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Found 1 hit Enz. Inhib. hit(s) with Target = '3-oxo-5-alpha-steroid 4-dehydrogenase 1' and Ligand = 'BDBM50070045'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-oxo-5-alpha-steroid 4-dehydrogenase 1


(Homo sapiens (Human))		BDBM50070045
PNG
(2-((4aR,10bR)-4,10b-Dimethyl-3-oxo-1,2,3,4,4a,5,6,...)
Show SMILES CN1[C@@H]2CCc3cc(CC(=O)Nc4ccccc4)ccc3[C@@]2(C)CCC1=O
Show InChI InChI=1S/C23H26N2O2/c1-23-13-12-22(27)25(2)20(23)11-9-17-14-16(8-10-19(17)23)15-21(26)24-18-6-4-3-5-7-18/h3-8,10,14,20H,9,11-13,15H2,1-2H3,(H,24,26)/t20-,23-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Steroid 5-alpha-reductase type 1 enzyme based on the conversion of [3H]-T to [3H]-DHT in nuclear membrane preparations fr...

Bioorg Med Chem Lett 8: 395-8 (1999)


BindingDB Entry DOI: 10.7270/Q2CN732C
More data for this
Ligand-Target Pair