Compile Data Set for Download or QSAR

Found 605 hits Enz. Inhib. hit(s) with all data for entry = 5611   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405060 (1-[2-fluoro-4-(4-{2-[2-fluoro-5- (trifluoromethoxy...) Show SMILES FC(CCn1cc(NC(=O)Cc2cc(OC(F)(F)F)ccc2F)nn1)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C26H21F9N8O4/c27-16(11-43-12-21(38-40-43)24(45)36-10-15-8-18(2-4-20(15)29)47-26(33,34)35)5-6-42-13-22(39-41-42)37-23(44)9-14-7-17(1-3-19(14)28)46-25(30,31)32/h1-4,7-8,12-13,16H,5-6,9-11H2,(H,36,45)(H,37,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405061 (1-(2-fluoro-4-{4-[2-(6-methylpyridin- 3-yl)acetami...) Show SMILES Cc1ccc(CC(=O)Nc2cn(CCC(F)Cn3cc(nn3)C(=O)NCc3cc(OC(F)(F)F)ccc3F)nn2)cn1 Show InChI InChI=1S/C25H24F5N9O3/c1-15-2-3-16(10-31-15)8-23(40)33-22-14-38(37-35-22)7-6-18(26)12-39-13-21(34-36-39)24(41)32-11-17-9-19(4-5-20(17)27)42-25(28,29)30/h2-5,9-10,13-14,18H,6-8,11-12H2,1H3,(H,32,41)(H,33,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405062 (1-[2-fluoro-4-(4-{2-[3- (trifluoromethoxy)phenyl]a...) Show SMILES FC(CCn1cc(NC(=O)Cc2cccc(OC(F)(F)F)c2)nn1)Cn1cc(nn1)C(=O)NCc1ncccc1F Show InChI InChI=1S/C24H22F5N9O3/c25-16(12-38-13-20(33-35-38)23(40)31-11-19-18(26)5-2-7-30-19)6-8-37-14-21(34-36-37)32-22(39)10-15-3-1-4-17(9-15)41-24(27,28)29/h1-5,7,9,13-14,16H,6,8,10-12H2,(H,31,40)(H,32,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405063 (1-[2-fluoro-4-(4-{2-[3- (trifluoromethoxy)phenyl]a...) Show SMILES FC(CCn1cc(NC(=O)Cc2cccc(OC(F)(F)F)c2)nn1)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H22F7N9O3/c26-17(12-41-13-20(36-38-41)23(43)34-11-18-10-16(4-6-33-18)24(27,28)29)5-7-40-14-21(37-39-40)35-22(42)9-15-2-1-3-19(8-15)44-25(30,31)32/h1-4,6,8,10,13-14,17H,5,7,9,11-12H2,(H,34,43)(H,35,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405064 (1-[2-fluoro-4-(4-{2-[3- (trifluoromethoxy)phenyl]a...) Show SMILES FC(CCn1cc(NC(=O)Cc2cccc(OC(F)(F)F)c2)nn1)Cn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C26H23F7N8O4/c27-18(13-41-14-21(36-38-41)24(43)34-12-17-4-2-6-20(10-17)45-26(31,32)33)7-8-40-15-22(37-39-40)35-23(42)11-16-3-1-5-19(9-16)44-25(28,29)30/h1-6,9-10,14-15,18H,7-8,11-13H2,(H,34,43)(H,35,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405067 (1-[3-fluoro-4-(4-{2-[3- (trifluoromethoxy)phenyl]a...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ccc(nc1)C(F)(F)F)Cn1cc(NC(=O)Cc2cccc(OC(F)(F)F)c2)nn1 Show InChI InChI=1S/C25H22F7N9O3/c26-17(6-7-40-13-19(36-38-40)23(43)34-11-16-4-5-20(33-10-16)24(27,28)29)12-41-14-21(37-39-41)35-22(42)9-15-2-1-3-18(8-15)44-25(30,31)32/h1-5,8,10,13-14,17H,6-7,9,11-12H2,(H,34,43)(H,35,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405068 (1-[3-fluoro-4-(4-{2-[2-fluoro-5- (trifluoromethoxy...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ccc(nc1)C(F)(F)F)Cn1cc(NC(=O)Cc2cc(OC(F)(F)F)ccc2F)nn1 Show InChI InChI=1S/C25H21F8N9O3/c26-16(5-6-41-12-19(37-39-41)23(44)35-10-14-1-4-20(34-9-14)24(28,29)30)11-42-13-21(38-40-42)36-22(43)8-15-7-17(2-3-18(15)27)45-25(31,32)33/h1-4,7,9,12-13,16H,5-6,8,10-11H2,(H,35,44)(H,36,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405069 (1-[4-(4-{2-[2-fluoro-5- (trifluoromethoxy)phenyl]a...) Show SMILES FC(CCn1cc(NC(=O)Cc2cc(OC(F)(F)F)ccc2F)nn1)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H21F8N9O3/c26-16(11-42-12-20(37-39-42)23(44)35-10-17-9-15(3-5-34-17)24(28,29)30)4-6-41-13-21(38-40-41)36-22(43)8-14-7-18(1-2-19(14)27)45-25(31,32)33/h1-3,5,7,9,12-13,16H,4,6,8,10-11H2,(H,35,44)(H,36,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405070 (1-[4-(4-{2-[3- (trifluoromethoxy)phenyl]acetamido}...) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2cn(CCCCn3cc(nn3)C(=O)NCc3cc(ccn3)C(F)(F)F)nn2)c1 Show InChI InChI=1S/C25H23F6N9O3/c26-24(27,28)17-6-7-32-18(12-17)13-33-23(42)20-14-39(37-35-20)8-1-2-9-40-15-21(36-38-40)34-22(41)11-16-4-3-5-19(10-16)43-25(29,30)31/h3-7,10,12,14-15H,1-2,8-9,11,13H2,(H,33,42)(H,34,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405071 (1-(4-{4-[2-(5-chloro-2- fluorophenyl)acetamido]-1H...) Show SMILES Fc1ccc(Cl)cc1CNC(=O)c1cn(CCCCn2cc(NC(=O)Cc3cc(Cl)ccc3F)nn2)nn1 Show InChI InChI=1S/C24H22Cl2F2N8O2/c25-17-3-5-19(27)15(9-17)11-23(37)30-22-14-36(34-32-22)8-2-1-7-35-13-21(31-33-35)24(38)29-12-16-10-18(26)4-6-20(16)28/h3-6,9-10,13-14H,1-2,7-8,11-12H2,(H,29,38)(H,30,37)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405072 (1-[2-fluoro-4-(4-{2-[2-fluoro-5- (trifluoromethoxy...) Show SMILES FC(CCn1cc(NC(=O)Cc2cc(OC(F)(F)F)ccc2F)nn1)Cn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C26H22F8N8O4/c27-17(12-42-13-21(37-39-42)24(44)35-11-15-2-1-3-18(8-15)45-25(29,30)31)6-7-41-14-22(38-40-41)36-23(43)10-16-9-19(4-5-20(16)28)46-26(32,33)34/h1-5,8-9,13-14,17H,6-7,10-12H2,(H,35,44)(H,36,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405073 (1-[2-fluoro-4-(4-{2-[2-fluoro-5- (trifluoromethoxy...) Show SMILES FC(CCn1cc(NC(=O)Cc2cc(OC(F)(F)F)ccc2F)nn1)Cn1cc(nn1)C(=O)NCc1ncccc1F Show InChI InChI=1S/C24H21F6N9O3/c25-15(11-39-12-20(34-36-39)23(41)32-10-19-18(27)2-1-6-31-19)5-7-38-13-21(35-37-38)33-22(40)9-14-8-16(3-4-17(14)26)42-24(28,29)30/h1-4,6,8,12-13,15H,5,7,9-11H2,(H,32,41)(H,33,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405069 (1-[4-(4-{2-[2-fluoro-5- (trifluoromethoxy)phenyl]a...) Show SMILES FC(CCn1cc(NC(=O)Cc2cc(OC(F)(F)F)ccc2F)nn1)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H21F8N9O3/c26-16(11-42-12-20(37-39-42)23(44)35-10-17-9-15(3-5-34-17)24(28,29)30)4-6-41-13-21(38-40-41)36-22(43)8-14-7-18(1-2-19(14)27)45-25(31,32)33/h1-3,5,7,9,12-13,16H,4,6,8,10-11H2,(H,35,44)(H,36,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405075 (1-(2-fluoro-4-{4-[2-(pyridin-2- yl)acetamido]-1H-1...) Show SMILES FC(CCn1cc(NC(=O)Cc2ccccn2)nn1)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C24H22F5N9O3/c25-16(6-8-37-14-21(34-36-37)32-22(39)10-17-3-1-2-7-30-17)12-38-13-20(33-35-38)23(40)31-11-15-9-18(4-5-19(15)26)41-24(27,28)29/h1-5,7,9,13-14,16H,6,8,10-12H2,(H,31,40)(H,32,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405076 (5-[3-fluoro-4-(4-{[(6-methylpyridin- 3-yl)methyl]c...) Show SMILES Cc1ccc(CNC(=O)c2cn(CC(F)CCc3nnc(s3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1 Show InChI InChI=1S/C25H24F4N8O3S/c1-15-5-6-17(11-30-15)12-31-22(38)20-14-37(36-33-20)13-18(26)7-8-21-34-35-24(41-21)23(39)32-10-16-3-2-4-19(9-16)40-25(27,28)29/h2-6,9,11,14,18H,7-8,10,12-13H2,1H3,(H,31,38)(H,32,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405077 (1-{2-fluoro-4-[4-({[6- (trifluoromethyl)pyridin-3-...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ccc(nc1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C25H21F8N9O3/c26-16(5-6-41-12-19(37-39-41)22(43)35-9-14-1-4-21(34-8-14)24(28,29)30)11-42-13-20(38-40-42)23(44)36-10-15-7-17(2-3-18(15)27)45-25(31,32)33/h1-4,7-8,12-13,16H,5-6,9-11H2,(H,35,43)(H,36,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405078 (1-{2-fluoro-4-[4-({[6- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C25H21F8N9O3/c26-15(6-7-41-12-19(37-39-41)23(44)35-10-16-2-1-3-21(36-16)24(28,29)30)11-42-13-20(38-40-42)22(43)34-9-14-8-17(4-5-18(14)27)45-25(31,32)33/h1-5,8,12-13,15H,6-7,9-11H2,(H,34,43)(H,35,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405079 (1-{2-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F)Cn1cc(nn1)C(=O)NCc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C25H21F8N9O3/c26-16(11-42-13-21(38-40-42)23(44)36-10-17-2-1-15(9-34-17)24(28,29)30)5-6-41-12-20(37-39-41)22(43)35-8-14-7-18(3-4-19(14)27)45-25(31,32)33/h1-4,7,9,12-13,16H,5-6,8,10-11H2,(H,35,43)(H,36,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405080 (1-{2-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F)Cn1cc(nn1)C(=O)NCc1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C25H21F8N9O3/c26-16(11-42-13-20(38-40-42)22(43)35-9-14-1-4-21(34-8-14)24(28,29)30)5-6-41-12-19(37-39-41)23(44)36-10-15-7-17(2-3-18(15)27)45-25(31,32)33/h1-4,7-8,12-13,16H,5-6,9-11H2,(H,35,43)(H,36,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405081 (1-{2-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F)Cn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F Show InChI InChI=1S/C25H21F8N9O3/c26-15(11-42-13-20(38-40-42)23(44)35-10-16-2-1-3-21(36-16)24(28,29)30)6-7-41-12-19(37-39-41)22(43)34-9-14-8-17(4-5-18(14)27)45-25(31,32)33/h1-5,8,12-13,15H,6-7,9-11H2,(H,34,43)(H,35,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405082 (1-{2-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H21F8N9O3/c26-16(11-42-13-21(38-40-42)23(44)36-10-17-8-15(3-5-34-17)24(28,29)30)4-6-41-12-20(37-39-41)22(43)35-9-14-7-18(1-2-19(14)27)45-25(31,32)33/h1-3,5,7-8,12-13,16H,4,6,9-11H2,(H,35,43)(H,36,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405083 (1-{2-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F)Cn1cc(nn1)C(=O)NCc1ncccc1F Show InChI InChI=1S/C24H21F6N9O3/c25-15(11-39-13-21(35-37-39)23(41)33-10-19-18(27)2-1-6-31-19)5-7-38-12-20(34-36-38)22(40)32-9-14-8-16(3-4-17(14)26)42-24(28,29)30/h1-4,6,8,12-13,15H,5,7,9-11H2,(H,32,40)(H,33,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405084 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H22F7N9O3/c26-17(12-41-14-21(37-39-41)23(43)35-11-18-9-16(4-6-33-18)24(27,28)29)5-7-40-13-20(36-38-40)22(42)34-10-15-2-1-3-19(8-15)44-25(30,31)32/h1-4,6,8-9,13-14,17H,5,7,10-12H2,(H,34,42)(H,35,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405085 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1)Cn1cc(nn1)C(=O)NCc1ncccc1F Show InChI InChI=1S/C24H22F5N9O3/c25-16(12-38-14-21(34-36-38)23(40)32-11-19-18(26)5-2-7-30-19)6-8-37-13-20(33-35-37)22(39)31-10-15-3-1-4-17(9-15)41-24(27,28)29/h1-5,7,9,13-14,16H,6,8,10-12H2,(H,31,39)(H,32,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405086 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES Cc1ccc(CNC(=O)c2cn(CC(F)CCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1 Show InChI InChI=1S/C25H25F4N9O3/c1-16-5-6-18(11-30-16)12-32-24(40)22-15-38(36-34-22)13-19(26)7-8-37-14-21(33-35-37)23(39)31-10-17-3-2-4-20(9-17)41-25(27,28)29/h2-6,9,11,14-15,19H,7-8,10,12-13H2,1H3,(H,31,39)(H,32,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405087 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1)Cn1cc(nn1)C(=O)NCc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C25H22F7N9O3/c26-17(12-41-14-21(37-39-41)23(43)35-11-18-5-4-16(10-33-18)24(27,28)29)6-7-40-13-20(36-38-40)22(42)34-9-15-2-1-3-19(8-15)44-25(30,31)32/h1-5,8,10,13-14,17H,6-7,9,11-12H2,(H,34,42)(H,35,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405088 (1-{2-fluoro-4-[4-({[4- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C25H21F8N9O3/c26-16(4-6-41-12-20(37-39-41)23(44)36-10-17-8-15(3-5-34-17)24(28,29)30)11-42-13-21(38-40-42)22(43)35-9-14-7-18(1-2-19(14)27)45-25(31,32)33/h1-3,5,7-8,12-13,16H,4,6,9-11H2,(H,35,43)(H,36,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405089 (1-{2-fluoro-4-[4-({[5- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ccc(cn1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H22F7N9O3/c26-17(6-7-40-13-20(36-38-40)23(43)35-11-18-5-4-16(10-33-18)24(27,28)29)12-41-14-21(37-39-41)22(42)34-9-15-2-1-3-19(8-15)44-25(30,31)32/h1-5,8,10,13-14,17H,6-7,9,11-12H2,(H,34,42)(H,35,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405090 (1-[2-fluoro-4-(4-{[(6-methylpyridin- 3-yl)methyl]c...) Show SMILES Cc1ccc(CNC(=O)c2cn(CCC(F)Cn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1 Show InChI InChI=1S/C25H25F4N9O3/c1-16-5-6-18(11-30-16)12-32-23(39)21-14-37(35-33-21)8-7-19(26)13-38-15-22(34-36-38)24(40)31-10-17-3-2-4-20(9-17)41-25(27,28)29/h2-6,9,11,14-15,19H,7-8,10,12-13H2,1H3,(H,31,40)(H,32,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405091 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1)Cn1cc(nn1)C(=O)NCc1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C25H22F7N9O3/c26-17(12-41-14-20(37-39-41)23(43)35-11-16-4-5-21(33-10-16)24(27,28)29)6-7-40-13-19(36-38-40)22(42)34-9-15-2-1-3-18(8-15)44-25(30,31)32/h1-5,8,10,13-14,17H,6-7,9,11-12H2,(H,34,42)(H,35,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405092 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1)Cn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F Show InChI InChI=1S/C25H22F7N9O3/c26-16(12-41-14-20(37-39-41)23(43)34-11-17-4-2-6-21(35-17)24(27,28)29)7-8-40-13-19(36-38-40)22(42)33-10-15-3-1-5-18(9-15)44-25(30,31)32/h1-6,9,13-14,16H,7-8,10-12H2,(H,33,42)(H,34,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405093 (1-{3-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ccc(nc1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H22F7N9O3/c26-17(6-7-40-13-19(36-38-40)22(42)35-11-16-4-5-21(33-10-16)24(27,28)29)12-41-14-20(37-39-41)23(43)34-9-15-2-1-3-18(8-15)44-25(30,31)32/h1-5,8,10,13-14,17H,6-7,9,11-12H2,(H,34,43)(H,35,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405094 (1-{3-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H22F7N9O3/c26-16(7-8-40-13-19(36-38-40)23(43)34-11-17-4-2-6-21(35-17)24(27,28)29)12-41-14-20(37-39-41)22(42)33-10-15-3-1-5-18(9-15)44-25(30,31)32/h1-6,9,13-14,16H,7-8,10-12H2,(H,33,42)(H,34,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405095 (1-{3-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C25H22F7N9O3/c26-17(5-7-40-13-20(36-38-40)23(43)35-11-18-9-16(4-6-33-18)24(27,28)29)12-41-14-21(37-39-41)22(42)34-10-15-2-1-3-19(8-15)44-25(30,31)32/h1-4,6,8-9,13-14,17H,5,7,10-12H2,(H,34,42)(H,35,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405096 (1-{3-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ncccc1F)Cn1cc(nn1)C(=O)NCc1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H22F5N9O3/c25-16(6-8-37-13-20(33-35-37)23(40)32-11-19-18(26)5-2-7-30-19)12-38-14-21(34-36-38)22(39)31-10-15-3-1-4-17(9-15)41-24(27,28)29/h1-5,7,9,13-14,16H,6,8,10-12H2,(H,31,39)(H,32,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405097 (1-{2-fluoro-4-[4-({[5- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ccc(cn1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C25H21F8N9O3/c26-16(5-6-41-12-20(37-39-41)23(44)36-10-17-2-1-15(9-34-17)24(28,29)30)11-42-13-21(38-40-42)22(43)35-8-14-7-18(3-4-19(14)27)45-25(31,32)33/h1-4,7,9,12-13,16H,5-6,8,10-11H2,(H,35,43)(H,36,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405098 (5-{3-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES Cc1ccc(CNC(=O)c2nnc(CCC(F)Cn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)s2)cn1 Show InChI InChI=1S/C25H24F4N8O3S/c1-15-5-6-17(11-30-15)12-32-23(39)24-35-34-21(41-24)8-7-18(26)13-37-14-20(33-36-37)22(38)31-10-16-3-2-4-19(9-16)40-25(27,28)29/h2-6,9,11,14,18H,7-8,10,12-13H2,1H3,(H,31,38)(H,32,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405099 (5-{3-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES Cc1ccc(CNC(=O)c2nnc(CCC(F)Cn3cc(nn3)C(=O)NCc3cc(OC(F)(F)F)ccc3F)s2)cn1 Show InChI InChI=1S/C25H23F5N8O3S/c1-14-2-3-15(9-31-14)10-32-23(40)24-36-35-21(42-24)7-4-17(26)12-38-13-20(34-37-38)22(39)33-11-16-8-18(5-6-19(16)27)41-25(28,29)30/h2-3,5-6,8-9,13,17H,4,7,10-12H2,1H3,(H,32,40)(H,33,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405100 (1-{3-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ncccc1F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C24H21F6N9O3/c25-15(5-7-38-12-20(34-36-38)23(41)33-10-19-18(27)2-1-6-31-19)11-39-13-21(35-37-39)22(40)32-9-14-8-16(3-4-17(14)26)42-24(28,29)30/h1-4,6,8,12-13,15H,5,7,9-11H2,(H,32,40)(H,33,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405101 (5-{3-fluoro-4-[4-({[5- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCc1nnc(s1)C(=O)NCc1cccc(OC(F)(F)F)c1)Cn1cc(nn1)C(=O)NCc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C25H21F7N8O3S/c26-16(12-40-13-19(36-39-40)21(41)35-11-17-6-4-15(10-33-17)24(27,28)29)5-7-20-37-38-23(44-20)22(42)34-9-14-2-1-3-18(8-14)43-25(30,31)32/h1-4,6,8,10,13,16H,5,7,9,11-12H2,(H,34,42)(H,35,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405102 (5-{3-fluoro-4-[4-({[4- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCc1nnc(s1)C(=O)NCc1cccc(OC(F)(F)F)c1)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H21F7N8O3S/c26-16(12-40-13-19(36-39-40)21(41)35-11-17-9-15(6-7-33-17)24(27,28)29)4-5-20-37-38-23(44-20)22(42)34-10-14-2-1-3-18(8-14)43-25(30,31)32/h1-3,6-9,13,16H,4-5,10-12H2,(H,34,42)(H,35,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405103 (5-[3-fluoro-4-(4-{[(6-methylpyridin- 3-yl)methyl]c...) Show SMILES Cc1ccc(CNC(=O)c2cn(CC(F)CCc3nnc(s3)C(=O)NCc3cc(OC(F)(F)F)ccc3F)nn2)cn1 Show InChI InChI=1S/C25H23F5N8O3S/c1-14-2-3-15(9-31-14)10-32-22(39)20-13-38(37-34-20)12-17(26)4-7-21-35-36-24(42-21)23(40)33-11-16-8-18(5-6-19(16)27)41-25(28,29)30/h2-3,5-6,8-9,13,17H,4,7,10-12H2,1H3,(H,32,39)(H,33,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405104 (5-{3-fluoro-4-[4-({[5- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCc1nnc(s1)C(=O)NCc1cc(OC(F)(F)F)ccc1F)Cn1cc(nn1)C(=O)NCc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C25H20F8N8O3S/c26-15(11-41-12-19(37-40-41)21(42)36-10-16-3-1-14(9-34-16)24(28,29)30)2-6-20-38-39-23(45-20)22(43)35-8-13-7-17(4-5-18(13)27)44-25(31,32)33/h1,3-5,7,9,12,15H,2,6,8,10-11H2,(H,35,43)(H,36,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405105 (5-{3-fluoro-4-[4-({[4- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCc1nnc(s1)C(=O)NCc1cc(OC(F)(F)F)ccc1F)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H20F8N8O3S/c26-15(11-41-12-19(37-40-41)21(42)36-10-16-8-14(5-6-34-16)24(28,29)30)1-4-20-38-39-23(45-20)22(43)35-9-13-7-17(2-3-18(13)27)44-25(31,32)33/h2-3,5-8,12,15H,1,4,9-11H2,(H,35,43)(H,36,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405106 (N-benzyl-1-{2-fluoro-4-[4-({[4- (trifluoromethyl)p...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1ccccc1 Show InChI InChI=1S/C24H23F4N9O2/c25-18(13-37-15-21(33-35-37)22(38)30-11-16-4-2-1-3-5-16)7-9-36-14-20(32-34-36)23(39)31-12-19-10-17(6-8-29-19)24(26,27)28/h1-6,8,10,14-15,18H,7,9,11-13H2,(H,30,38)(H,31,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405107 (5-{3-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES FC(CCc1nnc(s1)C(=O)NCc1cc(ccn1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C25H20F8N8O3S/c26-15(1-4-20-38-39-23(45-20)22(43)36-10-16-8-14(5-6-34-16)24(28,29)30)11-41-12-19(37-40-41)21(42)35-9-13-7-17(2-3-18(13)27)44-25(31,32)33/h2-3,5-8,12,15H,1,4,9-11H2,(H,35,42)(H,36,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405108 (1-{2-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES OC[C@@H](NC(=O)c1cn(CC(F)CCn2cc(nn2)C(=O)NCc2cc(OC(F)(F)F)ccc2F)nn1)c1ccccc1 |r| Show InChI InChI=1S/C26H25F5N8O4/c27-18(12-39-14-22(35-37-39)25(42)33-23(15-40)16-4-2-1-3-5-16)8-9-38-13-21(34-36-38)24(41)32-11-17-10-19(6-7-20(17)28)43-26(29,30)31/h1-7,10,13-14,18,23,40H,8-9,11-12,15H2,(H,32,41)(H,33,42)/t18?,23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405109 (1-{2-fluoro-4-[4-({[2-fluoro-5- (trifluoromethoxy)...) Show SMILES OC[C@H](NC(=O)c1cn(CC(F)CCn2cc(nn2)C(=O)NCc2cc(OC(F)(F)F)ccc2F)nn1)c1ccccc1 |r| Show InChI InChI=1S/C26H25F5N8O4/c27-18(12-39-14-22(35-37-39)25(42)33-23(15-40)16-4-2-1-3-5-16)8-9-38-13-21(34-36-38)24(41)32-11-17-10-19(6-7-20(17)28)43-26(29,30)31/h1-7,10,13-14,18,23,40H,8-9,11-12,15H2,(H,32,41)(H,33,42)/t18?,23-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405110 (1-[2-fluoro-4-(4-{[(2- fluorophenyl)methyl]carbamo...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1ccccc1F)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C24H22F5N9O2/c25-17(6-8-37-13-20(33-35-37)22(39)31-10-15-3-1-2-4-19(15)26)12-38-14-21(34-36-38)23(40)32-11-18-9-16(5-7-30-18)24(27,28)29/h1-5,7,9,13-14,17H,6,8,10-12H2,(H,31,39)(H,32,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405111 (1-{2-fluoro-4-[4-({[3- (trifluoromethyl)phenyl]met...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(c1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C25H22F7N9O2/c26-18(12-41-14-21(37-39-41)23(43)35-11-19-9-17(4-6-33-19)25(30,31)32)5-7-40-13-20(36-38-40)22(42)34-10-15-2-1-3-16(8-15)24(27,28)29/h1-4,6,8-9,13-14,18H,5,7,10-12H2,(H,34,42)(H,35,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair

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