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Found 1 hit Enz. Inhib. hit(s) with Target = '1,3-beta-D-glucan synthase catalytic subunit' and Ligand = 'BDBM50485391'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
1,3-beta-D-glucan synthase catalytic subunit


(Candida albicans)		BDBM50485391
PNG
(CHEMBL2059485)
Show SMILES Clc1cccc(c1)-n1ncc(N2CCN(CC2)S(=O)(=O)Cc2cc(Cl)cc(Cl)c2)c(OC2CCCC2)c1=O
Show InChI InChI=1S/C26H27Cl3N4O4S/c27-19-4-3-5-22(15-19)33-26(34)25(37-23-6-1-2-7-23)24(16-30-33)31-8-10-32(11-9-31)38(35,36)17-18-12-20(28)14-21(29)13-18/h3-5,12-16,23H,1-2,6-11,17H2
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 351n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranes

Bioorg Med Chem Lett 22: 5268-71 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.091
BindingDB Entry DOI: 10.7270/Q2MC92WW
More data for this
Ligand-Target Pair