Compile Data Set for Download or QSAR

Found 227 hits Enz. Inhib. hit(s) with all data for entry = 9812   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490331 (US10968215, Compound 153) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCOCC2)c1C)-c1ccn[nH]1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.15	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490276 (US10968215, Compound 152) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCOCC2)c1C)-c1cn[nH]c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.65	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490279 (US10968215, Compound 156) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(N)nc1 Show InChI InChI=1S/C31H36F3N7O3/c1-18-13-26(44-4)24(30(43)38-18)16-37-29(42)23-14-25-22(21-5-6-27(35)36-15-21)7-8-41(25)28(19(23)2)20(3)40-11-9-39(10-12-40)17-31(32,33)34/h5-8,13-15,20H,9-12,16-17H2,1-4H3,(H2,35,36)(H,37,42)(H,38,43)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490279 (US10968215, Compound 156) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(N)nc1 Show InChI InChI=1S/C31H36F3N7O3/c1-18-13-26(44-4)24(30(43)38-18)16-37-29(42)23-14-25-22(21-5-6-27(35)36-15-21)7-8-41(25)28(19(23)2)20(3)40-11-9-39(10-12-40)17-31(32,33)34/h5-8,13-15,20H,9-12,16-17H2,1-4H3,(H2,35,36)(H,37,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.81	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490286 (US10968215, Compound 163) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1cccnc1C Show InChI InChI=1S/C32H37F3N6O3/c1-19-15-28(44-5)26(31(43)38-19)17-37-30(42)25-16-27-24(23-7-6-9-36-21(23)3)8-10-41(27)29(20(25)2)22(4)40-13-11-39(12-14-40)18-32(33,34)35/h6-10,15-16,22H,11-14,17-18H2,1-5H3,(H,37,42)(H,38,43)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490288 (US10968215, Compound 165) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccnc(Cl)c1 Show InChI InChI=1S/C31H34ClF3N6O3/c1-18-13-26(44-4)24(30(43)38-18)16-37-29(42)23-15-25-22(21-5-7-36-27(32)14-21)6-8-41(25)28(19(23)2)20(3)40-11-9-39(10-12-40)17-31(33,34)35/h5-8,13-15,20H,9-12,16-17H2,1-4H3,(H,37,42)(H,38,43)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490278 (US10968215, Compound 155) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccn[nH]1 Show InChI InChI=1S/C29H34F3N7O3/c1-17-13-25(42-4)22(28(41)35-17)15-33-27(40)21-14-24-20(23-5-7-34-36-23)6-8-39(24)26(18(21)2)19(3)38-11-9-37(10-12-38)16-29(30,31)32/h5-8,13-14,19H,9-12,15-16H2,1-4H3,(H,33,40)(H,34,36)(H,35,41)/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490280 (US10968215, Compound 157) Show SMILES CC(N1CCN(CC(F)(F)F)CC1)c1c(C)c(cc2c(ccn12)-c1ccc(N)nc1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490281 (US10968215, Compound 158) Show SMILES C[C@H](N1CCN(CC(F)(F)F)CC1)c1c(C)c(cc2c(ccn12)-c1ccc(N)nc1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C31H36F3N7O2/c1-18-13-19(2)38-30(43)25(18)16-37-29(42)24-14-26-23(22-5-6-27(35)36-15-22)7-8-41(26)28(20(24)3)21(4)40-11-9-39(10-12-40)17-31(32,33)34/h5-8,13-15,21H,9-12,16-17H2,1-4H3,(H2,35,36)(H,37,42)(H,38,43)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490281 (US10968215, Compound 158) Show SMILES C[C@H](N1CCN(CC(F)(F)F)CC1)c1c(C)c(cc2c(ccn12)-c1ccc(N)nc1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C31H36F3N7O2/c1-18-13-19(2)38-30(43)25(18)16-37-29(42)24-14-26-23(22-5-6-27(35)36-15-22)7-8-41(26)28(20(24)3)21(4)40-11-9-39(10-12-40)17-31(32,33)34/h5-8,13-15,21H,9-12,16-17H2,1-4H3,(H2,35,36)(H,37,42)(H,38,43)/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490282 (US10968215, Compound 159) Show SMILES COc1cc(C)c(CNC(=O)c2cc3c(ccn3c([C@H](C)N3CCN(CC(F)(F)F)CC3)c2C)-c2c(C)noc2C)c(=O)[nH]1 |wU:19.20,(3.33,-9.14,;4.67,-8.37,;4.67,-6.83,;3.33,-6.06,;3.33,-4.52,;2,-3.75,;4.67,-3.75,;4.67,-2.21,;3.33,-1.44,;3.33,.1,;4.67,.87,;2,.87,;.67,.1,;-.67,.87,;-2.13,.4,;-3.04,1.64,;-2.13,2.89,;-.67,2.41,;.67,3.18,;.67,4.72,;2,5.49,;-.67,5.49,;-2,4.72,;-3.33,5.49,;-3.33,7.03,;-4.67,7.8,;-6,7.03,;-7.34,6.26,;-6.77,8.37,;-5.23,5.7,;-2,7.8,;-.67,7.03,;2,2.41,;3.33,3.18,;-2.61,-1.07,;-4.07,-1.54,;-5.32,-.64,;-4.07,-3.08,;-2.61,-3.56,;-1.7,-2.31,;-.16,-2.31,;6,-4.52,;7.34,-3.75,;6,-6.06,)| Show InChI InChI=1S/C31H37F3N6O4/c1-17-13-26(43-6)36-30(42)24(17)15-35-29(41)23-14-25-22(27-19(3)37-44-21(27)5)7-8-40(25)28(18(23)2)20(4)39-11-9-38(10-12-39)16-31(32,33)34/h7-8,13-14,20H,9-12,15-16H2,1-6H3,(H,35,41)(H,36,42)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490282 (US10968215, Compound 159) Show SMILES COc1cc(C)c(CNC(=O)c2cc3c(ccn3c([C@H](C)N3CCN(CC(F)(F)F)CC3)c2C)-c2c(C)noc2C)c(=O)[nH]1 |wU:19.20,(3.33,-9.14,;4.67,-8.37,;4.67,-6.83,;3.33,-6.06,;3.33,-4.52,;2,-3.75,;4.67,-3.75,;4.67,-2.21,;3.33,-1.44,;3.33,.1,;4.67,.87,;2,.87,;.67,.1,;-.67,.87,;-2.13,.4,;-3.04,1.64,;-2.13,2.89,;-.67,2.41,;.67,3.18,;.67,4.72,;2,5.49,;-.67,5.49,;-2,4.72,;-3.33,5.49,;-3.33,7.03,;-4.67,7.8,;-6,7.03,;-7.34,6.26,;-6.77,8.37,;-5.23,5.7,;-2,7.8,;-.67,7.03,;2,2.41,;3.33,3.18,;-2.61,-1.07,;-4.07,-1.54,;-5.32,-.64,;-4.07,-3.08,;-2.61,-3.56,;-1.7,-2.31,;-.16,-2.31,;6,-4.52,;7.34,-3.75,;6,-6.06,)| Show InChI InChI=1S/C31H37F3N6O4/c1-17-13-26(43-6)36-30(42)24(17)15-35-29(41)23-14-25-22(27-19(3)37-44-21(27)5)7-8-40(25)28(18(23)2)20(4)39-11-9-38(10-12-39)16-31(32,33)34/h7-8,13-14,20H,9-12,15-16H2,1-6H3,(H,35,41)(H,36,42)/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490283 (US10968215, Compound 160) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(F)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490283 (US10968215, Compound 160) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490284 (US10968215, Compound 161) Show SMILES CNc1ccc(cn1)-c1ccn2c(C(C)N3CCN(CC(F)(F)F)CC3)c(C)c(cc12)C(=O)NCc1c(OC)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490285 (US10968215, Compound 162) Show SMILES CNc1ccc(cn1)-c1ccn2c([C@H](C)N3CCN(CC(F)(F)F)CC3)c(C)c(cc12)C(=O)NCc1c(OC)cc(C)[nH]c1=O Show InChI InChI=1S/C32H38F3N7O3/c1-19-14-27(45-5)25(31(44)39-19)17-38-30(43)24-15-26-23(22-6-7-28(36-4)37-16-22)8-9-42(26)29(20(24)2)21(3)41-12-10-40(11-13-41)18-32(33,34)35/h6-9,14-16,21H,10-13,17-18H2,1-5H3,(H,36,37)(H,38,43)(H,39,44)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490289 (US10968215, Compound 166) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccnc(c1)N(C)C Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490293 (US10968215, Compound 170) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1cc(C)nc(C)c1 Show InChI InChI=1S/C33H39F3N6O3/c1-19-13-24(14-20(2)38-19)25-7-8-42-28(25)16-26(31(43)37-17-27-29(45-6)15-21(3)39-32(27)44)22(4)30(42)23(5)41-11-9-40(10-12-41)18-33(34,35)36/h7-8,13-16,23H,9-12,17-18H2,1-6H3,(H,37,43)(H,39,44)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490294 (US10968215, Compound 171) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(C)nc1C Show InChI InChI=1S/C33H39F3N6O3/c1-19-7-8-24(22(4)38-19)25-9-10-42-28(25)16-26(31(43)37-17-27-29(45-6)15-20(2)39-32(27)44)21(3)30(42)23(5)41-13-11-40(12-14-41)18-33(34,35)36/h7-10,15-16,23H,11-14,17-18H2,1-6H3,(H,37,43)(H,39,44)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490296 (US10968215, Compound 173) Show SMILES CNc1cc(ccn1)-c1ccn2c(C(C)N3CCN(CC(F)(F)F)CC3)c(C)c(cc12)C(=O)NCc1c(OC)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490300 (US10968215, Compound 177) Show SMILES CCCc1cc(C)nc(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(N)nc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490303 (US10968215, Compound 180) Show SMILES CC(C)CN1CCc2c(C1)c(C)nc(=O)c2CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(N)nc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490306 (US10968215, Compound 183 | US10968215, Compound 18...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)OCc2nccs2)c1C)-c1ccn[nH]1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490306 (US10968215, Compound 183 | US10968215, Compound 18...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)OCc2nccs2)c1C)-c1ccn[nH]1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490310 (US10968215, Compound 187) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1cnc(C)nc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490314 (US10968215, Compound 191 | US10968215, Compound 20...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(N(C)C2CCN(CC(F)(F)F)CC2)c1C)-c1ccn[nH]1 Show InChI InChI=1S/C29H34F3N7O3/c1-17-13-25(42-4)22(27(41)35-17)15-33-26(40)21-14-24-20(23-5-9-34-36-23)8-12-39(24)28(18(21)2)37(3)19-6-10-38(11-7-19)16-29(30,31)32/h5,8-9,12-14,19H,6-7,10-11,15-16H2,1-4H3,(H,33,40)(H,34,36)(H,35,41)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490316 (US10968215, Compound 193 | US10968215, Compound 20...) Show SMILES CCN(C1CCN(CC(F)(F)F)CC1)c1c(C)c(cc2c(ncn12)-c1ccnc(c1)N(C)C)C(=O)NCc1c(OC)cc(C)[nH]c1=O Show InChI InChI=1S/C33H41F3N8O3/c1-7-43(23-9-12-42(13-10-23)18-33(34,35)36)32-21(3)24(30(45)38-17-25-27(47-6)14-20(2)40-31(25)46)16-26-29(39-19-44(26)32)22-8-11-37-28(15-22)41(4)5/h8,11,14-16,19,23H,7,9-10,12-13,17-18H2,1-6H3,(H,38,45)(H,40,46)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490317 (US10968215, Compound 194 | US10968215, Compound 20...) Show SMILES CCc1cc(ccn1)-c1ccn2c(C(C)N3CCN(CC(F)(F)F)CC3)c(C)c(cc12)C(=O)NCc1c(OC)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490319 (US10968215, Compound 196 | US10968215, Compound 20...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccnc2NCCc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490320 ((S)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridi...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccnc2NCCc12 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490321 ((R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridi...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccnc2NCCc12 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490322 (US10968215, Compound 199) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(C)nn1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490323 ((S)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridi...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(C)nn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490324 ((R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridi...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(C)nn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490314 (US10968215, Compound 191 | US10968215, Compound 20...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(N(C)C2CCN(CC(F)(F)F)CC2)c1C)-c1ccn[nH]1 Show InChI InChI=1S/C29H34F3N7O3/c1-17-13-25(42-4)22(27(41)35-17)15-33-26(40)21-14-24-20(23-5-9-34-36-23)8-12-39(24)28(18(21)2)37(3)19-6-10-38(11-7-19)16-29(30,31)32/h5,8-9,12-14,19H,6-7,10-11,15-16H2,1-4H3,(H,33,40)(H,34,36)(H,35,41)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490315 (US10968215, Compound 192 | US10968215, Compound 20...) Show SMILES CCN(C1CCN(CC(F)(F)F)CC1)c1c(C)c(cc2c(ccn12)-c1ccnc(c1)N(C)C)C(=O)NCc1c(OC)cc(C)[nH]c1=O Show InChI InChI=1S/C34H42F3N7O3/c1-7-43(24-9-13-42(14-10-24)20-34(35,36)37)33-22(3)26(31(45)39-19-27-29(47-6)16-21(2)40-32(27)46)18-28-25(11-15-44(28)33)23-8-12-38-30(17-23)41(4)5/h8,11-12,15-18,24H,7,9-10,13-14,19-20H2,1-6H3,(H,39,45)(H,40,46)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490316 (US10968215, Compound 193 | US10968215, Compound 20...) Show SMILES CCN(C1CCN(CC(F)(F)F)CC1)c1c(C)c(cc2c(ncn12)-c1ccnc(c1)N(C)C)C(=O)NCc1c(OC)cc(C)[nH]c1=O Show InChI InChI=1S/C33H41F3N8O3/c1-7-43(23-9-12-42(13-10-23)18-33(34,35)36)32-21(3)24(30(45)38-17-25-27(47-6)14-20(2)40-31(25)46)16-26-29(39-19-44(26)32)22-8-11-37-28(15-22)41(4)5/h8,11,14-16,19,23H,7,9-10,12-13,17-18H2,1-6H3,(H,38,45)(H,40,46)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490318 (US10968215, Compound 195 | US10968215, Compound 20...) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccnc(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490140 (US10968215, Compound 18) Show SMILES CC(OCc1nccs1)c1c(C)c(cc2cccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490143 (US10968215, Compound 21) Show SMILES CC(OCc1ccnn1C)c1c(C)c(cc2cccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490143 (US10968215, Compound 21) Show SMILES CC(OCc1ccnn1C)c1c(C)c(cc2cccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490147 (US10968215, Compound 25) Show SMILES CC(c1ccccc1)c1c(C)c(cc2cccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490148 (US10968215, Compound 26) Show SMILES CC(N1CCOCC1)c1c(C)c(cc2cccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490148 (US10968215, Compound 26) Show SMILES CC(N1CCOCC1)c1c(C)c(cc2cccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490150 (US10968215, Compound 27) Show SMILES CC(N1CCOCC1)c1c(C)c(cc2c(Cl)ccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM490150 (US10968215, Compound 27) Show SMILES CC(N1CCOCC1)c1c(C)c(cc2c(Cl)ccn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490151 (US10968215, Compound 28) Show SMILES CC(N1CCOCC1)c1c(C)c(cc2cc(Cl)cn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490153 (US10968215, Compound 30) Show SMILES CC(Oc1ccc(cc1)N(C)C)c1c(C)c(cc2cc(Br)cn12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490154 (US10968215, Compound 31) Show SMILES CC(N1CCOCC1)c1c(C)c(cc2cc(cn12)-c1ccc2OCOc2c1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM490156 (US10968215, Compound 33 | US10968215, Compound 35) Show SMILES CC(N1CCOCC1)c1c(C)c(cc2cc(cn12)-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...				US Patent US10968215 (2021) BindingDB Entry DOI: 10.7270/Q21C210W
					More data for this Ligand-Target Pair

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