Compile Data Set for Download or QSAR

Found 30 hits Enz. Inhib. hit(s) with all data for entry = 7760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214710 (US9296747, Example 5) Show SMILES COc1ccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)cc1 Show InChI InChI=1S/C20H19N5O2/c1-27-17-6-4-16(5-7-17)23-20-22-12-15-13-25(10-8-18(15)24-20)19(26)14-3-2-9-21-11-14/h2-7,9,11-12H,8,10,13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214717 (US9296747, Example 12) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2cc(C)nn2C)cc(OC)c1OC Show InChI InChI=1S/C22H26N6O4/c1-13-8-17(27(2)26-13)21(29)28-7-6-16-14(12-28)11-23-22(25-16)24-15-9-18(30-3)20(32-5)19(10-15)31-4/h8-11H,6-7,12H2,1-5H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214716 (US9296747, Example 11) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2occc2C)cc(OC)c1OC Show InChI InChI=1S/C22H24N4O5/c1-13-6-8-31-19(13)21(27)26-7-5-16-14(12-26)11-23-22(25-16)24-15-9-17(28-2)20(30-4)18(10-15)29-3/h6,8-11H,5,7,12H2,1-4H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214718 (US9296747, Example 13) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2cccs2)cc(OC)c1OC Show InChI InChI=1S/C21H22N4O4S/c1-27-16-9-14(10-17(28-2)19(16)29-3)23-21-22-11-13-12-25(7-6-15(13)24-21)20(26)18-5-4-8-30-18/h4-5,8-11H,6-7,12H2,1-3H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214712 (US9296747, Example 7) Show SMILES COc1ccccc1Nc1ncc2CN(CCc2n1)C(=O)c1cccnc1 Show InChI InChI=1S/C20H19N5O2/c1-27-18-7-3-2-6-17(18)24-20-22-12-15-13-25(10-8-16(15)23-20)19(26)14-5-4-9-21-11-14/h2-7,9,11-12H,8,10,13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214714 (US9296747, Example 9) Show SMILES O=C(N1CCc2nc(Nc3ccsc3)ncc2C1)c1cccnc1 Show InChI InChI=1S/C17H15N5OS/c23-16(12-2-1-5-18-8-12)22-6-3-15-13(10-22)9-19-17(21-15)20-14-4-7-24-11-14/h1-2,4-5,7-9,11H,3,6,10H2,(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214713 (US9296747, Example 8) Show SMILES Cn1nccc1Nc1ncc2CN(CCc2n1)C(=O)c1cccnc1 Show InChI InChI=1S/C17H17N7O/c1-23-15(4-7-20-23)22-17-19-10-13-11-24(8-5-14(13)21-17)16(25)12-3-2-6-18-9-12/h2-4,6-7,9-10H,5,8,11H2,1H3,(H,19,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214710 (US9296747, Example 5) Show SMILES COc1ccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)cc1 Show InChI InChI=1S/C20H19N5O2/c1-27-17-6-4-16(5-7-17)23-20-22-12-15-13-25(10-8-18(15)24-20)19(26)14-3-2-9-21-11-14/h2-7,9,11-12H,8,10,13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRbeta kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug of poly-Glu-Tyr (4:1) in 10 mM ...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214717 (US9296747, Example 12) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2cc(C)nn2C)cc(OC)c1OC Show InChI InChI=1S/C22H26N6O4/c1-13-8-17(27(2)26-13)21(29)28-7-6-16-14(12-28)11-23-22(25-16)24-15-9-18(30-3)20(32-5)19(10-15)31-4/h8-11H,6-7,12H2,1-5H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRbeta kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug of poly-Glu-Tyr (4:1) in 10 mM ...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214707 (US9296747, Example 2) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)cc(OC)c1OC Show InChI InChI=1S/C22H23N5O4/c1-29-18-9-16(10-19(30-2)20(18)31-3)25-22-24-12-15-13-27(8-6-17(15)26-22)21(28)14-5-4-7-23-11-14/h4-5,7,9-12H,6,8,13H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	89	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214721 (US9296747, Example 17) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)cc(OC)c1 Show InChI InChI=1S/C21H21N5O3/c1-28-17-8-16(9-18(10-17)29-2)24-21-23-12-15-13-26(7-5-19(15)25-21)20(27)14-4-3-6-22-11-14/h3-4,6,8-12H,5,7,13H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214713 (US9296747, Example 8) Show SMILES Cn1nccc1Nc1ncc2CN(CCc2n1)C(=O)c1cccnc1 Show InChI InChI=1S/C17H17N7O/c1-23-15(4-7-20-23)22-17-19-10-13-11-24(8-5-14(13)21-17)16(25)12-3-2-6-18-9-12/h2-4,6-7,9-10H,5,8,11H2,1H3,(H,19,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRbeta kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug of poly-Glu-Tyr (4:1) in 10 mM ...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214720 (US9296747, Example 16) Show SMILES COc1ccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)cc1OC Show InChI InChI=1S/C21H21N5O3/c1-28-18-6-5-16(10-19(18)29-2)24-21-23-12-15-13-26(9-7-17(15)25-21)20(27)14-4-3-8-22-11-14/h3-6,8,10-12H,7,9,13H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214716 (US9296747, Example 11) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2occc2C)cc(OC)c1OC Show InChI InChI=1S/C22H24N4O5/c1-13-6-8-31-19(13)21(27)26-7-5-16-14(12-26)11-23-22(25-16)24-15-9-17(28-2)20(30-4)18(10-15)29-3/h6,8-11H,5,7,12H2,1-4H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	239	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRbeta kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug of poly-Glu-Tyr (4:1) in 10 mM ...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214712 (US9296747, Example 7) Show SMILES COc1ccccc1Nc1ncc2CN(CCc2n1)C(=O)c1cccnc1 Show InChI InChI=1S/C20H19N5O2/c1-27-18-7-3-2-6-17(18)24-20-22-12-15-13-25(10-8-16(15)23-20)19(26)14-5-4-9-21-11-14/h2-7,9,11-12H,8,10,13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRbeta kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug of poly-Glu-Tyr (4:1) in 10 mM ...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214715 (US9296747, Example 10) Show SMILES Fc1cccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)c1 Show InChI InChI=1S/C19H16FN5O/c20-15-4-1-5-16(9-15)23-19-22-11-14-12-25(8-6-17(14)24-19)18(26)13-3-2-7-21-10-13/h1-5,7,9-11H,6,8,12H2,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	274	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214708 (US9296747, Example 3) Show SMILES O=C(Nc1cccnc1)N1CCc2nc(Nc3ccccc3)ncc2C1 Show InChI InChI=1S/C19H18N6O/c26-19(23-16-7-4-9-20-12-16)25-10-8-17-14(13-25)11-21-18(24-17)22-15-5-2-1-3-6-15/h1-7,9,11-12H,8,10,13H2,(H,23,26)(H,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	282	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214711 (US9296747, Example 6) Show SMILES COc1cccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)c1 Show InChI InChI=1S/C20H19N5O2/c1-27-17-6-2-5-16(10-17)23-20-22-12-15-13-25(9-7-18(15)24-20)19(26)14-4-3-8-21-11-14/h2-6,8,10-12H,7,9,13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	443	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214722 (US9296747, Example 18) Show SMILES COC(=O)N1CCc2nc(Nc3cc(OC)c(OC)c(OC)c3)ncc2C1 Show InChI InChI=1S/C18H22N4O5/c1-24-14-7-12(8-15(25-2)16(14)26-3)20-17-19-9-11-10-22(18(23)27-4)6-5-13(11)21-17/h7-9H,5-6,10H2,1-4H3,(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	749	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214706 (US9296747, Example 1) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2ccccc2)cc(OC)c1OC Show InChI InChI=1S/C23H24N4O4/c1-29-19-11-17(12-20(30-2)21(19)31-3)25-23-24-13-16-14-27(10-9-18(16)26-23)22(28)15-7-5-4-6-8-15/h4-8,11-13H,9-10,14H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	810	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214719 (US9296747, Example 15) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2ccccn2)cc(OC)c1OC Show InChI InChI=1S/C22H23N5O4/c1-29-18-10-15(11-19(30-2)20(18)31-3)25-22-24-12-14-13-27(9-7-16(14)26-22)21(28)17-6-4-5-8-23-17/h4-6,8,10-12H,7,9,13H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.85E+3	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214709 (US9296747, Example 4) Show SMILES O=C(N1CCc2nc(Nc3ccccc3)ncc2C1)c1cccnc1 Show InChI InChI=1S/C19H17N5O/c25-18(14-5-4-9-20-11-14)24-10-8-17-15(13-24)12-21-19(23-17)22-16-6-2-1-3-7-16/h1-7,9,11-12H,8,10,13H2,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.93E+3	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214719 (US9296747, Example 15) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2ccccn2)cc(OC)c1OC Show InChI InChI=1S/C22H23N5O4/c1-29-18-10-15(11-19(30-2)20(18)31-3)25-22-24-12-14-13-27(9-7-16(14)26-22)21(28)17-6-4-5-8-23-17/h4-6,8,10-12H,7,9,13H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214706 (US9296747, Example 1) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2ccccc2)cc(OC)c1OC Show InChI InChI=1S/C23H24N4O4/c1-29-19-11-17(12-20(30-2)21(19)31-3)25-23-24-13-16-14-27(10-9-18(16)26-23)22(28)15-7-5-4-6-8-15/h4-8,11-13H,9-10,14H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.76E+3	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214708 (US9296747, Example 3) Show SMILES O=C(Nc1cccnc1)N1CCc2nc(Nc3ccccc3)ncc2C1 Show InChI InChI=1S/C19H18N6O/c26-19(23-16-7-4-9-20-12-16)25-10-8-17-14(13-25)11-21-18(24-17)22-15-5-2-1-3-6-15/h1-7,9,11-12H,8,10,13H2,(H,23,26)(H,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214715 (US9296747, Example 10) Show SMILES Fc1cccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)c1 Show InChI InChI=1S/C19H16FN5O/c20-15-4-1-5-16(9-15)23-19-22-11-14-12-25(8-6-17(14)24-19)18(26)13-3-2-7-21-10-13/h1-5,7,9-11H,6,8,12H2,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRbeta kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug of poly-Glu-Tyr (4:1) in 10 mM ...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214711 (US9296747, Example 6) Show SMILES COc1cccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)c1 Show InChI InChI=1S/C20H19N5O2/c1-27-17-6-2-5-16(10-17)23-20-22-12-15-13-25(9-7-18(15)24-20)19(26)14-4-3-8-21-11-14/h2-6,8,10-12H,7,9,13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM214710 (US9296747, Example 5) Show SMILES COc1ccc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)cc1 Show InChI InChI=1S/C20H19N5O2/c1-27-17-6-4-16(5-7-17)23-20-22-12-15-13-25(10-8-18(15)24-20)19(26)14-3-2-9-21-11-14/h2-7,9,11-12H,8,10,13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	7.2	25
Allergan, Inc. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214709 (US9296747, Example 4) Show SMILES O=C(N1CCc2nc(Nc3ccccc3)ncc2C1)c1cccnc1 Show InChI InChI=1S/C19H17N5O/c25-18(14-5-4-9-20-11-14)24-10-8-17-15(13-24)12-21-19(23-17)22-16-6-2-1-3-7-16/h1-7,9,11-12H,8,10,13H2,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM214707 (US9296747, Example 2) Show SMILES COc1cc(Nc2ncc3CN(CCc3n2)C(=O)c2cccnc2)cc(OC)c1OC Show InChI InChI=1S/C22H23N5O4/c1-29-18-9-16(10-19(30-2)20(18)31-3)25-22-24-12-15-13-27(8-6-17(15)26-22)21(28)14-5-4-7-23-11-14/h4-5,7,9-12H,6,8,13H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9296747 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VGX
					More data for this Ligand-Target Pair