(H2,23,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277102 ((S) or (R)-8-methyl-7- {[1-(1-methylethyl)-1H- pyr...) Show SMILES CC(C)n1nccc1CN1CCc2c(cc(nc2C1C)C(N)=O)N1CCCCC1 Show InChI InChI=1S/C22H32N6O/c1-15(2)28-17(7-9-24-28)14-27-12-8-18-20(26-10-5-4-6-11-26)13-19(22(23)29)25-21(18)16(27)3/h7,9,13,15-16H,4-6,8,10-12,14H2,1-3H3,(H2,23,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277186 (7-{[2-(trifluoromethyl)pyrimidin-4- yl]methyl}-4-(...) Show SMILES NC(=O)c1cc(c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1)-c1c(F)cc(F)cc1F |(-8,-3.08,;-6.67,-3.85,;-6.67,-5.39,;-5.33,-3.08,;-5.33,-1.54,;-4,-.77,;-2.67,-1.54,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;2.67,-3.08,;2.67,-1.54,;4,-.77,;5.33,-1.54,;5.33,-3.08,;4,-3.85,;6.67,-3.85,;8,-3.08,;6.67,-5.39,;8,-4.62,;-1.33,-3.85,;-2.67,-3.08,;-4,-3.85,;-4,.77,;-5.33,1.54,;-6.67,.77,;-5.33,3.08,;-4,3.85,;-4,5.39,;-2.67,3.08,;-2.67,1.54,;-1.33,.77,)| Show InChI InChI=1S/C21H15F6N5O/c22-10-5-14(23)18(15(24)6-10)13-7-16(19(28)33)31-17-9-32(4-2-12(13)17)8-11-1-3-29-20(30-11)21(25,26)27/h1,3,5-7H,2,4,8-9H2,(H2,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277088 (4-(2,4-difluorophenyl)-7- [(1,3-dimethyl-1H- pyraz...) Show SMILES Cc1cc(CN2CCc3c(C2)nc(cc3-c2ccc(F)cc2F)C(N)=O)n(C)n1 Show InChI InChI=1S/C21H21F2N5O/c1-12-7-14(27(2)26-12)10-28-6-5-16-17(15-4-3-13(22)8-18(15)23)9-19(21(24)29)25-20(16)11-28/h3-4,7-9H,5-6,10-11H2,1-2H3,(H2,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277099 (4-(4-chloro-2- fluorophenyl)-7-[(1- methyl-1H-imid...) Show SMILES Cn1cncc1CN1CCc2c(C1)nc(cc2-c1ccc(Cl)cc1F)C(N)=O Show InChI InChI=1S/C20H19ClFN5O/c1-26-11-24-8-13(26)9-27-5-4-15-16(14-3-2-12(21)6-17(14)22)7-18(20(23)28)25-19(15)10-27/h2-3,6-8,11H,4-5,9-10H2,1H3,(H2,23,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277172 (4-(4-chloro-2-fluorophenyl)-7-[(2- methoxypyrimidi...) Show SMILES COc1nccc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)n1 Show InChI InChI=1S/C21H19ClFN5O2/c1-30-21-25-6-4-13(26-21)10-28-7-5-15-16(14-3-2-12(22)8-17(14)23)9-18(20(24)29)27-19(15)11-28/h2-4,6,8-9H,5,7,10-11H2,1H3,(H2,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277087 (4-(2,4-difluorophenyl)-7- [(1-methyl-1H-pyrazol-5-...) Show SMILES Cn1nccc1CN1CCc2c(C1)nc(cc2-c1ccc(F)cc1F)C(N)=O Show InChI InChI=1S/C20H19F2N5O/c1-26-13(4-6-24-26)10-27-7-5-15-16(14-3-2-12(21)8-17(14)22)9-18(20(23)28)25-19(15)11-27/h2-4,6,8-9H,5,7,10-11H2,1H3,(H2,23,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277180 (4-(4-chloro-2-fluorophenyl)-7-[(1-methyl- 1H-pyraz...) Show SMILES Cn1cc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)cn1 Show InChI InChI=1S/C20H19ClFN5O/c1-26-9-12(8-24-26)10-27-5-4-15-16(14-3-2-13(21)6-17(14)22)7-18(20(23)28)25-19(15)11-27/h2-3,6-9H,4-5,10-11H2,1H3,(H2,23,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277106 (US10072003, Example 1-23A | US10072003, Example 1-...) Show SMILES CC1(C)CC(CN2CCc3c(cc(nc3C2(C)C)C(N)=O)-c2ccc(F)cc2F)CCO1 Show InChI InChI=1S/C25H31F2N3O2/c1-24(2)13-15(8-10-32-24)14-30-9-7-18-19(17-6-5-16(26)11-20(17)27)12-21(23(28)31)29-22(18)25(30,3)4/h5-6,11-12,15H,7-10,13-14H2,1-4H3,(H2,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277200 (4-(4-chloro-2-fluorophenyl)-7- [(2-methoxypyridin-...) Show SMILES COc1cc(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)ccn1 Show InChI InChI=1S/C22H20ClFN4O2/c1-30-21-8-13(4-6-26-21)11-28-7-5-16-17(15-3-2-14(23)9-18(15)24)10-19(22(25)29)27-20(16)12-28/h2-4,6,8-10H,5,7,11-12H2,1H3,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277149 ((S) or (R)-4-(3- fluoropiperidin-1-yl)-7-((2- (tri...) Show SMILES NC(=O)c1cc(N2CCCC(F)C2)c2CCN(Cc3ccnc(c3)C(F)(F)F)Cc2n1 Show InChI InChI=1S/C21H23F4N5O/c22-14-2-1-6-30(11-14)18-9-16(20(26)31)28-17-12-29(7-4-15(17)18)10-13-3-5-27-19(8-13)21(23,24)25/h3,5,8-9,14H,1-2,4,6-7,10-12H2,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair

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