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Compile Data Set for Download or QSAR

Found 83 hits Enz. Inhib. hit(s) with all data for entry = 9955   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445676
PNG
(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)
Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H18N6O2S/c1-2-25-17-16(18(27)23-19(25)28)26(11-13-6-4-3-5-7-13)15(22-17)10-14-12-24-8-9-29-20(24)21-14/h3-9,12H,2,10-11H2,1H3,(H,23,27,28)
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n/an/a 11n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445677
PNG
(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)
Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N8O2S/c1-3-31-21-20(22(33)27-23(31)34)32(19(26-21)12-17-14-30-10-11-35-24(30)25-17)13-15-4-6-16(7-5-15)18-8-9-29(2)28-18/h4-11,14H,3,12-13H2,1-2H3,(H,27,33,34)
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n/an/a 14n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445685
PNG
(Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17ClN6O2S/c1-2-26-17-16(18(28)24-19(26)29)27(9-12-6-4-3-5-7-12)15(23-17)8-13-10-25-11-14(21)30-20(25)22-13/h3-7,10-11H,2,8-9H2,1H3,(H,24,28,29)
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n/an/a 15n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445694
PNG
(Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H23N7O3S/c1-4-29-20-19(21(32)27-22(29)33)30(11-15-5-7-16(8-6-15)24-14(3)31)18(26-20)9-17-12-28-10-13(2)34-23(28)25-17/h5-8,10,12H,4,9,11H2,1-3H3,(H,24,31)(H,27,32,33)
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n/an/a 16n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445680
PNG
(Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H20N6O2S/c1-3-26-18-17(19(28)24-20(26)29)27(11-14-7-5-4-6-8-14)16(23-18)9-15-12-25-10-13(2)30-21(25)22-15/h4-8,10,12H,3,9,11H2,1-2H3,(H,24,28,29)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445669
PNG
(Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H24N8O2/c1-3-33-24-23(25(35)29-26(33)36)34(15-17-7-9-18(10-8-17)20-11-13-31(2)30-20)22(28-24)14-19-16-32-12-5-4-6-21(32)27-19/h4-13,16H,3,14-15H2,1-2H3,(H,29,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445672
PNG
(Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3nccs3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H21N7O2S/c1-2-31-22-21(23(33)29-25(31)34)32(14-16-6-8-17(9-7-16)24-26-10-12-35-24)20(28-22)13-18-15-30-11-4-3-5-19(30)27-18/h3-12,15H,2,13-14H2,1H3,(H,29,33,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445692
PNG
(Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H20ClN7O3S/c1-3-29-19-18(20(32)27-21(29)33)30(9-13-4-6-14(7-5-13)24-12(2)31)17(26-19)8-15-10-28-11-16(23)34-22(28)25-15/h4-7,10-11H,3,8-9H2,1-2H3,(H,24,31)(H,27,32,33)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445696
PNG
(Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)N3CCCC3=O)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H25N7O3S/c1-3-30-22-21(23(34)28-24(30)35)32(13-16-6-8-18(9-7-16)31-10-4-5-20(31)33)19(27-22)11-17-14-29-12-15(2)36-25(29)26-17/h6-9,12,14H,3-5,10-11,13H2,1-2H3,(H,28,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445670
PNG
(Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3noc(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H22N8O3/c1-3-32-23-21(24(34)29-25(32)35)33(13-16-7-9-17(10-8-16)22-26-15(2)36-30-22)20(28-23)12-18-14-31-11-5-4-6-19(31)27-18/h4-11,14H,3,12-13H2,1-2H3,(H,29,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445675
PNG
(Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...)
Show SMILES CCn1c2nc(Cc3cn4nc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H19N7O2S/c1-3-25-17-16(18(28)23-19(25)29)26(10-13-7-5-4-6-8-13)15(22-17)9-14-11-27-20(21-14)30-12(2)24-27/h4-8,11H,3,9-10H2,1-2H3,(H,23,28,29)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445666
PNG
(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)C(=O)OC)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N6O4/c1-3-29-21-20(22(31)27-24(29)33)30(13-15-7-9-16(10-8-15)23(32)34-2)19(26-21)12-17-14-28-11-5-4-6-18(28)25-17/h4-11,14H,3,12-13H2,1-2H3,(H,27,31,33)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445674
PNG
(Ex. 12/KM-06-93/(I-12) | US10683309, Example 12 | ...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3nc(C)no3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H22N8O3/c1-3-32-22-21(23(34)29-25(32)35)33(13-16-7-9-17(10-8-16)24-26-15(2)30-36-24)20(28-22)12-18-14-31-11-5-4-6-19(31)27-18/h4-11,14H,3,12-13H2,1-2H3,(H,29,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445671
PNG
(Ex. 9/KM-06-89/(I-9) | US10683309, Example 9 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ncccn3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H22N8O2/c1-2-33-24-22(25(35)31-26(33)36)34(15-17-7-9-18(10-8-17)23-27-11-5-12-28-23)21(30-24)14-19-16-32-13-4-3-6-20(32)29-19/h3-13,16H,2,14-15H2,1H3,(H,31,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445681
PNG
(Ex. 17/KM-06-98/(I-17) | US10683309, Example 17 | ...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H24N8O2S/c1-4-32-22-21(23(34)28-24(32)35)33(13-16-5-7-17(8-6-16)19-9-10-30(3)29-19)20(27-22)11-18-14-31-12-15(2)36-25(31)26-18/h5-10,12,14H,4,11,13H2,1-3H3,(H,28,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445693
PNG
(Ex. 29/KM-06-149/(I-29) | US10683309, Example 29 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(cc3)-n3cncn3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H18ClN9O2S/c1-2-30-19-18(20(33)28-21(30)34)31(8-13-3-5-15(6-4-13)32-12-24-11-25-32)17(27-19)7-14-9-29-10-16(23)35-22(29)26-14/h3-6,9-12H,2,7-8H2,1H3,(H,28,33,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445684
PNG
(Ex. 20/KM-06-107/(I-20) | US10683309, Example 20 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H21ClN8O2S/c1-3-32-21-20(22(34)28-23(32)35)33(11-14-4-6-15(7-5-14)17-8-9-30(2)29-17)19(27-21)10-16-12-31-13-18(25)36-24(31)26-16/h4-9,12-13H,3,10-11H2,1-2H3,(H,28,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445691
PNG
(Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445703
PNG
(Ex. 39/KM-06-180/(I-39) | US10683309, Example 39 |...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3noc(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H26N8O3/c1-3-32-23-21(24(34)29-25(32)35)33(13-16-7-9-17(10-8-16)22-26-15(2)36-30-22)20(28-23)12-18-14-31-11-5-4-6-19(31)27-18/h7-10,14H,3-6,11-13H2,1-2H3,(H,29,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445697
PNG
(Ex. 33/KM-06-156/(I-33) | US10683309, Example 33 |...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-n3ccnc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H26N8O2/c1-2-32-23-22(24(34)29-25(32)35)33(14-17-6-8-19(9-7-17)31-12-10-26-16-31)21(28-23)13-18-15-30-11-4-3-5-20(30)27-18/h6-10,12,15-16H,2-5,11,13-14H2,1H3,(H,29,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445667
PNG
(Ex. 5/KM-06-79/(I-5) | US10683309, Example 5 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc4OCOc4c3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H20N6O4/c1-2-28-21-20(22(30)26-23(28)31)29(11-14-6-7-16-17(9-14)33-13-32-16)19(25-21)10-15-12-27-8-4-3-5-18(27)24-15/h3-9,12H,2,10-11,13H2,1H3,(H,26,30,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445682
PNG
(Ex. 18/KM-06-99/(I-18) | US10683309, Example 18 | ...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H28N8O2/c1-3-33-24-23(25(35)29-26(33)36)34(15-17-7-9-18(10-8-17)20-11-13-31(2)30-20)22(28-24)14-19-16-32-12-5-4-6-21(32)27-19/h7-11,13,16H,3-6,12,14-15H2,1-2H3,(H,29,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445700
PNG
(Ex. 36/KM-06-164/(I-36) | US10683309, Example 36 |...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)N3CCCC3=O)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H29N7O3/c1-2-31-24-23(25(35)29-26(31)36)33(15-17-8-10-19(11-9-17)32-13-5-7-22(32)34)21(28-24)14-18-16-30-12-4-3-6-20(30)27-18/h8-11,16H,2-7,12-15H2,1H3,(H,29,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445695
PNG
(Ex. 31/KM-06-151/(I-31) | US10683309, Example 31 |...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-n3cncn3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H25N9O2/c1-2-31-22-21(23(34)29-24(31)35)32(12-16-6-8-18(9-7-16)33-15-25-14-26-33)20(28-22)11-17-13-30-10-4-3-5-19(30)27-17/h6-9,13-15H,2-5,10-12H2,1H3,(H,29,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445701
PNG
(Ex. 37/KM-06-165/(I-37) | US10683309, Example 37 |...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)N3CC(F)(F)C3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H27F2N7O2/c1-2-33-22-21(23(35)30-24(33)36)34(12-16-6-8-18(9-7-16)32-14-25(26,27)15-32)20(29-22)11-17-13-31-10-4-3-5-19(31)28-17/h6-9,13H,2-5,10-12,14-15H2,1H3,(H,30,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445677
PNG
(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)
Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N8O2S/c1-3-31-21-20(22(33)27-23(31)34)32(19(26-21)12-17-14-30-10-11-35-24(30)25-17)13-15-4-6-16(7-5-15)18-8-9-29(2)28-18/h4-11,14H,3,12-13H2,1-2H3,(H,27,33,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445702
PNG
(Ex. 38/KM-06-176/(I-38) | US10683309, Example 38 |...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)N3CC(C3)OC)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H31N7O3/c1-3-32-24-23(25(34)29-26(32)35)33(13-17-7-9-19(10-8-17)31-15-20(16-31)36-2)22(28-24)12-18-14-30-11-5-4-6-21(30)27-18/h7-10,14,20H,3-6,11-13,15-16H2,1-2H3,(H,29,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445683
PNG
(Ex. 19/KM-06-106/(I-19) | US10683309, Example 19 |...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(CC(=O)OC)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H24N6O4/c1-3-30-23-22(24(33)28-25(30)34)31(14-17-9-7-16(8-10-17)12-21(32)35-2)20(27-23)13-18-15-29-11-5-4-6-19(29)26-18/h4-11,15H,3,12-14H2,1-2H3,(H,28,33,34)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445690
PNG
(Ex. 26/KM-06-114/(I-26) | US10683309, Example 26 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H19FN6O2S/c1-3-27-18-17(19(29)25-20(27)30)28(10-13-4-6-14(22)7-5-13)16(24-18)8-15-11-26-9-12(2)31-21(26)23-15/h4-7,9,11H,3,8,10H2,1-2H3,(H,25,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445665
PNG
(Ex. 3/KM-06-70/(I-3) | US10683309, Example 3 | US1...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C28H28N6O2/c1-2-33-26-25(27(35)31-28(33)36)34(17-19-11-13-21(14-12-19)20-8-4-3-5-9-20)24(30-26)16-22-18-32-15-7-6-10-23(32)29-22/h3-5,8-9,11-14,18H,2,6-7,10,15-17H2,1H3,(H,31,35,36)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445664
PNG
(Ex. 2/KM-06-57/(I-2) | US10683309, Example 2 | US1...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H24N6O2/c1-2-27-20-19(21(29)25-22(27)30)28(13-15-8-4-3-5-9-15)18(24-20)12-16-14-26-11-7-6-10-17(26)23-16/h3-5,8-9,14H,2,6-7,10-13H2,1H3,(H,25,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445663
PNG
(Ex. 1/KM-06-30/(I-1) | US10683309, Example 1 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H20N6O2/c1-2-27-20-19(21(29)25-22(27)30)28(13-15-8-4-3-5-9-15)18(24-20)12-16-14-26-11-7-6-10-17(26)23-16/h3-11,14H,2,12-13H2,1H3,(H,25,29,30)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445689
PNG
(Ex. 25/KM-06-113/(I-25) | US10683309, Example 25 |...)
Show SMILES CCCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H22N6O2/c1-2-11-28-21-20(22(30)26-23(28)31)29(14-16-8-4-3-5-9-16)19(25-21)13-17-15-27-12-7-6-10-18(27)24-17/h3-10,12,15H,2,11,13-14H2,1H3,(H,26,30,31)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445680
PNG
(Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C21H20N6O2S/c1-3-26-18-17(19(28)24-20(26)29)27(11-14-7-5-4-6-8-14)16(23-18)9-15-12-25-10-13(2)30-21(25)22-15/h4-8,10,12H,3,9,11H2,1-2H3,(H,24,28,29)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445694
PNG
(Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H23N7O3S/c1-4-29-20-19(21(32)27-22(29)33)30(11-15-5-7-16(8-6-15)24-14(3)31)18(26-20)9-17-12-28-10-13(2)34-23(28)25-17/h5-8,10,12H,4,9,11H2,1-3H3,(H,24,31)(H,27,32,33)
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n/an/a 56n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445686
PNG
(Ex. 22/KM-06-109/(I-22) | US10683309, Example 22 |...)
Show SMILES O=c1[nH]c(=O)c2n(Cc3ccccc3)c(Cc3cn4ccccc4n3)nc2n1C1CC1
Show InChI InChI=1S/C23H20N6O2/c30-22-20-21(29(17-9-10-17)23(31)26-22)25-19(28(20)13-15-6-2-1-3-7-15)12-16-14-27-11-5-4-8-18(27)24-16/h1-8,11,14,17H,9-10,12-13H2,(H,26,30,31)
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n/an/a 61n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445676
PNG
(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)
Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H18N6O2S/c1-2-25-17-16(18(27)23-19(25)28)26(11-13-6-4-3-5-7-13)15(22-17)10-14-12-24-8-9-29-20(24)21-14/h3-9,12H,2,10-11H2,1H3,(H,23,27,28)
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n/an/a 68n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445696
PNG
(Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)N3CCCC3=O)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H25N7O3S/c1-3-30-22-21(23(34)28-24(30)35)32(13-16-6-8-18(9-7-16)31-10-4-5-20(31)33)19(27-22)11-17-14-29-12-15(2)36-25(29)26-17/h6-9,12,14H,3-5,10-11,13H2,1-2H3,(H,28,34,35)
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n/an/a 69n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445687
PNG
(Ex. 23/KM-06-111/(I-23) | US10683309, Example 23 |...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(CCO)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H24N6O3/c1-2-29-22-21(23(32)27-24(29)33)30(14-17-8-6-16(7-9-17)10-12-31)20(26-22)13-18-15-28-11-4-3-5-19(28)25-18/h3-9,11,15,31H,2,10,12-14H2,1H3,(H,27,32,33)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM502700
PNG
(KM-06-91 | US11028104, Example 11)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ccc(cn3)C(F)(F)F)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C28H22F3N7O2/c1-2-37-25-24(26(39)35-27(37)40)38(23(34-25)13-20-16-36-12-4-3-5-22(36)33-20)15-17-6-8-18(9-7-17)21-11-10-19(14-32-21)28(29,30)31/h3-12,14,16H,2,13,15H2,1H3,(H,35,39,40)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445681
PNG
(Ex. 17/KM-06-98/(I-17) | US10683309, Example 17 | ...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H24N8O2S/c1-4-32-22-21(23(34)28-24(32)35)33(13-16-5-7-17(8-6-16)19-9-10-30(3)29-19)20(27-22)11-18-14-31-12-15(2)36-25(31)26-18/h5-10,12,14H,4,11,13H2,1-3H3,(H,28,34,35)
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n/an/a 84n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))		BDBM445698
PNG
(Ex. 34/KM-06-160/(I-34) | US10683309, Example 34 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(cc3)N3CC(F)(F)C3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C23H20ClF2N7O2S/c1-2-32-19-18(20(34)29-21(32)35)33(8-13-3-5-15(6-4-13)31-11-23(25,26)12-31)17(28-19)7-14-9-30-10-16(24)36-22(30)27-14/h3-6,9-10H,2,7-8,11-12H2,1H3,(H,29,34,35)
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n/an/a 96n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445692
PNG
(Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H20ClN7O3S/c1-3-29-19-18(20(32)27-21(29)33)30(9-13-4-6-14(7-5-13)24-12(2)31)17(26-19)8-15-10-28-11-16(23)34-22(28)25-15/h4-7,10-11H,3,8-9H2,1-2H3,(H,24,31)(H,27,32,33)
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n/an/a 116n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445691
PNG
(Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)
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n/an/a 133n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445685
PNG
(Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...)
Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H17ClN6O2S/c1-2-26-17-16(18(28)24-19(26)29)27(9-12-6-4-3-5-7-12)15(23-17)8-13-10-25-11-14(21)30-20(25)22-13/h3-7,10-11H,2,8-9H2,1H3,(H,24,28,29)
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n/an/a 162n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445669
PNG
(Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H24N8O2/c1-3-33-24-23(25(35)29-26(33)36)34(15-17-7-9-18(10-8-17)20-11-13-31(2)30-20)22(28-24)14-19-16-32-12-5-4-6-21(32)27-19/h4-13,16H,3,14-15H2,1-2H3,(H,29,35,36)
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n/an/a 177n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445703
PNG
(Ex. 39/KM-06-180/(I-39) | US10683309, Example 39 |...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3noc(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C25H26N8O3/c1-3-32-23-21(24(34)29-25(32)35)33(13-16-7-9-17(10-8-16)22-26-15(2)36-30-22)20(28-23)12-18-14-31-11-5-4-6-19(31)27-18/h7-10,14H,3-6,11-13H2,1-2H3,(H,29,34,35)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445666
PNG
(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)C(=O)OC)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C24H22N6O4/c1-3-29-21-20(22(31)27-24(29)33)30(13-15-7-9-16(10-8-15)23(32)34-2)19(26-21)12-17-14-28-11-5-4-6-18(28)25-17/h4-11,14H,3,12-13H2,1-2H3,(H,27,31,33)
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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445682
PNG
(Ex. 18/KM-06-99/(I-18) | US10683309, Example 18 | ...)
Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C26H28N8O2/c1-3-33-24-23(25(35)29-26(33)36)34(15-17-7-9-18(10-8-17)20-11-13-31(2)30-20)22(28-24)14-19-16-32-12-5-4-6-21(32)27-19/h7-11,13,16H,3-6,12,14-15H2,1-2H3,(H,29,35,36)
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n/an/a 209n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM445675
PNG
(Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...)
Show SMILES CCn1c2nc(Cc3cn4nc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
Show InChI InChI=1S/C20H19N7O2S/c1-3-25-17-16(18(28)23-19(25)29)26(10-13-7-5-4-6-8-13)15(22-17)9-14-11-27-20(21-14)30-12(2)24-27/h4-8,11H,3,9-10H2,1-2H3,(H,23,28,29)
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n/an/a 213n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent


Assay Description
The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...

US Patent US11028104 (2021)


BindingDB Entry DOI: 10.7270/Q2JM2DRC
More data for this
Ligand-Target Pair
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