Compile Data Set for Download or QSAR

Found 438 hits Enz. Inhib. hit(s) with all data for entry = 9546   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396944 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:32.36,35.40,(-5.98,12.64,;-6.45,11.17,;-7.96,10.85,;-8.44,9.39,;-7.41,8.24,;-5.9,8.56,;-4.65,7.66,;-3.41,8.56,;-3.88,10.03,;-3.11,11.36,;-3.88,12.7,;-3.11,14.03,;-1.57,14.03,;-.8,15.36,;.74,15.36,;1.51,14.03,;1.51,16.7,;.74,18.03,;1.51,19.36,;3.05,19.36,;3.82,18.03,;5.36,18.03,;6.13,16.7,;7.67,16.7,;8.44,18.03,;7.67,19.36,;6.13,19.36,;3.05,16.7,;3.82,15.36,;-.8,12.7,;-1.57,11.36,;-5.42,10.03,;-4.65,6.12,;-5.99,5.35,;-5.99,3.81,;-4.65,3.04,;-4.65,1.5,;-3.32,3.81,;-3.32,5.35,)| Show InChI InChI=1S/C30H28N6O3/c31-28-27-25(17-26(36(27)33-18-32-28)20-10-14-23(37)15-11-20)19-8-12-21(13-9-19)34-29(38)24-7-4-16-35(30(24)39)22-5-2-1-3-6-22/h1-9,12-13,16-18,20,23,37H,10-11,14-15H2,(H,34,38)(H2,31,32,33)/t20-,23+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396945 (N-{4-[4-Amino-7-(trans-4-hydroxycyclohexyl)pyrrolo...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@H]1CC[C@H](O)CC1 |r,wU:32.36,wD:35.40,(-5.98,12.64,;-6.45,11.17,;-7.96,10.85,;-8.44,9.39,;-7.41,8.24,;-5.9,8.56,;-4.65,7.66,;-3.41,8.56,;-3.88,10.03,;-3.11,11.36,;-3.88,12.7,;-3.11,14.03,;-1.57,14.03,;-.8,15.36,;.74,15.36,;1.51,14.03,;1.51,16.7,;.74,18.03,;1.51,19.36,;3.05,19.36,;3.82,18.03,;5.36,18.03,;6.13,16.7,;7.67,16.7,;8.44,18.03,;7.67,19.36,;6.13,19.36,;3.05,16.7,;3.82,15.36,;-.8,12.7,;-1.57,11.36,;-5.42,10.03,;-4.65,6.12,;-3.32,5.35,;-3.32,3.81,;-4.65,3.04,;-4.65,1.5,;-5.99,3.81,;-5.99,5.35,)| Show InChI InChI=1S/C30H28N6O3/c31-28-27-25(17-26(36(27)33-18-32-28)20-10-14-23(37)15-11-20)19-8-12-21(13-9-19)34-29(38)24-7-4-16-35(30(24)39)22-5-2-1-3-6-22/h1-9,12-13,16-18,20,23,37H,10-11,14-15H2,(H,34,38)(H2,31,32,33)/t20-,23-	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396945 (N-{4-[4-Amino-7-(trans-4-hydroxycyclohexyl)pyrrolo...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@H]1CC[C@H](O)CC1 |r,wU:32.36,wD:35.40,(-5.98,12.64,;-6.45,11.17,;-7.96,10.85,;-8.44,9.39,;-7.41,8.24,;-5.9,8.56,;-4.65,7.66,;-3.41,8.56,;-3.88,10.03,;-3.11,11.36,;-3.88,12.7,;-3.11,14.03,;-1.57,14.03,;-.8,15.36,;.74,15.36,;1.51,14.03,;1.51,16.7,;.74,18.03,;1.51,19.36,;3.05,19.36,;3.82,18.03,;5.36,18.03,;6.13,16.7,;7.67,16.7,;8.44,18.03,;7.67,19.36,;6.13,19.36,;3.05,16.7,;3.82,15.36,;-.8,12.7,;-1.57,11.36,;-5.42,10.03,;-4.65,6.12,;-3.32,5.35,;-3.32,3.81,;-4.65,3.04,;-4.65,1.5,;-5.99,3.81,;-5.99,5.35,)| Show InChI InChI=1S/C30H28N6O3/c31-28-27-25(17-26(36(27)33-18-32-28)20-10-14-23(37)15-11-20)19-8-12-21(13-9-19)34-29(38)24-7-4-16-35(30(24)39)22-5-2-1-3-6-22/h1-9,12-13,16-18,20,23,37H,10-11,14-15H2,(H,34,38)(H2,31,32,33)/t20-,23-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396950 (US10442810, Example 12 | US10844069, Example 12 | ...) Show SMILES CCc1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C26H21FN6O2/c1-2-17-14-21(23-24(28)29-15-30-33(17)23)19-11-10-16(13-22(19)27)31-25(34)20-9-6-12-32(26(20)35)18-7-4-3-5-8-18/h3-15H,2H2,1H3,(H,31,34)(H2,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396952 (US10442810, Example 14 | US10844069, Example 14 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396952 (US10442810, Example 14 | US10844069, Example 14 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396953 (US10442810, Example 15 | US10844069, Example 15 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-24-15-19(34-28(37)22-7-4-12-35(29(22)38)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-13-39-14-11-18)36-26(23)27(31)32-17-33-36/h1-9,12,15-18H,10-11,13-14H2,(H,34,37)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396953 (US10442810, Example 15 | US10844069, Example 15 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-24-15-19(34-28(37)22-7-4-12-35(29(22)38)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-13-39-14-11-18)36-26(23)27(31)32-17-33-36/h1-9,12,15-18H,10-11,13-14H2,(H,34,37)(H2,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396954 (US10442810, Example 16 | US10844069, Example 16 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCOCC1 Show InChI InChI=1S/C29H24F2N6O3/c30-18-3-6-20(7-4-18)36-11-1-2-22(29(36)39)28(38)35-19-5-8-21(24(31)14-19)23-15-25(17-9-12-40-13-10-17)37-26(23)27(32)33-16-34-37/h1-8,11,14-17H,9-10,12-13H2,(H,35,38)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396954 (US10442810, Example 16 | US10844069, Example 16 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCOCC1 Show InChI InChI=1S/C29H24F2N6O3/c30-18-3-6-20(7-4-18)36-11-1-2-22(29(36)39)28(38)35-19-5-8-21(24(31)14-19)23-15-25(17-9-12-40-13-10-17)37-26(23)27(32)33-16-34-37/h1-8,11,14-17H,9-10,12-13H2,(H,35,38)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396955 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:33.37,36.41,(-6.75,14.31,;-7.22,12.85,;-8.73,12.53,;-9.21,11.06,;-8.18,9.92,;-6.67,10.24,;-5.42,9.33,;-4.18,10.24,;-4.65,11.7,;-3.88,13.04,;-2.34,13.04,;-1.57,14.37,;-2.34,15.7,;-1.57,17.04,;-.03,17.04,;.74,15.7,;.74,18.37,;-.03,19.7,;.74,21.04,;2.28,21.04,;3.05,19.7,;4.59,19.7,;5.36,18.37,;6.9,18.37,;7.67,19.7,;9.21,19.7,;6.9,21.04,;5.36,21.04,;2.28,18.37,;3.05,17.04,;-3.88,15.7,;-4.65,14.37,;-6.19,11.7,;-5.42,7.79,;-6.76,7.02,;-6.76,5.48,;-5.42,4.71,;-5.42,3.17,;-4.09,5.48,;-4.09,7.02,)| Show InChI InChI=1S/C30H27FN6O3/c31-20-7-11-22(12-8-20)36-15-1-2-24(30(36)40)29(39)35-21-9-3-18(4-10-21)25-16-26(19-5-13-23(38)14-6-19)37-27(25)28(32)33-17-34-37/h1-4,7-12,15-17,19,23,38H,5-6,13-14H2,(H,35,39)(H2,32,33,34)/t19-,23+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396955 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:33.37,36.41,(-6.75,14.31,;-7.22,12.85,;-8.73,12.53,;-9.21,11.06,;-8.18,9.92,;-6.67,10.24,;-5.42,9.33,;-4.18,10.24,;-4.65,11.7,;-3.88,13.04,;-2.34,13.04,;-1.57,14.37,;-2.34,15.7,;-1.57,17.04,;-.03,17.04,;.74,15.7,;.74,18.37,;-.03,19.7,;.74,21.04,;2.28,21.04,;3.05,19.7,;4.59,19.7,;5.36,18.37,;6.9,18.37,;7.67,19.7,;9.21,19.7,;6.9,21.04,;5.36,21.04,;2.28,18.37,;3.05,17.04,;-3.88,15.7,;-4.65,14.37,;-6.19,11.7,;-5.42,7.79,;-6.76,7.02,;-6.76,5.48,;-5.42,4.71,;-5.42,3.17,;-4.09,5.48,;-4.09,7.02,)| Show InChI InChI=1S/C30H27FN6O3/c31-20-7-11-22(12-8-20)36-15-1-2-24(30(36)40)29(39)35-21-9-3-18(4-10-21)25-16-26(19-5-13-23(38)14-6-19)37-27(25)28(32)33-17-34-37/h1-4,7-12,15-17,19,23,38H,5-6,13-14H2,(H,35,39)(H2,32,33,34)/t19-,23+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396956 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:33.37,36.41,(-5.98,14.31,;-6.45,12.85,;-7.96,12.53,;-8.44,11.06,;-7.41,9.92,;-5.9,10.24,;-4.65,9.33,;-3.41,10.24,;-3.88,11.7,;-3.11,13.04,;-3.88,14.37,;-3.11,15.7,;-1.57,15.7,;-.8,17.04,;.74,17.04,;1.51,15.7,;1.51,18.37,;.74,19.7,;1.51,21.04,;3.05,21.04,;3.82,19.7,;5.36,19.7,;6.13,18.37,;7.67,18.37,;8.44,19.7,;7.67,21.04,;6.13,21.04,;3.05,18.37,;3.82,17.04,;-.8,14.37,;-1.57,13.04,;-.8,11.7,;-5.42,11.7,;-4.65,7.79,;-5.99,7.02,;-5.99,5.48,;-4.65,4.71,;-4.65,3.17,;-3.32,5.48,;-3.32,7.02,)| Show InChI InChI=1S/C30H27FN6O3/c31-25-15-19(35-29(39)23-7-4-14-36(30(23)40)20-5-2-1-3-6-20)10-13-22(25)24-16-26(18-8-11-21(38)12-9-18)37-27(24)28(32)33-17-34-37/h1-7,10,13-18,21,38H,8-9,11-12H2,(H,35,39)(H2,32,33,34)/t18-,21+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396956 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:33.37,36.41,(-5.98,14.31,;-6.45,12.85,;-7.96,12.53,;-8.44,11.06,;-7.41,9.92,;-5.9,10.24,;-4.65,9.33,;-3.41,10.24,;-3.88,11.7,;-3.11,13.04,;-3.88,14.37,;-3.11,15.7,;-1.57,15.7,;-.8,17.04,;.74,17.04,;1.51,15.7,;1.51,18.37,;.74,19.7,;1.51,21.04,;3.05,21.04,;3.82,19.7,;5.36,19.7,;6.13,18.37,;7.67,18.37,;8.44,19.7,;7.67,21.04,;6.13,21.04,;3.05,18.37,;3.82,17.04,;-.8,14.37,;-1.57,13.04,;-.8,11.7,;-5.42,11.7,;-4.65,7.79,;-5.99,7.02,;-5.99,5.48,;-4.65,4.71,;-4.65,3.17,;-3.32,5.48,;-3.32,7.02,)| Show InChI InChI=1S/C30H27FN6O3/c31-25-15-19(35-29(39)23-7-4-14-36(30(23)40)20-5-2-1-3-6-20)10-13-22(25)24-16-26(18-8-11-21(38)12-9-18)37-27(24)28(32)33-17-34-37/h1-7,10,13-18,21,38H,8-9,11-12H2,(H,35,39)(H2,32,33,34)/t18-,21+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396957 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:34.38,37.42,(-6.76,13.36,;-7.23,11.89,;-8.74,11.57,;-9.2,10.1,;-8.17,8.96,;-6.66,9.29,;-5.41,8.39,;-4.17,9.3,;-4.66,10.76,;-3.89,12.09,;-4.66,13.43,;-3.89,14.76,;-2.35,14.76,;-1.58,16.1,;-.04,16.1,;.73,14.76,;.73,17.43,;-.04,18.76,;.73,20.1,;2.27,20.1,;3.04,18.76,;4.58,18.76,;5.35,20.1,;6.89,20.1,;7.66,18.76,;9.2,18.76,;6.89,17.43,;5.35,17.43,;2.27,17.43,;3.04,16.1,;-1.58,13.43,;-2.35,12.09,;-1.58,10.76,;-6.2,10.75,;-5.22,6.85,;-6.44,5.91,;-6.23,4.38,;-4.8,3.8,;-4.59,2.27,;-3.59,4.74,;-3.79,6.27,)| Show InChI InChI=1S/C30H26F2N6O3/c31-18-5-8-20(9-6-18)37-13-1-2-23(30(37)41)29(40)36-19-7-12-22(25(32)14-19)24-15-26(17-3-10-21(39)11-4-17)38-27(24)28(33)34-16-35-38/h1-2,5-9,12-17,21,39H,3-4,10-11H2,(H,36,40)(H2,33,34,35)/t17-,21+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396957 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:34.38,37.42,(-6.76,13.36,;-7.23,11.89,;-8.74,11.57,;-9.2,10.1,;-8.17,8.96,;-6.66,9.29,;-5.41,8.39,;-4.17,9.3,;-4.66,10.76,;-3.89,12.09,;-4.66,13.43,;-3.89,14.76,;-2.35,14.76,;-1.58,16.1,;-.04,16.1,;.73,14.76,;.73,17.43,;-.04,18.76,;.73,20.1,;2.27,20.1,;3.04,18.76,;4.58,18.76,;5.35,20.1,;6.89,20.1,;7.66,18.76,;9.2,18.76,;6.89,17.43,;5.35,17.43,;2.27,17.43,;3.04,16.1,;-1.58,13.43,;-2.35,12.09,;-1.58,10.76,;-6.2,10.75,;-5.22,6.85,;-6.44,5.91,;-6.23,4.38,;-4.8,3.8,;-4.59,2.27,;-3.59,4.74,;-3.79,6.27,)| Show InChI InChI=1S/C30H26F2N6O3/c31-18-5-8-20(9-6-18)37-13-1-2-23(30(37)41)29(40)36-19-7-12-22(25(32)14-19)24-15-26(17-3-10-21(39)11-4-17)38-27(24)28(33)34-16-35-38/h1-2,5-9,12-17,21,39H,3-4,10-11H2,(H,36,40)(H2,33,34,35)/t17-,21+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396957 (N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:34.38,37.42,(-6.76,13.36,;-7.23,11.89,;-8.74,11.57,;-9.2,10.1,;-8.17,8.96,;-6.66,9.29,;-5.41,8.39,;-4.17,9.3,;-4.66,10.76,;-3.89,12.09,;-4.66,13.43,;-3.89,14.76,;-2.35,14.76,;-1.58,16.1,;-.04,16.1,;.73,14.76,;.73,17.43,;-.04,18.76,;.73,20.1,;2.27,20.1,;3.04,18.76,;4.58,18.76,;5.35,20.1,;6.89,20.1,;7.66,18.76,;9.2,18.76,;6.89,17.43,;5.35,17.43,;2.27,17.43,;3.04,16.1,;-1.58,13.43,;-2.35,12.09,;-1.58,10.76,;-6.2,10.75,;-5.22,6.85,;-6.44,5.91,;-6.23,4.38,;-4.8,3.8,;-4.59,2.27,;-3.59,4.74,;-3.79,6.27,)| Show InChI InChI=1S/C30H26F2N6O3/c31-18-5-8-20(9-6-18)37-13-1-2-23(30(37)41)29(40)36-19-7-12-22(25(32)14-19)24-15-26(17-3-10-21(39)11-4-17)38-27(24)28(33)34-16-35-38/h1-2,5-9,12-17,21,39H,3-4,10-11H2,(H,36,40)(H2,33,34,35)/t17-,21+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396959 (US10442810, Example 21 | US10844069, Example 21 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-15-12-20(13-16-36)26-17-25(27-28(32)33-18-34-38(26)27)19-4-8-22(9-5-19)35-29(39)24-3-2-14-37(30(24)40)23-10-6-21(31)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396961 (US10442810, Example 23 | US10844069, Example 23 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H27F2N7O2/c1-37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396961 (US10442810, Example 23 | US10844069, Example 23 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H27F2N7O2/c1-37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396962 (US10442810, Example 24 | US10844069, Example 24 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H29N7O3/c1-20(39)36-16-13-22(14-17-36)27-18-26(28-29(32)33-19-34-38(27)28)21-9-11-23(12-10-21)35-30(40)25-8-5-15-37(31(25)41)24-6-3-2-4-7-24/h2-12,15,18-19,22H,13-14,16-17H2,1H3,(H,35,40)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396962 (US10442810, Example 24 | US10844069, Example 24 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H29N7O3/c1-20(39)36-16-13-22(14-17-36)27-18-26(28-29(32)33-19-34-38(27)28)21-9-11-23(12-10-21)35-30(40)25-8-5-15-37(31(25)41)24-6-3-2-4-7-24/h2-12,15,18-19,22H,13-14,16-17H2,1H3,(H,35,40)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396963 (US10442810, Example 25 | US10844069, Example 25 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O3/c1-19(40)37-15-12-21(13-16-37)27-17-26(28-29(33)34-18-35-39(27)28)20-4-8-23(9-5-20)36-30(41)25-3-2-14-38(31(25)42)24-10-6-22(32)7-11-24/h2-11,14,17-18,21H,12-13,15-16H2,1H3,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396963 (US10442810, Example 25 | US10844069, Example 25 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O3/c1-19(40)37-15-12-21(13-16-37)27-17-26(28-29(33)34-18-35-39(27)28)20-4-8-23(9-5-20)36-30(41)25-3-2-14-38(31(25)42)24-10-6-22(32)7-11-24/h2-11,14,17-18,21H,12-13,15-16H2,1H3,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396964 (US10442810, Example 26 | US10844069, Example 26 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O3/c1-19(40)37-14-11-20(12-15-37)27-17-25(28-29(33)34-18-35-39(27)28)23-10-9-21(16-26(23)32)36-30(41)24-8-5-13-38(31(24)42)22-6-3-2-4-7-22/h2-10,13,16-18,20H,11-12,14-15H2,1H3,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396964 (US10442810, Example 26 | US10844069, Example 26 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O3/c1-19(40)37-14-11-20(12-15-37)27-17-25(28-29(33)34-18-35-39(27)28)23-10-9-21(16-26(23)32)36-30(41)24-8-5-13-38(31(24)42)22-6-3-2-4-7-22/h2-10,13,16-18,20H,11-12,14-15H2,1H3,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396965 (US10442810, Example 27 | US10844069, Example 27 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H27F2N7O3/c1-18(41)38-13-10-19(11-14-38)27-16-25(28-29(34)35-17-36-40(27)28)23-9-6-21(15-26(23)33)37-30(42)24-3-2-12-39(31(24)43)22-7-4-20(32)5-8-22/h2-9,12,15-17,19H,10-11,13-14H2,1H3,(H,37,42)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396965 (US10442810, Example 27 | US10844069, Example 27 | ...) Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H27F2N7O3/c1-18(41)38-13-10-19(11-14-38)27-16-25(28-29(34)35-17-36-40(27)28)23-9-6-21(15-26(23)33)37-30(42)24-3-2-12-39(31(24)43)22-7-4-20(32)5-8-22/h2-9,12,15-17,19H,10-11,13-14H2,1H3,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396966 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:32.36,35.43,(-5.98,13.04,;-6.45,11.58,;-7.96,11.26,;-8.44,9.79,;-7.41,8.65,;-5.9,8.97,;-4.65,8.06,;-3.41,8.97,;-3.88,10.43,;-3.11,11.76,;-1.57,11.76,;-.8,13.1,;-1.57,14.43,;-.8,15.77,;.74,15.77,;1.51,14.43,;1.51,17.1,;.74,18.43,;1.51,19.77,;3.05,19.77,;3.82,18.43,;5.36,18.43,;6.13,17.1,;7.67,17.1,;8.44,18.43,;7.67,19.77,;6.13,19.77,;3.05,17.1,;3.82,15.77,;-3.11,14.43,;-3.88,13.1,;-5.42,10.43,;-4.65,6.52,;-5.99,5.75,;-5.99,4.21,;-4.65,3.44,;-3.32,4.21,;-3.32,5.75,;-4.65,1.9,;-4.65,.36,)| Show InChI InChI=1S/C31H27N7O2/c32-18-20-8-10-22(11-9-20)27-17-26(28-29(33)34-19-35-38(27)28)21-12-14-23(15-13-21)36-30(39)25-7-4-16-37(31(25)40)24-5-2-1-3-6-24/h1-7,12-17,19-20,22H,8-11H2,(H,36,39)(H2,33,34,35)/t20-,22+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396966 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:32.36,35.43,(-5.98,13.04,;-6.45,11.58,;-7.96,11.26,;-8.44,9.79,;-7.41,8.65,;-5.9,8.97,;-4.65,8.06,;-3.41,8.97,;-3.88,10.43,;-3.11,11.76,;-1.57,11.76,;-.8,13.1,;-1.57,14.43,;-.8,15.77,;.74,15.77,;1.51,14.43,;1.51,17.1,;.74,18.43,;1.51,19.77,;3.05,19.77,;3.82,18.43,;5.36,18.43,;6.13,17.1,;7.67,17.1,;8.44,18.43,;7.67,19.77,;6.13,19.77,;3.05,17.1,;3.82,15.77,;-3.11,14.43,;-3.88,13.1,;-5.42,10.43,;-4.65,6.52,;-5.99,5.75,;-5.99,4.21,;-4.65,3.44,;-3.32,4.21,;-3.32,5.75,;-4.65,1.9,;-4.65,.36,)| Show InChI InChI=1S/C31H27N7O2/c32-18-20-8-10-22(11-9-20)27-17-26(28-29(33)34-19-35-38(27)28)21-12-14-23(15-13-21)36-30(39)25-7-4-16-37(31(25)40)24-5-2-1-3-6-24/h1-7,12-17,19-20,22H,8-11H2,(H,36,39)(H2,33,34,35)/t20-,22+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396967 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396967 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396968 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-5.98,13.38,;-6.45,11.92,;-7.96,11.6,;-8.44,10.13,;-7.41,8.99,;-5.9,9.31,;-4.65,8.4,;-3.41,9.31,;-3.88,10.77,;-3.11,12.11,;-3.88,13.44,;-3.11,14.78,;-1.57,14.78,;-.8,16.11,;.74,16.11,;1.51,14.78,;1.51,17.44,;.74,18.78,;1.51,20.11,;3.05,20.11,;3.82,18.78,;5.36,18.78,;6.13,17.44,;7.67,17.44,;8.44,18.78,;7.67,20.11,;6.13,20.11,;3.05,17.44,;3.82,16.11,;-.8,13.44,;-1.57,12.11,;-.8,10.77,;-5.42,10.77,;-4.65,6.86,;-5.99,6.09,;-5.99,4.55,;-4.65,3.78,;-3.32,4.55,;-3.32,6.09,;-4.65,2.24,;-4.65,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-26-15-21(37-30(40)24-7-4-14-38(31(24)41)22-5-2-1-3-6-22)12-13-23(26)25-16-27(20-10-8-19(17-33)9-11-20)39-28(25)29(34)35-18-36-39/h1-7,12-16,18-20H,8-11H2,(H,37,40)(H2,34,35,36)/t19-,20+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396968 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-5.98,13.38,;-6.45,11.92,;-7.96,11.6,;-8.44,10.13,;-7.41,8.99,;-5.9,9.31,;-4.65,8.4,;-3.41,9.31,;-3.88,10.77,;-3.11,12.11,;-3.88,13.44,;-3.11,14.78,;-1.57,14.78,;-.8,16.11,;.74,16.11,;1.51,14.78,;1.51,17.44,;.74,18.78,;1.51,20.11,;3.05,20.11,;3.82,18.78,;5.36,18.78,;6.13,17.44,;7.67,17.44,;8.44,18.78,;7.67,20.11,;6.13,20.11,;3.05,17.44,;3.82,16.11,;-.8,13.44,;-1.57,12.11,;-.8,10.77,;-5.42,10.77,;-4.65,6.86,;-5.99,6.09,;-5.99,4.55,;-4.65,3.78,;-3.32,4.55,;-3.32,6.09,;-4.65,2.24,;-4.65,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-26-15-21(37-30(40)24-7-4-14-38(31(24)41)22-5-2-1-3-6-22)12-13-23(26)25-16-27(20-10-8-19(17-33)9-11-20)39-28(25)29(34)35-18-36-39/h1-7,12-16,18-20H,8-11H2,(H,37,40)(H2,34,35,36)/t19-,20+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM415761 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CC[C@@H](CC1)C#N |r,wU:37.45,(-7.06,14.18,;-7.38,12.67,;-8.84,12.2,;-9.16,10.69,;-8.02,9.66,;-6.55,10.13,;-5.22,9.36,;-4.07,10.4,;-4.7,11.8,;-3.93,13.14,;-4.7,14.47,;-3.93,15.8,;-2.39,15.8,;-1.62,17.14,;-.08,17.14,;.69,15.8,;.69,18.47,;-.08,19.8,;.69,21.14,;2.23,21.14,;3,19.8,;4.54,19.8,;5.31,18.47,;6.85,18.47,;7.62,19.8,;9.16,19.8,;6.85,21.14,;5.31,21.14,;2.23,18.47,;3,17.14,;-1.62,14.47,;-2.39,13.14,;-1.62,11.8,;-6.23,11.64,;-5.06,7.83,;-6.3,6.93,;-6.14,5.4,;-4.73,4.77,;-3.49,5.68,;-3.65,7.21,;-4.57,3.24,;-4.41,1.71,)| Show InChI InChI=1S/C31H25F2N7O2/c32-20-7-10-22(11-8-20)39-13-1-2-24(31(39)42)30(41)38-21-9-12-23(26(33)14-21)25-15-27(19-5-3-18(16-34)4-6-19)40-28(25)29(35)36-17-37-40/h1-2,7-15,17-19H,3-6H2,(H,38,41)(H2,35,36,37)/t18-,19?	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM415761 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CC[C@@H](CC1)C#N |r,wU:37.45,(-7.06,14.18,;-7.38,12.67,;-8.84,12.2,;-9.16,10.69,;-8.02,9.66,;-6.55,10.13,;-5.22,9.36,;-4.07,10.4,;-4.7,11.8,;-3.93,13.14,;-4.7,14.47,;-3.93,15.8,;-2.39,15.8,;-1.62,17.14,;-.08,17.14,;.69,15.8,;.69,18.47,;-.08,19.8,;.69,21.14,;2.23,21.14,;3,19.8,;4.54,19.8,;5.31,18.47,;6.85,18.47,;7.62,19.8,;9.16,19.8,;6.85,21.14,;5.31,21.14,;2.23,18.47,;3,17.14,;-1.62,14.47,;-2.39,13.14,;-1.62,11.8,;-6.23,11.64,;-5.06,7.83,;-6.3,6.93,;-6.14,5.4,;-4.73,4.77,;-3.49,5.68,;-3.65,7.21,;-4.57,3.24,;-4.41,1.71,)| Show InChI InChI=1S/C31H25F2N7O2/c32-20-7-10-22(11-8-20)39-13-1-2-24(31(39)42)30(41)38-21-9-12-23(26(33)14-21)25-15-27(19-5-3-18(16-34)4-6-19)40-28(25)29(35)36-17-37-40/h1-2,7-15,17-19H,3-6H2,(H,38,41)(H2,35,36,37)/t18-,19?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396971 (US10442810, Example 33 | US10844069, Example 33 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-20-5-9-22(10-6-20)36-15-1-2-23(29(36)39)28(38)35-21-7-3-18(4-8-21)24-16-25(19-11-13-32-14-12-19)37-26(24)27(31)33-17-34-37/h1-10,15-17,19,32H,11-14H2,(H,35,38)(H2,31,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396971 (US10442810, Example 33 | US10844069, Example 33 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-20-5-9-22(10-6-20)36-15-1-2-23(29(36)39)28(38)35-21-7-3-18(4-8-21)24-16-25(19-11-13-32-14-12-19)37-26(24)27(31)33-17-34-37/h1-10,15-17,19,32H,11-14H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396973 (US10442810, Example 35 | US10844069, Example 35 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H25F2N7O2/c30-18-3-6-20(7-4-18)37-13-1-2-22(29(37)40)28(39)36-19-5-8-21(24(31)14-19)23-15-25(17-9-11-33-12-10-17)38-26(23)27(32)34-16-35-38/h1-8,13-17,33H,9-12H2,(H,36,39)(H2,32,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396973 (US10442810, Example 35 | US10844069, Example 35 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H25F2N7O2/c30-18-3-6-20(7-4-18)37-13-1-2-22(29(37)40)28(39)36-19-5-8-21(24(31)14-19)23-15-25(17-9-11-33-12-10-17)38-26(23)27(32)34-16-35-38/h1-8,13-17,33H,9-12H2,(H,36,39)(H2,32,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396975 (US10442810, Example 37 | US10844069, Example 37 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-15-12-20(13-16-37)26-17-25(27-28(33)34-18-35-39(26)27)19-4-8-22(9-5-19)36-29(40)24-3-2-14-38(30(24)41)23-10-6-21(32)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396975 (US10442810, Example 37 | US10844069, Example 37 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-15-12-20(13-16-37)26-17-25(27-28(33)34-18-35-39(26)27)19-4-8-22(9-5-19)36-29(40)24-3-2-14-38(30(24)41)23-10-6-21(32)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396976 (US10442810, Example 38 | US10844069, Example 38 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-14-11-19(12-15-37)26-17-24(27-28(33)34-18-35-39(26)27)22-10-9-20(16-25(22)32)36-29(40)23-8-5-13-38(30(23)41)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396976 (US10442810, Example 38 | US10844069, Example 38 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-14-11-19(12-15-37)26-17-24(27-28(33)34-18-35-39(26)27)22-10-9-20(16-25(22)32)36-29(40)23-8-5-13-38(30(23)41)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair

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