Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acid ceramidase (Homo sapiens (Human)) | BDBM50431264 (CHEMBL2333040 | US9428465, 14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | US Patent | n/a | n/a | 155 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Fondazione Istituto Italiano Di Technologia US Patent | Assay Description A hAC protein preparation (10 μg) was preincubated with inhibitors (final DMSO concentration 1%) in assay buffer (100 mM sodium phosphate, 0.1% ... | US Patent US9428465 (2016) BindingDB Entry DOI: 10.7270/Q26972GB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Rattus norvegicus (Rat)) | BDBM50431264 (CHEMBL2333040 | US9428465, 14) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL | Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub... | J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Rattus norvegicus (Rat)) | BDBM50431264 (CHEMBL2333040 | US9428465, 14) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | US Patent | n/a | n/a | 177 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Fondazione Istituto Italiano Di Technologia US Patent | Assay Description r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1... | US Patent US9428465 (2016) BindingDB Entry DOI: 10.7270/Q26972GB | |||||||||||
More data for this Ligand-Target Pair |