Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50273541 (CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 541 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Binding affinity to biotinylated AAK1 (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assay | J Med Chem 62: 5810-5831 (2019) Article DOI: 10.1021/acs.jmedchem.9b00136 BindingDB Entry DOI: 10.7270/Q2CR5XMR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50273541 (CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Binding affinity to biotinylated AAK1 (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assay | J Med Chem 62: 5810-5831 (2019) Article DOI: 10.1021/acs.jmedchem.9b00136 BindingDB Entry DOI: 10.7270/Q2CR5XMR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50273541 (CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00302 BindingDB Entry DOI: 10.7270/Q20Z779V | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50273541 (CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to human AAK1 | J Med Chem 51: 7898-914 (2008) Article DOI: 10.1021/jm8011036 BindingDB Entry DOI: 10.7270/Q2WS8T4C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50273541 (CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Binding affinity to wild type DNA-tagged human AAK1 (G25 to L333 residues) expressed in bacterial expression system by quantitative PCR based KINOMEs... | J Med Chem 62: 5810-5831 (2019) Article DOI: 10.1021/acs.jmedchem.9b00136 BindingDB Entry DOI: 10.7270/Q2CR5XMR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50273541 (CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Curated by ChEMBL | Assay Description Inhibition of AAK1 | J Med Chem 53: 1413-37 (2010) Article DOI: 10.1021/jm901132v BindingDB Entry DOI: 10.7270/Q2VD6ZK0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |