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Compile Data Set for Download or QSAR

Found 9 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 7' and Ligand = 'BDBM50204672'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
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Article
PubMed
5.20n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
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5.20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintil...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00110
BindingDB Entry DOI: 10.7270/Q2D50RTX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
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Article
PubMed
5.20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintil...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00110
BindingDB Entry DOI: 10.7270/Q2D50RTX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
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Article
PubMed
n/an/an/an/a 148n/an/an/an/a


TBA

Assay Description
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00110
BindingDB Entry DOI: 10.7270/Q2D50RTX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
PDB

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Article
PubMed
n/an/an/an/a 150n/an/an/an/a


TBA

Assay Description
Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00110
BindingDB Entry DOI: 10.7270/Q2D50RTX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
PDB

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Article
PubMed
n/an/an/an/a 457n/an/an/an/a


TBA

Assay Description
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00110
BindingDB Entry DOI: 10.7270/Q2D50RTX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
PDB

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PC sid
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Article
PubMed
n/an/an/an/a 460n/an/an/an/a


TBA

Assay Description
Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00110
BindingDB Entry DOI: 10.7270/Q2D50RTX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
PDB

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PC sid
UniChem

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Article
PubMed
n/an/an/an/a 550n/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
PDB

Reactome pathway
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PC sid
UniChem

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Article
PubMed
n/an/an/an/a 550n/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair