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Compile Data Set for Download or QSAR

Found 172 hits Enz. Inhib. hit(s) with all data for entry = 7135   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177650
PNG
(US9120769, 152 | US9663470, 152)
Show SMILES Cc1cc(cc2nc[nH]c12)C(=O)N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N |r|
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n/an/a 24n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177639
PNG
(US9120769, 107 | US9663470, 107)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1 |r|
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n/an/a 26n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177638
PNG
(US9120769, 106 | US9663470, 106)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1 |r|
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n/an/a 31n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177651
PNG
(US9120769, 153 | US9663470, 153)
Show SMILES Cc1cc2[nH]cnc2cc1C(=O)N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N |r|
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n/an/a 48n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177645
PNG
(US9120769, 146 | US9663470, 146)
Show SMILES C[C@H]1CCN([C@H]2Cc3ccccc3[C@@H]12)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 55n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177578
PNG
(US9120769, 1 | US9120769, 2 | US9663470, 1)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2c1 |r|
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n/an/a 65n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177672
PNG
(US9120769, 174 | US9663470, 174)
Show SMILES Cc1cc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2cc1C#N |r|
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n/an/a 67n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177661
PNG
(US9120769, 163 | US9663470, 163)
Show SMILES Cc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1 |r|
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n/an/a 67n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177653
PNG
(US9120769, 155 | US9663470, 155)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#C)c1ccc2[nH]cnc2c1 |r|
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n/an/a 83n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177630
PNG
(US9120769, 94)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccccc21)c1ccc2[nH]cnc2c1 |r|
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n/an/a 90n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177587
PNG
(US9120769, 11 | US9663470, 11)
Show SMILES C[C@]12CCCN([C@@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 94n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177578
PNG
(US9120769, 1 | US9120769, 2 | US9663470, 1)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2c1 |r|
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n/an/a 106n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177629
PNG
(US9120769, 93 | US9663470, 94)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]cnc2c1 |r|
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n/an/a 121n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177598
PNG
(US9120769, 22 | US9663470, 22)
Show SMILES COc1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 123n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177647
PNG
(US9120769, 149 | US9663470, 149)
Show SMILES COc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1 |r|
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n/an/a 141n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177640
PNG
(US9120769, 108 | US9663470, 108)
Show SMILES O=C(N1CCC[C@@H]2[C@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1 |r|
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n/an/a 150n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177610
PNG
(US9120769, 37 | US9663470, 37)
Show SMILES NC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 150n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177664
PNG
(US9120769, 166 | US9663470, 166)
Show SMILES CC(=O)Nc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 182n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99403
PNG
(US8497281, 181 | US9120769, 114 | US9663470, 114)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2cc[nH]c2c1 |r|
Show InChI InChI=1S/C21H20N2O/c24-21(16-8-7-14-9-10-22-19(14)12-16)23-11-3-6-18-17-5-2-1-4-15(17)13-20(18)23/h1-2,4-5,7-10,12,18,20,22H,3,6,11,13H2/t18?,20-/m0/s1
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n/an/a 185n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177649
PNG
(US9120769, 151 | US9663470, 151)
Show SMILES Nc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 188n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177659
PNG
(US9120769, 161 | US9663470, 161)
Show SMILES CC#Cc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1 |r|
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n/an/a 212n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99354
PNG
(US8497281, 132 | US9120769, 65 | US9663470, 65)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ncc2c1 |r|
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-19-16(12-15)13-22-23-19)24-11-3-6-18-17-5-2-1-4-14(17)8-10-20(18)24/h1-2,4-5,7,9,12-13,18,20H,3,6,8,10-11H2,(H,22,23)/t18?,20-/m0/s1
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n/an/a 212n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177646
PNG
(US9120769, 148 | US9663470, 148)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1cc(ccc21)C#N)c1ccc2[nH]cnc2c1 |r|
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n/an/a 214n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177669
PNG
(US9120769, 171 | US9663470, 171)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1cc3ncoc3cc21)c1ccc2[nH]cnc2c1 |r|
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n/an/a 218n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177596
PNG
(US9120769, 20 | US9663470, 20)
Show SMILES Fc1cc(F)c2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1 |r|
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n/an/a 227n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99411
PNG
(US8497281, 189 | US9120769, 122 | US9663470, 122)
Show SMILES Nc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r|
Show InChI InChI=1S/C19H19ClN2O/c20-16-10-13(7-8-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1
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n/an/a 230n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177627
PNG
(US9120769, 91 | US9663470, 91)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1 |r|
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n/an/a 244n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177668
PNG
(US9120769, 170 | US9663470, 170)
Show SMILES Cc1nc2cc3C[C@H]4[C@H](CCCN4C(=O)c4ccc5[nH]cnc5c4)c3cc2o1 |r|
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n/an/a 248n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177589
PNG
(US9120769, 13 | US9663470, 13)
Show SMILES Oc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12 |r|
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n/an/a 257n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99367
PNG
(US8497281, 145 | US9120769, 78 | US9663470, 78)
Show SMILES COc1cc(ccc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21 |r|
Show InChI InChI=1S/C21H24N2O2/c1-25-20-13-15(8-10-18(20)22)21(24)23-12-4-7-17-16-6-3-2-5-14(16)9-11-19(17)23/h2-3,5-6,8,10,13,17,19H,4,7,9,11-12,22H2,1H3/t17?,19-/m0/s1
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n/an/a 257n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177637
PNG
(US9120769, 105 | US9663470, 105)
Show SMILES CC[C@]12CCCN([C@@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 263n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177582
PNG
(US9120769, 6 | US9663470, 6)
Show SMILES COc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 296n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177603
PNG
(US9120769, 27)
Show SMILES Fc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12 |r|
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n/an/a 297n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177609
PNG
(US9120769, 36 | US9663470, 36)
Show SMILES CNC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 310n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177666
PNG
(US9120769, 168 | US9663470, 168)
Show SMILES Oc1cc2[C@H]3CCCN([C@H]3Cc2cc1[N+]([O-])=O)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 313n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99421
PNG
(US8497281, 199 | US9120769, 132 | US9663470, 132)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]ncc2c1 |r|
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-18-15(10-14)12-21-22-18)23-9-3-6-17-16-5-2-1-4-13(16)11-19(17)23/h1-2,4-5,7-8,10,12,17,19H,3,6,9,11H2,(H,21,22)/t17?,19-/m0/s1
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n/an/a 320n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177586
PNG
(US9120769, 10 | US9663470, 10)
Show SMILES C[C@]12CCCN([C@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 321n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99364
PNG
(US8497281, 142 | US9120769, 75 | US9663470, 75)
Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21 |r|
Show InChI InChI=1S/C20H20ClNO2/c21-17-12-14(8-10-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)7-9-18(16)22/h1-2,4-5,8,10,12,16,18,23H,3,6-7,9,11H2/t16?,18-/m0/s1
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n/an/a 324n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99430
PNG
(US8497281, 208 | US9120769, 141 | US9663470, 141)
Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r|
Show InChI InChI=1S/C19H18ClNO2/c20-16-10-13(7-8-18(16)22)19(23)21-9-3-6-15-14-5-2-1-4-12(14)11-17(15)21/h1-2,4-5,7-8,10,15,17,22H,3,6,9,11H2/t15?,17-/m0/s1
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n/an/a 326n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177584
PNG
(US9120769, 8 | US9663470, 8)
Show SMILES COc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12 |r|
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n/an/a 342n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99359
PNG
(US8497281, 137 | US9120769, 70 | US9663470, 70)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C22H22N2O/c25-22(19-14-23-20-10-4-3-8-17(19)20)24-13-5-9-18-16-7-2-1-6-15(16)11-12-21(18)24/h1-4,6-8,10,14,18,21,23H,5,9,11-13H2/t18?,21-/m0/s1
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n/an/a 350n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177660
PNG
(US9120769, 162 | US9663470, 162)
Show SMILES Cn1cc(cn1)-c1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1 |r|
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n/an/a 354n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99345
PNG
(US8497281, 123 | US9120769, 56 | US9663470, 56)
Show SMILES Nc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21 |r|
Show InChI InChI=1S/C20H21ClN2O/c21-17-12-14(7-9-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 356n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177641
PNG
(US9120769, 119 | US9663470, 119)
Show SMILES Oc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 365n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177658
PNG
(US9120769, 160 | US9663470, 160)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)-c1ccoc1)c1ccc2[nH]cnc2c1 |r|
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n/an/a 367n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177588
PNG
(US9120769, 12 | US9663470, 12)
Show SMILES COc1cccc2C3CCCN([C@@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1 |r|
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n/an/a 367n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99358
PNG
(US8497281, 136 | US9120769, 69 | US9663470, 69)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ccc2c1 |r|
Show InChI InChI=1S/C22H22N2O/c25-22(17-7-9-20-16(14-17)11-12-23-20)24-13-3-6-19-18-5-2-1-4-15(18)8-10-21(19)24/h1-2,4-5,7,9,11-12,14,19,21,23H,3,6,8,10,13H2/t19?,21-/m0/s1
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n/an/a 371n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99409
PNG
(US8497281, 187 | US9120769, 120 | US9663470, 120)
Show SMILES Cc1cc(ccc1O)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r|
Show InChI InChI=1S/C20H21NO2/c1-13-11-15(8-9-19(13)22)20(23)21-10-4-7-17-16-6-3-2-5-14(16)12-18(17)21/h2-3,5-6,8-9,11,17-18,22H,4,7,10,12H2,1H3/t17?,18-/m0/s1
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n/an/a 383n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM99423
PNG
(US8497281, 201 | US9120769, 134 | US9663470, 134)
Show SMILES Oc1ccc(cc1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r|
Show InChI InChI=1S/C19H19NO2/c21-15-9-7-13(8-10-15)19(22)20-11-3-6-17-16-5-2-1-4-14(16)12-18(17)20/h1-2,4-5,7-10,17-18,21H,3,6,11-12H2/t17?,18-/m0/s1
PDB
MMDB

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US Patent
n/an/a 389n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM177590
PNG
(US9120769, 14 | US9663470, 14)
Show SMILES COc1ccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 405n/an/an/an/a6.0n/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
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