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Found 1 hit Enz. Inhib. hit(s) with Target = '1,3-beta-D-glucan synthase catalytic subunit' and Ligand = 'BDBM50485385'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
1,3-beta-D-glucan synthase catalytic subunit


(Candida albicans)		BDBM50485385
PNG
(CHEMBL2059495)
Show SMILES CC1(COc2c(cnn(-c3cccc(Cl)c3)c2=O)N2CCN(CC2)S(=O)(=O)Cc2ccc(N)c(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C27H29ClF3N5O4S/c1-26(7-8-26)17-40-24-23(15-33-36(25(24)37)20-4-2-3-19(28)14-20)34-9-11-35(12-10-34)41(38,39)16-18-5-6-22(32)21(13-18)27(29,30)31/h2-6,13-15H,7-12,16-17,32H2,1H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 637n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranes

Bioorg Med Chem Lett 22: 5268-71 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.091
BindingDB Entry DOI: 10.7270/Q2MC92WW
More data for this
Ligand-Target Pair