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Found 1 hit Enz. Inhib. hit(s) with Target = 'ALK tyrosine kinase receptor' and Ligand = 'BDBM50246471'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50246471
PNG
(CHEMBL4073990)
Show SMILES Fc1ccc(Nc2ccnc3cc(ccc23)-c2cnn(c2)C2CCNCC2)cc1F
Show InChI InChI=1S/C23H21F2N5/c24-20-4-2-17(12-21(20)25)29-22-7-10-27-23-11-15(1-3-19(22)23)16-13-28-30(14-16)18-5-8-26-9-6-18/h1-4,7,10-14,18,26H,5-6,8-9H2,(H,27,29)
PDB

KEGG

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 181n/an/an/an/an/an/a



Korea Advanced Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...

J Med Chem 60: 9205-9221 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01039
BindingDB Entry DOI: 10.7270/Q26D5WF3
More data for this
Ligand-Target Pair