Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S]' and Ligand = 'BDBM32544'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S] (Homo sapiens (Human))	BDBM32544 (arylsulfonylpiperazine, 16) Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C#N Show InChI InChI=1S/C17H15F3N4O2S/c18-17(19,20)15-2-1-7-22-16(15)23-8-10-24(11-9-23)27(25,26)14-5-3-13(12-21)4-6-14/h1-7H,8-11H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	978	n/a	n/a	7.2	22
Amgen Inc.					Assay Description Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...				Bioorg Med Chem Lett 18: 3513-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.025 BindingDB Entry DOI: 10.7270/Q2J964Q1
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