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Found 1 hit Enz. Inhib. hit(s) with Target = '3-oxo-5-alpha-steroid 4-dehydrogenase 1' and Ligand = 'BDBM50070056'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-oxo-5-alpha-steroid 4-dehydrogenase 1


(Homo sapiens (Human))		BDBM50070056
PNG
(CHEMBL415016 | N-tert-Butyl-2-((4aR,10bR)-4,10b-di...)
Show SMILES CN1[C@@H]2CCc3cc(CC(=O)NC(C)(C)C)ccc3[C@@]2(C)CCC1=O
Show InChI InChI=1S/C21H30N2O2/c1-20(2,3)22-18(24)13-14-6-8-16-15(12-14)7-9-17-21(16,4)11-10-19(25)23(17)5/h6,8,12,17H,7,9-11,13H2,1-5H3,(H,22,24)/t17-,21-/m1/s1
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Similars
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Steroid 5-alpha-reductase type 1 enzyme based on the conversion of [3H]-T to [3H]-DHT in nuclear membrane preparations fr...

Bioorg Med Chem Lett 8: 395-8 (1999)


BindingDB Entry DOI: 10.7270/Q2CN732C
More data for this
Ligand-Target Pair