Compile Data Set for Download or QSAR

Found 294 hits Enz. Inhib. hit(s) with all data for entry = 9735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM484752 (1-(4-{6-[(3R)-3-amino-1,3-dihydrospiro[indene-2,4&...) Show SMILES CC(=O)N1CCN(c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4[C@@H]3N)CC2)c2ccccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484753 (US10934302, Example 2) Show SMILES CC(=O)N1CCN(c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4[C@H]3N)CC2)c2ccccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484754 (US10934302, Example 3) Show SMILES N[C@H]1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2nc(ccc12)-c1ccn[nH]1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484755 (US10934302, Example 4) Show SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2nc(ccc12)-c1ccn[nH]1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484756 (US10934302, Example 5) Show SMILES Cn1cc(cn1)-c1ccc2N(CCCc2n1)c1n[nH]c2nc(cnc12)N1CCC2(Cc3ccccc3[C@@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484757 (US10934302, Example 6) Show SMILES Cn1cc(cn1)-c1ccc2N(CCCc2n1)c1n[nH]c2nc(cnc12)N1CCC2(Cc3ccccc3[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484758 (US10934302, Example 7) Show SMILES NC1C2CC2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484759 (US10934302, Example 8) Show SMILES N[C@@H]1[C@H]2C[C@H]2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484760 (US10934302, Example 9) Show SMILES N[C@@H]1[C@@H]2C[C@H]2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484761 (US10934302, Example 10) Show SMILES N[C@H]1[C@H]2C[C@H]2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484762 (US10934302, Example 11) Show SMILES N[C@H]1[C@@H]2C[C@H]2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484763 (US10934302, Example 12) Show SMILES NC1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484764 (US10934302, Example 13 | US10934302, Example 15) Show SMILES NC1Cc2ccccc2C11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484765 (US10934302, Example 14) Show SMILES N[C@@H]1Cc2ccccc2C11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484768 (US10934302, Example 17) Show SMILES N[C@@H]1c2ccc(F)cc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484769 (US10934302, Example 18) Show SMILES N[C@H]1c2c(CC11CCN(CC1)c1cnc3c(n[nH]c3n1)N1CCCc3ncccc13)cccc2F |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484771 (US10934302, Example 20) Show SMILES Cc1nc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)c(CO)nc1-c1cccc(Cl)c1Cl |r| Show InChI InChI=1S/C25H26Cl2N4O/c1-15-22(18-7-4-8-19(26)21(18)27)30-20(14-32)24(29-15)31-11-9-25(10-12-31)13-16-5-2-3-6-17(16)23(25)28/h2-8,23,32H,9-14,28H2,1H3/t23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484772 ((3R)-1′-[6-amino-5-(2,3-dichlorophenyl)pyraz...) Show SMILES N[C@H]1c2ccccc2CC11CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl |r| Show InChI InChI=1S/C23H23Cl2N5/c24-17-7-3-6-16(19(17)25)20-22(27)29-18(13-28-20)30-10-8-23(9-11-30)12-14-4-1-2-5-15(14)21(23)26/h1-7,13,21H,8-12,26H2,(H2,27,29)/t21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484773 (US10934302, Example 22) Show SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl |r| Show InChI InChI=1S/C23H23Cl2N5/c24-17-7-3-6-16(19(17)25)20-22(27)29-18(13-28-20)30-10-8-23(9-11-30)12-14-4-1-2-5-15(14)21(23)26/h1-7,13,21H,8-12,26H2,(H2,27,29)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484775 (US10934302, Example 24) Show SMILES N[C@H]1c2cccc(F)c2CC11CCN(CC1)c1cnc2cn[nH]c2n1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484776 (US10934302, Example 25) Show SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484777 (US10934302, Example 26) Show SMILES N[C@H]1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484778 (US10934302, Example 27) Show SMILES CN(C)C(=O)c1ccc2CC3(CCN(CC3)c3cnc4c(n[nH]c4n3)N3CCCc4ncccc34)[C@H](N)c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484779 (US10934302, Example 28) Show SMILES CN(C)C(=O)c1ccc2CC3(CCN(CC3)c3cnc4c(n[nH]c4n3)N3CCCc4ncccc34)[C@@H](N)c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484780 (US10934302, Example 29) Show SMILES N[C@@H]1c2cc(ccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12)C#N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484781 (US10934302, Example 30) Show SMILES N[C@@H]1c2cccc(F)c2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484782 (US10934302, Example 31) Show SMILES CS(=O)(=O)c1cccc2N(CCCc12)c1n[nH]c2nc(cnc12)N1CCC2(Cc3ccccc3C2N)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484783 (US10934302, Example 32) Show SMILES CO[C@H]1C[C@H](C1)N1CCN(c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4C3N)CC2)c2ccc(cc12)C#N |r,wU:4.6,2.1,(10.19,-3.99,;8.69,-3.67,;8.21,-2.21,;6.84,-1.51,;7.54,-.14,;8.91,-.83,;7.06,1.33,;8.09,2.47,;7.62,3.94,;6.11,4.26,;5.64,5.72,;6.54,6.97,;5.64,8.21,;4.17,7.74,;2.84,8.51,;1.5,7.74,;1.5,6.2,;2.84,5.43,;4.17,6.2,;.17,8.51,;-1.16,7.74,;-2.5,8.51,;-2.5,10.05,;-3.9,9.42,;-4.93,10.57,;-6.47,10.57,;-7.24,11.9,;-6.47,13.23,;-4.93,13.23,;-4.16,11.9,;-2.66,11.58,;-1.51,12.61,;-1.16,10.82,;.17,10.05,;5.08,3.11,;3.57,3.43,;2.54,2.29,;3.02,.82,;4.53,.5,;5.56,1.65,;1.99,-.32,;.9,-1.41,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484784 (US10934302, Example 33) Show SMILES CO[C@H]1C[C@@H](C1)N1CCN(c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4C3N)CC2)c2ccc(cc12)C#N |r,wU:4.6,wD:2.1,(10.19,-3.99,;8.69,-3.67,;8.21,-2.21,;8.91,-.83,;7.54,-.14,;6.84,-1.51,;7.06,1.33,;8.09,2.47,;7.62,3.94,;6.11,4.26,;5.64,5.72,;6.54,6.97,;5.64,8.21,;4.17,7.74,;2.84,8.51,;1.5,7.74,;1.5,6.2,;2.84,5.43,;4.17,6.2,;.17,8.51,;-1.16,7.74,;-2.5,8.51,;-2.5,10.05,;-3.9,9.42,;-4.93,10.57,;-6.47,10.57,;-7.24,11.9,;-6.47,13.23,;-4.93,13.23,;-4.16,11.9,;-2.66,11.58,;-1.51,12.61,;-1.16,10.82,;.17,10.05,;5.08,3.11,;3.57,3.43,;2.54,2.29,;3.02,.82,;4.53,.5,;5.56,1.65,;1.99,-.32,;.9,-1.41,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484785 (US10934302, Example 34) Show SMILES NC1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCN([C@@H]2C[C@H](O)C2)c2cc(ccc12)C#N |r,wU:28.32,30.35,(-.94,12.54,;-2.08,11.51,;-3.59,11.83,;-4.36,13.16,;-5.9,13.16,;-6.67,11.83,;-5.9,10.49,;-4.36,10.49,;-3.33,9.35,;-1.92,9.98,;-1.92,8.44,;-.59,7.67,;.75,8.44,;.75,9.98,;-.59,10.75,;2.08,7.67,;2.08,6.13,;3.41,5.36,;4.75,6.13,;6.21,5.65,;7.12,6.9,;6.21,8.14,;4.75,7.67,;3.41,8.44,;6.69,4.19,;8.2,3.87,;8.67,2.4,;7.64,1.26,;8.12,-.21,;7.42,-1.58,;8.79,-2.28,;9.27,-3.74,;9.49,-.91,;6.13,1.58,;5.1,.43,;3.6,.75,;3.12,2.22,;4.15,3.36,;5.66,3.04,;2.57,-.39,;1.48,-1.48,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484786 (US10934302, Example 35) Show SMILES NC1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCN([C@H]2C[C@H](O)C2)c2cc(ccc12)C#N |r,wU:28.32,wD:30.35,(-1.3,12.54,;-2.44,11.51,;-3.95,11.83,;-4.72,13.16,;-6.26,13.16,;-7.03,11.83,;-6.26,10.49,;-4.72,10.49,;-3.69,9.35,;-2.28,9.98,;-2.28,8.44,;-.95,7.67,;.39,8.44,;.39,9.98,;-.95,10.75,;1.72,7.67,;1.72,6.13,;3.05,5.36,;4.39,6.13,;5.85,5.65,;6.76,6.9,;5.85,8.14,;4.39,7.67,;3.05,8.44,;6.33,4.19,;7.83,3.87,;8.31,2.4,;7.28,1.26,;7.76,-.21,;9.13,-.91,;8.43,-2.28,;8.9,-3.74,;7.06,-1.58,;5.77,1.58,;4.74,.43,;3.24,.75,;2.76,2.22,;3.79,3.36,;5.3,3.04,;2.21,-.39,;1.12,-1.48,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484787 (US10934302, Example 36) Show SMILES N[C@@H]1c2cc(F)ccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484788 (US10934302, Example 37) Show SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2nc(ccc12)-c1ncco1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484789 (US10934302, Example 38) Show SMILES CS(=O)(=O)c1cccc2N(CCCc12)c1n[nH]c2nc(cnc12)N1CCC2(Cc3ccccc3[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484790 (US10934302, Example 39) Show SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCN(c2cc(ccc12)C#N)C1(CC1)C#N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484792 (US10934302, Example 41) Show SMILES CS(=O)(=O)c1cccc2N(CCCc12)c1n[nH]c2nc(cnc12)N1CCC2(Cc3ccc(F)cc3[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484793 (US10934302, Example 42) Show SMILES Cn1cc(cn1)-c1ccc2N(CCCc2n1)c1n[nH]c2nc(cnc12)N1CCC2(Cc3c(cccc3F)[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484794 (US10934302, Example 43) Show SMILES CN1CCN(c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4[C@H]3N)CC2)c2ccc(cc12)C#N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484795 (US10934302, Example 44) Show SMILES Cn1ccc2N(CCCc2c1=O)c1n[nH]c2nc(cnc12)N1CCC2(Cc3ccccc3[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484796 (US10934302, Example 45) Show SMILES NC1c2ncccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484797 (US10934302, Example 46) Show SMILES Cn1cc(cn1)-c1ccc2N(CCCc2n1)c1n[nH]c2nc(cnc12)N1CCC2(Cc3cccnc3C2N)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484798 (US10934302, Example 47) Show SMILES N[C@@H]1c2c(CC11CCN(CC1)c1cnc3c(n[nH]c3n1)N1CCCc3ncccc13)cccc2F |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484799 (US10934302, Example 48) Show SMILES Cn1cc(cn1)-c1ccc2N(CCCc2n1)c1n[nH]c2nc(cnc12)N1CCC2(Cc3cccc(F)c3[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484800 (US10934302, Example 49) Show SMILES N[C@@H]1c2cccnc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484801 (US10934302, Example 50) Show SMILES N[C@@H]1c2cnccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484802 (US10934302, Example 51) Show SMILES CN1Cc2c(ccc3N(CCCc23)c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4[C@H]3N)CC2)C1=O |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484803 (US10934302, Example 52) Show SMILES Cn1ccc2N(CCCc2c1=O)c1n[nH]c2nc(cnc12)N1CCC2(Cc3cc(F)ccc3[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484804 (US10934302, Example 53) Show SMILES Cn1ccc2N(CCCc2c1=O)c1n[nH]c2nc(cnc12)N1CCC2(Cc3c(cccc3F)[C@H]2N)CC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484805 (US10934302, Example 54) Show SMILES N[C@@H]1c2cccc(F)c2OC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM484806 (US10934302, Example 55) Show SMILES Cn1ccc2N(CCCc2c1=O)c1n[nH]c2nc(cnc12)N1CCC2(CC1)Oc1c(cccc1F)[C@H]2N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair

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