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Found 1 hit Enz. Inhib. hit(s) with Target = '1,3-beta-D-glucan synthase catalytic subunit' and Ligand = 'BDBM50485396'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
1,3-beta-D-glucan synthase catalytic subunit


(Candida albicans)		BDBM50485396
PNG
(CHEMBL2059643)
Show SMILES CC1(COc2c(cnn(-c3cccc(Cl)c3)c2=O)N2CCN(CC2)S(=O)(=O)Cc2ccc(N)nc2)CC1
Show InChI InChI=1S/C25H29ClN6O4S/c1-25(7-8-25)17-36-23-21(15-29-32(24(23)33)20-4-2-3-19(26)13-20)30-9-11-31(12-10-30)37(34,35)16-18-5-6-22(27)28-14-18/h2-6,13-15H,7-12,16-17H2,1H3,(H2,27,28)
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 91.7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranes

Bioorg Med Chem Lett 22: 5268-71 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.091
BindingDB Entry DOI: 10.7270/Q2MC92WW
More data for this
Ligand-Target Pair