Compile Data Set for Download or QSAR

Found 67 hits Enz. Inhib. hit(s) with all data for entry = 9845   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416666 ((2S)-2-Methoxy-2-[3-methoxy-5-(trifluoromethoxy)ph...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C21H22F3N7O4S/c1-33-14-8-12(9-15(10-14)35-21(22,23)24)17(34-2)18(32)27-20-30-29-19(36-20)26-13-5-7-31(11-13)16-4-3-6-25-28-16/h3-4,6,8-10,13,17H,5,7,11H2,1-2H3,(H,26,29)(H,27,30,32)/t13-,17+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.11	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416667 ((2R)-2-Methoxy-2-[3-methoxy-5-(trifluoromethoxy)ph...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C21H22F3N7O4S/c1-33-14-8-12(9-15(10-14)35-21(22,23)24)17(34-2)18(32)27-20-30-29-19(36-20)26-13-5-7-31(11-13)16-4-3-6-25-28-16/h3-4,6,8-10,13,17H,5,7,11H2,1-2H3,(H,26,29)(H,27,30,32)/t13-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.35	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416687 ((2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416687 ((2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416638 ((2S)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C22H25FN8O2S/c1-33-19(14-4-2-5-17(10-14)31-11-15(23)12-31)20(32)26-22-29-28-21(34-22)25-16-7-9-30(13-16)18-6-3-8-24-27-18/h2-6,8,10,15-16,19H,7,9,11-13H2,1H3,(H,25,28)(H,26,29,32)/t16-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20.6	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416681 ((2R)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)C1COC1 |r| Show InChI InChI=1S/C22H25N7O3S/c1-31-19(15-5-2-4-14(10-15)16-12-32-13-16)20(30)25-22-28-27-21(33-22)24-17-7-9-29(11-17)18-6-3-8-23-26-18/h2-6,8,10,16-17,19H,7,9,11-13H2,1H3,(H,24,27)(H,25,28,30)/t17-,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22.6	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492979 (2-(3,5-dimethoxyphenyl)-N-[5-[[(3R)-1-(6-fluoropyr...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C21H24FN7O4S/c1-31-14-8-12(9-15(10-14)32-2)18(33-3)19(30)24-21-28-27-20(34-21)23-13-6-7-29(11-13)17-5-4-16(22)25-26-17/h4-5,8-10,13,18H,6-7,11H2,1-3H3,(H,23,27)(H,24,28,30)/t13-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23.5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416677 ((2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C20H24N8O4S/c1-30-14-8-12(9-15(10-14)31-2)16(32-3)17(29)24-20-27-26-19(33-20)23-13-4-7-28(11-13)18-21-5-6-22-25-18/h5-6,8-10,13,16H,4,7,11H2,1-3H3,(H,23,26)(H,24,27,29)/t13-,16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.2	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416654 ((2S)-2-(3,5-Dimethoxyphenyl)-2-ethoxy-N-[5-[[(3R)-...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C22H27N7O4S/c1-4-33-19(14-10-16(31-2)12-17(11-14)32-3)20(30)25-22-28-27-21(34-22)24-15-7-9-29(13-15)18-6-5-8-23-26-18/h5-6,8,10-12,15,19H,4,7,9,13H2,1-3H3,(H,24,27)(H,25,28,30)/t15-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416652 ((2R)-3-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...) Show SMILES COC[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O3S/c1-30-13-17(14-5-3-6-16(11-14)31-2)19(29)24-21-27-26-20(32-21)23-15-8-10-28(12-15)18-7-4-9-22-25-18/h3-7,9,11,15,17H,8,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,17+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28.8	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416643 ((2S)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C23H28N8O3S/c1-33-18-13-31(14-18)17-6-3-5-15(11-17)20(34-2)21(32)26-23-29-28-22(35-23)25-16-8-10-30(12-16)19-7-4-9-24-27-19/h3-7,9,11,16,18,20H,8,10,12-14H2,1-2H3,(H,25,28)(H,26,29,32)/t16-,20+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.8	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416664 ((2S)-2-[3-(3-Fluoroazetidin-1-yl)-5-methoxy-phenyl...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C23H27FN8O3S/c1-34-18-9-14(8-17(10-18)32-11-15(24)12-32)20(35-2)21(33)27-23-30-29-22(36-23)26-16-5-7-31(13-16)19-4-3-6-25-28-19/h3-4,6,8-10,15-16,20H,5,7,11-13H2,1-2H3,(H,26,29)(H,27,30,33)/t16-,20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.9	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416683 ((2R)-2-Ethoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolid...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C21H22F3N7O3S/c1-2-33-17(13-5-3-6-15(11-13)34-21(22,23)24)18(32)27-20-30-29-19(35-20)26-14-8-10-31(12-14)16-7-4-9-25-28-16/h3-7,9,11,14,17H,2,8,10,12H2,1H3,(H,26,29)(H,27,30,32)/t14-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416650 ((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C22H27N7O4S/c1-13-5-6-18(26-25-13)29-8-7-15(12-29)23-21-27-28-22(34-21)24-20(30)19(33-4)14-9-16(31-2)11-17(10-14)32-3/h5-6,9-11,15,19H,7-8,12H2,1-4H3,(H,23,27)(H,24,28,30)/t15-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42.3	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416669 ((2R)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C24H30N8O3S/c1-15-7-8-20(28-27-15)31-10-9-17(12-31)25-23-29-30-24(36-23)26-22(33)21(35-3)16-5-4-6-18(11-16)32-13-19(14-32)34-2/h4-8,11,17,19,21H,9-10,12-14H2,1-3H3,(H,25,29)(H,26,30,33)/t17-,21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43.8	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492996 (2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-N-[5-[[(3R...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C22H23F3N8O2S/c1-35-18(13-3-2-4-15(9-13)33-11-22(24,25)12-33)19(34)27-21-31-30-20(36-21)26-14-7-8-32(10-14)17-6-5-16(23)28-29-17/h2-6,9,14,18H,7-8,10-12H2,1H3,(H,26,30)(H,27,31,34)/t14-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.7	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416686 ((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416686 ((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416686 ((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416679 ((2R)-[3-(Difluoromethoxy)phenyl]-2-ethoxy-N-[5-[[(...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C21H23F2N7O3S/c1-2-32-17(13-5-3-6-15(11-13)33-19(22)23)18(31)26-21-29-28-20(34-21)25-14-8-10-30(12-14)16-7-4-9-24-27-16/h3-7,9,11,14,17,19H,2,8,10,12H2,1H3,(H,25,28)(H,26,29,31)/t14-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492982 (2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-2-ethoxy-N...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C23H26F2N8O2S/c1-2-35-19(15-5-3-6-17(11-15)33-13-23(24,25)14-33)20(34)28-22-31-30-21(36-22)27-16-8-10-32(12-16)18-7-4-9-26-29-18/h3-7,9,11,16,19H,2,8,10,12-14H2,1H3,(H,27,30)(H,28,31,34)/t16-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416680 ((2S)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)C1COC1 |r| Show InChI InChI=1S/C22H25N7O3S/c1-31-19(15-5-2-4-14(10-15)16-12-32-13-16)20(30)25-22-28-27-21(33-22)24-17-7-9-29(11-17)18-6-3-8-23-26-18/h2-6,8,10,16-17,19H,7,9,11-13H2,1H3,(H,24,27)(H,25,28,30)/t17-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52.6	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416663 ((2R)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C23H27FN8O3S/c1-34-17-12-32(13-17)16-5-3-4-14(10-16)20(35-2)21(33)26-23-30-29-22(36-23)25-15-8-9-31(11-15)19-7-6-18(24)27-28-19/h3-7,10,15,17,20H,8-9,11-13H2,1-2H3,(H,25,29)(H,26,30,33)/t15-,20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	59.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416651 ((2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cc(OC)cc(OC)c1 |r| Show InChI InChI=1S/C22H27N7O4S/c1-13-5-6-18(26-25-13)29-8-7-15(12-29)23-21-27-28-22(34-21)24-20(30)19(33-4)14-9-16(31-2)11-17(10-14)32-3/h5-6,9-11,15,19H,7-8,12H2,1-4H3,(H,23,27)(H,24,28,30)/t15-,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	59.6	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416684 ((2S)-2-[4-Fluoro-3-(trifluoromethoxy)phenyl]-2-met...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C20H19F4N7O3S/c1-33-16(11-4-5-13(21)14(9-11)34-20(22,23)24)17(32)27-19-30-29-18(35-19)26-12-6-8-31(10-12)15-3-2-7-25-28-15/h2-5,7,9,12,16H,6,8,10H2,1H3,(H,26,29)(H,27,30,32)/t12-,16+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416657 ((2S)-2-[4-Fluoro-3-(3-fluoroazetidin-1-yl)phenyl]-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C22H24F2N8O2S/c1-34-19(13-4-5-16(24)17(9-13)32-10-14(23)11-32)20(33)27-22-30-29-21(35-22)26-15-6-8-31(12-15)18-3-2-7-25-28-18/h2-5,7,9,14-15,19H,6,8,10-12H2,1H3,(H,26,29)(H,27,30,33)/t15-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64.9	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416689 ((2R)-2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68.5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416688 ((2S)-2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68.5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416685 ((2R)-2-[4-Fluoro-3-(trifluoromethoxy)phenyl]-2-met...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C20H19F4N7O3S/c1-33-16(11-4-5-13(21)14(9-11)34-20(22,23)24)17(32)27-19-30-29-18(35-19)26-12-6-8-31(10-12)15-3-2-7-25-28-15/h2-5,7,9,12,16H,6,8,10H2,1H3,(H,26,29)(H,27,30,32)/t12-,16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	69.3	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416644 ((2R)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C23H28N8O3S/c1-33-18-13-31(14-18)17-6-3-5-15(11-17)20(34-2)21(32)26-23-29-28-22(35-23)25-16-8-10-30(12-16)19-7-4-9-24-27-19/h3-7,9,11,16,18,20H,8,10,12-14H2,1-2H3,(H,25,28)(H,26,29,32)/t16-,20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	72.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492944 ((2S)-2-[3-(3-Fluoroazetidin-1-yl)-5-methoxy-phenyl...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C23H27FN8O3S/c1-34-18-9-14(8-17(10-18)32-11-15(24)12-32)20(35-2)21(33)27-23-30-29-22(36-23)26-16-5-7-31(13-16)19-4-3-6-25-28-19/h3-4,6,8-10,15-16,20H,5,7,11-13H2,1-2H3,(H,26,29)(H,27,30,33)/t16-,20+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	72.2	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416639 ((2R)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C22H25FN8O2S/c1-33-19(14-4-2-5-17(10-14)31-11-15(23)12-31)20(32)26-22-29-28-21(34-22)25-16-7-9-30(13-16)18-6-3-8-24-27-18/h2-6,8,10,15-16,19H,7,9,11-13H2,1H3,(H,25,28)(H,26,29,32)/t16-,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	72.6	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416671 ((2R)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C22H27N9O3S/c1-33-17-12-31(13-17)16-5-3-4-14(10-16)18(34-2)19(32)26-22-29-28-21(35-22)25-15-6-9-30(11-15)20-23-7-8-24-27-20/h3-5,7-8,10,15,17-18H,6,9,11-13H2,1-2H3,(H,25,28)(H,26,29,32)/t15-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492990 (2-[3-(3-fluoroazetidin-1-yl)phenyl]-2-methoxy-N-[5...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C23H27FN8O2S/c1-14-6-7-19(28-27-14)31-9-8-17(13-31)25-22-29-30-23(35-22)26-21(33)20(34-2)15-4-3-5-18(10-15)32-11-16(24)12-32/h3-7,10,16-17,20H,8-9,11-13H2,1-2H3,(H,25,29)(H,26,30,33)/t17-,20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416675 ((2R)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C21H24FN9O2S/c1-33-17(13-3-2-4-16(9-13)31-10-14(22)11-31)18(32)26-21-29-28-20(34-21)25-15-5-8-30(12-15)19-23-6-7-24-27-19/h2-4,6-7,9,14-15,17H,5,8,10-12H2,1H3,(H,25,28)(H,26,29,32)/t15-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	77.6	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416641 ((2S)-2-[3-(3,3-Difluoroazetidin-1-yl)phenyl]-2-met...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C22H24F2N8O2S/c1-34-18(14-4-2-5-16(10-14)32-12-22(23,24)13-32)19(33)27-21-30-29-20(35-21)26-15-7-9-31(11-15)17-6-3-8-25-28-17/h2-6,8,10,15,18H,7,9,11-13H2,1H3,(H,26,29)(H,27,30,33)/t15-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	87.2	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416673 ((2R)-2-[3-(3,3-Difluoroazetidin-1-yl)phenyl]-2-met...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C21H23F2N9O2S/c1-34-16(13-3-2-4-15(9-13)32-11-21(22,23)12-32)17(33)27-20-30-29-19(35-20)26-14-5-8-31(10-14)18-24-6-7-25-28-18/h2-4,6-7,9,14,16H,5,8,10-12H2,1H3,(H,26,29)(H,27,30,33)/t14-,16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	91.5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416682 ((2S)-2-Ethoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolid...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C21H22F3N7O3S/c1-2-33-17(13-5-3-6-15(11-13)34-21(22,23)24)18(32)27-20-30-29-19(35-20)26-14-8-10-31(12-14)16-7-4-9-25-28-16/h3-7,9,11,14,17H,2,8,10,12H2,1H3,(H,26,29)(H,27,30,32)/t14-,17+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	96.1	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492984 (2-ethoxy-2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C23H27FN8O2S/c1-2-34-20(15-5-3-6-18(11-15)32-12-16(24)13-32)21(33)27-23-30-29-22(35-23)26-17-8-10-31(14-17)19-7-4-9-25-28-19/h3-7,9,11,16-17,20H,2,8,10,12-14H2,1H3,(H,26,29)(H,27,30,33)/t17-,20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	96.8	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416642 ((2R)-2-[3-(3,3-Difluoroazetidin-1-yl)phenyl]-2-met...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C22H24F2N8O2S/c1-34-18(14-4-2-5-16(10-14)32-12-22(23,24)13-32)19(33)27-21-30-29-20(35-21)26-15-7-9-31(11-15)17-6-3-8-25-28-17/h2-6,8,10,15,18H,7,9,11-13H2,1H3,(H,26,29)(H,27,30,33)/t15-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416680 ((2S)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)C1COC1 |r| Show InChI InChI=1S/C22H25N7O3S/c1-31-19(15-5-2-4-14(10-15)16-12-32-13-16)20(30)25-22-28-27-21(33-22)24-17-7-9-29(11-17)18-6-3-8-23-26-18/h2-6,8,10,16-17,19H,7,9,11-13H2,1H3,(H,24,27)(H,25,28,30)/t17-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416653 ((2R)-3-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...) Show SMILES COC[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O3S/c1-30-13-17(14-5-3-6-16(11-14)31-2)19(29)24-21-27-26-20(32-21)23-15-8-10-28(12-15)18-7-4-9-22-25-18/h3-7,9,11,15,17H,8,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492994 (2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-2-methoxy-...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C23H26F2N8O2S/c1-14-6-7-18(29-28-14)32-9-8-16(11-32)26-21-30-31-22(36-21)27-20(34)19(35-2)15-4-3-5-17(10-15)33-12-23(24,25)13-33/h3-7,10,16,19H,8-9,11-13H2,1-2H3,(H,26,30)(H,27,31,34)/t16-,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416688 ((2S)-2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416689 ((2R)-2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC |r| Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416713 ((2R)-3-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...) Show SMILES COC[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C21H25N7O2S/c1-14-8-9-18(25-24-14)28-11-10-16(12-28)22-20-26-27-21(31-20)23-19(29)17(13-30-2)15-6-4-3-5-7-15/h3-9,16-17H,10-13H2,1-2H3,(H,22,26)(H,23,27,29)/t16-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492992 (2-[3-(3,3-difluoroazetidin-1-yl)-4-fluoro-phenyl]-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(c1)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C22H23F3N8O2S/c1-35-18(13-4-5-15(23)16(9-13)33-11-22(24,25)12-33)19(34)28-21-31-30-20(36-21)27-14-6-8-32(10-14)17-3-2-7-26-29-17/h2-5,7,9,14,18H,6,8,10-12H2,1H3,(H,27,30)(H,28,31,34)/t14-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492980 (2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-[[(3R)-1-...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C22H24F2N8O2S/c1-34-19(13-3-2-4-16(9-13)32-10-14(23)11-32)20(33)26-22-30-29-21(35-22)25-15-7-8-31(12-15)18-6-5-17(24)27-28-18/h2-6,9,14-15,19H,7-8,10-12H2,1H3,(H,25,29)(H,26,30,33)/t15-,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM416678 ((2S)-[3-(Difluoromethoxy)phenyl]-2-ethoxy-N-[5-[[(...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C21H23F2N7O3S/c1-2-32-17(13-5-3-6-15(11-13)33-19(22)23)18(31)26-21-29-28-20(34-21)25-14-8-10-30(12-14)16-7-4-9-24-27-16/h3-7,9,11,14,17,19H,2,8,10,12H2,1H3,(H,25,28)(H,26,29,31)/t14-,17+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial [63-669] (Homo sapiens (Human))	BDBM492985 (2-ethoxy-2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1 |r| Show InChI InChI=1S/C23H27FN8O2S/c1-2-34-20(15-5-3-6-18(11-15)32-12-16(24)13-32)21(33)27-23-30-29-22(35-23)26-17-8-10-31(14-17)19-7-4-9-25-28-19/h3-7,9,11,16-17,20H,2,8,10,12-14H2,1H3,(H,26,29)(H,27,30,33)/t17-,20+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10981904 (2021) BindingDB Entry DOI: 10.7270/Q2RR22B3
					More data for this Ligand-Target Pair

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