Found 2 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50430147' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50430147
(CHEMBL2338264)Show SMILES CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccccc1 |r,wU:6.5,13.14,TLB:10:9:16:12.11.6,10:11:15.9.8:16,6:7:15:12.10.11,THB:6:11:15:8.7.16,5:6:15.9.8:16,(29.24,-4.12,;29.87,-5.53,;30.63,-4.18,;31.41,-5.57,;32.34,-6.8,;31.97,-8.29,;33.15,-9.28,;34.54,-8.69,;35.59,-9.91,;35.6,-11.5,;34.2,-12.08,;33.17,-10.81,;34.57,-11.14,;35.89,-10.64,;37.43,-10.62,;37.1,-11.9,;35.89,-9.15,;30.57,-8.92,;30.53,-10.46,;29.19,-8.22,;27.85,-8.98,;26.71,-7.94,;27.35,-6.53,;28.89,-6.71,;26.59,-5.2,;27.38,-3.87,;26.62,-2.54,;25.08,-2.52,;24.3,-3.86,;25.06,-5.19,)| Show InChI InChI=1S/C25H31N3O2/c1-24(2)8-9-27(21-17-10-16-11-18(21)14-25(30,12-16)13-17)23(29)20-15-26-28(22(20)24)19-6-4-3-5-7-19/h3-7,15-18,21,30H,8-14H2,1-2H3/t16?,17?,18?,21-,25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assay |
Bioorg Med Chem Lett 23: 1617-21 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.090
BindingDB Entry DOI: 10.7270/Q27P90RZ |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50430147
(CHEMBL2338264)Show SMILES CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccccc1 |r,wU:6.5,13.14,TLB:10:9:16:12.11.6,10:11:15.9.8:16,6:7:15:12.10.11,THB:6:11:15:8.7.16,5:6:15.9.8:16,(29.24,-4.12,;29.87,-5.53,;30.63,-4.18,;31.41,-5.57,;32.34,-6.8,;31.97,-8.29,;33.15,-9.28,;34.54,-8.69,;35.59,-9.91,;35.6,-11.5,;34.2,-12.08,;33.17,-10.81,;34.57,-11.14,;35.89,-10.64,;37.43,-10.62,;37.1,-11.9,;35.89,-9.15,;30.57,-8.92,;30.53,-10.46,;29.19,-8.22,;27.85,-8.98,;26.71,-7.94,;27.35,-6.53,;28.89,-6.71,;26.59,-5.2,;27.38,-3.87,;26.62,-2.54,;25.08,-2.52,;24.3,-3.86,;25.06,-5.19,)| Show InChI InChI=1S/C25H31N3O2/c1-24(2)8-9-27(21-17-10-16-11-18(21)14-25(30,12-16)13-17)23(29)20-15-26-28(22(20)24)19-6-4-3-5-7-19/h3-7,15-18,21,30H,8-14H2,1-2H3/t16?,17?,18?,21-,25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assay |
Bioorg Med Chem Lett 23: 1617-21 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.090
BindingDB Entry DOI: 10.7270/Q27P90RZ |
More data for this
Ligand-Target Pair | |
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