Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM472930 ((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]-LSB from recombinant human 5HT2BR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127872 BindingDB Entry DOI: 10.7270/Q2SF30VK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM472930 ((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 10.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals, Inc. US Patent | Assay Description Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin... | US Patent US10836764 (2020) BindingDB Entry DOI: 10.7270/Q22N55CP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM472930 ((R)-4-propyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127872 BindingDB Entry DOI: 10.7270/Q2SF30VK | |||||||||||
More data for this Ligand-Target Pair |