Found 4 hits Enz. Inhib. hit(s) with Target = 'Activin receptor type-1 [172-499]' and Ligand = 'BDBM451776' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451776
(US10710980, Example 8 | US10947218, Example 8)Show SMILES CC(C)N1CCN(CC1)c1ccc(c(F)c1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.28,wD:29.32,(10.76,-2.31,;9.43,-3.08,;9.43,-4.62,;8.09,-2.31,;6.76,-3.08,;5.43,-2.31,;5.43,-.77,;6.76,,;8.09,-.77,;4.09,,;2.76,-.77,;1.43,,;1.43,1.54,;2.76,2.31,;2.76,3.83,;4.09,1.54,;.09,2.31,;.09,3.85,;-1.24,4.62,;-2.57,3.85,;-3.91,4.62,;-2.57,2.31,;-1.24,1.54,;-3.91,1.54,;-3.91,,;-5.24,2.31,;-6.58,1.54,;-6.71,.01,;-8.11,-.64,;-9.37,.24,;-10.76,-.41,;-9.23,1.77,;-7.84,2.42,)| Show InChI InChI=1S/C25H34FN5O2/c1-16(2)30-9-11-31(12-10-30)19-5-8-21(23(26)14-19)17-13-22(24(27)28-15-17)25(33)29-18-3-6-20(32)7-4-18/h5,8,13-16,18,20,32H,3-4,6-7,9-12H2,1-2H3,(H2,27,28)(H,29,33)/t18-,20- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451776
(US10710980, Example 8 | US10947218, Example 8)Show SMILES CC(C)N1CCN(CC1)c1ccc(c(F)c1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.28,wD:29.32,(10.76,-2.31,;9.43,-3.08,;9.43,-4.62,;8.09,-2.31,;6.76,-3.08,;5.43,-2.31,;5.43,-.77,;6.76,,;8.09,-.77,;4.09,,;2.76,-.77,;1.43,,;1.43,1.54,;2.76,2.31,;2.76,3.83,;4.09,1.54,;.09,2.31,;.09,3.85,;-1.24,4.62,;-2.57,3.85,;-3.91,4.62,;-2.57,2.31,;-1.24,1.54,;-3.91,1.54,;-3.91,,;-5.24,2.31,;-6.58,1.54,;-6.71,.01,;-8.11,-.64,;-9.37,.24,;-10.76,-.41,;-9.23,1.77,;-7.84,2.42,)| Show InChI InChI=1S/C25H34FN5O2/c1-16(2)30-9-11-31(12-10-30)19-5-8-21(23(26)14-19)17-13-22(24(27)28-15-17)25(33)29-18-3-6-20(32)7-4-18/h5,8,13-16,18,20,32H,3-4,6-7,9-12H2,1-2H3,(H2,27,28)(H,29,33)/t18-,20- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451776
(US10710980, Example 8 | US10947218, Example 8)Show SMILES CC(C)N1CCN(CC1)c1ccc(c(F)c1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.28,wD:29.32,(10.76,-2.31,;9.43,-3.08,;9.43,-4.62,;8.09,-2.31,;6.76,-3.08,;5.43,-2.31,;5.43,-.77,;6.76,,;8.09,-.77,;4.09,,;2.76,-.77,;1.43,,;1.43,1.54,;2.76,2.31,;2.76,3.83,;4.09,1.54,;.09,2.31,;.09,3.85,;-1.24,4.62,;-2.57,3.85,;-3.91,4.62,;-2.57,2.31,;-1.24,1.54,;-3.91,1.54,;-3.91,,;-5.24,2.31,;-6.58,1.54,;-6.71,.01,;-8.11,-.64,;-9.37,.24,;-10.76,-.41,;-9.23,1.77,;-7.84,2.42,)| Show InChI InChI=1S/C25H34FN5O2/c1-16(2)30-9-11-31(12-10-30)19-5-8-21(23(26)14-19)17-13-22(24(27)28-15-17)25(33)29-18-3-6-20(32)7-4-18/h5,8,13-16,18,20,32H,3-4,6-7,9-12H2,1-2H3,(H2,27,28)(H,29,33)/t18-,20- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451776
(US10710980, Example 8 | US10947218, Example 8)Show SMILES CC(C)N1CCN(CC1)c1ccc(c(F)c1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.28,wD:29.32,(10.76,-2.31,;9.43,-3.08,;9.43,-4.62,;8.09,-2.31,;6.76,-3.08,;5.43,-2.31,;5.43,-.77,;6.76,,;8.09,-.77,;4.09,,;2.76,-.77,;1.43,,;1.43,1.54,;2.76,2.31,;2.76,3.83,;4.09,1.54,;.09,2.31,;.09,3.85,;-1.24,4.62,;-2.57,3.85,;-3.91,4.62,;-2.57,2.31,;-1.24,1.54,;-3.91,1.54,;-3.91,,;-5.24,2.31,;-6.58,1.54,;-6.71,.01,;-8.11,-.64,;-9.37,.24,;-10.76,-.41,;-9.23,1.77,;-7.84,2.42,)| Show InChI InChI=1S/C25H34FN5O2/c1-16(2)30-9-11-31(12-10-30)19-5-8-21(23(26)14-19)17-13-22(24(27)28-15-17)25(33)29-18-3-6-20(32)7-4-18/h5,8,13-16,18,20,32H,3-4,6-7,9-12H2,1-2H3,(H2,27,28)(H,29,33)/t18-,20- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
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