Compile Data Set for Download or QSAR

Found 72 hits Enz. Inhib. hit(s) with all data for entry = 9758   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486396 (US10947222, Example 27-A) Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C26H21F3N2O4S/c27-18-5-7-20(8-6-18)31-14-23(16-2-1-3-21(12-16)35-26(28)29)22-9-4-17(13-24(22)31)25(32)30-19-10-11-36(33,34)15-19/h1-9,12-14,19,26H,10-11,15H2,(H,30,32)/t19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486376 (3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-...) Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1 |r| Show InChI InChI=1S/C28H26FN3O3S/c1-28(11-12-36(34,35)17-28)31-27(33)21-7-9-23-24(20-4-2-3-19(13-20)18-5-6-18)16-32(25(23)14-21)26-10-8-22(29)15-30-26/h2-4,7-10,13-16,18H,5-6,11-12,17H2,1H3,(H,31,33)/t28-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486393 (3-(5-(difluoromethoxy)pyridin- 3-yl)-1-(4-fluoroph...) Show SMILES CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1cncc(OC(F)F)c1 Show InChI InChI=1S/C26H22F3N3O4S/c1-26(8-9-37(34,35)15-26)31-24(33)16-2-7-21-22(17-10-20(13-30-12-17)36-25(28)29)14-32(23(21)11-16)19-5-3-18(27)4-6-19/h2-7,10-14,25H,8-9,15H2,1H3,(H,31,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486375 (3-(3-cyclopropylphenyl)-1-(5- fluoropyridin-2-yl)-...) Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(c1)C1CC1 |r| Show InChI InChI=1S/C28H26FN3O3S/c1-28(11-12-36(34,35)17-28)31-27(33)21-7-9-23-24(20-4-2-3-19(13-20)18-5-6-18)16-32(25(23)14-21)26-10-8-22(29)15-30-26/h2-4,7-10,13-16,18H,5-6,11-12,17H2,1H3,(H,31,33)/t28-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486386 (3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidi...) Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C25H21F3N4O4S/c1-25(7-8-37(34,35)14-25)31-22(33)16-5-6-19-20(15-3-2-4-18(9-15)36-23(27)28)13-32(21(19)10-16)24-29-11-17(26)12-30-24/h2-6,9-13,23H,7-8,14H2,1H3,(H,31,33)/t25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486372 (3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyridin-...) Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C26H22F3N3O4S/c1-26(9-10-37(34,35)15-26)31-24(33)17-5-7-20-21(16-3-2-4-19(11-16)36-25(28)29)14-32(22(20)12-17)23-8-6-18(27)13-30-23/h2-8,11-14,25H,9-10,15H2,1H3,(H,31,33)/t26-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486373 (3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyridin-...) Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C26H22F3N3O4S/c1-26(9-10-37(34,35)15-26)31-24(33)17-5-7-20-21(16-3-2-4-19(11-16)36-25(28)29)14-32(22(20)12-17)23-8-6-18(27)13-30-23/h2-8,11-14,25H,9-10,15H2,1H3,(H,31,33)/t26-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486408 (3-[3-(difluoromethoxy)phenyl]-N- (1,1-dioxidotetra...) Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C26H21F3N2O4S/c27-18-5-7-20(8-6-18)31-14-23(16-2-1-3-21(12-16)35-26(28)29)22-9-4-17(13-24(22)31)25(32)30-19-10-11-36(33,34)15-19/h1-9,12-14,19,26H,10-11,15H2,(H,30,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486387 (3-(3-(difluoromethoxy)phenyl)-N-(1,1- dioxidotetra...) Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ncc(F)cn2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C24H19F3N4O4S/c25-16-10-28-24(29-11-16)31-12-20(14-2-1-3-18(8-14)35-23(26)27)19-5-4-15(9-21(19)31)22(32)30-17-6-7-36(33,34)13-17/h1-5,8-12,17,23H,6-7,13H2,(H,30,32)/t17-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486385 (3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidi...) Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C25H21F3N4O4S/c1-25(7-8-37(34,35)14-25)31-22(33)16-5-6-19-20(15-3-2-4-18(9-15)36-23(27)28)13-32(21(19)10-16)24-29-11-17(26)12-30-24/h2-6,9-13,23H,7-8,14H2,1H3,(H,31,33)/t25-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486377 (3-(3-(difluoromethoxy)phenyl)-N-(1,1- dioxidotetra...) Show SMILES FC(F)Oc1cccc(c1)-c1cn(-c2ccc(F)cn2)c2cc(ccc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C25H20F3N3O4S/c26-17-5-7-23(29-12-17)31-13-21(15-2-1-3-19(10-15)35-25(27)28)20-6-4-16(11-22(20)31)24(32)30-18-8-9-36(33,34)14-18/h1-7,10-13,18,25H,8-9,14H2,(H,30,32)/t18-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486374 (3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...) Show SMILES Fc1ccc(nc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C27H24FN3O3S/c28-21-7-9-26(29-14-21)31-15-24(19-3-1-2-18(12-19)17-4-5-17)23-8-6-20(13-25(23)31)27(32)30-22-10-11-35(33,34)16-22/h1-3,6-9,12-15,17,22H,4-5,10-11,16H2,(H,30,32)/t22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486416 (3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C28H25FN2O3S/c29-22-7-9-24(10-8-22)31-16-26(20-3-1-2-19(14-20)18-4-5-18)25-11-6-21(15-27(25)31)28(32)30-23-12-13-35(33,34)17-23/h1-3,6-11,14-16,18,23H,4-5,12-13,17H2,(H,30,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486382 (3-(3-cyclopropylphenyl)-1-(5- fluoropyrimidin-2-yl...) Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(c1)C1CC1 |r| Show InChI InChI=1S/C27H25FN4O3S/c1-27(9-10-36(34,35)16-27)31-25(33)20-7-8-22-23(19-4-2-3-18(11-19)17-5-6-17)15-32(24(22)12-20)26-29-13-21(28)14-30-26/h2-4,7-8,11-15,17H,5-6,9-10,16H2,1H3,(H,31,33)/t27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486394 (US10947222, Example 26-A) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C28H25FN2O3S/c29-22-7-9-24(10-8-22)31-16-26(20-3-1-2-19(14-20)18-4-5-18)25-11-6-21(15-27(25)31)28(32)30-23-12-13-35(33,34)17-23/h1-3,6-11,14-16,18,23H,4-5,12-13,17H2,(H,30,32)/t23-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486401 (US10947222, Example 32 | methyl 3-{6-[(1,1- dioxid...) Show SMILES COC(=O)c1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C27H23FN2O5S/c1-35-27(32)19-4-2-3-17(13-19)24-15-30(22-8-6-20(28)7-9-22)25-14-18(5-10-23(24)25)26(31)29-21-11-12-36(33,34)16-21/h2-10,13-15,21H,11-12,16H2,1H3,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486384 (3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...) Show SMILES Fc1cnc(nc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C26H23FN4O3S/c27-20-12-28-26(29-13-20)31-14-23(18-3-1-2-17(10-18)16-4-5-16)22-7-6-19(11-24(22)31)25(32)30-21-8-9-35(33,34)15-21/h1-3,6-7,10-14,16,21H,4-5,8-9,15H2,(H,30,32)/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486402 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES COc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C26H23FN2O4S/c1-33-22-4-2-3-17(13-22)24-15-29(21-8-6-19(27)7-9-21)25-14-18(5-10-23(24)25)26(30)28-20-11-12-34(31,32)16-20/h2-10,13-15,20H,11-12,16H2,1H3,(H,28,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486354 (3-(2-chlorophenyl)-1-(4-fluorophenyl)- N-(3-methyl...) Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| Show InChI InChI=1S/C26H22ClFN2O3S/c1-26(12-13-34(32,33)16-26)29-25(31)17-6-11-21-22(20-4-2-3-5-23(20)27)15-30(24(21)14-17)19-9-7-18(28)8-10-19/h2-11,14-15H,12-13,16H2,1H3,(H,29,31)/t26-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486355 (3-(2-chlorophenyl)-1-(4-fluorophenyl)- N-(3-methyl...) Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl |r| Show InChI InChI=1S/C26H22ClFN2O3S/c1-26(12-13-34(32,33)16-26)29-25(31)17-6-11-21-22(20-4-2-3-5-23(20)27)15-30(24(21)14-17)19-9-7-18(28)8-10-19/h2-11,14-15H,12-13,16H2,1H3,(H,29,31)/t26-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486352 (US10947222, Example 1) Show SMILES CC1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)-c1ccccc1Cl Show InChI InChI=1S/C26H22ClFN2O3S/c1-26(12-13-34(32,33)16-26)29-25(31)17-6-11-21-22(20-4-2-3-5-23(20)27)15-30(24(21)14-17)19-9-7-18(28)8-10-19/h2-11,14-15H,12-13,16H2,1H3,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486379 (3-(2-chlorophenyl)-1-(5-fluoropyridin- 2-yl)-N-(3-...) Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl |r| Show InChI InChI=1S/C25H21ClFN3O3S/c1-25(10-11-34(32,33)15-25)29-24(31)16-6-8-19-20(18-4-2-3-5-21(18)26)14-30(22(19)12-16)23-9-7-17(27)13-28-23/h2-9,12-14H,10-11,15H2,1H3,(H,29,31)/t25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486403 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Cc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C26H23FN2O3S/c1-17-3-2-4-18(13-17)24-15-29(22-8-6-20(27)7-9-22)25-14-19(5-10-23(24)25)26(30)28-21-11-12-33(31,32)16-21/h2-10,13-15,21H,11-12,16H2,1H3,(H,28,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486415 (3-(3-cyanophenyl)-N-(1,1- dioxidotetrahydrothiophe...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C#N)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C26H20FN3O3S/c27-20-5-7-22(8-6-20)30-15-24(18-3-1-2-17(12-18)14-28)23-9-4-19(13-25(23)30)26(31)29-21-10-11-34(32,33)16-21/h1-9,12-13,15,21H,10-11,16H2,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486430 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(OC(F)(F)F)c2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C26H20F4N2O4S/c27-18-5-7-20(8-6-18)32-14-23(16-2-1-3-21(12-16)36-26(28,29)30)22-9-4-17(13-24(22)32)25(33)31-19-10-11-37(34,35)15-19/h1-9,12-14,19H,10-11,15H2,(H,31,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486407 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)-n2cccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C28H23FN4O3S/c29-21-6-8-23(9-7-21)32-17-26(19-3-1-4-24(15-19)33-13-2-12-30-33)25-10-5-20(16-27(25)32)28(34)31-22-11-14-37(35,36)18-22/h1-10,12-13,15-17,22H,11,14,18H2,(H,31,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486378 (3-(2-chlorophenyl)-1-(5-fluoropyridin- 2-yl)-N-(3-...) Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl |r| Show InChI InChI=1S/C25H21ClFN3O3S/c1-25(10-11-34(32,33)15-25)29-24(31)16-6-8-19-20(18-4-2-3-5-21(18)26)14-30(22(19)12-16)23-9-7-17(27)13-28-23/h2-9,12-14H,10-11,15H2,1H3,(H,29,31)/t25-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486397 (US10947222, Example 28) Show SMILES Cc1c(-c2cccc(OC(F)F)c2)c2ccc(cc2n1-c1ccc(F)cc1)C(=O)NC1(C)CCS(=O)(=O)C1 Show InChI InChI=1S/C28H25F3N2O4S/c1-17-25(18-4-3-5-22(14-18)37-27(30)31)23-11-6-19(26(34)32-28(2)12-13-38(35,36)16-28)15-24(23)33(17)21-9-7-20(29)8-10-21/h3-11,14-15,27H,12-13,16H2,1-2H3,(H,32,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486399 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)C(F)(F)F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C26H20F4N2O3S/c27-19-5-7-21(8-6-19)32-14-23(16-2-1-3-18(12-16)26(28,29)30)22-9-4-17(13-24(22)32)25(33)31-20-10-11-36(34,35)15-20/h1-9,12-14,20H,10-11,15H2,(H,31,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486414 (3-(2,3-dichlorophenyl)-N-(1,1- dioxidotetrahydroth...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(Cl)c2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H19Cl2FN2O3S/c26-22-3-1-2-20(24(22)27)21-13-30(18-7-5-16(28)6-8-18)23-12-15(4-9-19(21)23)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486410 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-3-(2-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H20F2N2O3S/c26-17-6-8-19(9-7-17)29-14-22(20-3-1-2-4-23(20)27)21-10-5-16(13-24(21)29)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486400 (3-(3-chlorophenyl)-N-(1,1- dioxidotetrahydrothioph...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(Cl)c2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H20ClFN2O3S/c26-18-3-1-2-16(12-18)23-14-29(21-7-5-19(27)6-8-21)24-13-17(4-9-22(23)24)25(30)28-20-10-11-33(31,32)15-20/h1-9,12-14,20H,10-11,15H2,(H,28,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486381 (3-(2-chlorophenyl)-1-(5- fluoropyrimidin-2-yl)-N-(...) Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1ccccc1Cl |r| Show InChI InChI=1S/C24H20ClFN4O3S/c1-24(8-9-34(32,33)14-24)29-22(31)15-6-7-18-19(17-4-2-3-5-20(17)25)13-30(21(18)10-15)23-27-11-16(26)12-28-23/h2-7,10-13H,8-9,14H2,1H3,(H,29,31)/t24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486358 (US10947222, Example 2-B) Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C25H20ClFN2O3S/c26-23-4-2-1-3-20(23)22-14-29(19-8-6-17(27)7-9-19)24-13-16(5-10-21(22)24)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)/t18-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486418 (3-(2,6-difluorophenyl)-N-(1,1- dioxidotetrahydroth...) Show SMILES Fc1ccc(cc1)-n1cc(-c2c(F)cccc2F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 |(6.35,-6.37,;5.87,-4.91,;6.9,-3.76,;6.43,-2.3,;4.92,-1.98,;3.89,-3.12,;4.37,-4.59,;4.45,-.51,;5.35,.73,;4.45,1.98,;4.92,3.44,;3.89,4.59,;2.38,4.27,;4.37,6.05,;5.87,6.37,;6.9,5.23,;6.43,3.76,;7.46,2.62,;2.98,1.5,;1.65,2.27,;.31,1.5,;.31,-.04,;1.65,-.81,;2.98,-.04,;-1.02,-.81,;-1.02,-2.35,;-2.35,-.04,;-3.69,-.81,;-3.85,-2.34,;-5.35,-2.66,;-6.12,-1.33,;-7.46,-.56,;-7.46,-2.1,;-5.09,-.18,)| Show InChI InChI=1S/C25H19F3N2O3S/c26-16-5-7-18(8-6-16)30-13-20(24-21(27)2-1-3-22(24)28)19-9-4-15(12-23(19)30)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486413 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H21FN2O3S/c26-19-7-9-21(10-8-19)28-15-23(17-4-2-1-3-5-17)22-11-6-18(14-24(22)28)25(29)27-20-12-13-32(30,31)16-20/h1-11,14-15,20H,12-13,16H2,(H,27,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486405 (3-biphenyl-3-yl-N-(1,1- dioxidotetrahydrothiophen-...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(c2)-c2ccccc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C31H25FN2O3S/c32-25-10-12-27(13-11-25)34-19-29(23-8-4-7-22(17-23)21-5-2-1-3-6-21)28-14-9-24(18-30(28)34)31(35)33-26-15-16-38(36,37)20-26/h1-14,17-19,26H,15-16,20H2,(H,33,35)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486356 (US10947222, Example 2) Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H20ClFN2O3S/c26-23-4-2-1-3-20(23)22-14-29(19-8-6-17(27)7-9-19)24-13-16(5-10-21(22)24)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486380 (3-(2-chlorophenyl)-1-(5- fluoropyrimidin-2-yl)-N-(...) Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1ccccc1Cl |r| Show InChI InChI=1S/C24H20ClFN4O3S/c1-24(8-9-34(32,33)14-24)29-22(31)15-6-7-18-19(17-4-2-3-5-20(17)25)13-30(21(18)10-15)23-27-11-16(26)12-28-23/h2-7,10-13H,8-9,14H2,1H3,(H,29,31)/t24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486411 (3-(3,5-dichlorophenyl)-N-(1,1- dioxidotetrahydroth...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cc(Cl)cc(Cl)c2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H19Cl2FN2O3S/c26-17-9-16(10-18(27)12-17)23-13-30(21-4-2-19(28)3-5-21)24-11-15(1-6-22(23)24)25(31)29-20-7-8-34(32,33)14-20/h1-6,9-13,20H,7-8,14H2,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486404 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-3-(3-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccc(F)c2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H20F2N2O3S/c26-18-5-7-21(8-6-18)29-14-23(16-2-1-3-19(27)12-16)22-9-4-17(13-24(22)29)25(30)28-20-10-11-33(31,32)15-20/h1-9,12-14,20H,10-11,15H2,(H,28,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486422 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Cn1ccc2cc(ccc12)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C28H24FN3O3S/c1-31-12-10-19-14-18(3-9-26(19)31)25-16-32(23-6-4-21(29)5-7-23)27-15-20(2-8-24(25)27)28(33)30-22-11-13-36(34,35)17-22/h2-10,12,14-16,22H,11,13,17H2,1H3,(H,30,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486412 (3-[2-(difluoromethoxy)phenyl]-N- (1,1-dioxidotetra...) Show SMILES FC(F)Oc1ccccc1-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C26H21F3N2O4S/c27-17-6-8-19(9-7-17)31-14-22(21-3-1-2-4-24(21)35-26(28)29)20-10-5-16(13-23(20)31)25(32)30-18-11-12-36(33,34)15-18/h1-10,13-14,18,26H,11-12,15H2,(H,30,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486391 (N-(1,1- dioxidotetrahydrothiophen-3- yl)-1-(4-fluo...) Show SMILES Cc1ccnc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H22FN3O3S/c1-16-8-10-27-23(12-16)22-14-29(20-5-3-18(26)4-6-20)24-13-17(2-7-21(22)24)25(30)28-19-9-11-33(31,32)15-19/h2-8,10,12-14,19H,9,11,15H2,1H3,(H,28,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486428 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2ccc(cc2)-n2cccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C28H23FN4O3S/c29-21-5-9-23(10-6-21)32-17-26(19-2-7-24(8-3-19)33-14-1-13-30-33)25-11-4-20(16-27(25)32)28(34)31-22-12-15-37(35,36)18-22/h1-11,13-14,16-17,22H,12,15,18H2,(H,31,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486424 (N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluor...) Show SMILES Fc1ccc(cc1)-n1cc(-c2cccnc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C24H20FN3O3S/c25-18-4-6-20(7-5-18)28-14-22(17-2-1-10-26-13-17)21-8-3-16(12-23(21)28)24(29)27-19-9-11-32(30,31)15-19/h1-8,10,12-14,19H,9,11,15H2,(H,27,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486419 (3-(2-chloro-6-fluorophenyl)-N- (1,1-dioxidotetrahy...) Show SMILES Fc1ccc(cc1)-n1cc(-c2c(F)cccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 |(6.35,-6.37,;5.87,-4.91,;6.9,-3.76,;6.43,-2.3,;4.92,-1.98,;3.89,-3.12,;4.37,-4.59,;4.45,-.51,;5.35,.73,;4.45,1.98,;4.92,3.44,;6.43,3.76,;7.46,2.62,;6.9,5.23,;5.87,6.37,;4.37,6.05,;3.89,4.59,;2.38,4.27,;2.98,1.5,;1.65,2.27,;.31,1.5,;.31,-.04,;1.65,-.81,;2.98,-.04,;-1.02,-.81,;-1.02,-2.35,;-2.35,-.04,;-3.69,-.81,;-3.85,-2.34,;-5.35,-2.66,;-6.12,-1.33,;-7.46,-.56,;-7.46,-2.1,;-5.09,-.18,)| Show InChI InChI=1S/C25H19ClF2N2O3S/c26-21-2-1-3-22(28)24(21)20-13-30(18-7-5-16(27)6-8-18)23-12-15(4-9-19(20)23)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	155	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486406 (3-[3-(acetylamino)phenyl]-N-(1,1- dioxidotetrahydr...) Show SMILES CC(=O)Nc1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C27H24FN3O4S/c1-17(32)29-21-4-2-3-18(13-21)25-15-31(23-8-6-20(28)7-9-23)26-14-19(5-10-24(25)26)27(33)30-22-11-12-36(34,35)16-22/h2-10,13-15,22H,11-12,16H2,1H3,(H,29,32)(H,30,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	163	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486357 (US10947222, Example 2-A) Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| Show InChI InChI=1S/C25H20ClFN2O3S/c26-23-4-2-1-3-20(23)22-14-29(19-8-6-17(27)7-9-19)24-13-16(5-10-21(22)24)25(30)28-18-11-12-33(31,32)15-18/h1-10,13-14,18H,11-12,15H2,(H,28,30)/t18-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	171	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486432 (US10947222, Example 60 | methyl 4-{6-[(1,1- dioxid...) Show SMILES COC(=O)c1cc(cs1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 Show InChI InChI=1S/C25H21FN2O5S2/c1-33-25(30)23-11-16(13-34-23)21-12-28(19-5-3-17(26)4-6-19)22-10-15(2-7-20(21)22)24(29)27-18-8-9-35(31,32)14-18/h2-7,10-13,18H,8-9,14H2,1H3,(H,27,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 72 total )  |  Next  |  Last  >>

Jump to: