Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 [51-359]' and Ligand = 'BDBM282378'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 [51-359] (Homo sapiens (Human))	BDBM282378 ((S)-3-(3-(2-aminoquinazolin- 6-yl)prop-2-ynylamino...) Show SMILES C[C@H](NC(=O)c1nc(cnc1NCC#Cc1ccc2nc(N)ncc2c1)C#N)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C25H18F2N8O/c1-14(16-5-6-19(26)20(27)10-16)33-24(36)22-23(31-13-18(11-28)34-22)30-8-2-3-15-4-7-21-17(9-15)12-32-25(29)35-21/h4-7,9-10,12-14H,8H2,1H3,(H,30,31)(H,33,36)(H2,29,32,35)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc. US Patent					Assay Description PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...				US Patent US10030016 (2018) BindingDB Entry DOI: 10.7270/Q2S46V16
					More data for this Ligand-Target Pair