Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM435718![]() (US10570155, Compound 2II | US11332479, Compound 2I...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM435718![]() (US10570155, Compound 2II | US11332479, Compound 2I...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM435718![]() (US10570155, Compound 2II | US11332479, Compound 2I...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM435722![]() (US10570155, Compound 31III) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM435721![]() (US10570155, Compound 25III | US11332479, Compound ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM435711![]() (US10570155, Compound 1II | US11332479, Compound 1I...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.85 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50289149![]() (GW305074X | GW5074 | US10570155, GW5074 | US113324...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.58 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM435711![]() (US10570155, Compound 1II | US11332479, Compound 1I...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.95 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM50289149![]() (GW305074X | GW5074 | US10570155, GW5074 | US113324...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.96 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM435711![]() (US10570155, Compound 1II | US11332479, Compound 1I...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.23 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM435722![]() (US10570155, Compound 31III) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.19 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM435721![]() (US10570155, Compound 25III | US11332479, Compound ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM435722![]() (US10570155, Compound 31III) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.83 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50289149![]() (GW305074X | GW5074 | US10570155, GW5074 | US113324...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.52 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM50396483![]() (PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50396483![]() (PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM435719![]() (US10570155, Compound 2III | US11332479, Compound 2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM435720![]() (US10570155, Compound 8III | US11332479, Compound 8...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50396483![]() (PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM435719![]() (US10570155, Compound 2III | US11332479, Compound 2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 459 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM435720![]() (US10570155, Compound 8III | US11332479, Compound 8...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 687 | n/a | n/a | n/a | n/a | n/a | n/a |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY US Patent | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | US Patent US10570155 (2020) BindingDB Entry DOI: 10.7270/Q2N300B1 | |||||||||||
More data for this Ligand-Target Pair |