Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = '5'-AMP-activated protein kinase catalytic subunit alpha-2' and Ligand = 'BDBM328303'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM328303 (6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- ca...) Show SMILES FC(F)(F)Oc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)c1 Show InChI InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-5-3-4-25(22-31)24-42-18-14-29(15-19-42)41-34(46)28-8-11-32(40-23-28)35(47)44-20-12-27(13-21-44)33(45)26-6-9-30(10-7-26)43-16-1-2-17-43/h3-11,22-23,27,29H,1-2,12-21,24H2,(H,41,46)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM328303 (6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- ca...) Show SMILES FC(F)(F)Oc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)c1 Show InChI InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-5-3-4-25(22-31)24-42-18-14-29(15-19-42)41-34(46)28-8-11-32(40-23-28)35(47)44-20-12-27(13-21-44)33(45)26-6-9-30(10-7-26)43-16-1-2-17-43/h3-11,22-23,27,29H,1-2,12-21,24H2,(H,41,46)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US9663496 (2017) BindingDB Entry DOI: 10.7270/Q26975P8
					More data for this Ligand-Target Pair