Compile Data Set for Download or QSAR

Found 52 hits Enz. Inhib. hit(s) with all data for entry = 9968   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM504308 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5CC6(CC6)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479344 ((3-((3S,4)S-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](COCC6CC6)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C29H40N6O4S/c1-18-26(30)29(17-39-18)5-8-34(9-6-29)27-22(13-36)33-24(11-32-27)40-23-4-7-31-28-25(23)38-16-21-10-20(12-35(21)28)15-37-14-19-2-3-19/h4,7,11,18-21,26,36H,2-3,5-6,8-10,12-17,30H2,1H3/t18-,20-,21-,26+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479347 ((3-((S)-5-amino-5,7-dihydrospiro[cyclo- penta[b]py...) Show SMILES COC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(Cc7ncccc7[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C29H35N7O3S/c1-38-16-18-11-19-17-39-25-23(4-8-32-28(25)36(19)14-18)40-24-13-33-27(22(15-37)34-24)35-9-5-29(6-10-35)12-21-20(26(29)30)3-2-7-31-21/h2-4,7-8,13,18-19,26,37H,5-6,9-12,14-17,30H2,1H3/t18-,19-,26+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479327 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)OCC3CC3)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C28H38N6O4S/c1-17-25(29)28(16-38-17)5-8-33(9-6-28)26-21(13-35)32-23(11-31-26)39-22-4-7-30-27-24(22)37-15-19-10-20(12-34(19)27)36-14-18-2-3-18/h4,7,11,17-20,25,35H,2-3,5-6,8-10,12-16,29H2,1H3/t17-,19-,20-,25+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504292 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5CCC[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479359 ((3-((S)-5-amino-5,7-dihydro- spiro[cyclopenta[b]py...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(Cc7ncccc7[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C30H37N7O4S/c1-39-18-40-16-19-11-20-17-41-26-24(4-8-33-29(26)37(20)14-19)42-25-13-34-28(23(15-38)35-25)36-9-5-30(6-10-36)12-22-21(27(30)31)3-2-7-32-22/h2-4,7-8,13,19-20,27,38H,5-6,9-12,14-18,31H2,1H3/t19-,20-,27+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479361 ((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...) Show SMILES COCOC[C@@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C27H38N6O5S/c1-17-24(28)27(15-38-17)4-7-32(8-5-27)25-20(12-34)31-22(10-30-25)39-21-3-6-29-26-23(21)37-14-19-9-18(11-33(19)26)13-36-16-35-2/h3,6,10,17-19,24,34H,4-5,7-9,11-16,28H2,1-2H3/t17-,18+,19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479340 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES COC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C26H36N6O4S/c1-16-23(27)26(15-36-16)4-7-31(8-5-26)24-19(12-33)30-21(10-29-24)37-20-3-6-28-25-22(20)35-14-18-9-17(13-34-2)11-32(18)25/h3,6,10,16-18,23,33H,4-5,7-9,11-15,27H2,1-2H3/t16-,17-,18-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504343 ((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...) Show SMILES COCOC[C@@H]1C[C@@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479341 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES COC[C@@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C26H36N6O4S/c1-16-23(27)26(15-36-16)4-7-31(8-5-26)24-19(12-33)30-21(10-29-24)37-20-3-6-28-25-22(20)35-14-18-9-17(13-34-2)11-32(18)25/h3,6,10,16-18,23,33H,4-5,7-9,11-15,27H2,1-2H3/t16-,17+,18-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479357 ((S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4cnc(cn4)N4CCC5(Cc6ncccc6[C@H]5N)CC4)ccnc3N2C1 |r| Show InChI InChI=1S/C29H35N7O3S/c1-37-18-38-16-19-11-20-17-39-26-23(4-8-32-28(26)36(20)15-19)40-25-14-33-24(13-34-25)35-9-5-29(6-10-35)12-22-21(27(29)30)3-2-7-31-22/h2-4,7-8,13-14,19-20,27H,5-6,9-12,15-18,30H2,1H3/t19-,20-,27+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504323 ((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...) Show SMILES COCCOC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504293 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5CCC[C@@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479348 ((3-((S)-5-amino-5,7-dihydrospiro[cyclo- penta[b]py...) Show SMILES COC[C@@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(Cc7ncccc7[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C29H35N7O3S/c1-38-16-18-11-19-17-39-25-23(4-8-32-28(25)36(19)14-18)40-24-13-33-27(22(15-37)34-24)35-9-5-29(6-10-35)12-21-20(26(29)30)3-2-7-31-21/h2-4,7-8,13,18-19,26,37H,5-6,9-12,14-17,30H2,1H3/t18-,19+,26-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479342 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C27H38N6O5S/c1-17-24(28)27(15-38-17)4-7-32(8-5-27)25-20(12-34)31-22(10-30-25)39-21-3-6-29-26-23(21)37-14-19-9-18(11-33(19)26)13-36-16-35-2/h3,6,10,17-19,24,34H,4-5,7-9,11-16,28H2,1-2H3/t17-,18-,19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479354 ((3S,4S)-8-(5-(((6aS,8S)-8-(methoxymethyl)-6a,7,8,9...) Show SMILES COC[C@H]1C[C@H]2COc3c(Sc4cnc(cn4)N4CCC5(CO[C@@H](C)[C@H]5N)CC4)ccnc3N2C1 |r| Show InChI InChI=1S/C25H34N6O3S/c1-16-23(26)25(15-34-16)4-7-30(8-5-25)20-10-29-21(11-28-20)35-19-3-6-27-24-22(19)33-14-18-9-17(13-32-2)12-31(18)24/h3,6,10-11,16-18,23H,4-5,7-9,12-15,26H2,1-2H3/t16-,17-,18-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504342 ((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...) Show SMILES COCOC[C@H]1C[C@@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504295 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](F)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479352 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](CO)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C25H34N6O4S/c1-15-22(26)25(14-35-15)3-6-30(7-4-25)23-18(12-33)29-20(9-28-23)36-19-2-5-27-24-21(19)34-13-17-8-16(11-32)10-31(17)24/h2,5,9,15-17,22,32-33H,3-4,6-8,10-14,26H2,1H3/t15-,16-,17-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479325 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES COCO[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C26H36N6O5S/c1-16-23(27)26(14-36-16)4-7-31(8-5-26)24-19(12-33)30-21(10-29-24)38-20-3-6-28-25-22(20)35-13-17-9-18(11-32(17)25)37-15-34-2/h3,6,10,16-18,23,33H,4-5,7-9,11-15,27H2,1-2H3/t16-,17-,18-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479349 ((3-((S)-5-amino-13-oxa-9- azadispiro[3.1.56.24]tri...) Show SMILES COC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(COC7(CCC7)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C28H38N6O4S/c1-36-15-18-11-19-16-37-23-21(3-8-30-25(23)34(19)13-18)39-22-12-31-24(20(14-35)32-22)33-9-6-27(7-10-33)17-38-28(26(27)29)4-2-5-28/h3,8,12,18-19,26,35H,2,4-7,9-11,13-17,29H2,1H3/t18-,19-,26-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479353 ((3S,4S)-8-(5-(((6aS,8S)-8-((methoxymethoxy)methyl)...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4cnc(cn4)N4CCC5(CO[C@@H](C)[C@H]5N)CC4)ccnc3N2C1 |r| Show InChI InChI=1S/C26H36N6O4S/c1-17-24(27)26(15-36-17)4-7-31(8-5-26)21-10-30-22(11-29-21)37-20-3-6-28-25-23(20)35-14-19-9-18(12-32(19)25)13-34-16-33-2/h3,6,10-11,17-19,24H,4-5,7-9,12-16,27H2,1-2H3/t17-,18-,19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479351 ((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...) Show SMILES COCOCOC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C28H40N6O6S/c1-18-25(29)28(15-40-18)4-7-33(8-5-28)26-21(12-35)32-23(10-31-26)41-22-3-6-30-27-24(22)39-14-20-9-19(11-34(20)27)13-37-17-38-16-36-2/h3,6,10,18-20,25,35H,4-5,7-9,11-17,29H2,1-2H3/t18-,19-,20-,25+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479355 ((3S,4S)-8-(6-amino-5-(((6aS,8S)-8-((methoxymeth- o...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4ncc(nc4N)N4CCC5(CO[C@@H](C)[C@H]5N)CC4)ccnc3N2C1 |r| Show InChI InChI=1S/C26H37N7O4S/c1-16-22(27)26(14-37-16)4-7-32(8-5-26)20-10-30-25(23(28)31-20)38-19-3-6-29-24-21(19)36-13-18-9-17(11-33(18)24)12-35-15-34-2/h3,6,10,16-18,22H,4-5,7-9,11-15,27H2,1-2H3,(H2,28,31)/t16-,17-,18-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504297 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES CO[C@@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479333 ((6aS,8S)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- ...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)OC(N)=O)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C25H33N7O5S/c1-14-21(26)25(13-36-14)3-6-31(7-4-25)22-17(11-33)30-19(9-29-22)38-18-2-5-28-23-20(18)35-12-15-8-16(10-32(15)23)37-24(27)34/h2,5,9,14-16,21,33H,3-4,6-8,10-13,26H2,1H3,(H2,27,34)/t14-,15-,16-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504298 ((6aS,8S)-4-((5-((3S,4S)-4-amino-3- methyl-2-oxa-8-...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](O)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479345 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](COCC6COC6)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C29H40N6O5S/c1-18-26(30)29(17-40-18)3-6-34(7-4-29)27-22(11-36)33-24(9-32-27)41-23-2-5-31-28-25(23)39-16-21-8-19(10-35(21)28)12-37-13-20-14-38-15-20/h2,5,9,18-21,26,36H,3-4,6-8,10-17,30H2,1H3/t18-,19-,21-,26+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479350 ((3-((S)-5-amino-13-oxa-9- azadispiro[3.1.56.24]tri...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(COC7(CCC7)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C29H40N6O5S/c1-37-18-38-15-19-11-20-16-39-24-22(3-8-31-26(24)35(20)13-19)41-23-12-32-25(21(14-36)33-23)34-9-6-28(7-10-34)17-40-29(27(28)30)4-2-5-29/h3,8,12,19-20,27,36H,2,4-7,9-11,13-18,30H2,1H3/t19-,20-,27-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479324 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)OC3COC3)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C27H36N6O5S/c1-16-24(28)27(15-37-16)3-6-32(7-4-27)25-20(11-34)31-22(9-30-25)39-21-2-5-29-26-23(21)36-12-17-8-18(10-33(17)26)38-19-13-35-14-19/h2,5,9,16-19,24,34H,3-4,6-8,10-15,28H2,1H3/t16-,17-,18-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479338 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5CCOC[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C24H32N6O4S/c1-15-21(25)24(14-34-15)3-6-29(7-4-24)22-17(11-31)28-19(10-27-22)35-18-2-5-26-23-20(18)33-13-16-12-32-9-8-30(16)23/h2,5,10,15-16,21,31H,3-4,6-9,11-14,25H2,1H3/t15-,16-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479334 ((6aS,8R)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- ...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](C[C@H]5COc34)OC(N)=O)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C25H33N7O5S/c1-14-21(26)25(13-36-14)3-6-31(7-4-25)22-17(11-33)30-19(9-29-22)38-18-2-5-28-23-20(18)35-12-15-8-16(10-32(15)23)37-24(27)34/h2,5,9,14-16,21,33H,3-4,6-8,10-13,26H2,1H3,(H2,27,34)/t14-,15-,16+,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479330 ((6aS,8R)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- ...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@](C)(O)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C25H34N6O4S/c1-15-21(26)25(14-35-15)4-7-30(8-5-25)22-17(11-32)29-19(10-28-22)36-18-3-6-27-23-20(18)34-12-16-9-24(2,33)13-31(16)23/h3,6,10,15-16,21,32-33H,4-5,7-9,11-14,26H2,1-2H3/t15-,16-,21+,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504299 ((6aS,8R)-4-((5-((3S,4S)-4-amino-3- methyl-2-oxa-8-...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](O)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504296 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES CO[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479320 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES CO[C@@H]1C[C@@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C25H34N6O4S/c1-15-22(26)25(14-35-15)4-7-30(8-5-25)23-18(12-32)29-20(10-28-23)36-19-3-6-27-24-21(19)34-13-16-9-17(33-2)11-31(16)24/h3,6,10,15-17,22,32H,4-5,7-9,11-14,26H2,1-2H3/t15-,16+,17+,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479358 ((S)-1'-(6-amino-5-(((6aS,8S)-8-((methoxy- methoxy)...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4ncc(nc4N)N4CCC5(Cc6ncccc6[C@H]5N)CC4)ccnc3N2C1 |r| Show InChI InChI=1S/C29H36N8O3S/c1-38-17-39-15-18-11-19-16-40-24-22(4-8-33-27(24)37(19)14-18)41-28-26(31)35-23(13-34-28)36-9-5-29(6-10-36)12-21-20(25(29)30)3-2-7-32-21/h2-4,7-8,13,18-19,25H,5-6,9-12,14-17,30H2,1H3,(H2,31,35)/t18-,19-,25+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479356 ((3S,4S)-8-(6-amino-5-(((6aS,8S)-8-(methoxymethyl)-...) Show SMILES COC[C@H]1C[C@H]2COc3c(Sc4ncc(nc4N)N4CCC5(CO[C@@H](C)[C@H]5N)CC4)ccnc3N2C1 |r| Show InChI InChI=1S/C25H35N7O3S/c1-15-21(26)25(14-35-15)4-7-31(8-5-25)19-10-29-24(22(27)30-19)36-18-3-6-28-23-20(18)34-13-17-9-16(12-33-2)11-32(17)23/h3,6,10,15-17,21H,4-5,7-9,11-14,26H2,1-2H3,(H2,27,30)/t15-,16-,17-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479326 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES COCCO[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C27H38N6O5S/c1-17-24(28)27(16-38-17)4-7-32(8-5-27)25-20(14-34)31-22(12-30-25)39-21-3-6-29-26-23(21)37-15-18-11-19(13-33(18)26)36-10-9-35-2/h3,6,12,17-19,24,34H,4-5,7-11,13-16,28H2,1-2H3/t17-,18-,19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479337 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5CCOC[C@@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C24H32N6O4S/c1-15-21(25)24(14-34-15)3-6-29(7-4-24)22-17(11-31)28-19(10-27-22)35-18-2-5-26-23-20(18)33-13-16-12-32-9-8-30(16)23/h2,5,10,15-16,21,31H,3-4,6-9,11-14,25H2,1H3/t15-,16+,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479335 ((6-(((6aS,8S)-8-(1H-pyrazol-1-yl)-6a,7,8,9-tetrahy...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)n3cccn3)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C27H34N8O3S/c1-17-24(28)27(16-38-17)4-9-33(10-5-27)25-20(14-36)32-22(12-30-25)39-21-3-7-29-26-23(21)37-15-19-11-18(13-34(19)26)35-8-2-6-31-35/h2-3,6-8,12,17-19,24,36H,4-5,9-11,13-16,28H2,1H3/t17-,18-,19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479321 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES CO[C@H]1C[C@@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r| Show InChI InChI=1S/C25H34N6O4S/c1-15-22(26)25(14-35-15)4-7-30(8-5-25)23-18(12-32)29-20(10-28-23)36-19-3-6-27-24-21(19)34-13-16-9-17(33-2)11-31(16)24/h3,6,10,15-17,22,32H,4-5,7-9,11-14,26H2,1-2H3/t15-,16+,17-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479331 ((6aS,8S)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- ...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)C#N)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C25H31N7O3S/c1-15-22(27)25(14-35-15)3-6-31(7-4-25)23-18(12-33)30-20(10-29-23)36-19-2-5-28-24-21(19)34-13-17-8-16(9-26)11-32(17)24/h2,5,10,15-17,22,33H,3-4,6-8,11-14,27H2,1H3/t15-,16+,17-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479336 ((6-(((6aS,84R)-8-(1H-pyrazol-1-yl)-6a,7,8,9-tetrah...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](C[C@H]5COc34)n3cccn3)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C27H34N8O3S/c1-17-24(28)27(16-38-17)4-9-33(10-5-27)25-20(14-36)32-22(12-30-25)39-21-3-7-29-26-23(21)37-15-19-11-18(13-34(19)26)35-8-2-6-31-35/h2-3,6-8,12,17-19,24,36H,4-5,9-11,13-16,28H2,1H3/t17-,18+,19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479323 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azasprio[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)OC3CCOC3)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C28H38N6O5S/c1-17-25(29)28(16-38-17)4-7-33(8-5-28)26-21(13-35)32-23(11-31-26)40-22-2-6-30-27-24(22)37-14-18-10-20(12-34(18)27)39-19-3-9-36-15-19/h2,6,11,17-20,25,35H,3-5,7-10,12-16,29H2,1H3/t17-,18-,19?,20-,25+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479360 ((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...) Show SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4nc(CO)c(nc4C)N4CCC5(CO[C@@H](C)[C@H]5N)CC4)ccnc3N2C1 |r| Show InChI InChI=1S/C28H40N6O5S/c1-17-27(32-21(12-35)25(31-17)33-8-5-28(6-9-33)15-39-18(2)24(28)29)40-22-4-7-30-26-23(22)38-14-20-10-19(11-34(20)26)13-37-16-36-3/h4,7,18-20,24,35H,5-6,8-16,29H2,1-3H3/t18-,19-,20-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479339 (4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5CCS(=O)(=O)CC5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C24H32N6O5S2/c1-15-21(25)24(14-35-15)3-6-29(7-4-24)22-17(11-31)28-19(10-27-22)36-18-2-5-26-23-20(18)34-12-16-13-37(32,33)9-8-30(16)23/h2,5,10,15-16,21,31H,3-4,6-9,11-14,25H2,1H3/t15-,16?,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479332 ((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)S(C)(=O)=O)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C25H34N6O5S2/c1-15-22(26)25(14-36-15)4-7-30(8-5-25)23-18(12-32)29-20(10-28-23)37-19-3-6-27-24-21(19)35-13-16-9-17(11-31(16)24)38(2,33)34/h3,6,10,15-17,22,32H,4-5,7-9,11-14,26H2,1-2H3/t15-,16-,17-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM479329 ((6aS,8S)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- ...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@](C)(O)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI InChI=1S/C25H34N6O4S/c1-15-21(26)25(14-35-15)4-7-30(8-5-25)22-17(11-32)29-19(10-28-22)36-18-3-6-27-23-20(18)34-12-16-9-24(2,33)13-31(16)23/h3,6,10,15-16,21,32-33H,4-5,7-9,11-14,26H2,1-2H3/t15-,16-,21+,24-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair
SH2B adapter protein 2 (Human)	BDBM504294 ((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](F)C[C@H]5COc34)nc2CO)[C@@H]1N |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2VT1W7X
					More data for this Ligand-Target Pair

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