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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'ALK tyrosine kinase receptor' and Ligand = 'BDBM50382649'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382649
PNG
(CHEMBL2024000)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Oc3ccccc3)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O5/c1-39-27-18-24(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-10-23(21-37)31(38)34-20-22-9-7-13-26(17-22)42-25-11-5-4-6-12-25/h4-7,9,11-15,17-19,23H,8,10,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t23-/m0/s1
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Article
PubMed
n/an/a 192n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair